ENSG00000197535

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356338 ENSG00000197535 HEK293_OSMI2_6hA HEK293_TMG_6hB MYO5A protein_coding protein_coding 3.92726 2.333017 5.989393 0.5275903 0.2193299 1.356449 0.04096128 0.06947278 0.0000000 0.06947278 0.00000000 -2.990461 0.01410417 0.05436667 0.00000000 -0.05436667 7.824531e-01 2.472358e-08 FALSE TRUE
ENST00000399229 ENSG00000197535 HEK293_OSMI2_6hA HEK293_TMG_6hB MYO5A protein_coding protein_coding 3.92726 2.333017 5.989393 0.5275903 0.2193299 1.356449 0.51257886 0.38438165 0.8212653 0.16179044 0.03544380 1.075716 0.12444583 0.14316667 0.13756667 -0.00560000 9.940329e-01 2.472358e-08 FALSE TRUE
ENST00000399231 ENSG00000197535 HEK293_OSMI2_6hA HEK293_TMG_6hB MYO5A protein_coding protein_coding 3.92726 2.333017 5.989393 0.5275903 0.2193299 1.356449 0.13249021 0.14962439 0.0000000 0.01820404 0.00000000 -3.996609 0.05111667 0.07740000 0.00000000 -0.07740000 7.330024e-04 2.472358e-08 FALSE TRUE
ENST00000686603 ENSG00000197535 HEK293_OSMI2_6hA HEK293_TMG_6hB MYO5A protein_coding retained_intron 3.92726 2.333017 5.989393 0.5275903 0.2193299 1.356449 0.28952156 0.50401002 0.1480815 0.17936985 0.09118864 -1.701128 0.12142917 0.21680000 0.02386667 -0.19293333 3.131690e-02 2.472358e-08 FALSE TRUE
ENST00000687574 ENSG00000197535 HEK293_OSMI2_6hA HEK293_TMG_6hB MYO5A protein_coding protein_coding 3.92726 2.333017 5.989393 0.5275903 0.2193299 1.356449 0.44441261 0.19473853 0.6587901 0.10212593 0.35025659 1.707771 0.10172500 0.06816667 0.10616667 0.03800000 9.916292e-01 2.472358e-08 FALSE TRUE
MSTRG.10854.18 ENSG00000197535 HEK293_OSMI2_6hA HEK293_TMG_6hB MYO5A protein_coding   3.92726 2.333017 5.989393 0.5275903 0.2193299 1.356449 0.70683653 0.00000000 1.5553620 0.00000000 0.26702221 7.290352 0.12130417 0.00000000 0.25843333 0.25843333 2.472358e-08 2.472358e-08 FALSE TRUE
MSTRG.10854.5 ENSG00000197535 HEK293_OSMI2_6hA HEK293_TMG_6hB MYO5A protein_coding   3.92726 2.333017 5.989393 0.5275903 0.2193299 1.356449 0.30908617 0.22495627 0.6896109 0.22495627 0.68961085 1.574160 0.08992083 0.07803333 0.11090000 0.03286667 9.705530e-01 2.472358e-08 FALSE TRUE
MSTRG.10854.7 ENSG00000197535 HEK293_OSMI2_6hA HEK293_TMG_6hB MYO5A protein_coding   3.92726 2.333017 5.989393 0.5275903 0.2193299 1.356449 0.58354942 0.21764094 0.9094913 0.21764094 0.54040851 2.014076 0.10530417 0.07666667 0.15846667 0.08180000 8.096142e-01 2.472358e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000197535 E001 0.0000000       15 52307281 52307282 2 -      
ENSG00000197535 E002 0.0000000       15 52307283 52307285 3 -      
ENSG00000197535 E003 0.8030126 0.306079952 0.6104089167   15 52307286 52307295 10 - 0.196 0.322 0.945
ENSG00000197535 E004 1.9358710 0.017103028 0.4720575089 0.681592830 15 52307296 52307313 18 - 0.373 0.565 0.976
