ENSG00000197771

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369077 ENSG00000197771 HEK293_OSMI2_6hA HEK293_TMG_6hB MCMBP protein_coding protein_coding 59.12885 26.49918 87.40829 5.480361 4.512615 1.721443 12.705708 5.172918 19.8959407 1.0592199 0.2408992 1.9413627 0.2102833 0.19583333 0.22856667 0.032733333 6.305342e-01 2.012846e-20 FALSE TRUE
ENST00000466047 ENSG00000197771 HEK293_OSMI2_6hA HEK293_TMG_6hB MCMBP protein_coding processed_transcript 59.12885 26.49918 87.40829 5.480361 4.512615 1.721443 2.910435 2.931594 2.3940893 1.4850989 1.4666914 -0.2911075 0.0712750 0.09873333 0.02613333 -0.072600000 3.756923e-01 2.012846e-20 FALSE TRUE
MSTRG.4734.4 ENSG00000197771 HEK293_OSMI2_6hA HEK293_TMG_6hB MCMBP protein_coding   59.12885 26.49918 87.40829 5.480361 4.512615 1.721443 4.573150 0.000000 5.9136290 0.0000000 0.0100308 9.2103375 0.0521750 0.00000000 0.06806667 0.068066667 2.012846e-20 2.012846e-20 FALSE TRUE
MSTRG.4734.5 ENSG00000197771 HEK293_OSMI2_6hA HEK293_TMG_6hB MCMBP protein_coding   59.12885 26.49918 87.40829 5.480361 4.512615 1.721443 3.150097 1.380627 0.2982473 0.8397260 0.2212143 -2.1735752 0.0515000 0.05646667 0.00320000 -0.053266667 5.971925e-01 2.012846e-20 FALSE TRUE
MSTRG.4734.6 ENSG00000197771 HEK293_OSMI2_6hA HEK293_TMG_6hB MCMBP protein_coding   59.12885 26.49918 87.40829 5.480361 4.512615 1.721443 7.859150 5.745140 19.8035318 0.9893079 1.2018522 1.7835632 0.1502042 0.22450000 0.22766667 0.003166667 1.000000e+00 2.012846e-20 FALSE TRUE
MSTRG.4734.7 ENSG00000197771 HEK293_OSMI2_6hA HEK293_TMG_6hB MCMBP protein_coding   59.12885 26.49918 87.40829 5.480361 4.512615 1.721443 23.847163 10.819531 35.7989562 2.2894590 2.5049973 1.7253497 0.4141625 0.40953333 0.41033333 0.000800000 1.000000e+00 2.012846e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000197771 E001 1.5239877 0.0572821943 3.039189e-01 5.444924e-01 10 119829318 119829403 86 - 0.297 0.497 1.126
ENSG00000197771 E002 0.9818539 0.0183966023 2.414641e-01   10 119829404 119829439 36 - 0.200 0.415 1.453
ENSG00000197771 E003 152.1808145 0.0007060070 3.716810e-02 1.473595e-01 10 119829440 119830189 750 - 2.152 2.083 -0.229
ENSG00000197771 E004 473.2091853 0.0006662085 6.567245e-21 2.144749e-18 10 119830190 119831090 901 - 2.675 2.463 -0.707
ENSG00000197771 E005 97.7234408 0.0038456499 8.508598e-04 8.695124e-03 10 119831091 119831200 110 - 1.985 1.812 -0.581
ENSG00000197771 E006 75.8200235 0.0007407029 1.739406e-01 3.958046e-01 10 119831201 119831279 79 - 1.849 1.788 -0.206
ENSG00000197771 E007 57.9706004 0.0077448231 2.354509e-01 4.713931e-01 10 119831280 119831280 1 - 1.739 1.659 -0.270
ENSG00000197771 E008 556.9559874 0.0017192347 4.331321e-01 6.535562e-01 10 119831281 119831600 320 - 2.690 2.710 0.068
ENSG00000197771 E009 351.4557594 0.0004024297 1.508365e-02 7.840202e-02 10 119832012 119832096 85 - 2.483 2.540 0.191
ENSG00000197771 E010 180.6122763 0.0027680391 1.718147e-01 3.929543e-01 10 119832097 119832100 4 - 2.196 2.252 0.186
