ENSG00000197969

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-8 / 8
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000360280	ENSG00000197969	HEK293_OSMI2_6hA	HEK293_TMG_6hB	VPS13A	protein_coding	protein_coding	5.627647	2.020535	10.52197	0.04536444	0.3531127	2.374843	0.01922144	0.1399070	0.0000000	0.13990704	0.00000000	-3.905996	0.01037083	0.06840000	0.00000000	-0.06840000	6.448371e-01	8.135408e-13	FALSE	TRUE
ENST00000376646	ENSG00000197969	HEK293_OSMI2_6hA	HEK293_TMG_6hB	VPS13A	protein_coding	processed_transcript	5.627647	2.020535	10.52197	0.04536444	0.3531127	2.374843	0.03200102	0.2560082	0.0000000	0.18766169	0.00000000	-4.733399	0.01558750	0.12470000	0.00000000	-0.12470000	9.338123e-02	8.135408e-13	FALSE	FALSE
ENST00000471439	ENSG00000197969	HEK293_OSMI2_6hA	HEK293_TMG_6hB	VPS13A	protein_coding	processed_transcript	5.627647	2.020535	10.52197	0.04536444	0.3531127	2.374843	0.32532106	0.1423347	0.4159932	0.02976816	0.15128208	1.483586	0.06392500	0.07033333	0.03946667	-0.03086667	7.111429e-01	8.135408e-13		FALSE
ENST00000484581	ENSG00000197969	HEK293_OSMI2_6hA	HEK293_TMG_6hB	VPS13A	protein_coding	processed_transcript	5.627647	2.020535	10.52197	0.04536444	0.3531127	2.374843	0.72717492	0.2750242	0.8955091	0.19405374	0.14790038	1.667645	0.21601667	0.14013333	0.08480000	-0.05533333	1.000000e+00	8.135408e-13	FALSE	FALSE
ENST00000643348	ENSG00000197969	HEK293_OSMI2_6hA	HEK293_TMG_6hB	VPS13A	protein_coding	protein_coding	5.627647	2.020535	10.52197	0.04536444	0.3531127	2.374843	0.68108063	0.3473350	0.9458236	0.01974207	0.05848966	1.419467	0.14222917	0.17243333	0.08986667	-0.08256667	1.893731e-01	8.135408e-13	FALSE	TRUE
ENST00000645632	ENSG00000197969	HEK293_OSMI2_6hA	HEK293_TMG_6hB	VPS13A	protein_coding	protein_coding	5.627647	2.020535	10.52197	0.04536444	0.3531127	2.374843	1.39484850	0.3353210	2.4480890	0.03853446	0.10134860	2.831527	0.20046250	0.16606667	0.23350000	0.06743333	6.367769e-01	8.135408e-13	FALSE	TRUE
MSTRG.32893.2	ENSG00000197969	HEK293_OSMI2_6hA	HEK293_TMG_6hB	VPS13A	protein_coding		5.627647	2.020535	10.52197	0.04536444	0.3531127	2.374843	1.01905125	0.0000000	2.8926182	0.00000000	0.09759163	8.181211	0.10592083	0.00000000	0.27490000	0.27490000	8.135408e-13	8.135408e-13	TRUE	TRUE
MSTRG.32893.7	ENSG00000197969	HEK293_OSMI2_6hA	HEK293_TMG_6hB	VPS13A	protein_coding		5.627647	2.020535	10.52197	0.04536444	0.3531127	2.374843	0.74410996	0.3237628	1.6339132	0.17331696	0.11041785	2.300239	0.13530833	0.16013333	0.15633333	-0.00380000	9.466648e-01	8.135408e-13	TRUE	TRUE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

Rows: 1-10 / 95
Columns:
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groupID
featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_6hB