ENSG00000197535 E005 21.2167466 0.373207642 0.0494487883 0.178295538 15 52307314 52307582 269 - 1.045 1.636 2.064
ENSG00000197535 E006 203.9507455 1.463232578 0.3140290927 0.554251827 15 52307583 52312664 5082 - 2.095 2.529 1.450
ENSG00000197535 E007 18.7099892 0.430926813 0.3180322550 0.557968807 15 52312665 52313108 444 - 1.164 1.414 0.878
ENSG00000197535 E008 3.6160247 0.038886474 0.0406304863 0.156384368 15 52313109 52313109 1 - 0.468 0.873 1.739
ENSG00000197535 E009 3.6160247 0.038886474 0.0406304863 0.156384368 15 52313110 52313110 1 - 0.468 0.873 1.739
ENSG00000197535 E010 3.7774404 0.051515401 0.0643388532 0.212448319 15 52313111 52313125 15 - 0.496 0.874 1.607
ENSG00000197535 E011 2.9180848 0.014816395 0.0435012367 0.163850124 15 52313126 52313128 3 - 0.407 0.803 1.784
ENSG00000197535 E012 4.0930696 0.064349104 0.1318019006 0.334633928 15 52313129 52313162 34 - 0.545 0.876 1.380
ENSG00000197535 E013 3.3841710 0.056946215 0.3304468343 0.569391040 15 52313163 52313170 8 - 0.520 0.767 1.069
ENSG00000197535 E014 3.3544312 0.183093658 0.6332218904 0.792468817 15 52313171 52313173 3 - 0.540 0.730 0.824
ENSG00000197535 E015 3.2117966 0.147580402 0.5497447382 0.736109539 15 52313174 52313174 1 - 0.517 0.729 0.927
ENSG00000197535 E016 3.0090624 0.095486656 0.6692616379 0.815755991 15 52313175 52313178 4 - 0.519 0.678 0.710
ENSG00000197535 E017 2.8180946 0.124367068 0.8591637797 0.929892869 15 52313179 52313180 2 - 0.542 0.568 0.120
ENSG00000197535 E018 4.6719487 0.286405987 0.7313061992 0.854979503 15 52313181 52313194 14 - 0.726 0.682 -0.182
ENSG00000197535 E019 4.6414011 0.265500758 0.8841937958 0.943507845 15 52313195 52313212 18 - 0.710 0.724 0.057
ENSG00000197535 E020 6.6677316 0.281248714 0.7246629549 0.850906072 15 52313213 52313260 48 - 0.795 0.943 0.566
ENSG00000197535 E021 7.3871115 0.222395412 0.5142962272 0.711191774 15 52313261 52313281 21 - 0.821 1.011 0.721
ENSG00000197535 E022 41.5984492 0.701888054 0.3489759188 0.586373047 15 52313282 52313675 394 - 1.489 1.758 0.916
ENSG00000197535 E023 10.7651473 0.263086260 0.1181895888 0.312876035 15 52313676 52313695 20 - 0.881 1.270 1.417
ENSG00000197535 E024 20.8137165 0.439134312 0.1683534921 0.388352432 15 52313696 52313848 153 - 1.152 1.529 1.314
ENSG00000197535 E025 23.4588481 0.020757565 0.2168287921 0.449658436 15 52314123 52314203 81 - 1.269 1.481 0.734
ENSG00000197535 E026 0.1779838 0.069418338 1.0000000000   15 52314204 52315323 1120 - 0.077 0.000 -16.289
ENSG00000197535 E027 32.1879518 0.001328615 0.5377346161 0.727476296 15 52317048 52317222 175 - 1.427 1.572 0.500
ENSG00000197535 E028 0.0000000       15 52317223 52318362 1140 -      
ENSG00000197535 E029 44.6212888 0.001128767 0.2267042141 0.461404479 15 52319060 52319342 283 - 1.602 1.641 0.132
