ENSG00000197948

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000435817 ENSG00000197948 HEK293_OSMI2_6hA HEK293_TMG_6hB FCHSD1 protein_coding protein_coding 5.626811 7.753604 3.628378 1.004634 0.2545565 -1.093431 0.7640318 1.2742384 0.04939969 0.6026373 0.04939969 -4.4343139 0.12701250 0.19076667 0.01223333 -0.17853333 0.349766723 0.001379494 FALSE TRUE
ENST00000519800 ENSG00000197948 HEK293_OSMI2_6hA HEK293_TMG_6hB FCHSD1 protein_coding protein_coding 5.626811 7.753604 3.628378 1.004634 0.2545565 -1.093431 0.4931055 0.5058570 0.51043141 0.1189041 0.14210092 0.0127367 0.09036667 0.06316667 0.13840000 0.07523333 0.329414821 0.001379494 FALSE TRUE
ENST00000520747 ENSG00000197948 HEK293_OSMI2_6hA HEK293_TMG_6hB FCHSD1 protein_coding retained_intron 5.626811 7.753604 3.628378 1.004634 0.2545565 -1.093431 0.5241592 0.6366984 0.52537995 0.4625782 0.05701979 -0.2725299 0.09184167 0.07093333 0.14423333 0.07330000 0.624364274 0.001379494   FALSE
ENST00000522126 ENSG00000197948 HEK293_OSMI2_6hA HEK293_TMG_6hB FCHSD1 protein_coding nonsense_mediated_decay 5.626811 7.753604 3.628378 1.004634 0.2545565 -1.093431 0.1509538 0.0000000 0.27819955 0.0000000 0.17982810 4.8489962 0.02822917 0.00000000 0.07380000 0.07380000 0.162829073 0.001379494 TRUE TRUE
ENST00000522386 ENSG00000197948 HEK293_OSMI2_6hA HEK293_TMG_6hB FCHSD1 protein_coding processed_transcript 5.626811 7.753604 3.628378 1.004634 0.2545565 -1.093431 0.3173725 0.5969502 0.15371583 0.3566637 0.15371583 -1.8903842 0.05598750 0.07683333 0.04860000 -0.02823333 0.806202917 0.001379494   FALSE
ENST00000522763 ENSG00000197948 HEK293_OSMI2_6hA HEK293_TMG_6hB FCHSD1 protein_coding processed_transcript 5.626811 7.753604 3.628378 1.004634 0.2545565 -1.093431 0.2135980 0.2124201 0.34514300 0.1079576 0.17338902 0.6751131 0.04111667 0.02426667 0.08983333 0.06556667 0.798481227 0.001379494   FALSE
ENST00000522783 ENSG00000197948 HEK293_OSMI2_6hA HEK293_TMG_6hB FCHSD1 protein_coding protein_coding 5.626811 7.753604 3.628378 1.004634 0.2545565 -1.093431 0.2607733 0.4549929 0.00000000 0.1140599 0.00000000 -5.5391369 0.04008750 0.05990000 0.00000000 -0.05990000 0.001379494 0.001379494 TRUE TRUE
ENST00000523856 ENSG00000197948 HEK293_OSMI2_6hA HEK293_TMG_6hB FCHSD1 protein_coding processed_transcript 5.626811 7.753604 3.628378 1.004634 0.2545565 -1.093431 0.5037824 0.7629367 0.48664862 0.2293733 0.06507764 -0.6381247 0.09090000 0.09383333 0.13810000 0.04426667 0.773888562 0.001379494 FALSE TRUE
MSTRG.27075.7 ENSG00000197948 HEK293_OSMI2_6hA HEK293_TMG_6hB FCHSD1 protein_coding   5.626811 7.753604 3.628378 1.004634 0.2545565 -1.093431 2.1454864 3.2804638 1.24643364 0.6578575 0.06978572 -1.3889565 0.38565833 0.41530000 0.34440000 -0.07090000 0.733481815 0.001379494 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000197948 E001 0.1426347 0.031293823 0.127933456   5 141639302 141639302 1 - 0.202 0.000 -11.558
ENSG00000197948 E002 0.1426347 0.031293823 0.127933456   5 141639303 141639307 5 - 0.202 0.000 -11.563
ENSG00000197948 E003 69.7012549 0.477929383 0.368212093 0.60257372 5 141639308 141640981 1674 - 1.667 1.799 0.448
ENSG00000197948 E004 6.2651883 0.019216117 0.159835968 0.37654256 5 141640982 141640986 5 - 0.597 0.844 1.020
ENSG00000197948 E005 29.8095547 0.076071102 0.101079089 0.28373714 5 141640987 141641208 222 - 1.235 1.456 0.770
ENSG00000197948 E006 63.2786749 0.363501213 0.201164285 0.43116825 5 141641209 141641563 355 - 1.537 1.775 0.808
