ENSG00000197170

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356126 ENSG00000197170 HEK293_OSMI2_6hA HEK293_TMG_6hB PSMD12 protein_coding protein_coding 53.67628 28.37576 84.75343 6.387209 4.731717 1.578274 10.588331 2.388981 15.454590 0.490518 0.598125 2.688475 0.1851125 0.08656667 0.1828333 0.09626667 0.003118442 0.003118442 FALSE TRUE
ENST00000584289 ENSG00000197170 HEK293_OSMI2_6hA HEK293_TMG_6hB PSMD12 protein_coding retained_intron 53.67628 28.37576 84.75343 6.387209 4.731717 1.578274 11.459514 7.697298 18.337748 2.136675 2.205263 1.251306 0.1947250 0.28020000 0.2148333 -0.06536667 0.785515140 0.003118442 FALSE TRUE
MSTRG.14953.3 ENSG00000197170 HEK293_OSMI2_6hA HEK293_TMG_6hB PSMD12 protein_coding   53.67628 28.37576 84.75343 6.387209 4.731717 1.578274 4.149671 4.873667 2.795566 1.421213 1.917643 -0.799673 0.1218792 0.16490000 0.0333000 -0.13160000 0.486668697 0.003118442 FALSE TRUE
MSTRG.14953.4 ENSG00000197170 HEK293_OSMI2_6hA HEK293_TMG_6hB PSMD12 protein_coding   53.67628 28.37576 84.75343 6.387209 4.731717 1.578274 23.603794 11.986869 42.206194 2.917109 2.432450 1.815139 0.4384333 0.41696667 0.4989000 0.08193333 0.417032404 0.003118442 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000197170 E001 358.5460157 0.0067415517 4.278379e-11 3.272825e-09 17 67337916 67339802 1887 - 2.579 2.255 -1.079
ENSG00000197170 E002 173.7607209 0.0003148596 1.630114e-25 8.761923e-23 17 67339803 67340563 761 - 2.275 1.899 -1.257
ENSG00000197170 E003 108.8542378 0.0011251349 8.989602e-01 9.513336e-01 17 67340564 67340687 124 - 1.998 1.985 -0.044
ENSG00000197170 E004 187.1243245 0.0075026575 4.342733e-01 6.544520e-01 17 67340688 67340773 86 - 2.240 2.196 -0.146
ENSG00000197170 E005 447.3896152 0.0015708272 6.482306e-01 8.023415e-01 17 67340774 67340974 201 - 2.605 2.610 0.017
ENSG00000197170 E006 345.8574591 0.0003119951 2.853324e-01 5.259011e-01 17 67340975 67341052 78 - 2.491 2.507 0.053
ENSG00000197170 E007 334.3438642 0.0004555641 2.476837e-01 4.854958e-01 17 67342186 67342263 78 - 2.475 2.494 0.062
ENSG00000197170 E008 4.1158964 0.0483776157 9.383034e-01 9.714514e-01 17 67342264 67342484 221 - 0.678 0.669 -0.041
ENSG00000197170 E009 494.8787922 0.0002122067 1.225026e-03 1.161508e-02 17 67344606 67344780 175 - 2.637 2.686 0.165
ENSG00000197170 E010 2.6972051 0.0089426981 7.405190e-01 8.607432e-01 17 67345612 67345744 133 - 0.555 0.490 -0.310
ENSG00000197170 E011 354.1755752 0.0006939851 6.552818e-05 1.049631e-03 17 67345745 67345857 113 - 2.483 2.565 0.275
ENSG00000197170 E012 341.3353433 0.0005564413 1.095011e-03 1.063650e-02 17 67347116 67347250 135 - 2.473 2.541 0.225
ENSG00000197170 E013 470.5987603 0.0001633303 9.309233e-01 9.674869e-01 17 67347336 67347485 150 - 2.633 2.627 -0.021
ENSG00000197170 E014 427.7329277 0.0001577403 5.946070e-01 7.667503e-01 17 67348550 67348654 105 - 2.595 2.577 -0.061
ENSG00000197170 E015 280.0048347 0.0001946531 8.853228e-01 9.441194e-01 17 67350229 67350257 29 - 2.408 2.403 -0.016
ENSG00000197170 E016 302.3873291 0.0005304540 6.363040e-01 7.945244e-01 17 67350258 67350298 41 - 2.440 2.443 0.010
ENSG00000197170 E017 238.5638564 0.0035232336 5.684895e-01 7.491420e-01 17 67350299 67350336 38 - 2.346 2.315 -0.106
ENSG00000197170 E018 0.9335208 0.0157705228 5.539630e-01   17 67355341 67355422 82 - 0.300 0.182 -0.934
ENSG00000197170 E019 0.3641499 0.0315110256 4.672362e-01   17 67357152 67357302 151 - 0.079 0.183 1.392
ENSG00000197170 E020 337.0736796 0.0021998224 1.899355e-01 4.168455e-01 17 67357303 67357431 129 - 2.479 2.506 0.089
ENSG00000197170 E021 1.2212927 0.0224381154 3.790466e-01   17 67357432 67357518 87 - 0.255 0.410 0.979
ENSG00000197170 E022 194.2324075 0.0007535356 3.597771e-03 2.692035e-02 17 67357519 67357578 60 - 2.227 2.303 0.256
ENSG00000197170 E023 0.8815333 0.0620693775 7.378277e-01   17 67361095 67361261 167 - 0.256 0.183 -0.611
ENSG00000197170 E024 1.8310021 0.1837842438 9.374596e-01 9.709328e-01 17 67362776 67362892 117 - 0.420 0.409 -0.060
ENSG00000197170 E025 229.4230394 0.0060376981 2.999225e-01 5.403480e-01 17 67366412 67366605 194 - 2.310 2.343 0.110