ENSG00000197375

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000245407 ENSG00000197375 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC22A5 protein_coding protein_coding 14.93811 15.21199 14.52933 0.7842938 0.4404923 -0.06619591 8.5243201 8.818334 8.1381253 0.5875192 0.1870956 -0.1156731 0.5756125 0.5808000 0.56186667 -0.01893333 9.598663e-01 1.976552e-08 FALSE TRUE
ENST00000447841 ENSG00000197375 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC22A5 protein_coding nonsense_mediated_decay 14.93811 15.21199 14.52933 0.7842938 0.4404923 -0.06619591 2.6917036 2.124712 1.8017281 0.8715092 0.8487802 -0.2366747 0.1779583 0.1381667 0.12080000 -0.01736667 9.904770e-01 1.976552e-08 FALSE FALSE
ENST00000686757 ENSG00000197375 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC22A5 protein_coding nonsense_mediated_decay 14.93811 15.21199 14.52933 0.7842938 0.4404923 -0.06619591 0.2344161 0.000000 0.9028622 0.0000000 0.2044536 6.5123252 0.0156000 0.0000000 0.06236667 0.06236667 1.976552e-08 1.976552e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000197375 E001 11.193210 0.1019776128 0.0070687326 0.044947539 5 132369710 132369816 107 + 0.745 1.249 1.876
ENSG00000197375 E002 11.457329 0.1336599992 0.0058426298 0.038965320 5 132369817 132369838 22 + 0.718 1.262 2.032
ENSG00000197375 E003 18.275497 0.0958129785 0.0004062505 0.004790021 5 132369839 132369899 61 + 0.841 1.468 2.260
ENSG00000197375 E004 26.309179 0.2471033932 0.0160745710 0.082080458 5 132369900 132369972 73 + 1.047 1.606 1.955
ENSG00000197375 E005 85.839220 0.0916815136 0.0305844025 0.129101366 5 132369973 132370365 393 + 1.734 2.052 1.069
ENSG00000197375 E006 7.098289 0.0046273889 0.3406430130 0.578588544 5 132376086 132378163 2078 + 0.824 0.965 0.540
ENSG00000197375 E007 1.118071 0.0147852103 0.0990013009   5 132378164 132378167 4 + 0.132 0.441 2.317
ENSG00000197375 E008 1.897738 0.0105972470 0.1871976603 0.413304229 5 132378168 132378235 68 + 0.314 0.562 1.318
ENSG00000197375 E009 49.737306 0.0009866517 0.6856241230 0.826260810 5 132378378 132378432 55 + 1.697 1.706 0.028
ENSG00000197375 E010 56.095565 0.0006807324 0.0174873023 0.087245418 5 132378433 132378481 49 + 1.796 1.713 -0.281
ENSG00000197375 E011 66.963901 0.0279084844 0.5749131486 0.753603446 5 132378482 132382470 3989 + 1.825 1.833 0.026
ENSG00000197375 E012 28.083639 0.0365572513 0.8902040137 0.946786053 5 132382471 132384146 1676 + 1.420 1.491 0.244
ENSG00000197375 E013 106.051572 0.0010624669 0.0076137560 0.047539925 5 132384147 132384301 155 + 2.059 1.990 -0.230
ENSG00000197375 E014 7.691521 0.0064188622 0.0362017530 0.144773385 5 132384302 132384314 13 + 1.038 0.819 -0.825
ENSG00000197375 E015 6.489989 0.0046665938 0.0891292688 0.262175875 5 132384315 132384320 6 + 0.961 0.779 -0.701
ENSG00000197375 E016 20.803365 0.0780784203 0.5886892002 0.762799471 5 132384321 132384849 529 + 1.327 1.335 0.027
ENSG00000197375 E017 14.080805 0.0282064317 0.8065627016 0.900057638 5 132384850 132385327 478 + 1.160 1.177 0.061
ENSG00000197375 E018 66.843702 0.0006842757 0.0003079123 0.003809323 5 132385328 132385375 48 + 1.891 1.762 -0.433
ENSG00000197375 E019 85.274503 0.0012777849 0.0004538413 0.005255195 5 132385376 132385499 124 + 1.989 1.875 -0.383
ENSG00000197375 E020 10.417474 0.0814376318 0.8742585410 0.938344836 5 132385500 132386252 753 + 0.992 1.101 0.399
ENSG00000197375 E021 5.312257 0.0196295568 0.5338760674 0.724824355 5 132386253 132386370 118 + 0.720 0.840 0.481
ENSG00000197375 E022 16.237756 0.1302657710 0.8331352258 0.915538725 5 132386371 132386989 619 + 1.178 1.279 0.358
ENSG00000197375 E023 4.564253 0.0168680986 0.9534699692 0.978670576 5 132386990 132387024 35 + 0.720 0.757 0.153
ENSG00000197375 E024 60.584245 0.0025444286 0.0049159006 0.034175249 5 132387025 132387061 37 + 1.844 1.735 -0.369
ENSG00000197375 E025 89.167593 0.0005665673 0.0155637700 0.080219926 5 132387062 132387151 90 + 1.983 1.921 -0.207
ENSG00000197375 E026 1.213778 0.0150324832 0.2818683590   5 132387813 132387828 16 + 0.232 0.441 1.317
ENSG00000197375 E027 2.040373 0.0101292691 0.3487053873 0.586150462 5 132387829 132387866 38 + 0.383 0.562 0.903
ENSG00000197375 E028 17.410955 0.1303709299 0.6466492743 0.801270002 5 132387867 132388910 1044 + 1.126 1.346 0.777
ENSG00000197375 E029 3.105975 0.1084764343 0.7548318464 0.869581418 5 132388911 132388920 10 + 0.540 0.661 0.537
ENSG00000197375 E030 75.356623 0.0005840439 0.2530565443 0.491317093 5 132388921 132388959 39 + 1.887 1.869 -0.059
ENSG00000197375 E031 77.552032 0.0005062443 0.7334186845 0.856305594 5 132388960 132389021 62 + 1.881 1.896 0.052
ENSG00000197375 E032 30.349980 0.0249191347 0.3034360815 0.543988785 5 132389022 132390689 1668 + 1.402 1.549 0.504
ENSG00000197375 E033 93.926417 0.0004211924 0.5254261242 0.718774947 5 132390690 132390775 86 + 1.941 1.993 0.176
ENSG00000197375 E034 104.487480 0.0111243026 0.4990743233 0.700161540 5 132390776 132390904 129 + 1.979 2.047 0.228
ENSG00000197375 E035 5.846689 0.0062382343 0.1188043449 0.313902470 5 132390905 132392432 1528 + 0.689 0.922 0.920
ENSG00000197375 E036 134.681539 0.0068763234 0.9292556840 0.966658834 5 132392433 132392615 183 + 2.110 2.142 0.109
ENSG00000197375 E037 5.329683 0.0147814104 0.3260832906 0.565267623 5 132393234 132393675 442 + 0.690 0.857 0.667
ENSG00000197375 E038 153.079335 0.0003444917 0.3825567838 0.614292313 5 132393676 132393811 136 + 2.180 2.184 0.015
ENSG00000197375 E039 596.614267 0.0052335273 0.9087567826 0.956446421 5 132394185 132395613 1429 + 2.758 2.785 0.089