ENSG00000197386

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355072 ENSG00000197386 HEK293_OSMI2_6hA HEK293_TMG_6hB HTT protein_coding protein_coding 31.52475 44.68484 28.283 5.165536 1.439938 -0.6596629 12.0444012 20.756482 8.535619 2.9357012 0.2932495 -1.28099991 0.38020000 0.46146667 0.30263333 -0.15883333 1.824646e-03 2.813937e-17 FALSE TRUE
ENST00000512068 ENSG00000197386 HEK293_OSMI2_6hA HEK293_TMG_6hB HTT protein_coding retained_intron 31.52475 44.68484 28.283 5.165536 1.439938 -0.6596629 1.5690530 1.908282 1.985022 0.6570068 0.2226266 0.05658967 0.05314583 0.04763333 0.07016667 0.02253333 7.039828e-01 2.813937e-17 FALSE FALSE
MSTRG.24499.10 ENSG00000197386 HEK293_OSMI2_6hA HEK293_TMG_6hB HTT protein_coding   31.52475 44.68484 28.283 5.165536 1.439938 -0.6596629 2.0073881 0.000000 2.363565 0.0000000 1.3993977 7.89091185 0.08220833 0.00000000 0.08116667 0.08116667 2.560982e-01 2.813937e-17 FALSE TRUE
MSTRG.24499.12 ENSG00000197386 HEK293_OSMI2_6hA HEK293_TMG_6hB HTT protein_coding   31.52475 44.68484 28.283 5.165536 1.439938 -0.6596629 0.3894934 0.000000 1.682188 0.0000000 0.4070643 7.40274630 0.01442500 0.00000000 0.05936667 0.05936667 6.067788e-13 2.813937e-17 FALSE TRUE
MSTRG.24499.13 ENSG00000197386 HEK293_OSMI2_6hA HEK293_TMG_6hB HTT protein_coding   31.52475 44.68484 28.283 5.165536 1.439938 -0.6596629 1.4667925 1.960379 4.978097 0.2178770 0.6671104 1.34001671 0.05046250 0.04636667 0.17850000 0.13213333 4.121672e-03 2.813937e-17 TRUE TRUE
MSTRG.24499.17 ENSG00000197386 HEK293_OSMI2_6hA HEK293_TMG_6hB HTT protein_coding   31.52475 44.68484 28.283 5.165536 1.439938 -0.6596629 3.9874822 7.527751 5.339613 1.1709479 0.2085171 -0.49469961 0.13559167 0.16703333 0.18903333 0.02200000 7.821313e-01 2.813937e-17 TRUE TRUE
MSTRG.24499.18 ENSG00000197386 HEK293_OSMI2_6hA HEK293_TMG_6hB HTT protein_coding   31.52475 44.68484 28.283 5.165536 1.439938 -0.6596629 4.1936178 6.721374 0.000000 1.6589258 0.0000000 -9.39475730 0.10892500 0.14550000 0.00000000 -0.14550000 2.813937e-17 2.813937e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000197386 E001 0.0000000       4 3041363 3041421 59 +      
ENSG00000197386 E002 0.0000000       4 3041422 3041561 140 +      
ENSG00000197386 E003 0.0000000       4 3041562 3041747 186 +      
ENSG00000197386 E004 0.0000000       4 3041748 3041928 181 +      
ENSG00000197386 E005 0.0000000       4 3041929 3042245 317 +      
ENSG00000197386 E006 0.1426347 0.0325157463 2.231960e-01   4 3062476 3062692 217 + 0.169 0.000 -10.067
ENSG00000197386 E007 0.3150090 0.0312171094 5.698950e-01   4 3071236 3071396 161 + 0.169 0.086 -1.114
ENSG00000197386 E008 0.1723744 0.0406531173 1.000000e+00   4 3073358 3073479 122 + 0.000 0.086 10.576
ENSG00000197386 E009 44.5706633 0.0055102726 2.996816e-02 1.272480e-01 4 3074681 3074972 292 + 1.719 1.585 -0.455