HEK293_OSMI2_6hA
log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_6hB	HEK293_OSMI2_6hA	log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB

ENSG00000197969	E001	0.0000000				9	77177445	77177533	89	+
ENSG00000197969	E002	0.0000000				9	77177534	77177535	2	+
ENSG00000197969	E003	8.8469167	0.5411749644	6.128871e-01	7.788700e-01	9	77177536	77177804	269	+	0.877	0.965	0.331
ENSG00000197969	E004	8.5776680	0.1598646871	7.304900e-01	8.545102e-01	9	77199945	77199988	44	+	0.876	0.930	0.206
ENSG00000197969	E005	9.0089481	0.0237720285	4.338618e-01	6.541168e-01	9	77201365	77201407	43	+	0.884	1.001	0.439
ENSG00000197969	E006	14.0469783	0.0067849160	4.646190e-01	6.763323e-01	9	77205313	77205408	96	+	1.085	1.004	-0.297
ENSG00000197969	E007	17.7990547	0.0127807033	1.381187e-03	1.276436e-02	9	77205978	77206079	102	+	1.214	0.772	-1.645
ENSG00000197969	E008	15.9409472	0.0025786724	7.030950e-03	4.478630e-02	9	77209423	77209487	65	+	1.158	0.820	-1.258
ENSG00000197969	E009	13.4364908	0.0181406077	1.271198e-01	3.272475e-01	9	77209488	77209532	45	+	1.077	0.864	-0.792
ENSG00000197969	E010	14.4362203	0.0023749113	3.990266e-02	1.544528e-01	9	77210616	77210675	60	+	1.116	0.863	-0.936
ENSG00000197969	E011	4.9277764	0.0051669021	2.798818e-01	5.199633e-01	9	77211213	77211617	405	+	0.645	0.819	0.711
ENSG00000197969	E012	9.9220834	0.0521892203	6.296960e-01	7.902926e-01	9	77212790	77212968	179	+	0.937	0.870	-0.255
ENSG00000197969	E013	15.2560341	0.0026433262	4.506048e-01	6.661387e-01	9	77212969	77213028	60	+	1.111	1.034	-0.280
ENSG00000197969	E014	16.8340499	0.0026236814	3.540115e-01	5.908473e-01	9	77213234	77213314	81	+	1.154	1.061	-0.336
ENSG00000197969	E015	17.5687352	0.0019998284	2.270722e-02	1.049880e-01	9	77214329	77214386	58	+	1.197	0.939	-0.936
ENSG00000197969	E016	26.0945155	0.0014287236	4.031735e-03	2.934642e-02	9	77219954	77220081	128	+	1.362	1.086	-0.976
ENSG00000197969	E017	23.6264847	0.0181010877	7.343787e-02	2.316604e-01	9	77220277	77220383	107	+	1.308	1.111	-0.699
ENSG00000197969	E018	28.9829393	0.0093902710	1.344175e-02	7.215801e-02	9	77221185	77221356	172	+	1.398	1.156	-0.852
ENSG00000197969	E019	16.5543110	0.0022649565	3.617019e-04	4.353934e-03	9	77225926	77225988	63	+	1.189	0.716	-1.782
ENSG00000197969	E020	24.1335028	0.0014492389	1.250772e-03	1.179727e-02	9	77226466	77226598	133	+	1.336	1.004	-1.185
ENSG00000197969	E021	20.0329400	0.0025718303	9.064719e-03	5.411079e-02	9	77227391	77227485	95	+	1.258	0.973	-1.027
ENSG00000197969	E022	22.5355434	0.0074316713	6.387169e-03	4.162272e-02	9	77228122	77228264	143	+	1.307	1.004	-1.083
ENSG00000197969	E023	18.2091695	0.0022632840	1.023735e-01	2.860215e-01	9	77238002	77238191	190	+	1.204	1.033	-0.616
