ENSG00000197969

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360280 ENSG00000197969 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13A protein_coding protein_coding 5.627647 2.020535 10.52197 0.04536444 0.3531127 2.374843 0.01922144 0.1399070 0.0000000 0.13990704 0.00000000 -3.905996 0.01037083 0.06840000 0.00000000 -0.06840000 6.448371e-01 8.135408e-13 FALSE TRUE
ENST00000376646 ENSG00000197969 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13A protein_coding processed_transcript 5.627647 2.020535 10.52197 0.04536444 0.3531127 2.374843 0.03200102 0.2560082 0.0000000 0.18766169 0.00000000 -4.733399 0.01558750 0.12470000 0.00000000 -0.12470000 9.338123e-02 8.135408e-13 FALSE FALSE
ENST00000471439 ENSG00000197969 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13A protein_coding processed_transcript 5.627647 2.020535 10.52197 0.04536444 0.3531127 2.374843 0.32532106 0.1423347 0.4159932 0.02976816 0.15128208 1.483586 0.06392500 0.07033333 0.03946667 -0.03086667 7.111429e-01 8.135408e-13   FALSE
ENST00000484581 ENSG00000197969 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13A protein_coding processed_transcript 5.627647 2.020535 10.52197 0.04536444 0.3531127 2.374843 0.72717492 0.2750242 0.8955091 0.19405374 0.14790038 1.667645 0.21601667 0.14013333 0.08480000 -0.05533333 1.000000e+00 8.135408e-13 FALSE FALSE
ENST00000643348 ENSG00000197969 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13A protein_coding protein_coding 5.627647 2.020535 10.52197 0.04536444 0.3531127 2.374843 0.68108063 0.3473350 0.9458236 0.01974207 0.05848966 1.419467 0.14222917 0.17243333 0.08986667 -0.08256667 1.893731e-01 8.135408e-13 FALSE TRUE
ENST00000645632 ENSG00000197969 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13A protein_coding protein_coding 5.627647 2.020535 10.52197 0.04536444 0.3531127 2.374843 1.39484850 0.3353210 2.4480890 0.03853446 0.10134860 2.831527 0.20046250 0.16606667 0.23350000 0.06743333 6.367769e-01 8.135408e-13 FALSE TRUE
MSTRG.32893.2 ENSG00000197969 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13A protein_coding   5.627647 2.020535 10.52197 0.04536444 0.3531127 2.374843 1.01905125 0.0000000 2.8926182 0.00000000 0.09759163 8.181211 0.10592083 0.00000000 0.27490000 0.27490000 8.135408e-13 8.135408e-13 TRUE TRUE
MSTRG.32893.7 ENSG00000197969 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13A protein_coding   5.627647 2.020535 10.52197 0.04536444 0.3531127 2.374843 0.74410996 0.3237628 1.6339132 0.17331696 0.11041785 2.300239 0.13530833 0.16013333 0.15633333 -0.00380000 9.466648e-01 8.135408e-13 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000197969 E001 0.0000000       9 77177445 77177533 89 +      
ENSG00000197969 E002 0.0000000       9 77177534 77177535 2 +      
ENSG00000197969 E003 8.8469167 0.5411749644 6.128871e-01 7.788700e-01 9 77177536 77177804 269 + 0.877 0.965 0.331
ENSG00000197969 E004 8.5776680 0.1598646871 7.304900e-01 8.545102e-01 9 77199945 77199988 44 + 0.876 0.930 0.206
ENSG00000197969 E005 9.0089481 0.0237720285 4.338618e-01 6.541168e-01 9 77201365 77201407 43 + 0.884 1.001 0.439
ENSG00000197969 E006 14.0469783 0.0067849160 4.646190e-01 6.763323e-01 9 77205313 77205408 96 + 1.085 1.004 -0.297
ENSG00000197969 E007 17.7990547 0.0127807033 1.381187e-03 1.276436e-02 9 77205978 77206079 102 + 1.214 0.772 -1.645
