ENSG00000198040

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000438628 ENSG00000198040 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF84 protein_coding protein_coding 4.444249 1.672322 6.707389 0.1086185 0.5606955 1.997446 0.6492421 0.09006769 0.0000000 0.09006769 0.00000000 -3.3229043 0.14185833 0.04803333 0.00000000 -0.04803333 6.411545e-01 1.903396e-10   FALSE
ENST00000535439 ENSG00000198040 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF84 protein_coding protein_coding 4.444249 1.672322 6.707389 0.1086185 0.5606955 1.997446 0.3280289 0.13843488 0.2415892 0.13843488 0.17019449 0.7612398 0.11439167 0.09203333 0.03766667 -0.05436667 9.822264e-01 1.903396e-10 FALSE TRUE
ENST00000536123 ENSG00000198040 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF84 protein_coding protein_coding 4.444249 1.672322 6.707389 0.1086185 0.5606955 1.997446 0.6397865 0.00000000 1.9629119 0.00000000 0.09290927 7.6241827 0.10303750 0.00000000 0.29513333 0.29513333 1.903396e-10 1.903396e-10   FALSE
ENST00000539354 ENSG00000198040 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF84 protein_coding protein_coding 4.444249 1.672322 6.707389 0.1086185 0.5606955 1.997446 1.1041900 0.58057253 1.4070516 0.14741843 0.35805134 1.2627061 0.27970417 0.35180000 0.20390000 -0.14790000 6.071216e-01 1.903396e-10 FALSE TRUE
ENST00000542358 ENSG00000198040 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF84 protein_coding retained_intron 4.444249 1.672322 6.707389 0.1086185 0.5606955 1.997446 0.3303693 0.13738624 0.6730219 0.01077406 0.07095874 2.2123299 0.07090833 0.08236667 0.10033333 0.01796667 9.129562e-01 1.903396e-10   FALSE
ENST00000543310 ENSG00000198040 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF84 protein_coding protein_coding 4.444249 1.672322 6.707389 0.1086185 0.5606955 1.997446 0.3838167 0.14577289 0.3881278 0.14577289 0.38812777 1.3537873 0.07343333 0.08903333 0.05023333 -0.03880000 9.576839e-01 1.903396e-10   FALSE
MSTRG.8368.4 ENSG00000198040 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF84 protein_coding   4.444249 1.672322 6.707389 0.1086185 0.5606955 1.997446 0.2023417 0.06298062 0.7649083 0.06298062 0.20517469 3.4084402 0.04247917 0.04186667 0.12020000 0.07833333 5.384743e-01 1.903396e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000198040 E001 0.1723744 0.030868730 0.1658372359   12 133037292 133037300 9 + 0.000 0.188 11.026
ENSG00000198040 E002 0.1723744 0.030868730 0.1658372359   12 133037301 133037310 10 + 0.000 0.188 12.833
ENSG00000198040 E003 0.7962354 0.018175263 0.1197117156   12 133037311 133037393 83 + 0.141 0.419 2.074
ENSG00000198040 E004 1.2538790 0.101389854 0.2084989791   12 133037394 133037478 85 + 0.247 0.500 1.500
ENSG00000198040 E005 1.7488971 0.011345821 0.0519115276 0.184212580 12 133037479 133037502 24 + 0.293 0.628 1.754
ENSG00000198040 E006 1.4636278 0.012024298 0.0128829181 0.069967565 12 133037503 133037508 6 + 0.198 0.628 2.490
ENSG00000198040 E007 2.5633659 0.009183688 0.0488234042 0.176836585 12 133037509 133037524 16 + 0.405 0.726 1.487
ENSG00000198040 E008 3.2916658 0.007690253 0.0271021287 0.118586128 12 133037525 133037529 5 + 0.466 0.807 1.489
ENSG00000198040 E009 6.8173190 0.004863574 0.1910460020 0.418221528 12 133037530 133037545 16 + 0.792 0.960 0.641
ENSG00000198040 E010 1.7703389 0.112519955 0.5917939298 0.764969938 12 133037546 133037554 9 + 0.438 0.317 -0.696
ENSG00000198040 E011 2.1576601 0.030694131 0.8575138516 0.929098878 12 133037580 133037969 390 + 0.465 0.499 0.168
ENSG00000198040 E012 2.0963066 0.030697911 0.7456841454 0.864109060 12 133038875 133038887 13 + 0.437 0.500 0.319
ENSG00000198040 E013 5.0869793 0.005162445 0.8628122609 0.931918392 12 133038888 133039012 125 + 0.750 0.726 -0.095
ENSG00000198040 E014 1.4736294 0.015329186 0.2658213541 0.505248486 12 133039013 133039047 35 + 0.405 0.188 -1.511
ENSG00000198040 E015 10.9236665 0.002849397 0.0221086380 0.102951965 12 133040434 133041099 666 + 1.085 0.807 -1.046
ENSG00000198040 E016 10.5213680 0.003205843 0.3362659487 0.574694740 12 133041100 133041277 178 + 1.042 0.933 -0.404
ENSG00000198040 E017 13.1852286 0.003129478 0.9277673477 0.965952033 12 133041278 133041284 7 + 1.099 1.110 0.041
ENSG00000198040 E018 34.0101234 0.001364410 0.9272091244 0.965648107 12 133041285 133041482 198 + 1.492 1.488 -0.015
ENSG00000198040 E019 0.1426347 0.031526958 1.0000000000   12 133041483 133041485 3 + 0.076 0.000 -11.500
ENSG00000198040 E020 0.0000000       12 133047621 133047929 309 +      
ENSG00000198040 E021 0.0000000       12 133047930 133047954 25 +      
ENSG00000198040 E022 30.1963790 0.001474157 0.5588638503 0.742442703 12 133047955 133048081 127 + 1.452 1.413 -0.137
ENSG00000198040 E023 4.0563468 0.006760913 0.4693265388 0.679593134 12 133048082 133048752 671 + 0.686 0.569 -0.509
ENSG00000198040 E024 26.1679025 0.001886930 0.0324272791 0.134475295 12 133048753 133048848 96 + 1.419 1.249 -0.591
ENSG00000198040 E025 0.9750270 0.015664782 0.5820207682   12 133050524 133050586 63 + 0.293 0.188 -0.832
ENSG00000198040 E026 11.3924224 0.016500508 0.1943716852 0.422603845 12 133056954 133056956 3 + 1.073 0.906 -0.618
ENSG00000198040 E027 306.0628376 0.001048021 0.8500037770 0.924977838 12 133056957 133063078 6122 + 2.433 2.438 0.016
ENSG00000198040 E028 4.9802030 0.005808703 0.0002777747 0.003506469 12 133063079 133063304 226 + 0.544 1.031 1.960