ENSG00000197299

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355112 ENSG00000197299 HEK293_OSMI2_6hA HEK293_TMG_6hB BLM protein_coding protein_coding 15.36275 7.403754 25.96627 0.1413157 0.9134308 1.808918 3.796955 1.0043410 6.696258 0.58375628 0.3264345 2.7249651 0.2108083 0.13446667 0.2582667 0.1238000 0.7465820 0.0043341 FALSE TRUE
ENST00000560136 ENSG00000197299 HEK293_OSMI2_6hA HEK293_TMG_6hB BLM protein_coding processed_transcript 15.36275 7.403754 25.96627 0.1413157 0.9134308 1.808918 2.220603 2.5447509 1.924014 0.08314262 1.0256958 -0.4015842 0.2153333 0.34370000 0.0731000 -0.2706000 0.4364687 0.0043341 FALSE TRUE
ENST00000681142 ENSG00000197299 HEK293_OSMI2_6hA HEK293_TMG_6hB BLM protein_coding protein_coding 15.36275 7.403754 25.96627 0.1413157 0.9134308 1.808918 5.943354 0.7208313 13.600298 0.36044570 0.6491090 4.2190164 0.2727375 0.09893333 0.5250000 0.4260667 0.2504182 0.0043341 FALSE TRUE
MSTRG.11546.2 ENSG00000197299 HEK293_OSMI2_6hA HEK293_TMG_6hB BLM protein_coding   15.36275 7.403754 25.96627 0.1413157 0.9134308 1.808918 1.639076 1.8351008 1.122656 0.05898353 0.5613694 -0.7039902 0.1538708 0.24790000 0.0436000 -0.2043000 0.0043341 0.0043341 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000197299 E001 0.4279040 0.5972552262 7.591780e-01   15 90717304 90717342 39 + 0.180 0.000 -9.087
ENSG00000197299 E002 0.4279040 0.5972552262 7.591780e-01   15 90717343 90717345 3 + 0.180 0.000 -11.221
ENSG00000197299 E003 4.5998831 0.0861013934 3.693959e-01 6.035575e-01 15 90717346 90717362 17 + 0.638 0.838 0.817
ENSG00000197299 E004 13.5144799 0.0274011581 8.071140e-01 9.003851e-01 15 90717363 90717393 31 + 1.090 1.142 0.188
ENSG00000197299 E005 16.1868490 0.0125832525 4.020419e-01 6.300845e-01 15 90717394 90717403 10 + 1.144 1.255 0.394
ENSG00000197299 E006 28.1169634 0.0101538216 3.207961e-01 5.603868e-01 15 90717404 90717440 37 + 1.371 1.481 0.379
ENSG00000197299 E007 6.2709425 0.0572566874 2.252275e-05 4.230596e-04 15 90724034 90724071 38 + 0.521 1.207 2.703
ENSG00000197299 E008 7.6666483 0.0070198584 5.311448e-09 2.651400e-07 15 90724072 90724143 72 + 0.585 1.294 2.713
ENSG00000197299 E009 23.9346611 0.0047806760 5.967182e-01 7.681137e-01 15 90747389 90747389 1 + 1.338 1.319 -0.066
ENSG00000197299 E010 45.8660187 0.0114159404 1.167340e-01 3.103595e-01 15 90747390 90747490 101 + 1.629 1.532 -0.331
ENSG00000197299 E011 2.8416927 0.0102376177 1.559970e-01 3.709100e-01 15 90747491 90747661 171 + 0.585 0.336 -1.286
ENSG00000197299 E012 232.2908042 0.0002358214 3.220252e-17 6.557228e-15 15 90749367 90750007 641 + 2.343 2.126 -0.725
ENSG00000197299 E013 71.5754626 0.0005291667 2.386387e-04 3.096213e-03 15 90750008 90750067 60 + 1.828 1.668 -0.540
ENSG00000197299 E014 107.6216321 0.0016063673 3.190846e-05 5.692604e-04 15 90751787 90751946 160 + 1.998 1.838 -0.540
ENSG00000197299 E015 101.9794430 0.0012227536 1.002430e-02 5.826399e-02 15 90754811 90754938 128 + 1.961 1.876 -0.284