ENSG00000197969 E008 15.9409472 0.0025786724 7.030950e-03 4.478630e-02 9 77209423 77209487 65 + 1.158 0.820 -1.258
ENSG00000197969 E009 13.4364908 0.0181406077 1.271198e-01 3.272475e-01 9 77209488 77209532 45 + 1.077 0.864 -0.792
ENSG00000197969 E010 14.4362203 0.0023749113 3.990266e-02 1.544528e-01 9 77210616 77210675 60 + 1.116 0.863 -0.936
ENSG00000197969 E011 4.9277764 0.0051669021 2.798818e-01 5.199633e-01 9 77211213 77211617 405 + 0.645 0.819 0.711
ENSG00000197969 E012 9.9220834 0.0521892203 6.296960e-01 7.902926e-01 9 77212790 77212968 179 + 0.937 0.870 -0.255
ENSG00000197969 E013 15.2560341 0.0026433262 4.506048e-01 6.661387e-01 9 77212969 77213028 60 + 1.111 1.034 -0.280
ENSG00000197969 E014 16.8340499 0.0026236814 3.540115e-01 5.908473e-01 9 77213234 77213314 81 + 1.154 1.061 -0.336
ENSG00000197969 E015 17.5687352 0.0019998284 2.270722e-02 1.049880e-01 9 77214329 77214386 58 + 1.197 0.939 -0.936
ENSG00000197969 E016 26.0945155 0.0014287236 4.031735e-03 2.934642e-02 9 77219954 77220081 128 + 1.362 1.086 -0.976
ENSG00000197969 E017 23.6264847 0.0181010877 7.343787e-02 2.316604e-01 9 77220277 77220383 107 + 1.308 1.111 -0.699
ENSG00000197969 E018 28.9829393 0.0093902710 1.344175e-02 7.215801e-02 9 77221185 77221356 172 + 1.398 1.156 -0.852
ENSG00000197969 E019 16.5543110 0.0022649565 3.617019e-04 4.353934e-03 9 77225926 77225988 63 + 1.189 0.716 -1.782
ENSG00000197969 E020 24.1335028 0.0014492389 1.250772e-03 1.179727e-02 9 77226466 77226598 133 + 1.336 1.004 -1.185
ENSG00000197969 E021 20.0329400 0.0025718303 9.064719e-03 5.411079e-02 9 77227391 77227485 95 + 1.258 0.973 -1.027
ENSG00000197969 E022 22.5355434 0.0074316713 6.387169e-03 4.162272e-02 9 77228122 77228264 143 + 1.307 1.004 -1.083
ENSG00000197969 E023 18.2091695 0.0022632840 1.023735e-01 2.860215e-01 9 77238002 77238191 190 + 1.204 1.033 -0.616
ENSG00000197969 E024 18.8265695 0.0044909399 4.717322e-03 3.309551e-02 9 77238272 77238386 115 + 1.235 0.903 -1.211
ENSG00000197969 E025 25.1889217 0.0024186765 5.045608e-02 1.807303e-01 9 77247259 77247395 137 + 1.336 1.155 -0.639
ENSG00000197969 E026 27.7875375 0.0013543499 3.953552e-02 1.535528e-01 9 77250097 77250229 133 + 1.376 1.196 -0.631
ENSG00000197969 E027 30.7334632 0.0012523154 2.025918e-04 2.703713e-03 9 77252235 77252352 118 + 1.434 1.086 -1.225
ENSG00000197969 E028 28.6132160 0.0049017520 3.834175e-02 1.504844e-01 9 77260086 77260224 139 + 1.385 1.196 -0.663
ENSG00000197969 E029 24.7399158 0.0019399304 1.240254e-02 6.805726e-02 9 77273280 77273364 85 + 1.330 1.086 -0.864
ENSG00000197969 E030 31.8963153 0.0013971685 2.734968e-02 1.193525e-01 9 77275498 77275652 155 + 1.432 1.250 -0.634
ENSG00000197969 E031 31.6286713 0.0028411477 1.048173e-01 2.903153e-01 9 77276065 77276221 157 + 1.429 1.298 -0.455
ENSG00000197969 E032 0.0000000       9 77279846 77279959 114 +      
ENSG00000197969 E033 25.3547837 0.0100259813 1.342265e-02 7.209421e-02 9 77280159 77280238 80 + 1.350 1.085 -0.938
ENSG00000197969 E034 22.1473254 0.0034328331 7.353248e-02 2.318340e-01 9 77281867 77281926 60 + 1.285 1.110 -0.622
ENSG00000197969 E035 29.6168219 0.0014402238 1.076407e-01 2.950935e-01 9 77282121 77282274 154 + 1.397 1.267 -0.454
ENSG00000197969 E036 23.0770812 0.0020421193 1.365366e-01 3.421822e-01 9 77283355 77283471 117 + 1.292 1.155 -0.483
