ENSG00000197818

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361573 ENSG00000197818 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC9A8 protein_coding protein_coding 4.154735 5.202076 3.011622 0.4418077 0.05804399 -0.7865346 1.6274638 1.80895211 0.7824007 0.35057949 0.25806896 -1.1988056 0.3972333 0.34546667 0.26313333 -0.08233333 0.84426818 0.01573829 FALSE TRUE
ENST00000490250 ENSG00000197818 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC9A8 protein_coding processed_transcript 4.154735 5.202076 3.011622 0.4418077 0.05804399 -0.7865346 0.8308636 1.42469828 0.3480920 0.21930731 0.02728004 -2.0023451 0.1853500 0.27106667 0.11536667 -0.15570000 0.01573829 0.01573829   FALSE
MSTRG.20828.3 ENSG00000197818 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC9A8 protein_coding   4.154735 5.202076 3.011622 0.4418077 0.05804399 -0.7865346 1.3730851 1.75549612 1.4727284 0.28535974 0.18647853 -0.2518193 0.3375542 0.34106667 0.48700000 0.14593333 0.57567976 0.01573829 FALSE TRUE
MSTRG.20828.4 ENSG00000197818 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC9A8 protein_coding   4.154735 5.202076 3.011622 0.4418077 0.05804399 -0.7865346 0.2161399 0.07310655 0.2741193 0.03764907 0.07461999 1.7734626 0.0546250 0.01406667 0.09063333 0.07656667 0.04692228 0.01573829 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000197818 E001 0.1308682 0.0316507223 9.252852e-01   20 49812713 49812827 115 + 0.000 0.090 8.875
ENSG00000197818 E002 2.5543598 0.0119021196 7.487397e-01 8.659461e-01 20 49812828 49812891 64 + 0.569 0.520 -0.227
ENSG00000197818 E003 3.3034795 0.0104629456 9.848174e-01 9.942373e-01 20 49812892 49812892 1 + 0.618 0.626 0.036
ENSG00000197818 E004 3.4461141 0.0087674943 7.881964e-01 8.894773e-01 20 49812893 49812893 1 + 0.663 0.627 -0.156
ENSG00000197818 E005 16.1814048 0.0022923953 1.754201e-01 3.977366e-01 20 49812894 49812948 55 + 1.279 1.166 -0.399
ENSG00000197818 E006 28.8728881 0.0013744593 3.818313e-01 6.137701e-01 20 49815008 49815189 182 + 1.481 1.426 -0.189
ENSG00000197818 E007 0.3559677 0.4109740922 1.407418e-01   20 49815190 49815444 255 + 0.284 0.000 -12.869
ENSG00000197818 E008 19.9813542 0.0397259816 9.484882e-01 9.765114e-01 20 49823061 49823141 81 + 1.301 1.289 -0.044
ENSG00000197818 E009 15.3206125 0.0027234397 7.895573e-01 8.902676e-01 20 49839541 49839599 59 + 1.200 1.179 -0.076
ENSG00000197818 E010 14.7012062 0.0024867401 3.499201e-01 5.871927e-01 20 49845036 49845119 84 + 1.224 1.144 -0.285
ENSG00000197818 E011 21.3094082 0.0022423340 1.342784e-01 3.385553e-01 20 49849579 49849680 102 + 1.395 1.285 -0.385
ENSG00000197818 E012 1.3327596 0.0132013027 8.217264e-01   20 49850762 49850809 48 + 0.371 0.334 -0.224
ENSG00000197818 E013 6.3843807 0.0087484917 7.123800e-01 8.432742e-01 20 49850810 49850844 35 + 0.806 0.861 0.214
ENSG00000197818 E014 28.5097959 0.0020104829 8.112623e-03 4.984200e-02 20 49855438 49855581 144 + 1.552 1.382 -0.586
ENSG00000197818 E015 29.6522971 0.0013861184 3.816585e-02 1.500349e-01 20 49862929 49863067 139 + 1.541 1.411 -0.450
ENSG00000197818 E016 26.7186284 0.0014915578 4.848040e-02 1.761540e-01 20 49864739 49864844 106 + 1.500 1.370 -0.451
ENSG00000197818 E017 25.7176764 0.0015417502 8.538915e-01 9.270613e-01 20 49874705 49874821 117 + 1.403 1.395 -0.029
ENSG00000197818 E018 24.4293559 0.0015301794 5.939318e-01 7.662955e-01 20 49877981 49878063 83 + 1.403 1.370 -0.117
ENSG00000197818 E019 26.8275454 0.0032620278 4.818214e-01 6.883145e-01 20 49880924 49881035 112 + 1.448 1.403 -0.154
ENSG00000197818 E020 53.3866834 0.0007746832 5.556428e-03 3.750306e-02 20 49883846 49884066 221 + 1.791 1.661 -0.438
ENSG00000197818 E021 19.1659216 0.0420091207 3.400271e-01 5.779645e-01 20 49886371 49886751 381 + 1.164 1.323 0.558
ENSG00000197818 E022 49.9133381 0.0025827389 8.370533e-03 5.102696e-02 20 49886752 49886898 147 + 1.768 1.632 -0.461
ENSG00000197818 E023 466.7131328 0.0004101879 1.186681e-10 8.286423e-09 20 49887829 49892307 4479 + 2.581 2.670 0.299