ENSG00000197386 E010 4.0952755 0.0066615254 6.239491e-01 7.865737e-01 4 3074973 3074993 21 + 0.722 0.654 -0.287
ENSG00000197386 E011 2.9939601 0.0302147700 1.343410e-01 3.386451e-01 4 3074994 3075040 47 + 0.723 0.474 -1.114
ENSG00000197386 E012 12.3899833 0.0028404726 9.059219e-02 2.648642e-01 4 3075041 3075088 48 + 1.197 1.036 -0.578
ENSG00000197386 E013 48.7302214 0.0008264188 4.748500e-06 1.100386e-04 4 3086939 3087022 84 + 1.808 1.575 -0.789
ENSG00000197386 E014 87.1503495 0.0035514590 1.854064e-08 8.200407e-07 4 3099274 3099394 121 + 2.075 1.810 -0.892
ENSG00000197386 E015 74.6920725 0.0015900923 5.339366e-11 3.989209e-09 4 3103824 3103883 60 + 2.024 1.734 -0.975
ENSG00000197386 E016 94.3764312 0.0017757048 2.919913e-11 2.318225e-09 4 3105357 3105436 80 + 2.116 1.845 -0.910
ENSG00000197386 E017 132.8620669 0.0012606979 1.111976e-14 1.612631e-12 4 3107285 3107423 139 + 2.259 1.992 -0.894
ENSG00000197386 E018 0.0000000       4 3112864 3113052 189 +      
ENSG00000197386 E019 65.7220887 0.0015120870 4.623336e-09 2.340235e-07 4 3115304 3115328 25 + 1.958 1.688 -0.914
ENSG00000197386 E020 124.7784335 0.0004377269 6.076820e-23 2.486708e-20 4 3115329 3115445 117 + 2.260 1.942 -1.066
ENSG00000197386 E021 153.1555321 0.0016950360 5.369726e-21 1.777589e-18 4 3116085 3116263 179 + 2.351 2.028 -1.079
ENSG00000197386 E022 163.9860033 0.0036298091 2.582162e-14 3.582602e-12 4 3121228 3121399 172 + 2.371 2.069 -1.011
ENSG00000197386 E023 94.5723616 0.0025097695 3.316056e-08 1.380590e-06 4 3121400 3121432 33 + 2.100 1.864 -0.791
ENSG00000197386 E024 3.5301091 0.0075144949 5.197993e-01 7.148950e-01 4 3121433 3121712 280 + 0.681 0.586 -0.415
ENSG00000197386 E025 83.8711247 0.0006889920 8.162856e-06 1.758519e-04 4 3122889 3122936 48 + 2.014 1.839 -0.587
ENSG00000197386 E026 4.8438134 0.0506336638 8.416665e-03 5.123094e-02 4 3122937 3123466 530 + 0.981 0.560 -1.708
ENSG00000197386 E027 103.9034229 0.0003837173 5.821060e-10 3.539383e-08 4 3125549 3125629 81 + 2.127 1.911 -0.724
ENSG00000197386 E028 284.5454507 0.0011531562 1.950472e-16 3.592571e-14 4 3127264 3127604 341 + 2.561 2.345 -0.720
ENSG00000197386 E029 4.8118927 0.1385846658 2.318018e-01 4.672643e-01 4 3128339 3129923 1585 + 0.893 0.618 -1.112
ENSG00000197386 E030 145.6276570 0.0044901394 8.589153e-09 4.097291e-07 4 3129924 3129999 76 + 2.291 2.037 -0.847
ENSG00000197386 E031 99.9949455 0.0004524771 5.155556e-09 2.584978e-07 4 3130000 3130047 48 + 2.105 1.896 -0.702
ENSG00000197386 E032 0.4764247 0.0211445345 2.150960e-01   4 3130048 3130304 257 + 0.290 0.086 -2.115
ENSG00000197386 E033 173.0966412 0.0061657059 7.288160e-07 2.157046e-05 4 3130305 3130423 119 + 2.355 2.123 -0.773
ENSG00000197386 E034 147.0416329 0.0138167705 1.437718e-03 1.316923e-02 4 3131286 3131397 112 + 2.269 2.066 -0.679