ENSG00000197969	E024	18.8265695	0.0044909399	4.717322e-03	3.309551e-02	9	77238272	77238386	115	+	1.235	0.903	-1.211
ENSG00000197969	E025	25.1889217	0.0024186765	5.045608e-02	1.807303e-01	9	77247259	77247395	137	+	1.336	1.155	-0.639
ENSG00000197969	E026	27.7875375	0.0013543499	3.953552e-02	1.535528e-01	9	77250097	77250229	133	+	1.376	1.196	-0.631
ENSG00000197969	E027	30.7334632	0.0012523154	2.025918e-04	2.703713e-03	9	77252235	77252352	118	+	1.434	1.086	-1.225
ENSG00000197969	E028	28.6132160	0.0049017520	3.834175e-02	1.504844e-01	9	77260086	77260224	139	+	1.385	1.196	-0.663
ENSG00000197969	E029	24.7399158	0.0019399304	1.240254e-02	6.805726e-02	9	77273280	77273364	85	+	1.330	1.086	-0.864
ENSG00000197969	E030	31.8963153	0.0013971685	2.734968e-02	1.193525e-01	9	77275498	77275652	155	+	1.432	1.250	-0.634
ENSG00000197969	E031	31.6286713	0.0028411477	1.048173e-01	2.903153e-01	9	77276065	77276221	157	+	1.429	1.298	-0.455
ENSG00000197969	E032	0.0000000				9	77279846	77279959	114	+
ENSG00000197969	E033	25.3547837	0.0100259813	1.342265e-02	7.209421e-02	9	77280159	77280238	80	+	1.350	1.085	-0.938
ENSG00000197969	E034	22.1473254	0.0034328331	7.353248e-02	2.318340e-01	9	77281867	77281926	60	+	1.285	1.110	-0.622
ENSG00000197969	E035	29.6168219	0.0014402238	1.076407e-01	2.950935e-01	9	77282121	77282274	154	+	1.397	1.267	-0.454
ENSG00000197969	E036	23.0770812	0.0020421193	1.365366e-01	3.421822e-01	9	77283355	77283471	117	+	1.292	1.155	-0.483
ENSG00000197969	E037	20.5198754	0.0054689650	2.447821e-01	4.819724e-01	9	77283547	77283650	104	+	1.246	1.133	-0.402
ENSG00000197969	E038	22.9271945	0.0016309816	5.313529e-02	1.870897e-01	9	77293341	77293493	153	+	1.296	1.110	-0.657
ENSG00000197969	E039	11.5139157	0.0030078472	2.297886e-02	1.058872e-01	9	77293494	77293508	15	+	1.034	0.716	-1.226
ENSG00000197969	E040	38.8279966	0.0011588252	8.335817e-03	5.086645e-02	9	77295542	77295846	305	+	1.516	1.314	-0.700
ENSG00000197969	E041	32.8559446	0.0011653284	5.824956e-03	3.887798e-02	9	77302915	77303062	148	+	1.448	1.215	-0.814
ENSG00000197969	E042	0.0000000				9	77305557	77305637	81	+
ENSG00000197969	E043	31.1369028	0.0016369664	8.646304e-03	5.224881e-02	9	77307945	77308098	154	+	1.425	1.196	-0.799
ENSG00000197969	E044	29.9424490	0.0022859314	6.945476e-02	2.236785e-01	9	77313992	77314119	128	+	1.402	1.250	-0.530
ENSG00000197969	E045	31.6117669	0.0214157148	1.169335e-01	3.107229e-01	9	77314495	77314664	170	+	1.429	1.264	-0.573
ENSG00000197969	E046	30.8796544	0.0197744376	6.287513e-01	7.896848e-01	9	77315253	77315470	218	+	1.400	1.356	-0.153
ENSG00000197969	E047	40.8009375	0.0009439529	6.060325e-01	7.742307e-01	9	77316174	77316406	233	+	1.510	1.483	-0.095
