ENSG00000197381

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360697 ENSG00000197381 HEK293_OSMI2_6hA HEK293_TMG_6hB ADARB1 protein_coding protein_coding 13.97086 17.31329 13.22501 1.532704 0.1970921 -0.3883539 1.9858294 1.997222 0.3918611 1.15133455 0.3918611 -2.32043100 0.1364500 0.10836667 0.03016667 -0.078200000 6.665778e-01 1.890141e-09 FALSE TRUE
ENST00000389863 ENSG00000197381 HEK293_OSMI2_6hA HEK293_TMG_6hB ADARB1 protein_coding protein_coding 13.97086 17.31329 13.22501 1.532704 0.1970921 -0.3883539 1.4070451 1.723509 1.3741514 0.04425818 0.3334764 -0.32469335 0.1021708 0.10060000 0.10323333 0.002633333 1.000000e+00 1.890141e-09 FALSE TRUE
ENST00000462214 ENSG00000197381 HEK293_OSMI2_6hA HEK293_TMG_6hB ADARB1 protein_coding processed_transcript 13.97086 17.31329 13.22501 1.532704 0.1970921 -0.3883539 1.5514825 1.765727 1.0780211 0.24612226 0.3969722 -0.70670338 0.1158708 0.10250000 0.08080000 -0.021700000 8.524766e-01 1.890141e-09   FALSE
ENST00000631642 ENSG00000197381 HEK293_OSMI2_6hA HEK293_TMG_6hB ADARB1 protein_coding processed_transcript 13.97086 17.31329 13.22501 1.532704 0.1970921 -0.3883539 0.7921091 1.414217 0.0000000 0.25667932 0.0000000 -7.15402487 0.0525750 0.08323333 0.00000000 -0.083233333 1.890141e-09 1.890141e-09   FALSE
MSTRG.21480.10 ENSG00000197381 HEK293_OSMI2_6hA HEK293_TMG_6hB ADARB1 protein_coding   13.97086 17.31329 13.22501 1.532704 0.1970921 -0.3883539 0.9146462 2.473286 2.5297108 0.58543872 0.4396269 0.03241371 0.0664750 0.14843333 0.19086667 0.042433333 8.348912e-01 1.890141e-09 FALSE TRUE
MSTRG.21480.21 ENSG00000197381 HEK293_OSMI2_6hA HEK293_TMG_6hB ADARB1 protein_coding   13.97086 17.31329 13.22501 1.532704 0.1970921 -0.3883539 0.5624409 0.522274 1.7236934 0.52227403 0.1515148 1.70360769 0.0441625 0.03370000 0.13066667 0.096966667 2.470301e-01 1.890141e-09 TRUE TRUE
MSTRG.21480.31 ENSG00000197381 HEK293_OSMI2_6hA HEK293_TMG_6hB ADARB1 protein_coding   13.97086 17.31329 13.22501 1.532704 0.1970921 -0.3883539 1.7087399 1.665322 2.1043282 0.84753377 0.0768262 0.33576092 0.1172042 0.09060000 0.15920000 0.068600000 6.264985e-01 1.890141e-09 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000197381 E001 0.0000000       21 45072423 45072847 425 +      
ENSG00000197381 E002 0.5339515 0.8101833205 0.20867543   21 45072848 45073458 611 + 0.366 0.000 -11.900
ENSG00000197381 E003 1.8743434 0.1223174779 0.75431788 0.86929734 21 45073459 45073852 394 + 0.488 0.437 -0.257
ENSG00000197381 E004 6.4775034 0.0197820891 0.49106302 0.69472009 21 45073853 45073903 51 + 0.808 0.900 0.354
ENSG00000197381 E005 0.0000000       21 45074569 45074579 11 +      
ENSG00000197381 E006 0.0000000       21 45074580 45074589 10 +      
ENSG00000197381 E007 0.0000000       21 45074590 45074590 1 +      
ENSG00000197381 E008 0.0000000       21 45074591 45074599 9 +      
ENSG00000197381 E009 0.9209465 0.2375066067 0.90335820   21 45074600 45074711 112 + 0.268 0.292 0.174
ENSG00000197381 E010 1.3668236 0.0595799171 0.84586724   21 45074712 45074716 5 + 0.354 0.393 0.224
ENSG00000197381 E011 3.7276276 0.0665265496 0.76695059 0.87679836 21 45074717 45074754 38 + 0.639 0.691 0.219
ENSG00000197381 E012 8.5801756 0.0175693964 0.51720567 0.71313619 21 45074755 45074793 39 + 1.027 0.948 -0.293
ENSG00000197381 E013 1.0348663 0.0255992704 0.27974323   21 45113596 45113625 30 + 0.152 0.352 1.574
ENSG00000197381 E014 1.6822373 0.6285911572 0.15172343 0.36483530 21 45116932 45116932 1 + 0.000 0.550 14.303
ENSG00000197381 E015 3.5214217 0.1902738174 0.96526505 0.98452977 21 45116933 45117038 106 + 0.599 0.658 0.256
ENSG00000197381 E016 1.5761922 0.0473426345 0.09438510 0.27188996 21 45118418 45118563 146 + 0.152 0.478 2.255
ENSG00000197381 E017 4.6764129 0.0053092620 0.23836840 0.47476439 21 45118564 45118619 56 + 0.837 0.674 -0.657
ENSG00000197381 E018 9.9897001 0.0031059491 0.84822115 0.92394624 21 45120794 45120899 106 + 1.010 1.029 0.071
