ENSG00000198146

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356321 ENSG00000198146 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF770 protein_coding protein_coding 11.67504 3.527738 22.88791 0.9482528 0.5346771 2.694317 10.88712 3.527738 21.33669 0.9482528 1.107949 2.593114 0.9594208 1 0.9309667 -0.06903333 0.005048197 0.0004711128 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000198146 E001 241.86244 1.584585150 0.308154075 0.54876837 15 34978341 34979411 1071 - 2.127 2.596 1.565
ENSG00000198146 E002 171.58208 1.489250338 0.420606626 0.64413995 15 34979412 34979848 437 - 2.018 2.359 1.141
ENSG00000198146 E003 666.86651 0.013506251 0.183493960 0.40845571 15 34979849 34982095 2247 - 2.661 2.747 0.289
ENSG00000198146 E004 356.38535 0.038606792 0.001830285 0.01591694 15 34982096 34983037 942 - 2.420 2.286 -0.447
ENSG00000198146 E005 180.91645 0.030337413 0.001356095 0.01257899 15 34983038 34983490 453 - 2.131 1.973 -0.528
ENSG00000198146 E006 56.45533 0.003709654 0.173523506 0.39525562 15 34987557 34987673 117 - 1.617 1.639 0.075
ENSG00000198146 E007 31.23002 0.695759656 0.469042517 0.67942220 15 34988116 34988287 172 - 1.336 1.496 0.551