ENSG00000197969	E048	25.0971205	0.0445466345	5.614269e-01	7.442723e-01	9	77317606	77317698	93	+	1.315	1.257	-0.203
ENSG00000197969	E049	36.9072375	0.3171992704	3.027644e-01	5.433468e-01	9	77318235	77318520	286	+	1.423	1.629	0.704
ENSG00000197969	E050	18.9543859	0.6519735691	2.478407e-01	4.856655e-01	9	77318521	77318591	71	+	1.119	1.427	1.081
ENSG00000197969	E051	22.3969187	0.0786382662	7.214375e-02	2.291145e-01	9	77319572	77319673	102	+	1.205	1.460	0.889
ENSG00000197969	E052	33.3906704	0.0263932586	5.261301e-01	7.193122e-01	9	77321169	77321327	159	+	1.411	1.479	0.236
ENSG00000197969	E053	45.9297411	0.0010107603	3.259243e-01	5.651823e-01	9	77321491	77321746	256	+	1.547	1.619	0.246
ENSG00000197969	E054	41.8873165	0.0008440668	6.330707e-01	7.923580e-01	9	77323067	77323227	161	+	1.514	1.556	0.143
ENSG00000197969	E055	36.5531662	0.0010276765	8.200000e-02	2.487582e-01	9	77332010	77332113	104	+	1.484	1.356	-0.441
ENSG00000197969	E056	49.0263910	0.0039672941	3.770169e-01	6.098658e-01	9	77337255	77337537	283	+	1.594	1.539	-0.186
ENSG00000197969	E057	5.7079258	0.0053674945	3.781363e-03	2.791889e-02	9	77337538	77339182	1645	+	0.631	1.033	1.580
ENSG00000197969	E058	27.3663735	0.0262276857	1.548172e-01	3.691178e-01	9	77339516	77339582	67	+	1.365	1.199	-0.585
ENSG00000197969	E059	57.4410132	0.0006523970	4.833707e-01	6.893240e-01	9	77339583	77339911	329	+	1.659	1.626	-0.113
ENSG00000197969	E060	16.3470040	0.0020697095	4.248122e-04	4.975372e-03	9	77340178	77340200	23	+	1.184	0.716	-1.766
ENSG00000197969	E061	24.5089035	0.0014940880	6.533320e-03	4.238484e-02	9	77340201	77340282	82	+	1.330	1.061	-0.957
ENSG00000197969	E062	36.9768294	0.0011061946	1.188482e-02	6.595159e-02	9	77340404	77340550	147	+	1.494	1.299	-0.677
ENSG00000197969	E063	2.3469804	0.1387702139	3.274879e-01	5.665665e-01	9	77340551	77340711	161	+	0.473	0.231	-1.487
ENSG00000197969	E064	35.6035367	0.0013439488	2.220904e-02	1.033033e-01	9	77344153	77344281	129	+	1.477	1.299	-0.620
ENSG00000197969	E065	42.7040892	0.0013397779	1.076850e-02	6.140210e-02	9	77345009	77345142	134	+	1.554	1.369	-0.638
ENSG00000197969	E066	0.0000000				9	77350917	77351316	400	+
ENSG00000197969	E067	36.4737411	0.0011831372	5.914316e-02	2.008613e-01	9	77351317	77351446	130	+	1.484	1.342	-0.489
ENSG00000197969	E068	62.6848762	0.0007425408	1.644319e-01	3.832919e-01	9	77353409	77353641	233	+	1.700	1.626	-0.250
ENSG00000197969	E069	47.8629655	0.0008614721	7.651851e-01	8.757692e-01	9	77356714	77356867	154	+	1.575	1.565	-0.035
ENSG00000197969	E070	45.1343787	0.0030631507	3.766167e-01	6.095668e-01	9	77357692	77357838	147	+	1.537	1.605	0.233
ENSG00000197969	E071	31.3794620	0.0012026321	4.423416e-01	6.602949e-01	9	77358357	77358438	82	+	1.384	1.452	0.235