ENSG00000197969 E037 20.5198754 0.0054689650 2.447821e-01 4.819724e-01 9 77283547 77283650 104 + 1.246 1.133 -0.402
ENSG00000197969 E038 22.9271945 0.0016309816 5.313529e-02 1.870897e-01 9 77293341 77293493 153 + 1.296 1.110 -0.657
ENSG00000197969 E039 11.5139157 0.0030078472 2.297886e-02 1.058872e-01 9 77293494 77293508 15 + 1.034 0.716 -1.226
ENSG00000197969 E040 38.8279966 0.0011588252 8.335817e-03 5.086645e-02 9 77295542 77295846 305 + 1.516 1.314 -0.700
ENSG00000197969 E041 32.8559446 0.0011653284 5.824956e-03 3.887798e-02 9 77302915 77303062 148 + 1.448 1.215 -0.814
ENSG00000197969 E042 0.0000000       9 77305557 77305637 81 +      
ENSG00000197969 E043 31.1369028 0.0016369664 8.646304e-03 5.224881e-02 9 77307945 77308098 154 + 1.425 1.196 -0.799
ENSG00000197969 E044 29.9424490 0.0022859314 6.945476e-02 2.236785e-01 9 77313992 77314119 128 + 1.402 1.250 -0.530
ENSG00000197969 E045 31.6117669 0.0214157148 1.169335e-01 3.107229e-01 9 77314495 77314664 170 + 1.429 1.264 -0.573
ENSG00000197969 E046 30.8796544 0.0197744376 6.287513e-01 7.896848e-01 9 77315253 77315470 218 + 1.400 1.356 -0.153
ENSG00000197969 E047 40.8009375 0.0009439529 6.060325e-01 7.742307e-01 9 77316174 77316406 233 + 1.510 1.483 -0.095
ENSG00000197969 E048 25.0971205 0.0445466345 5.614269e-01 7.442723e-01 9 77317606 77317698 93 + 1.315 1.257 -0.203
ENSG00000197969 E049 36.9072375 0.3171992704 3.027644e-01 5.433468e-01 9 77318235 77318520 286 + 1.423 1.629 0.704
ENSG00000197969 E050 18.9543859 0.6519735691 2.478407e-01 4.856655e-01 9 77318521 77318591 71 + 1.119 1.427 1.081
ENSG00000197969 E051 22.3969187 0.0786382662 7.214375e-02 2.291145e-01 9 77319572 77319673 102 + 1.205 1.460 0.889
ENSG00000197969 E052 33.3906704 0.0263932586 5.261301e-01 7.193122e-01 9 77321169 77321327 159 + 1.411 1.479 0.236
ENSG00000197969 E053 45.9297411 0.0010107603 3.259243e-01 5.651823e-01 9 77321491 77321746 256 + 1.547 1.619 0.246
ENSG00000197969 E054 41.8873165 0.0008440668 6.330707e-01 7.923580e-01 9 77323067 77323227 161 + 1.514 1.556 0.143
ENSG00000197969 E055 36.5531662 0.0010276765 8.200000e-02 2.487582e-01 9 77332010 77332113 104 + 1.484 1.356 -0.441
ENSG00000197969 E056 49.0263910 0.0039672941 3.770169e-01 6.098658e-01 9 77337255 77337537 283 + 1.594 1.539 -0.186
ENSG00000197969 E057 5.7079258 0.0053674945 3.781363e-03 2.791889e-02 9 77337538 77339182 1645 + 0.631 1.033 1.580
ENSG00000197969 E058 27.3663735 0.0262276857 1.548172e-01 3.691178e-01 9 77339516 77339582 67 + 1.365 1.199 -0.585
ENSG00000197969 E059 57.4410132 0.0006523970 4.833707e-01 6.893240e-01 9 77339583 77339911 329 + 1.659 1.626 -0.113
ENSG00000197969 E060 16.3470040 0.0020697095 4.248122e-04 4.975372e-03 9 77340178 77340200 23 + 1.184 0.716 -1.766
ENSG00000197969 E061 24.5089035 0.0014940880 6.533320e-03 4.238484e-02 9 77340201 77340282 82 + 1.330 1.061 -0.957
ENSG00000197969 E062 36.9768294 0.0011061946 1.188482e-02 6.595159e-02 9 77340404 77340550 147 + 1.494 1.299 -0.677
ENSG00000197969 E063 2.3469804 0.1387702139 3.274879e-01 5.665665e-01 9 77340551 77340711 161 + 0.473 0.231 -1.487
ENSG00000197969 E064 35.6035367 0.0013439488 2.220904e-02 1.033033e-01 9 77344153 77344281 129 + 1.477 1.299 -0.620
ENSG00000197969 E065 42.7040892 0.0013397779 1.076850e-02 6.140210e-02 9 77345009 77345142 134 + 1.554 1.369 -0.638