ENSG00000197386 E035 163.1460795 0.0058069521 4.261237e-06 1.002571e-04 4 3131638 3131775 138 + 2.319 2.105 -0.717
ENSG00000197386 E036 207.5625200 0.0031933071 3.265275e-09 1.705687e-07 4 3132562 3132720 159 + 2.424 2.206 -0.728
ENSG00000197386 E037 145.0465703 0.0069543627 3.100533e-04 3.831904e-03 4 3132814 3132911 98 + 2.248 2.065 -0.614
ENSG00000197386 E038 163.3145447 0.0092950437 1.298264e-04 1.858823e-03 4 3134401 3134540 140 + 2.316 2.105 -0.708
ENSG00000197386 E039 141.8101772 0.0079733433 9.350965e-06 1.978827e-04 4 3135904 3135967 64 + 2.269 2.036 -0.780
ENSG00000197386 E040 136.3131134 0.0028410903 1.222338e-07 4.442137e-06 4 3136226 3136326 101 + 2.238 2.030 -0.699
ENSG00000197386 E041 162.7698417 0.0021410863 7.152920e-08 2.751918e-06 4 3140510 3140656 147 + 2.303 2.113 -0.636
ENSG00000197386 E042 1.1436295 0.0142081370 8.787275e-01   4 3142745 3142765 21 + 0.290 0.321 0.206
ENSG00000197386 E043 194.1046886 0.0017396996 2.176283e-08 9.471625e-07 4 3142766 3142886 121 + 2.373 2.196 -0.593
ENSG00000197386 E044 144.9540933 0.0039551661 2.361418e-03 1.945297e-02 4 3145152 3145228 77 + 2.215 2.090 -0.416
ENSG00000197386 E045 213.2940280 0.0005710185 2.450003e-09 1.323368e-07 4 3146797 3146948 152 + 2.400 2.244 -0.519
ENSG00000197386 E046 98.7519621 0.0004911537 1.981775e-06 5.177706e-05 4 3148005 3148008 4 + 2.075 1.902 -0.579
ENSG00000197386 E047 268.5211098 0.0002245542 6.525449e-20 1.910640e-17 4 3148009 3148207 199 + 2.527 2.325 -0.675
ENSG00000197386 E048 209.2421208 0.0014694073 2.276136e-12 2.205022e-10 4 3154293 3154419 127 + 2.425 2.212 -0.710
ENSG00000197386 E049 233.5448232 0.0002797118 1.725599e-19 4.696991e-17 4 3157072 3157199 128 + 2.476 2.261 -0.718
ENSG00000197386 E050 194.2893467 0.0003151203 4.189584e-10 2.605228e-08 4 3160282 3160361 80 + 2.364 2.201 -0.545
ENSG00000197386 E051 161.3910102 0.0003656142 6.135465e-06 1.374232e-04 4 3160362 3160392 31 + 2.262 2.133 -0.432
ENSG00000197386 E052 197.3349978 0.0003063112 5.466744e-07 1.675774e-05 4 3172320 3172397 78 + 2.348 2.218 -0.433
ENSG00000197386 E053 294.7219727 0.0002057185 1.957618e-06 5.122680e-05 4 3172908 3173131 224 + 2.506 2.406 -0.332
ENSG00000197386 E054 4.8750626 0.0167773236 8.116422e-01 9.032590e-01 4 3173132 3173218 87 + 0.723 0.763 0.165
ENSG00000197386 E055 2.1565260 0.3531507390 6.463155e-01 8.010746e-01 4 3173219 3173331 113 + 0.590 0.426 -0.793
ENSG00000197386 E056 181.6124304 0.0047452679 3.526051e-03 2.649929e-02 4 3174721 3174799 79 + 2.312 2.187 -0.416
ENSG00000197386 E057 250.1627554 0.0037245271 7.127691e-04 7.549462e-03 4 3174946 3175107 162 + 2.449 2.322 -0.425
ENSG00000197386 E058 153.3173347 0.0047232882 7.637206e-03 4.764780e-02 4 3177332 3177387 56 + 2.232 2.113 -0.398