ENSG00000197771 E011 450.6525848 0.0008408924 1.273815e-04 1.828134e-03 10 119835540 119835700 161 - 2.581 2.672 0.302
ENSG00000197771 E012 196.3466613 0.0036817038 3.210173e-02 1.335150e-01 10 119835701 119835704 4 - 2.221 2.315 0.312
ENSG00000197771 E013 510.5768487 0.0005516563 7.573434e-05 1.185058e-03 10 119836896 119837029 134 - 2.637 2.720 0.276
ENSG00000197771 E014 557.7177877 0.0001663340 2.361836e-03 1.945547e-02 10 119838535 119838700 166 - 2.683 2.738 0.182
ENSG00000197771 E015 435.0019265 0.0023343826 3.471086e-02 1.408161e-01 10 119840843 119840960 118 - 2.572 2.632 0.203
ENSG00000197771 E016 388.5026258 0.0014019480 1.060680e-01 2.924684e-01 10 119842472 119842595 124 - 2.530 2.573 0.144
ENSG00000197771 E017 0.1779838 0.0363562761 1.000000e+00   10 119842782 119843247 466 - 0.077 0.000 -7.706
ENSG00000197771 E018 60.9602236 0.0020167347 4.821546e-01 6.885069e-01 10 119843248 119843253 6 - 1.757 1.722 -0.119
ENSG00000197771 E019 491.4430489 0.0002074779 9.754713e-01 9.895574e-01 10 119843254 119843426 173 - 2.643 2.647 0.012
ENSG00000197771 E020 400.5431424 0.0001936895 4.112554e-01 6.369996e-01 10 119847613 119847713 101 - 2.558 2.546 -0.042
ENSG00000197771 E021 495.8761837 0.0004015006 2.154232e-01 4.479785e-01 10 119849425 119849576 152 - 2.640 2.668 0.095
ENSG00000197771 E022 502.1502375 0.0001715684 5.252748e-01 7.186317e-01 10 119853050 119853172 123 - 2.649 2.665 0.051
ENSG00000197771 E023 289.0675339 0.0003232012 1.673092e-01 3.869762e-01 10 119853173 119853194 22 - 2.422 2.391 -0.102
ENSG00000197771 E024 245.3410804 0.0010505573 1.073681e-02 6.127286e-02 10 119857338 119857346 9 - 2.360 2.287 -0.245
ENSG00000197771 E025 451.6507138 0.0001468466 2.089152e-05 3.963458e-04 10 119857347 119857439 93 - 2.626 2.547 -0.264
ENSG00000197771 E026 3.1371129 0.0098152229 8.614451e-01 9.311454e-01 10 119857440 119858237 798 - 0.593 0.565 -0.128
ENSG00000197771 E027 271.4743229 0.0002043227 5.169525e-04 5.830152e-03 10 119858884 119858925 42 - 2.407 2.323 -0.280
ENSG00000197771 E028 237.7904201 0.0017834197 4.716199e-02 1.729175e-01 10 119859041 119859049 9 - 2.345 2.277 -0.225
ENSG00000197771 E029 396.0473995 0.0008528561 5.444613e-02 1.901299e-01 10 119859050 119859181 132 - 2.561 2.516 -0.151
ENSG00000197771 E030 194.6871753 0.0002699954 5.241982e-01 7.179511e-01 10 119859799 119859884 86 - 2.238 2.260 0.074
ENSG00000197771 E031 111.8405329 0.0027141844 4.026239e-03 2.931326e-02 10 119872527 119872967 441 - 1.965 2.094 0.433
ENSG00000197771 E032 0.7254668 0.2136629689 6.808343e-02   10 119873431 119873621 191 - 0.078 0.422 3.065
ENSG00000197771 E033 3.8290841 0.0124848174 2.801839e-01 5.203375e-01 10 119890785 119890978 194 - 0.594 0.764 0.717
ENSG00000197771 E034 2.4320204 0.0194872365 3.928885e-01 6.227115e-01 10 119892239 119892312 74 - 0.469 0.622 0.711
ENSG00000197771 E035 4.0980226 0.0167880612 1.179560e-01 3.124908e-01 10 119892470 119892556 87 - 0.594 0.836 0.999