ENSG00000197299 E016 4.9003989 0.0113740171 6.526634e-03 4.234715e-02 15 90759981 90760146 166 + 0.585 0.989 1.621
ENSG00000197299 E017 45.4053510 0.0051486724 8.966509e-01 9.501675e-01 15 90760147 90760150 4 + 1.591 1.610 0.066
ENSG00000197299 E018 96.2755751 0.0055211548 4.852034e-02 1.762304e-01 15 90760151 90760279 129 + 1.937 1.855 -0.276
ENSG00000197299 E019 263.6638304 0.0014172635 4.012175e-05 6.894259e-04 15 90760594 90761255 662 + 2.374 2.279 -0.318
ENSG00000197299 E020 0.4812263 0.0217681645 1.284267e-01   15 90762364 90762395 32 + 0.071 0.336 2.712
ENSG00000197299 E021 0.3503582 0.0313763368 4.140065e-01   15 90762396 90762422 27 + 0.071 0.200 1.714
ENSG00000197299 E022 117.5348868 0.0004434916 7.323788e-02 2.313054e-01 15 90762966 90763157 192 + 2.015 1.975 -0.132
ENSG00000197299 E023 104.6668861 0.0015884401 3.649376e-01 5.998916e-01 15 90765296 90765414 119 + 1.955 1.945 -0.033
ENSG00000197299 E024 113.9143931 0.0034113678 4.392577e-01 6.581609e-01 15 90766910 90767023 114 + 1.993 1.988 -0.017
ENSG00000197299 E025 101.5919367 0.0012292634 7.443622e-01 8.632743e-01 15 90769133 90769231 99 + 1.939 1.956 0.056
ENSG00000197299 E026 129.8263448 0.0003692939 1.743250e-01 3.962945e-01 15 90769438 90769586 149 + 2.053 2.033 -0.065
ENSG00000197299 E027 106.8657156 0.0004262025 3.702909e-01 6.041941e-01 15 90782822 90782928 107 + 1.968 1.962 -0.021
ENSG00000197299 E028 140.0151096 0.0002847770 4.642331e-01 6.760317e-01 15 90784921 90785081 161 + 2.080 2.084 0.015
ENSG00000197299 E029 18.3881446 0.0020873524 2.372116e-05 4.418072e-04 15 90789253 90790648 1396 + 1.093 1.472 1.330
ENSG00000197299 E030 153.3798006 0.0004252797 8.831005e-01 9.428804e-01 15 90790649 90790844 196 + 2.112 2.146 0.116
ENSG00000197299 E031 0.1779838 0.0366254334 1.000000e+00   15 90793801 90794166 366 + 0.071 0.000 -10.666
ENSG00000197299 E032 150.3470024 0.0022260009 9.682861e-01 9.859793e-01 15 90794167 90794357 191 + 2.104 2.137 0.108
ENSG00000197299 E033 151.0821867 0.0021108088 9.842979e-01 9.940097e-01 15 90798190 90798337 148 + 2.106 2.136 0.101
ENSG00000197299 E034 209.5630525 0.0039757572 3.593169e-01 5.952800e-01 15 90803521 90803720 200 + 2.236 2.301 0.217
ENSG00000197299 E035 173.6236243 0.0062174810 4.481173e-02 1.671623e-01 15 90804167 90804359 193 + 2.140 2.262 0.407
ENSG00000197299 E036 3.6962538 0.0160442407 6.580146e-06 1.462261e-04 15 90808771 90808941 171 + 0.316 1.016 3.133
ENSG00000197299 E037 107.6135006 0.0006058879 6.860515e-07 2.047221e-05 15 90809137 90809259 123 + 1.905 2.120 0.721
ENSG00000197299 E038 131.2626310 0.0136758269 3.214854e-05 5.727012e-04 15 90811205 90811406 202 + 1.967 2.254 0.959
ENSG00000197299 E039 2.0849000 0.0582943187 4.081645e-02 1.568371e-01 15 90811678 90811800 123 + 0.315 0.708 1.943
ENSG00000197299 E040 2.2884420 0.0870278652 1.759950e-01 3.984535e-01 15 90811845 90811956 112 + 0.383 0.658 1.325
ENSG00000197299 E041 120.2492985 0.5082094189 1.527310e-01 3.662625e-01 15 90815102 90816166 1065 + 1.896 2.263 1.229