ENSG00000197444

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374103 ENSG00000197444 HEK293_OSMI2_6hA HEK293_TMG_6hB OGDHL protein_coding protein_coding 9.066131 13.02547 5.102809 0.7550044 0.1793762 -1.350255 3.5748801 5.3139863 1.8839810 0.95044129 0.26424038 -1.4910850 0.39931667 0.41766667 0.36803333 -0.04963333 9.476324e-01 4.928948e-06 FALSE TRUE
ENST00000432695 ENSG00000197444 HEK293_OSMI2_6hA HEK293_TMG_6hB OGDHL protein_coding protein_coding 9.066131 13.02547 5.102809 0.7550044 0.1793762 -1.350255 0.8591450 0.6494228 0.1851657 0.64942275 0.18516574 -1.7565039 0.08658750 0.04616667 0.03846667 -0.00770000 9.721379e-01 4.928948e-06 FALSE TRUE
ENST00000490844 ENSG00000197444 HEK293_OSMI2_6hA HEK293_TMG_6hB OGDHL protein_coding processed_transcript 9.066131 13.02547 5.102809 0.7550044 0.1793762 -1.350255 1.2529506 1.9582800 0.6447592 0.63775999 0.08095029 -1.5878992 0.12977083 0.14896667 0.12566667 -0.02330000 9.644539e-01 4.928948e-06 FALSE TRUE
ENST00000496884 ENSG00000197444 HEK293_OSMI2_6hA HEK293_TMG_6hB OGDHL protein_coding processed_transcript 9.066131 13.02547 5.102809 0.7550044 0.1793762 -1.350255 1.1721061 1.7685206 0.8308095 0.36365537 0.14845940 -1.0808269 0.13169583 0.13406667 0.16120000 0.02713333 8.939259e-01 4.928948e-06 FALSE TRUE
MSTRG.3966.7 ENSG00000197444 HEK293_OSMI2_6hA HEK293_TMG_6hB OGDHL protein_coding   9.066131 13.02547 5.102809 0.7550044 0.1793762 -1.350255 0.2082731 0.7197750 0.0000000 0.01672724 0.00000000 -6.1893799 0.02010833 0.05550000 0.00000000 -0.05550000 4.928948e-06 4.928948e-06 FALSE TRUE
MSTRG.3966.8 ENSG00000197444 HEK293_OSMI2_6hA HEK293_TMG_6hB OGDHL protein_coding   9.066131 13.02547 5.102809 0.7550044 0.1793762 -1.350255 1.3318999 1.5254347 0.9804234 0.31992614 0.19656009 -0.6325299 0.15407500 0.11530000 0.19356667 0.07826667 5.728929e-01 4.928948e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000197444 E001 0.6966548 0.1183546038 3.617417e-01   10 49734641 49734643 3 - 0.341 0.179 -1.229
ENSG00000197444 E002 1.4165121 0.0125084324 9.699034e-01 0.9867938794 10 49734644 49734645 2 - 0.342 0.345 0.020
ENSG00000197444 E003 62.2323138 0.4477246240 3.131005e-01 0.5533675247 10 49734646 49734964 319 - 1.566 1.757 0.650
ENSG00000197444 E004 46.2233069 0.4335755002 5.262264e-01 0.7193709028 10 49734965 49735038 74 - 1.541 1.610 0.234
ENSG00000197444 E005 30.6019900 0.3417669217 7.056215e-01 0.8391099182 10 49735039 49735049 11 - 1.420 1.423 0.011
ENSG00000197444 E006 37.5521239 0.3625777266 5.432577e-01 0.7313913417 10 49735050 49735107 58 - 1.454 1.522 0.233
ENSG00000197444 E007 24.9888297 0.2223717050 4.995516e-01 0.7004714909 10 49735108 49735134 27 - 1.261 1.360 0.346
ENSG00000197444 E008 79.3059880 0.5210479781 3.045563e-01 0.5451510777 10 49735135 49735351 217 - 1.647 1.864 0.733
ENSG00000197444 E009 81.0910702 0.0007256960 3.590879e-05 0.0006288037 10 49736023 49736177 155 - 1.645 1.877 0.785
ENSG00000197444 E010 79.8879137 0.0091152815 3.478730e-02 0.1410325256 10 49736357 49736520 164 - 1.701 1.858 0.531
