ENSG00000197601

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354817 ENSG00000197601 HEK293_OSMI2_6hA HEK293_TMG_6hB FAR1 protein_coding protein_coding 26.5024 4.339602 46.89011 0.7562713 1.221019 3.430636 16.313734 3.877807 26.99076 0.7119854 0.4324562 2.795971 0.7388625 0.8900667 0.5760000 -0.3140667 1.351145e-12 8.440916e-17 FALSE TRUE
ENST00000532701 ENSG00000197601 HEK293_OSMI2_6hA HEK293_TMG_6hB FAR1 protein_coding protein_coding 26.5024 4.339602 46.89011 0.7562713 1.221019 3.430636 7.005605 0.000000 13.04609 0.0000000 1.2873835 10.350508 0.1459625 0.0000000 0.2771667 0.2771667 8.440916e-17 8.440916e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000197601 E001 0.9099381 0.0331597889 5.145145e-01   11 13668629 13668667 39 + 0.224 0.000 -15.287
ENSG00000197601 E002 7.9574597 0.0401967577 9.668299e-01 9.853151e-01 11 13668668 13668710 43 + 0.779 0.816 0.147
ENSG00000197601 E003 50.8766276 0.0044192234 8.858923e-01 9.444686e-01 11 13668711 13668806 96 + 1.515 1.568 0.183
ENSG00000197601 E004 0.9680622 0.2822080956 6.286202e-02   11 13669023 13669121 99 + 0.129 0.568 2.961
ENSG00000197601 E005 1.6467438 0.0522511352 6.786096e-02 2.202919e-01 11 13671113 13671200 88 + 0.253 0.667 2.205
ENSG00000197601 E006 0.1614157 0.0331234797 7.903355e-01   11 13694756 13694758 3 + 0.046 0.000 -12.697
ENSG00000197601 E007 115.7120928 0.0025198102 4.298705e-01 6.509542e-01 11 13694759 13694899 141 + 1.869 1.894 0.085
ENSG00000197601 E008 105.9497803 0.0005086357 5.853080e-01 7.605014e-01 11 13694900 13694954 55 + 1.828 1.869 0.137
ENSG00000197601 E009 159.5952363 0.0006581966 4.800639e-02 1.750091e-01 11 13700317 13700492 176 + 2.009 1.991 -0.063
ENSG00000197601 E010 0.6544085 0.0189165533 4.703232e-01   11 13700493 13700567 75 + 0.127 0.284 1.449
ENSG00000197601 E011 213.5516609 0.0006294497 4.105146e-06 9.709584e-05 11 13707900 13708079 180 + 2.145 2.026 -0.399
ENSG00000197601 E012 136.4737172 0.0003356988 1.493301e-05 2.970909e-04 11 13710693 13710723 31 + 1.955 1.804 -0.505
ENSG00000197601 E013 236.5745559 0.0002069877 1.700206e-03 1.501789e-02 11 13710724 13710870 147 + 2.181 2.139 -0.144
ENSG00000197601 E014 8.9717774 0.0043295743 2.123005e-01 4.444521e-01 11 13710871 13711099 229 + 0.830 0.672 -0.640
ENSG00000197601 E015 126.6811494 0.0045919706 4.306950e-01 6.516564e-01 11 13711764 13711808 45 + 1.905 1.924 0.064
ENSG00000197601 E016 89.8162752 0.0047656390 4.807850e-01 6.876198e-01 11 13711928 13711931 4 + 1.758 1.778 0.068
ENSG00000197601 E017 185.0404848 0.0031749591 1.438892e-02 7.583782e-02 11 13711932 13712046 115 + 2.076 2.025 -0.173
ENSG00000197601 E018 3.6782895 0.0064219159 2.648485e-02 1.167212e-01 11 13712047 13712055 9 + 0.556 0.000 -17.220
ENSG00000197601 E019 131.5778052 0.0028332643 9.266528e-04 9.312206e-03 11 13712966 13713033 68 + 1.938 1.821 -0.392
ENSG00000197601 E020 2.2950630 0.0103169003 5.248690e-01 7.184005e-01 11 13713034 13713084 51 + 0.392 0.284 -0.668
ENSG00000197601 E021 200.6372595 0.0003428231 2.473255e-03 2.015043e-02 11 13714509 13714680 172 + 2.112 2.062 -0.167
ENSG00000197601 E022 3.8213337 0.0063084545 2.638129e-01 5.030756e-01 11 13715801 13715843 43 + 0.497 0.749 1.106
ENSG00000197601 E023 59.3447349 0.0045937014 3.242091e-01 5.634904e-01 11 13719903 13721729 1827 + 1.564 1.698 0.457
ENSG00000197601 E024 192.9490792 0.0002586835 7.737053e-02 2.395802e-01 11 13721730 13721859 130 + 2.089 2.089 0.002
ENSG00000197601 E025 200.3158375 0.0008701386 7.220453e-01 8.493094e-01 11 13727556 13727683 128 + 2.099 2.155 0.188
ENSG00000197601 E026 1438.6884383 0.0055498854 1.468899e-07 5.241706e-06 11 13728612 13732346 3735 + 2.933 3.115 0.606