ENSG00000197930

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395686 ENSG00000197930 HEK293_OSMI2_6hA HEK293_TMG_6hB ERO1A protein_coding protein_coding 22.55728 10.7047 36.34998 2.001495 0.19311 1.76276 14.970140 10.0213441 23.364484 2.2241285 0.3989092 1.220420 0.76535833 0.91966667 0.6428000 -0.2768667 0.013675614 0.005002318 FALSE TRUE
ENST00000554019 ENSG00000197930 HEK293_OSMI2_6hA HEK293_TMG_6hB ERO1A protein_coding nonsense_mediated_decay 22.55728 10.7047 36.34998 2.001495 0.19311 1.76276 4.412019 0.2518562 7.953953 0.2518562 0.9475824 4.926638 0.12645833 0.03756667 0.2186667 0.1811000 0.168528994 0.005002318 TRUE TRUE
MSTRG.9546.6 ENSG00000197930 HEK293_OSMI2_6hA HEK293_TMG_6hB ERO1A protein_coding   22.55728 10.7047 36.34998 2.001495 0.19311 1.76276 2.334811 0.1879458 3.902607 0.1062014 0.5431101 4.304952 0.06745417 0.01696667 0.1074667 0.0905000 0.005002318 0.005002318 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000197930 E001 992.3214497 2.023081560 0.396304722 0.62538648 14 52639915 52643215 3301 - 2.791 3.202 1.366
ENSG00000197930 E002 32.2044256 0.805974805 0.574467129 0.75330667 14 52643216 52643287 72 - 1.406 1.606 0.684
ENSG00000197930 E003 42.4088279 0.764844647 0.379227603 0.61157762 14 52643288 52643404 117 - 1.495 1.765 0.917
ENSG00000197930 E004 168.9716763 1.485330257 0.520735209 0.71540061 14 52643405 52643630 226 - 2.107 2.325 0.730
ENSG00000197930 E005 115.3442537 0.043113523 0.606895311 0.77480666 14 52646154 52646191 38 - 1.981 2.088 0.359
ENSG00000197930 E006 161.5209146 0.004067575 0.141043816 0.34909865 14 52646192 52646251 60 - 2.114 2.260 0.491
ENSG00000197930 E007 151.0352622 0.002882936 0.575713085 0.75415624 14 52646252 52646287 36 - 2.108 2.178 0.234
ENSG00000197930 E008 2.6531598 0.127229061 0.685035741 0.82592182 14 52646288 52646374 87 - 0.491 0.625 0.615
ENSG00000197930 E009 118.9060626 0.001948862 0.816551780 0.90618434 14 52646375 52646378 4 - 2.002 2.085 0.278
ENSG00000197930 E010 207.5008498 0.005574724 0.336963298 0.57535262 14 52646379 52646461 83 - 2.250 2.300 0.167
ENSG00000197930 E011 2.0302222 0.009901603 0.235157100 0.47108259 14 52646462 52647124 663 - 0.368 0.631 1.294
ENSG00000197930 E012 171.5898765 0.014833245 0.075402126 0.23567916 14 52652239 52652308 70 - 2.189 2.161 -0.093
ENSG00000197930 E013 336.5058493 0.016049174 0.010268808 0.05926829 14 52653069 52653315 247 - 2.492 2.420 -0.239
ENSG00000197930 E014 142.0475668 0.015648324 0.007356411 0.04634545 14 52657917 52657948 32 - 2.125 2.027 -0.328
ENSG00000197930 E015 164.8607575 0.012479498 0.006375308 0.04157255 14 52657949 52658009 61 - 2.185 2.107 -0.260
ENSG00000197930 E016 0.3040503 0.024441170 0.562022492   14 52658010 52658026 17 - 0.140 0.000 -11.127
ENSG00000197930 E017 133.1052797 0.009149942 0.001350978 0.01253974 14 52658124 52658150 27 - 2.095 2.010 -0.286
ENSG00000197930 E018 4.8025178 0.005658778 0.217627789 0.45056694 14 52658151 52658541 391 - 0.746 0.631 -0.483
ENSG00000197930 E019 110.9832999 0.019390771 0.037843403 0.14920575 14 52661293 52661304 12 - 2.011 1.956 -0.183
ENSG00000197930 E020 0.8026527 0.017865699 0.122547713   14 52663781 52663800 20 - 0.291 0.000 -12.450
ENSG00000197930 E021 178.5356942 0.020300046 0.021731732 0.10169600 14 52663801 52663847 47 - 2.218 2.147 -0.237
ENSG00000197930 E022 0.1779838 0.050660043 1.000000000   14 52663848 52664202 355 - 0.076 0.000 -10.130
ENSG00000197930 E023 126.1545689 0.028210843 0.155040419 0.36952029 14 52666375 52666376 2 - 2.058 2.029 -0.098
ENSG00000197930 E024 213.7667334 0.024132959 0.049232043 0.17775179 14 52666377 52666495 119 - 2.293 2.235 -0.193
ENSG00000197930 E025 0.1426347 0.031795532 1.000000000   14 52671574 52671629 56 - 0.076 0.000 -10.126
ENSG00000197930 E026 183.7822742 0.018928000 0.026711319 0.11740550 14 52671630 52671703 74 - 2.228 2.167 -0.207
ENSG00000197930 E027 143.5981702 0.025029413 0.014110056 0.07478581 14 52671795 52671824 30 - 2.132 2.029 -0.344
ENSG00000197930 E028 165.3595446 0.022909700 0.026140944 0.11576441 14 52671825 52671871 47 - 2.187 2.106 -0.273
ENSG00000197930 E029 0.1308682 0.032649190 0.207736713   14 52671872 52672235 364 - 0.000 0.189 13.122
ENSG00000197930 E030 0.4466850 0.024441170 0.324265810   14 52678319 52678433 115 - 0.196 0.000 -11.710
ENSG00000197930 E031 137.5253630 0.017843605 0.026624340 0.11713542 14 52678434 52678472 39 - 2.105 2.038 -0.223
ENSG00000197930 E032 184.8637879 0.019475524 0.029420711 0.12563021 14 52682325 52682408 84 - 2.232 2.162 -0.234
ENSG00000197930 E033 152.1834147 0.020025283 0.053565593 0.18801590 14 52683788 52683907 120 - 2.145 2.090 -0.185
ENSG00000197930 E034 104.3305778 0.010619898 0.889742594 0.94655614 14 52695368 52695900 533 - 1.946 2.031 0.287