ENSG00000198176

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375370 ENSG00000198176 HEK293_OSMI2_6hA HEK293_TMG_6hB TFDP1 protein_coding protein_coding 110.6067 82.75047 118.9908 12.94209 4.41372 0.5239574 25.314059 7.4938851 20.286372 1.9293219 1.242725 1.4355123 0.21302083 0.089166667 0.170166667 0.08100000 0.09260146 0.01266985 FALSE TRUE
ENST00000408980 ENSG00000198176 HEK293_OSMI2_6hA HEK293_TMG_6hB TFDP1 protein_coding protein_coding 110.6067 82.75047 118.9908 12.94209 4.41372 0.5239574 3.988962 0.3204834 6.706315 0.3204834 1.276446 4.3450203 0.03177917 0.005433333 0.057333333 0.05190000 0.11449226 0.01266985 FALSE TRUE
ENST00000464794 ENSG00000198176 HEK293_OSMI2_6hA HEK293_TMG_6hB TFDP1 protein_coding processed_transcript 110.6067 82.75047 118.9908 12.94209 4.41372 0.5239574 27.977525 29.7680705 17.545699 7.0792464 2.930177 -0.7623109 0.25837500 0.349533333 0.146133333 -0.20340000 0.01266985 0.01266985   FALSE
MSTRG.9109.17 ENSG00000198176 HEK293_OSMI2_6hA HEK293_TMG_6hB TFDP1 protein_coding   110.6067 82.75047 118.9908 12.94209 4.41372 0.5239574 6.154572 0.8800982 16.777911 0.8800982 2.137667 4.2373143 0.06029167 0.014900000 0.140100000 0.12520000 0.10822315 0.01266985 FALSE TRUE
MSTRG.9109.19 ENSG00000198176 HEK293_OSMI2_6hA HEK293_TMG_6hB TFDP1 protein_coding   110.6067 82.75047 118.9908 12.94209 4.41372 0.5239574 16.449661 18.8167725 35.664202 1.8000753 1.326069 0.9220955 0.16286667 0.237033333 0.299733333 0.06270000 0.65777741 0.01266985 FALSE TRUE
MSTRG.9109.6 ENSG00000198176 HEK293_OSMI2_6hA HEK293_TMG_6hB TFDP1 protein_coding   110.6067 82.75047 118.9908 12.94209 4.41372 0.5239574 7.210339 4.9036618 1.080975 1.2694375 1.080975 -2.1711810 0.05595833 0.058100000 0.009766667 -0.04833333 0.16432048 0.01266985 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000198176 E001 0.0000000       13 113584396 113584569 174 +      
ENSG00000198176 E002 0.0000000       13 113584570 113584588 19 +      
ENSG00000198176 E003 0.2027342 0.0396424706 2.980589e-01   13 113584589 113584633 45 + 0.000 0.155 10.546
ENSG00000198176 E004 17.5965234 0.0020092558 4.615004e-05 7.768202e-04 13 113584634 113584720 87 + 1.086 1.447 1.270
ENSG00000198176 E005 19.8887716 0.0018530810 3.187545e-06 7.824529e-05 13 113584721 113584730 10 + 1.119 1.508 1.362
ENSG00000198176 E006 1.2074332 0.0261180097 5.054002e-03   13 113584731 113584732 2 + 0.095 0.600 3.614
ENSG00000198176 E007 1.6000376 0.1749999830 7.505218e-03 4.705599e-02 13 113584733 113584742 10 + 0.095 0.705 4.058
ENSG00000198176 E008 1.9032801 0.1266416789 1.484548e-03 1.350712e-02 13 113584743 113584752 10 + 0.095 0.773 4.336
ENSG00000198176 E009 13.8708240 0.0135729790 6.615715e-11 4.859450e-09 13 113584753 113584798 46 + 0.750 1.485 2.677
ENSG00000198176 E010 105.3665074 0.0128664257 3.935852e-10 2.458250e-08 13 113584799 113584888 90 + 1.794 2.238 1.489
ENSG00000198176 E011 0.1723744 0.0340079357 2.981999e-01   13 113584993 113585000 8 + 0.000 0.155 12.178
ENSG00000198176 E012 1.3269625 0.0136968632 3.994436e-03   13 113585001 113585047 47 + 0.094 0.602 3.627
ENSG00000198176 E013 1.3325720 0.0132383005 3.518876e-02   13 113585048 113585064 17 + 0.172 0.553 2.403