ENSG00000197969 E066 0.0000000       9 77350917 77351316 400 +      
ENSG00000197969 E067 36.4737411 0.0011831372 5.914316e-02 2.008613e-01 9 77351317 77351446 130 + 1.484 1.342 -0.489
ENSG00000197969 E068 62.6848762 0.0007425408 1.644319e-01 3.832919e-01 9 77353409 77353641 233 + 1.700 1.626 -0.250
ENSG00000197969 E069 47.8629655 0.0008614721 7.651851e-01 8.757692e-01 9 77356714 77356867 154 + 1.575 1.565 -0.035
ENSG00000197969 E070 45.1343787 0.0030631507 3.766167e-01 6.095668e-01 9 77357692 77357838 147 + 1.537 1.605 0.233
ENSG00000197969 E071 31.3794620 0.0012026321 4.423416e-01 6.602949e-01 9 77358357 77358438 82 + 1.384 1.452 0.235
ENSG00000197969 E072 34.2405695 0.0010582965 6.223855e-01 7.854654e-01 9 77359333 77359402 70 + 1.427 1.473 0.158
ENSG00000197969 E073 31.3178355 0.0024619991 9.657966e-02 2.757704e-01 9 77360536 77360641 106 + 1.375 1.511 0.468
ENSG00000197969 E074 34.9122840 0.0013465875 1.199413e-04 1.737210e-03 9 77365460 77365573 114 + 1.384 1.654 0.926
ENSG00000197969 E075 53.6874839 0.0006958107 1.957973e-03 1.678660e-02 9 77366727 77366872 146 + 1.587 1.771 0.626
ENSG00000197969 E076 43.7723752 0.0013003616 4.293907e-01 6.505814e-01 9 77368055 77368136 82 + 1.528 1.589 0.209
ENSG00000197969 E077 47.7086693 0.0008952071 9.566906e-01 9.802114e-01 9 77369299 77369412 114 + 1.575 1.581 0.020
ENSG00000197969 E078 41.9437485 0.0008949196 8.811731e-01 9.419164e-01 9 77370257 77370332 76 + 1.522 1.521 -0.004
ENSG00000197969 E079 67.2931405 0.0005650881 1.449205e-01 3.548531e-01 9 77370415 77370578 164 + 1.705 1.791 0.293
ENSG00000197969 E080 40.8379732 0.0009329331 8.580325e-01 9.293199e-01 9 77370890 77370935 46 + 1.508 1.530 0.074
ENSG00000197969 E081 64.1691139 0.0024487240 5.746270e-01 7.534039e-01 9 77371026 77371149 124 + 1.691 1.734 0.145
ENSG00000197969 E082 55.9580976 0.0032294173 2.675373e-01 5.072197e-01 9 77381976 77382087 112 + 1.625 1.705 0.273
ENSG00000197969 E083 39.3143770 0.0010294395 4.140305e-01 6.390275e-01 9 77382279 77383006 728 + 1.482 1.547 0.226
ENSG00000197969 E084 20.9531489 0.0144372102 8.050717e-06 1.738967e-04 9 77384585 77385191 607 + 1.113 1.547 1.517
ENSG00000197969 E085 4.6384592 0.0408879559 6.478673e-01 8.021140e-01 9 77389711 77389994 284 + 0.663 0.580 -0.360
ENSG00000197969 E086 3.6694015 0.0353881581 9.573786e-01 9.805435e-01 9 77389995 77390142 148 + 0.567 0.581 0.062
ENSG00000197969 E087 0.7007164 0.4334234603 2.646627e-01   9 77395710 77395868 159 + 0.116 0.385 2.222
ENSG00000197969 E088 31.1982418 0.0012842487 4.094329e-02 1.571609e-01 9 77403236 77403321 86 + 1.359 1.521 0.557
ENSG00000197969 E089 36.0490160 0.0016077856 4.811644e-01 6.878817e-01 9 77405864 77405967 104 + 1.442 1.502 0.209
ENSG00000197969 E090 20.7416188 0.0252021515 2.004006e-01 4.302481e-01 9 77405968 77405987 20 + 1.193 1.342 0.522
ENSG00000197969 E091 31.3190814 0.0076358253 1.001118e-01 2.820185e-01 9 77407533 77407607 75 + 1.366 1.511 0.499
ENSG00000197969 E092 0.0000000       9 77407608 77407659 52 +      
ENSG00000197969 E093 46.1484908 0.0032757362 1.677228e-04 2.308574e-03 9 77415956 77416179 224 + 1.501 1.750 0.849
ENSG00000197969 E094 243.2510526 0.0003519319 1.879253e-42 3.668280e-39 9 77416180 77421537 5358 + 2.184 2.536 1.175
ENSG00000197969 E095 0.0000000       9 77436464 77436501 38 +