ENSG00000197386 E059 151.9833622 0.0021068878 9.326775e-05 1.410671e-03 4 3178298 3178346 49 + 2.243 2.101 -0.474
ENSG00000197386 E060 181.5266126 0.0005510442 3.606222e-07 1.159446e-05 4 3178347 3178446 100 + 2.322 2.181 -0.472
ENSG00000197386 E061 229.9511219 0.0021408043 1.894285e-03 1.636616e-02 4 3180515 3180651 137 + 2.397 2.297 -0.334
ENSG00000197386 E062 1.3050451 0.0137931186 7.127116e-01   4 3180652 3180794 143 + 0.385 0.321 -0.379
ENSG00000197386 E063 258.2835646 0.0017443706 4.343554e-02 1.636766e-01 4 3182354 3182470 117 + 2.421 2.362 -0.196
ENSG00000197386 E064 274.3679236 0.0014597282 7.341690e-02 2.316373e-01 4 3186597 3186719 123 + 2.441 2.392 -0.162
ENSG00000197386 E065 390.0920619 0.0001677125 7.018543e-03 4.473129e-02 4 3187651 3187886 236 + 2.591 2.544 -0.156
ENSG00000197386 E066 1.4088774 0.4628161633 7.022258e-01 8.369769e-01 4 3187887 3188950 1064 + 0.285 0.403 0.721
ENSG00000197386 E067 267.3348618 0.0002002859 2.611814e-01 5.002155e-01 4 3188951 3189093 143 + 2.411 2.391 -0.068
ENSG00000197386 E068 342.2203845 0.0001541550 3.987575e-01 6.272523e-01 4 3199732 3199939 208 + 2.488 2.512 0.081
ENSG00000197386 E069 20.8847192 0.0235412869 9.553301e-01 9.795679e-01 4 3199940 3201450 1511 + 1.293 1.303 0.033
ENSG00000197386 E070 14.0657352 0.0287006319 2.296967e-01 4.647988e-01 4 3202977 3202981 5 + 1.041 1.199 0.571
ENSG00000197386 E071 26.5940219 0.0021314049 5.400803e-01 7.290552e-01 4 3202982 3203066 85 + 1.377 1.428 0.178
ENSG00000197386 E072 321.4409184 0.0002342902 1.133759e-01 3.047803e-01 4 3204007 3204148 142 + 2.496 2.468 -0.093
ENSG00000197386 E073 378.2994247 0.0009808805 5.260016e-01 7.192668e-01 4 3206496 3206675 180 + 2.530 2.552 0.073
ENSG00000197386 E074 347.2643334 0.0014567403 9.677155e-02 2.760631e-01 4 3206807 3206983 177 + 2.471 2.523 0.171
ENSG00000197386 E075 138.4532972 0.0013631278 5.723640e-02 1.965633e-01 4 3207281 3207285 5 + 2.056 2.131 0.254
ENSG00000197386 E076 258.1918751 0.0015361279 4.217155e-01 6.449192e-01 4 3207286 3207357 72 + 2.359 2.390 0.101
ENSG00000197386 E077 188.3890178 0.0003614633 3.208629e-01 5.604590e-01 4 3208773 3208802 30 + 2.260 2.238 -0.073
ENSG00000197386 E078 314.7771494 0.0013759608 5.580056e-01 7.418597e-01 4 3208803 3208911 109 + 2.476 2.465 -0.037
ENSG00000197386 E079 312.3308283 0.0007649014 2.134652e-01 4.457803e-01 4 3209827 3209949 123 + 2.439 2.475 0.120
ENSG00000197386 E080 0.3926045 0.3933020336 4.886414e-01   4 3211912 3211928 17 + 0.000 0.210 11.007
ENSG00000197386 E081 343.2968081 0.0012780388 6.012520e-04 6.588361e-03 4 3211929 3212142 214 + 2.435 2.536 0.336
ENSG00000197386 E082 258.3720751 0.0012816455 7.344913e-05 1.156225e-03 4 3212564 3212709 146 + 2.291 2.418 0.425
ENSG00000197386 E083 7.5858894 0.1360201085 7.250551e-01 8.511578e-01 4 3212710 3213055 346 + 0.829 0.932 0.394