ENSG00000197535 E030 0.0000000       15 52319343 52321358 2016 -      
ENSG00000197535 E031 28.9418489 0.006518697 0.8081927158 0.901144483 15 52321359 52321509 151 - 1.407 1.496 0.308
ENSG00000197535 E032 0.1723744 0.095495485 0.2287883643   15 52321510 52321818 309 - 0.000 0.186 19.164
ENSG00000197535 E033 24.4516785 0.012342684 0.6374097708 0.795316130 15 52323355 52323444 90 - 1.316 1.470 0.536
ENSG00000197535 E034 0.1308682 0.032649190 0.2269180141   15 52323445 52323576 132 - 0.000 0.186 19.157
ENSG00000197535 E035 0.0000000       15 52323577 52323937 361 -      
ENSG00000197535 E036 34.5646166 0.046489690 0.9954955785 0.999320492 15 52327852 52328006 155 - 1.462 1.598 0.465
ENSG00000197535 E037 30.3923925 0.082599050 0.7760028812 0.882387524 15 52330353 52330499 147 - 1.417 1.525 0.369
ENSG00000197535 E038 0.1723744 0.095495485 0.2287883643   15 52330500 52331698 1199 - 0.000 0.186 19.164
ENSG00000197535 E039 0.0000000       15 52331699 52331836 138 -      
ENSG00000197535 E040 18.2271611 0.003134581 0.5348775058 0.725553754 15 52336463 52336556 94 - 1.220 1.270 0.177
ENSG00000197535 E041 0.0000000       15 52336557 52337809 1253 -      
ENSG00000197535 E042 0.1723744 0.095495485 0.2287883643   15 52337810 52337884 75 - 0.000 0.186 19.164
ENSG00000197535 E043 0.1723744 0.095495485 0.2287883643   15 52337885 52340195 2311 - 0.000 0.186 19.164
ENSG00000197535 E044 26.6403320 0.002771609 0.5123389207 0.709721511 15 52340196 52340394 199 - 1.343 1.498 0.532
ENSG00000197535 E045 0.7499275 0.017111313 0.7008822257   15 52340395 52340704 310 - 0.200 0.315 0.871
ENSG00000197535 E046 10.0591789 0.003825552 0.2131431189 0.445423838 15 52343117 52343197 81 - 0.925 1.157 0.849
ENSG00000197535 E047 21.5813777 0.024386881 0.8962758980 0.949924246 15 52346361 52346461 101 - 1.277 1.377 0.348
ENSG00000197535 E048 0.7367559 0.082185351 0.5852361781   15 52346462 52348717 2256 - 0.249 0.185 -0.546
ENSG00000197535 E049 0.1308682 0.032649190 0.2269180141   15 52348718 52348817 100 - 0.000 0.186 19.157
ENSG00000197535 E050 5.8521743 0.082385044 0.4773134912 0.685231787 15 52348818 52348826 9 - 0.734 0.948 0.830
ENSG00000197535 E051 1.4166997 0.310911091 0.1228758862 0.320283956 15 52348827 52350529 1703 - 0.199 0.621 2.452
ENSG00000197535 E052 27.1932059 0.064532098 0.7658772146 0.876153442 15 52351254 52351481 228 - 1.377 1.469 0.318
ENSG00000197535 E053 14.4747432 0.062766833 0.3607937757 0.596265803 15 52353605 52353658 54 - 1.148 1.146 -0.007
ENSG00000197535 E054 21.8944531 0.015279116 0.0733022501 0.231426065 15 52353871 52354014 144 - 1.332 1.266 -0.231
ENSG00000197535 E055 0.0000000       15 52357499 52359967 2469 -      
ENSG00000197535 E056 22.7243583 0.087340862 0.0547472065 0.190769346 15 52359968 52360069 102 - 1.375 1.184 -0.672