ENSG00000197444 E011 48.4602295 0.0092118171 6.991387e-01 0.8350574574 10 49737786 49737858 73 - 1.576 1.624 0.163
ENSG00000197444 E012 66.8658639 0.0007657126 7.113413e-01 0.8426486653 10 49737947 49738072 126 - 1.725 1.764 0.130
ENSG00000197444 E013 14.0836267 0.0282475546 5.390537e-01 0.7283583693 10 49738073 49738190 118 - 1.024 1.129 0.381
ENSG00000197444 E014 48.6837949 0.0015999445 3.169147e-01 0.5568974877 10 49738191 49738262 72 - 1.651 1.610 -0.139
ENSG00000197444 E015 38.7240153 0.1164270840 3.882219e-01 0.6191069174 10 49738263 49739499 1237 - 1.574 1.503 -0.243
ENSG00000197444 E016 52.9307773 0.0007802496 7.720079e-01 0.8798028332 10 49739661 49739839 179 - 1.656 1.659 0.008
ENSG00000197444 E017 58.4241838 0.0109487752 4.842248e-01 0.6899811966 10 49740710 49740837 128 - 1.720 1.692 -0.098
ENSG00000197444 E018 69.7087551 0.0008019603 6.195551e-01 0.7835348842 10 49742828 49742978 151 - 1.776 1.771 -0.019
ENSG00000197444 E019 19.5592914 0.0384602003 3.699209e-01 0.6038930979 10 49743571 49743993 423 - 1.304 1.217 -0.305
ENSG00000197444 E020 56.6858995 0.0227843895 9.111270e-01 0.9577474309 10 49743994 49744122 129 - 1.660 1.684 0.082
ENSG00000197444 E021 49.0178782 0.0262736454 9.439415e-01 0.9743296145 10 49744650 49744752 103 - 1.612 1.619 0.024
ENSG00000197444 E022 54.8312954 0.0027432704 1.039748e-01 0.2888073074 10 49745344 49745496 153 - 1.575 1.697 0.415
ENSG00000197444 E023 54.2312630 0.0008621121 7.710097e-01 0.8792729772 10 49745798 49745977 180 - 1.639 1.675 0.122
ENSG00000197444 E024 45.7994568 0.0024700706 9.927405e-01 0.9980238081 10 49746750 49746878 129 - 1.581 1.601 0.068
ENSG00000197444 E025 54.9540011 0.0007642312 1.235831e-01 0.3214121947 10 49747029 49747208 180 - 1.721 1.656 -0.220
ENSG00000197444 E026 31.3151535 0.0036559273 4.462950e-01 0.6629370840 10 49749726 49749816 91 - 1.465 1.426 -0.135
ENSG00000197444 E027 54.2691793 0.0100019158 1.497590e-01 0.3619567108 10 49750839 49750985 147 - 1.730 1.649 -0.273
ENSG00000197444 E028 51.8480252 0.0061219725 3.095688e-02 0.1302280032 10 49751827 49751981 155 - 1.739 1.617 -0.414
ENSG00000197444 E029 42.0189753 0.0040461364 1.648912e-01 0.3838569329 10 49752133 49752248 116 - 1.614 1.539 -0.256
ENSG00000197444 E030 35.5495160 0.0051288421 9.377169e-02 0.2707665016 10 49752638 49752740 103 - 1.567 1.463 -0.357
ENSG00000197444 E031 3.1669546 0.0083452213 4.017650e-03 0.0292664745 10 49756590 49756775 186 - 0.845 0.409 -1.937
ENSG00000197444 E032 42.7943947 0.0065848931 2.609175e-02 0.1156189242 10 49756776 49756946 171 - 1.663 1.524 -0.474
ENSG00000197444 E033 30.4615583 0.0015611969 1.800180e-02 0.0890353835 10 49758389 49758593 205 - 1.531 1.382 -0.514
ENSG00000197444 E034 1.0462052 0.0263691954 6.417939e-01   10 49761969 49762238 270 - 0.204 0.309 0.789
ENSG00000197444 E035 4.3605961 0.0062444316 2.897741e-02 0.1242928491 10 49762239 49762332 94 - 0.881 0.577 -1.248
ENSG00000197444 E036 0.3447487 0.4219706976 1.000000e+00   10 49762333 49762379 47 - 0.001 0.131 8.096