ENSG00000197386 E084 6.1310954 0.2530253616 5.922731e-01 7.651350e-01 4 3213917 3213957 41 + 0.895 0.784 -0.433
ENSG00000197386 E085 353.7375276 0.0008906227 8.508435e-04 8.695124e-03 4 3213958 3214135 178 + 2.453 2.543 0.301
ENSG00000197386 E086 6.7909376 0.2523984023 7.979567e-01 8.951620e-01 4 3214136 3214156 21 + 0.944 0.835 -0.414
ENSG00000197386 E087 297.2823819 0.0002752035 1.379727e-02 7.353191e-02 4 3215110 3215211 102 + 2.396 2.460 0.214
ENSG00000197386 E088 420.4397695 0.0018730630 1.284253e-02 6.979060e-02 4 3217765 3217952 188 + 2.537 2.612 0.251
ENSG00000197386 E089 399.3190649 0.0013146704 1.135323e-01 3.050309e-01 4 3220182 3220308 127 + 2.537 2.583 0.152
ENSG00000197386 E090 363.7342992 0.0001938748 9.024485e-03 5.393697e-02 4 3222387 3222487 101 + 2.486 2.547 0.204
ENSG00000197386 E091 429.6078951 0.0016420058 1.315685e-04 1.879805e-03 4 3223406 3223560 155 + 2.520 2.632 0.373
ENSG00000197386 E092 365.2808566 0.0030292129 4.839632e-05 8.088582e-04 4 3223992 3224131 140 + 2.423 2.571 0.493
ENSG00000197386 E093 273.9515841 0.0012880306 1.912431e-08 8.423798e-07 4 3225661 3225743 83 + 2.278 2.453 0.585
ENSG00000197386 E094 167.3296478 0.0012964124 1.920539e-05 3.695351e-04 4 3228615 3228644 30 + 2.079 2.238 0.532
ENSG00000197386 E095 251.8008556 0.0022063625 2.890134e-08 1.220444e-06 4 3228645 3228712 68 + 2.223 2.423 0.668
ENSG00000197386 E096 211.9800304 0.0004889027 9.149044e-09 4.338783e-07 4 3228713 3228745 33 + 2.168 2.344 0.587
ENSG00000197386 E097 14.3404710 0.0527477225 6.189982e-02 2.070965e-01 4 3228746 3228879 134 + 1.311 1.057 -0.903
ENSG00000197386 E098 365.1607587 0.0001778782 7.471645e-13 7.827619e-11 4 3228880 3229009 130 + 2.414 2.576 0.538
ENSG00000197386 E099 394.6257228 0.0002775296 1.136969e-12 1.148623e-10 4 3229887 3230042 156 + 2.450 2.609 0.530
ENSG00000197386 E100 434.6602823 0.0004140373 8.770411e-09 4.174376e-07 4 3233163 3233353 191 + 2.514 2.641 0.424
ENSG00000197386 E101 386.0051967 0.0003725720 3.506449e-09 1.818802e-07 4 3235284 3235398 115 + 2.456 2.593 0.454
ENSG00000197386 E102 0.6730019 0.0193874923 4.398351e-01   4 3235424 3235564 141 + 0.290 0.158 -1.118
ENSG00000197386 E103 497.2315619 0.0002771498 6.124397e-20 1.805666e-17 4 3235565 3235778 214 + 2.531 2.717 0.618
ENSG00000197386 E104 370.7299115 0.0001864396 5.693285e-20 1.684409e-17 4 3236149 3236254 106 + 2.388 2.594 0.688
ENSG00000197386 E105 323.4811242 0.0022362958 3.448786e-08 1.429193e-06 4 3238447 3238528 82 + 2.342 2.527 0.616
ENSG00000197386 E106 353.3611027 0.0049339444 1.981247e-05 3.791968e-04 4 3238529 3238609 81 + 2.384 2.564 0.600
ENSG00000197386 E107 505.0964114 0.0033871832 1.111053e-10 7.809702e-09 4 3238818 3238978 161 + 2.502 2.730 0.759
ENSG00000197386 E108 2166.8817263 0.0003799490 1.835374e-89 3.097067e-85 4 3239846 3243957 4112 + 3.115 3.368 0.842