ENSG00000197535 E057 14.8070049 0.065029520 0.1249178279 0.323608285 15 52360070 52360081 12 - 1.185 1.073 -0.402
ENSG00000197535 E058 13.8263684 0.056644069 0.1832191172 0.408068567 15 52364554 52364556 3 - 1.150 1.074 -0.272
ENSG00000197535 E059 24.2902464 0.033184384 0.2686161568 0.508292309 15 52364557 52364702 146 - 1.361 1.351 -0.032
ENSG00000197535 E060 17.1596431 0.051626011 0.8679642157 0.934846123 15 52367031 52367124 94 - 1.169 1.310 0.498
ENSG00000197535 E061 0.0000000       15 52369922 52370168 247 -      
ENSG00000197535 E062 27.5159504 0.028644120 0.3334139507 0.571967567 15 52370169 52370417 249 - 1.400 1.416 0.054
ENSG00000197535 E063 26.9915730 0.009360376 0.1109176031 0.300449374 15 52372124 52372363 240 - 1.404 1.380 -0.084
ENSG00000197535 E064 0.1614157 0.032444899 1.0000000000   15 52372957 52375303 2347 - 0.077 0.000 -16.286
ENSG00000197535 E065 19.2760302 0.011389869 0.0308119641 0.129785951 15 52375304 52375460 157 - 1.289 1.174 -0.405
ENSG00000197535 E066 21.7457736 0.016044326 0.0012714214 0.011945593 15 52376347 52376558 212 - 1.363 1.125 -0.840
ENSG00000197535 E067 0.0000000       15 52376559 52376787 229 -      
ENSG00000197535 E068 0.1426347 0.032555345 1.0000000000   15 52376788 52376945 158 - 0.077 0.000 -16.284
ENSG00000197535 E069 0.1426347 0.032555345 1.0000000000   15 52376946 52377627 682 - 0.077 0.000 -16.284
ENSG00000197535 E070 0.0000000       15 52379295 52379624 330 -      
ENSG00000197535 E071 16.7989320 0.002122523 0.0063948933 0.041658674 15 52379625 52379733 109 - 1.244 1.087 -0.563
ENSG00000197535 E072 13.7315214 0.003071849 0.0069647742 0.044477075 15 52379822 52379908 87 - 1.166 0.980 -0.675
ENSG00000197535 E073 2.6776341 0.202100702 0.0077228356 0.048023255 15 52379909 52381022 1114 - 0.623 0.000 -20.323
ENSG00000197535 E074 2.7004637 0.086447471 0.6165827792 0.781418304 15 52381023 52381384 362 - 0.471 0.671 0.911
ENSG00000197535 E075 0.9278436 0.630366200 0.2006405130   15 52381385 52381542 158 - 0.076 0.586 3.901
ENSG00000197535 E076 1.3471715 0.026967019 0.3019776929   15 52381543 52381704 162 - 0.250 0.498 1.463
ENSG00000197535 E077 1.5548951 0.012818196 0.1500236357 0.362353883 15 52381705 52382181 477 - 0.250 0.565 1.780
ENSG00000197535 E078 1.6859509 0.013308992 0.2403746136 0.476991761 15 52382182 52382777 596 - 0.295 0.565 1.457
ENSG00000197535 E079 0.9803762 0.688317328 0.6847092466   15 52382778 52383090 313 - 0.198 0.424 1.518
ENSG00000197535 E080 21.0111389 0.003564396 0.0130002766 0.070451733 15 52383091 52383188 98 - 1.328 1.216 -0.391
ENSG00000197535 E081 26.6896549 0.020156158 0.0015140109 0.013712740 15 52384161 52384322 162 - 1.444 1.228 -0.754
ENSG00000197535 E082 0.0000000       15 52387750 52387828 79 -      
ENSG00000197535 E083 19.1111673 0.001765346 0.0010352008 0.010174738 15 52387829 52387912 84 - 1.303 1.106 -0.700