ENSG00000198176 E014 1.1888398 0.0179917337 3.794122e-02   13 113585065 113585106 42 + 0.172 0.551 2.396
ENSG00000198176 E015 1.3558650 0.0198513906 3.053611e-01   13 113585107 113585149 43 + 0.295 0.496 1.130
ENSG00000198176 E016 1.9337078 0.0101324258 4.795521e-02 1.748968e-01 13 113585246 113585250 5 + 0.295 0.646 1.815
ENSG00000198176 E017 2.8094439 0.0088621959 2.884671e-02 1.239207e-01 13 113585251 113585272 22 + 0.391 0.757 1.690
ENSG00000198176 E018 2.6370696 0.0120840963 5.367076e-02 1.882817e-01 13 113585273 113585285 13 + 0.391 0.723 1.552
ENSG00000198176 E019 5.7335632 0.0055835908 1.015914e-02 5.880821e-02 13 113585286 113585332 47 + 0.644 1.000 1.400
ENSG00000198176 E020 14.7051258 0.0024468804 3.314753e-04 4.051542e-03 13 113585333 113585425 93 + 1.030 1.374 1.220
ENSG00000198176 E021 10.3603602 0.0081096263 2.272926e-03 1.888018e-02 13 113585426 113585427 2 + 0.892 1.245 1.287
ENSG00000198176 E022 1.9398648 0.0100924335 4.717124e-02 1.729439e-01 13 113585428 113585579 152 + 0.295 0.646 1.818
ENSG00000198176 E023 12.9485151 0.0528137590 4.934582e-03 3.428127e-02 13 113585580 113585677 98 + 0.919 1.367 1.609
ENSG00000198176 E024 166.4317392 0.0111471546 4.981323e-08 1.988583e-06 13 113585774 113585799 26 + 2.048 2.395 1.161
ENSG00000198176 E025 323.8384966 0.0072468393 2.882425e-07 9.512282e-06 13 113585800 113585849 50 + 2.383 2.642 0.863
ENSG00000198176 E026 214.5742573 0.0198231541 6.399756e-11 4.713035e-09 13 113585966 113586180 215 + 2.056 2.570 1.717
ENSG00000198176 E027 269.7101464 0.0006121040 2.203781e-03 1.842985e-02 13 113610996 113611062 67 + 2.435 2.387 -0.159
ENSG00000198176 E028 406.8353409 0.0022800002 1.943380e-02 9.395622e-02 13 113623180 113623286 107 + 2.610 2.569 -0.138
ENSG00000198176 E029 502.9503374 0.0026235259 2.404128e-01 4.770418e-01 13 113631623 113631744 122 + 2.690 2.682 -0.025
ENSG00000198176 E030 7.2128379 0.0042340279 3.625920e-01 5.978158e-01 13 113631745 113631905 161 + 0.931 0.845 -0.330
ENSG00000198176 E031 660.7699853 0.0007352217 2.053889e-06 5.343102e-05 13 113633120 113633285 166 + 2.827 2.766 -0.201
ENSG00000198176 E032 1.0654865 0.0560268050 8.398046e-01   13 113633286 113633287 2 + 0.295 0.270 -0.175
ENSG00000198176 E033 571.4947131 0.0001313581 9.230666e-15 1.367870e-12 13 113633890 113634033 144 + 2.774 2.682 -0.309
ENSG00000198176 E034 361.2519244 0.0004405100 1.404849e-11 1.180484e-09 13 113634534 113634602 69 + 2.582 2.465 -0.391
ENSG00000198176 E035 515.0367388 0.0001961106 3.053420e-02 1.289422e-01 13 113635977 113636128 152 + 2.700 2.693 -0.024
ENSG00000198176 E036 632.9928581 0.0001416992 3.119827e-02 1.309269e-01 13 113636534 113636700 167 + 2.788 2.786 -0.008
ENSG00000198176 E037 13.8259923 0.0840563262 5.135481e-01 7.106412e-01 13 113637151 113637242 92 + 1.177 1.106 -0.254
ENSG00000198176 E038 24.7914724 0.0721772189 6.061611e-01 7.743067e-01 13 113637620 113637817 198 + 1.343 1.474 0.452
ENSG00000198176 E039 449.4947542 0.0002184176 1.579317e-02 8.106522e-02 13 113637818 113637884 67 + 2.644 2.630 -0.046
ENSG00000198176 E040 245.1829431 0.0028184506 5.424303e-01 7.308366e-01 13 113637885 113637896 12 + 2.374 2.384 0.032
ENSG00000198176 E041 1990.5342224 0.0011115020 1.149644e-01 3.074176e-01 13 113640120 113641473 1354 + 3.283 3.286 0.010