ENSG00000197948 E007 19.9710536 0.024162952 0.060230643 0.20335700 5 141641702 141641757 56 - 1.064 1.299 0.836
ENSG00000197948 E008 12.8179189 0.274737308 0.085410211 0.25534951 5 141641758 141642396 639 - 1.242 1.001 -0.867
ENSG00000197948 E009 7.6553231 0.070735954 0.176873782 0.39956884 5 141642397 141642503 107 - 1.016 0.822 -0.734
ENSG00000197948 E010 4.7930071 0.163309408 0.005521144 0.03732836 5 141642504 141642704 201 - 1.041 0.518 -2.121
ENSG00000197948 E011 27.4332727 0.001301265 0.056250595 0.19420682 5 141643001 141643088 88 - 1.244 1.418 0.604
ENSG00000197948 E012 47.0005255 0.001062502 0.314859530 0.55500227 5 141644218 141644438 221 - 1.555 1.632 0.262
ENSG00000197948 E013 30.0003546 0.001343640 0.589408153 0.76329894 5 141644573 141644629 57 - 1.381 1.437 0.193
ENSG00000197948 E014 29.8739128 0.001630937 0.303377588 0.54392986 5 141644630 141644690 61 - 1.348 1.443 0.327
ENSG00000197948 E015 27.8924101 0.001500629 0.154539338 0.36879904 5 141644859 141644938 80 - 1.286 1.417 0.456
ENSG00000197948 E016 17.0736981 0.073633552 0.844672553 0.92194097 5 141644939 141644942 4 - 1.151 1.190 0.140
ENSG00000197948 E017 34.1419387 0.052563211 0.968366399 0.98601349 5 141645020 141645148 129 - 1.464 1.471 0.025
ENSG00000197948 E018 19.7964890 0.030699718 0.173487935 0.39520866 5 141645771 141645821 51 - 1.349 1.214 -0.473
ENSG00000197948 E019 28.7361164 0.001517575 0.211706983 0.44376916 5 141645822 141645932 111 - 1.459 1.384 -0.260
ENSG00000197948 E020 29.9443345 0.001702885 0.551689012 0.73747250 5 141646087 141646191 105 - 1.441 1.414 -0.093
ENSG00000197948 E021 9.5722203 0.063749345 0.042543290 0.16136216 5 141646192 141646507 316 - 1.149 0.876 -1.007
ENSG00000197948 E022 5.1176531 0.082015714 0.104299934 0.28936429 5 141646508 141646602 95 - 0.909 0.653 -1.023
ENSG00000197948 E023 20.8901751 0.026933552 0.136193571 0.34165804 5 141646603 141646671 69 - 1.372 1.239 -0.463
ENSG00000197948 E024 18.3814016 0.002239905 0.536805082 0.72688155 5 141646672 141646722 51 - 1.244 1.203 -0.146
ENSG00000197948 E025 23.5835996 0.001719023 0.390567492 0.62088557 5 141647135 141647230 96 - 1.359 1.305 -0.189
ENSG00000197948 E026 32.2882445 0.001734753 0.165816957 0.38486658 5 141647398 141647520 123 - 1.509 1.427 -0.284
ENSG00000197948 E027 7.7974078 0.118526783 0.034583225 0.14045600 5 141647521 141647831 311 - 1.110 0.768 -1.291
ENSG00000197948 E028 3.1116567 0.008194574 0.004732948 0.03318038 5 141647884 141647967 84 - 0.840 0.412 -1.900
ENSG00000197948 E029 21.7912800 0.002243626 0.546654198 0.73389822 5 141647968 141648096 129 - 1.312 1.274 -0.132
ENSG00000197948 E030 20.7398634 0.002112555 0.314062156 0.55430241 5 141648957 141649020 64 - 1.324 1.253 -0.251
ENSG00000197948 E031 28.7864268 0.001633384 0.186460494 0.41238888 5 141649172 141649308 137 - 1.468 1.387 -0.280
ENSG00000197948 E032 25.5578980 0.002419980 0.825962223 0.91146932 5 141649395 141649530 136 - 1.359 1.357 -0.007
ENSG00000197948 E033 2.0111107 0.012307947 0.828097800 0.91264879 5 141649531 141649536 6 - 0.443 0.413 -0.161
ENSG00000197948 E034 21.2156975 0.002159947 0.218199642 0.45127774 5 141649887 141649954 68 - 1.348 1.261 -0.305
ENSG00000197948 E035 23.3655201 0.002028403 0.623046157 0.78586705 5 141650359 141650404 46 - 1.273 1.330 0.201
ENSG00000197948 E036 26.2504326 0.003666348 0.244153863 0.48123191 5 141651020 141651117 98 - 1.273 1.387 0.398
ENSG00000197948 E037 17.7708215 0.002245749 0.117187091 0.31112912 5 141651348 141651418 71 - 1.066 1.239 0.619