ENSG00000197381 E019 6.9193620 0.0042487553 0.13567700 0.34085439 21 45120900 45120959 60 + 0.749 0.940 0.741
ENSG00000197381 E020 27.2204174 0.0145306433 0.23716752 0.47329797 21 45128402 45128452 51 + 1.371 1.472 0.349
ENSG00000197381 E021 52.0666212 0.0008533270 0.34207277 0.57980971 21 45128453 45128573 121 + 1.677 1.724 0.159
ENSG00000197381 E022 0.1723744 0.0308179748 0.77152041   21 45132215 45132306 92 + 0.000 0.096 12.397
ENSG00000197381 E023 0.9638080 0.2071244682 0.54999929   21 45133559 45133682 124 + 0.351 0.244 -0.719
ENSG00000197381 E024 18.9822190 0.0081504330 0.08555299 0.25560898 21 45134715 45134795 81 + 1.171 1.328 0.553
ENSG00000197381 E025 18.1937494 0.0038409722 0.06187538 0.20704740 21 45134796 45134832 37 + 1.146 1.310 0.581
ENSG00000197381 E026 9.9486062 0.0230018057 0.40656378 0.63345335 21 45137081 45137326 246 + 0.951 1.053 0.377
ENSG00000197381 E027 9.8414112 0.0032293018 0.84351116 0.92135453 21 45144631 45144962 332 + 1.009 1.029 0.070
ENSG00000197381 E028 21.2373143 0.0016455424 0.24560298 0.48310130 21 45145164 45146295 1132 + 1.270 1.359 0.313
ENSG00000197381 E029 9.2296400 0.0056992364 0.05874240 0.19995209 21 45160101 45160223 123 + 0.837 1.059 0.832
ENSG00000197381 E030 33.6075383 0.0013955331 0.83906847 0.91885995 21 45171610 45171641 32 + 1.528 1.513 -0.051
ENSG00000197381 E031 38.2612486 0.0011098551 0.05644928 0.19470279 21 45171642 45171684 43 + 1.649 1.538 -0.380
ENSG00000197381 E032 1.5187535 0.4406310178 0.22483815 0.45922461 21 45171685 45171759 75 + 0.553 0.246 -1.755
ENSG00000197381 E033 205.7246807 0.0027031605 0.03018132 0.12788130 21 45175730 45176409 680 + 2.344 2.268 -0.254
ENSG00000197381 E034 118.3094051 0.0134514506 0.51022787 0.70817468 21 45176410 45176664 255 + 2.089 2.041 -0.163
ENSG00000197381 E035 3.3146488 0.0076000297 0.07224982 0.22931256 21 45177067 45177547 481 + 0.780 0.510 -1.170
ENSG00000197381 E036 72.9369758 0.0046206739 0.36491104 0.59986533 21 45180330 45180435 106 + 1.882 1.832 -0.171
ENSG00000197381 E037 41.8441485 0.0011306273 0.06443678 0.21264765 21 45180436 45180444 9 + 1.681 1.577 -0.355
ENSG00000197381 E038 8.8739409 0.1115583971 0.27850785 0.51859650 21 45181070 45181232 163 + 1.073 0.924 -0.552
ENSG00000197381 E039 8.3533622 0.3301077860 0.16485021 0.38382421 21 45181322 45181479 158 + 1.080 0.864 -0.807
ENSG00000197381 E040 5.8974768 0.1070706254 0.11980585 0.31555601 21 45181480 45181516 37 + 0.979 0.696 -1.103
ENSG00000197381 E041 96.3474200 0.0005016169 0.53439866 0.72518803 21 45182585 45182753 169 + 1.985 1.960 -0.084
ENSG00000197381 E042 100.6129999 0.0005783532 0.94845468 0.97649196 21 45183362 45183510 149 + 1.989 1.984 -0.014
ENSG00000197381 E043 87.0279958 0.0084719442 0.83223975 0.91511723 21 45184474 45184593 120 + 1.935 1.922 -0.046
ENSG00000197381 E044 117.2582042 0.0062809174 0.31239739 0.55270407 21 45184923 45185091 169 + 2.092 2.038 -0.181
ENSG00000197381 E045 107.6441975 0.0091230608 0.53395313 0.72487508 21 45204555 45204736 182 + 2.046 2.009 -0.126
ENSG00000197381 E046 111.1570681 0.0016620992 0.56382902 0.74598680 21 45220836 45220970 135 + 2.050 2.026 -0.080
ENSG00000197381 E047 66.2296111 0.0006016590 0.35677736 0.59315709 21 45220971 45221014 44 + 1.836 1.793 -0.144
ENSG00000197381 E048 96.4719647 0.0007238848 0.83221500 0.91511666 21 45222018 45222107 90 + 1.976 1.966 -0.033
ENSG00000197381 E049 51.6020305 0.0007637348 0.50385536 0.70348451 21 45222108 45222111 4 + 1.681 1.713 0.110
ENSG00000197381 E050 71.2621786 0.0005978980 0.32068166 0.56029410 21 45222112 45222280 169 + 1.814 1.856 0.142
ENSG00000197381 E051 75.9657611 0.0005608345 0.72623065 0.85190763 21 45222281 45222760 480 + 1.859 1.872 0.045
ENSG00000197381 E052 138.8926411 0.0003314104 0.16494157 0.38390322 21 45222761 45223577 817 + 2.102 2.143 0.139
ENSG00000197381 E053 222.9658941 0.0075326080 0.28430273 0.52481067 21 45223578 45225546 1969 + 2.296 2.355 0.195
ENSG00000197381 E054 267.8713656 0.0020304105 0.01809120 0.08932689 21 45225547 45226560 1014 + 2.368 2.438 0.233