ENSG00000197969	E072	34.2405695	0.0010582965	6.223855e-01	7.854654e-01	9	77359333	77359402	70	+	1.427	1.473	0.158
ENSG00000197969	E073	31.3178355	0.0024619991	9.657966e-02	2.757704e-01	9	77360536	77360641	106	+	1.375	1.511	0.468
ENSG00000197969	E074	34.9122840	0.0013465875	1.199413e-04	1.737210e-03	9	77365460	77365573	114	+	1.384	1.654	0.926
ENSG00000197969	E075	53.6874839	0.0006958107	1.957973e-03	1.678660e-02	9	77366727	77366872	146	+	1.587	1.771	0.626
ENSG00000197969	E076	43.7723752	0.0013003616	4.293907e-01	6.505814e-01	9	77368055	77368136	82	+	1.528	1.589	0.209
ENSG00000197969	E077	47.7086693	0.0008952071	9.566906e-01	9.802114e-01	9	77369299	77369412	114	+	1.575	1.581	0.020
ENSG00000197969	E078	41.9437485	0.0008949196	8.811731e-01	9.419164e-01	9	77370257	77370332	76	+	1.522	1.521	-0.004
ENSG00000197969	E079	67.2931405	0.0005650881	1.449205e-01	3.548531e-01	9	77370415	77370578	164	+	1.705	1.791	0.293
ENSG00000197969	E080	40.8379732	0.0009329331	8.580325e-01	9.293199e-01	9	77370890	77370935	46	+	1.508	1.530	0.074
ENSG00000197969	E081	64.1691139	0.0024487240	5.746270e-01	7.534039e-01	9	77371026	77371149	124	+	1.691	1.734	0.145
ENSG00000197969	E082	55.9580976	0.0032294173	2.675373e-01	5.072197e-01	9	77381976	77382087	112	+	1.625	1.705	0.273
ENSG00000197969	E083	39.3143770	0.0010294395	4.140305e-01	6.390275e-01	9	77382279	77383006	728	+	1.482	1.547	0.226
ENSG00000197969	E084	20.9531489	0.0144372102	8.050717e-06	1.738967e-04	9	77384585	77385191	607	+	1.113	1.547	1.517
ENSG00000197969	E085	4.6384592	0.0408879559	6.478673e-01	8.021140e-01	9	77389711	77389994	284	+	0.663	0.580	-0.360
ENSG00000197969	E086	3.6694015	0.0353881581	9.573786e-01	9.805435e-01	9	77389995	77390142	148	+	0.567	0.581	0.062
ENSG00000197969	E087	0.7007164	0.4334234603	2.646627e-01		9	77395710	77395868	159	+	0.116	0.385	2.222
ENSG00000197969	E088	31.1982418	0.0012842487	4.094329e-02	1.571609e-01	9	77403236	77403321	86	+	1.359	1.521	0.557
ENSG00000197969	E089	36.0490160	0.0016077856	4.811644e-01	6.878817e-01	9	77405864	77405967	104	+	1.442	1.502	0.209
ENSG00000197969	E090	20.7416188	0.0252021515	2.004006e-01	4.302481e-01	9	77405968	77405987	20	+	1.193	1.342	0.522
ENSG00000197969	E091	31.3190814	0.0076358253	1.001118e-01	2.820185e-01	9	77407533	77407607	75	+	1.366	1.511	0.499
ENSG00000197969	E092	0.0000000				9	77407608	77407659	52	+
ENSG00000197969	E093	46.1484908	0.0032757362	1.677228e-04	2.308574e-03	9	77415956	77416179	224	+	1.501	1.750	0.849
ENSG00000197969	E094	243.2510526	0.0003519319	1.879253e-42	3.668280e-39	9	77416180	77421537	5358	+	2.184	2.536	1.175
ENSG00000197969	E095	0.0000000				9	77436464	77436501	38	+

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000197969

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3