ENSG00000197535 E084 0.1723744 0.095495485 0.2287883643   15 52387913 52389237 1325 - 0.000 0.186 19.164
ENSG00000197535 E085 21.0217413 0.013758560 0.0189867409 0.092415744 15 52389238 52389363 126 - 1.329 1.190 -0.488
ENSG00000197535 E086 0.2922838 0.025466461 0.5759457435   15 52389364 52390081 718 - 0.077 0.186 1.452
ENSG00000197535 E087 22.4877874 0.003316989 0.0007752519 0.008075049 15 52391930 52392070 141 - 1.365 1.173 -0.674
ENSG00000197535 E088 0.0000000       15 52393401 52396315 2915 -      
ENSG00000197535 E089 14.6445256 0.003790582 0.0128140332 0.069691515 15 52396316 52396397 82 - 1.183 1.026 -0.565
ENSG00000197535 E090 0.1426347 0.032555345 1.0000000000   15 52396398 52396613 216 - 0.077 0.000 -16.284
ENSG00000197535 E091 0.0000000       15 52396614 52397027 414 -      
ENSG00000197535 E092 0.0000000       15 52397028 52397200 173 -      
ENSG00000197535 E093 26.5093710 0.001426695 0.0122272973 0.067356471 15 52397201 52397466 266 - 1.414 1.328 -0.296
ENSG00000197535 E094 0.0000000       15 52405108 52405286 179 -      
ENSG00000197535 E095 17.9089282 0.003459827 0.2366427221 0.472690221 15 52405287 52405393 107 - 1.234 1.231 -0.011
ENSG00000197535 E096 16.1354683 0.002553924 0.0239729968 0.109001086 15 52407292 52407399 108 - 1.219 1.105 -0.407
ENSG00000197535 E097 13.0730631 0.018673367 0.0265641545 0.116970581 15 52408059 52408136 78 - 1.142 0.978 -0.597
ENSG00000197535 E098 7.6540741 0.023290360 0.0116854897 0.065166981 15 52408137 52408140 4 - 0.955 0.674 -1.108
ENSG00000197535 E099 0.3150090 0.044056943 0.5688691989   15 52408141 52410332 2192 - 0.077 0.186 1.459
ENSG00000197535 E100 22.8661673 0.029223808 0.0340172214 0.138901337 15 52410333 52410476 144 - 1.364 1.227 -0.480
ENSG00000197535 E101 0.0000000       15 52410477 52410730 254 -      
ENSG00000197535 E102 0.0000000       15 52415116 52415202 87 -      
ENSG00000197535 E103 0.0000000       15 52416005 52416144 140 -      
ENSG00000197535 E104 23.5735435 0.016441314 0.0233715696 0.107117644 15 52416145 52416301 157 - 1.374 1.255 -0.414
ENSG00000197535 E105 20.4976997 0.013964366 0.0025606103 0.020723944 15 52425830 52425974 145 - 1.329 1.123 -0.726
ENSG00000197535 E106 8.3634730 0.024399565 0.0027393117 0.021800837 15 52428398 52428400 3 - 0.991 0.626 -1.447
ENSG00000197535 E107 19.1801886 0.023909938 0.0006777270 0.007248166 15 52428401 52428569 169 - 1.316 1.007 -1.104
ENSG00000197535 E108 8.6739743 0.037332987 0.0087031030 0.052498628 15 52433175 52433285 111 - 1.000 0.679 -1.255
ENSG00000197535 E109 0.0000000       15 52524083 52524202 120 -      
ENSG00000197535 E110 0.1779838 0.069418338 1.0000000000   15 52526913 52527014 102 - 0.077 0.000 -16.289
ENSG00000197535 E111 1.8941925 0.010830789 0.2398238425 0.476424361 15 52528780 52529132 353 - 0.470 0.316 -0.868