ENSG00000197324

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359591 ENSG00000197324 HEK293_OSMI2_6hA HEK293_TMG_6hB LRP10 protein_coding protein_coding 11.17292 15.84429 7.413447 2.451776 0.4875568 -1.094712 2.642232 3.026211 2.2077278 0.3653411 0.12633136 -0.4531898 0.2555125 0.1956333 0.30060000 0.1049667 0.30034971 0.03711637 FALSE TRUE
ENST00000553002 ENSG00000197324 HEK293_OSMI2_6hA HEK293_TMG_6hB LRP10 protein_coding retained_intron 11.17292 15.84429 7.413447 2.451776 0.4875568 -1.094712 3.863956 5.068013 3.4737200 1.0631880 0.14836878 -0.5436353 0.3578458 0.3151667 0.46993333 0.1547667 0.03711637 0.03711637 FALSE TRUE
MSTRG.9202.1 ENSG00000197324 HEK293_OSMI2_6hA HEK293_TMG_6hB LRP10 protein_coding   11.17292 15.84429 7.413447 2.451776 0.4875568 -1.094712 1.342551 2.940219 0.2947196 0.2660359 0.29471957 -3.2752681 0.1099583 0.1899333 0.03523333 -0.1547000 0.19491279 0.03711637 FALSE TRUE
MSTRG.9202.3 ENSG00000197324 HEK293_OSMI2_6hA HEK293_TMG_6hB LRP10 protein_coding   11.17292 15.84429 7.413447 2.451776 0.4875568 -1.094712 3.197581 4.744465 1.3612870 0.9658605 0.07717418 -1.7937526 0.2646958 0.2956000 0.18450000 -0.1111000 0.22264084 0.03711637 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000197324 E001 0.1308682 0.0326491905 1.000000e+00   14 22871649 22871739 91 + 0.000 0.075 7.778
ENSG00000197324 E002 21.4409050 0.1464568887 2.828166e-01 5.232611e-01 14 22871740 22871824 85 + 1.140 1.338 0.697
ENSG00000197324 E003 39.3203519 0.2964370699 2.018041e-01 4.318746e-01 14 22871825 22871897 73 + 1.340 1.600 0.894
ENSG00000197324 E004 41.5887890 0.2665694590 1.219567e-01 3.189948e-01 14 22871898 22871938 41 + 1.309 1.633 1.115
ENSG00000197324 E005 102.5085288 0.5908590422 1.968266e-01 4.255827e-01 14 22871939 22872303 365 + 1.685 2.018 1.122
ENSG00000197324 E006 39.8397500 0.2814197481 1.547285e-01 3.690136e-01 14 22872304 22872337 34 + 1.307 1.612 1.049
ENSG00000197324 E007 45.8596548 0.0151369244 5.272850e-02 1.860562e-01 14 22872738 22872782 45 + 1.474 1.657 0.623
ENSG00000197324 E008 0.2617363 0.0742839800 7.715193e-01   14 22873085 22873310 226 + 0.000 0.139 10.401
ENSG00000197324 E009 91.5969913 0.0004243668 1.383133e-01 3.449818e-01 14 22873311 22873446 136 + 1.845 1.932 0.293
ENSG00000197324 E010 81.0405387 0.0005387248 2.116869e-01 4.437504e-01 14 22875055 22875135 81 + 1.881 1.850 -0.106
ENSG00000197324 E011 102.6333977 0.0007746095 6.081639e-03 4.013220e-02 14 22875136 22875245 110 + 2.022 1.937 -0.285
ENSG00000197324 E012 93.4790111 0.0079530570 5.238393e-01 7.177026e-01 14 22875355 22875465 111 + 1.933 1.915 -0.060
ENSG00000197324 E013 391.8463236 0.0001943249 4.827530e-03 3.367947e-02 14 22875466 22876372 907 + 2.561 2.531 -0.100
ENSG00000197324 E014 53.1425019 0.0021060775 7.004660e-01 8.359410e-01 14 22876689 22876716 28 + 1.678 1.678 -0.001
ENSG00000197324 E015 82.9129524 0.0005954402 8.633781e-01 9.322328e-01 14 22876717 22876818 102 + 1.856 1.872 0.054
ENSG00000197324 E016 102.8943922 0.0004428839 7.871448e-01 8.888458e-01 14 22876940 22877053 114 + 1.934 1.968 0.114
ENSG00000197324 E017 83.0784744 0.0005607909 5.197585e-02 1.843465e-01 14 22877054 22877128 75 + 1.780 1.892 0.380
ENSG00000197324 E018 170.9503828 0.0064339848 8.578892e-02 2.560445e-01 14 22877129 22877426 298 + 2.092 2.201 0.367
ENSG00000197324 E019 148.7700130 0.0032431891 4.005094e-01 6.287097e-01 14 22877427 22877596 170 + 2.071 2.132 0.205
ENSG00000197324 E020 203.0474768 0.0003233033 8.592967e-01 9.299695e-01 14 22877597 22877983 387 + 2.231 2.260 0.096
ENSG00000197324 E021 81.1581921 0.0062565234 6.143948e-01 7.798183e-01 14 22877984 22878503 520 + 1.860 1.850 -0.032
ENSG00000197324 E022 15.3511446 0.0025850224 1.299987e-01 3.318468e-01 14 22878504 22878570 67 + 1.242 1.119 -0.435
ENSG00000197324 E023 46.7277041 0.0149741969 1.164586e-01 3.098886e-01 14 22878571 22879198 628 + 1.701 1.591 -0.374
ENSG00000197324 E024 169.3408738 0.0043572594 4.070816e-08 1.657837e-06 14 22879199 22881713 2515 + 2.314 2.109 -0.685