ENSG00000197136

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355703 ENSG00000197136 HEK293_OSMI2_6hA HEK293_TMG_6hB PCNX3 protein_coding protein_coding 30.53209 40.38703 22.30201 2.1971 0.9510572 -0.8564288 4.808901 7.280936 4.5522937 0.6923656 0.30877179 -0.67634476 0.16355417 0.17970000 0.206000000 0.0263000000 0.856312464 0.002607003 FALSE TRUE
ENST00000439247 ENSG00000197136 HEK293_OSMI2_6hA HEK293_TMG_6hB PCNX3 protein_coding retained_intron 30.53209 40.38703 22.30201 2.1971 0.9510572 -0.8564288 11.845380 16.270832 5.9206018 1.0087512 0.41859835 -1.45692399 0.36195000 0.40290000 0.265033333 -0.1378666667 0.002607003 0.002607003 FALSE TRUE
MSTRG.5730.11 ENSG00000197136 HEK293_OSMI2_6hA HEK293_TMG_6hB PCNX3 protein_coding   30.53209 40.38703 22.30201 2.1971 0.9510572 -0.8564288 1.589193 2.531671 2.6524567 0.6059858 0.71852780 0.06698086 0.05613750 0.06156667 0.117466667 0.0559000000 0.565461041 0.002607003 FALSE TRUE
MSTRG.5730.6 ENSG00000197136 HEK293_OSMI2_6hA HEK293_TMG_6hB PCNX3 protein_coding   30.53209 40.38703 22.30201 2.1971 0.9510572 -0.8564288 2.126359 2.474421 1.3618560 0.2295365 0.23766234 -0.85678050 0.07123333 0.06123333 0.062000000 0.0007666667 1.000000000 0.002607003 FALSE TRUE
MSTRG.5730.7 ENSG00000197136 HEK293_OSMI2_6hA HEK293_TMG_6hB PCNX3 protein_coding   30.53209 40.38703 22.30201 2.1971 0.9510572 -0.8564288 1.640315 1.325897 0.1011006 0.2144890 0.05095416 -3.58787080 0.05518750 0.03323333 0.004366667 -0.0288666667 0.004681725 0.002607003 TRUE TRUE
MSTRG.5730.8 ENSG00000197136 HEK293_OSMI2_6hA HEK293_TMG_6hB PCNX3 protein_coding   30.53209 40.38703 22.30201 2.1971 0.9510572 -0.8564288 4.791084 6.768010 4.2828361 0.3156776 0.32012647 -0.65893063 0.16237917 0.16806667 0.193600000 0.0255333333 0.842097698 0.002607003 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000197136 E001 0.6479912 0.1285532052 1.944077e-01   11 65614370 65614394 25 + 0.001 0.278 9.124
ENSG00000197136 E002 6.8196591 0.1661967216 5.890790e-01 7.630182e-01 11 65615339 65615402 64 + 0.807 0.895 0.339
ENSG00000197136 E003 8.1432116 0.0147999540 5.092032e-01 7.073282e-01 11 65615403 65615530 128 + 0.992 0.912 -0.301
ENSG00000197136 E004 6.4775872 0.0047221333 1.890665e-01 4.157968e-01 11 65615531 65615612 82 + 0.950 0.789 -0.620
ENSG00000197136 E005 9.0286915 0.0119447340 1.160221e-01 3.092108e-01 11 65615613 65615775 163 + 1.086 0.900 -0.686
ENSG00000197136 E006 69.2328701 0.0005258601 4.030995e-01 6.308106e-01 11 65615776 65615997 222 + 1.841 1.808 -0.113
ENSG00000197136 E007 59.9686833 0.0108909074 3.146563e-01 5.548223e-01 11 65615998 65616313 316 + 1.705 1.779 0.250
ENSG00000197136 E008 17.6920785 0.0021983006 9.086143e-01 9.564424e-01 11 65616314 65616326 13 + 1.249 1.244 -0.020
ENSG00000197136 E009 16.2819110 0.0023651146 6.135071e-01 7.792700e-01 11 65616327 65616327 1 + 1.238 1.197 -0.144
ENSG00000197136 E010 21.1317281 0.0018283704 6.142052e-01 7.796896e-01 11 65616328 65616335 8 + 1.341 1.306 -0.124
ENSG00000197136 E011 32.6806924 0.0051295983 4.912193e-01 6.947873e-01 11 65616336 65616354 19 + 1.527 1.481 -0.156
ENSG00000197136 E012 36.6657025 0.0030972137 2.029264e-01 4.332573e-01 11 65616355 65616364 10 + 1.599 1.521 -0.266
ENSG00000197136 E013 54.1797965 0.0045468222 2.042873e-01 4.350117e-01 11 65616365 65616392 28 + 1.759 1.690 -0.235
ENSG00000197136 E014 67.6879682 0.0044200124 2.349084e-01 4.707530e-01 11 65616393 65616414 22 + 1.849 1.789 -0.201
ENSG00000197136 E015 92.2305065 0.0010052116 1.286955e-02 6.991283e-02 11 65616415 65616464 50 + 2.005 1.909 -0.321
ENSG00000197136 E016 169.1133460 0.0053340399 8.991000e-03 5.378227e-02 11 65616824 65617011 188 + 2.275 2.163 -0.373
ENSG00000197136 E017 123.8256129 0.0009871757 3.366491e-05 5.954668e-04 11 65617250 65617349 100 + 2.159 2.016 -0.479
ENSG00000197136 E018 88.1806163 0.0004410863 1.182256e-06 3.282770e-05 11 65617470 65617509 40 + 2.039 1.855 -0.619
ENSG00000197136 E019 119.0240222 0.0003409715 8.638722e-07 2.502224e-05 11 65617611 65617706 96 + 2.155 1.994 -0.539
ENSG00000197136 E020 566.0927224 0.0002010296 9.487277e-04 9.492476e-03 11 65617940 65619067 1128 + 2.759 2.708 -0.168
ENSG00000197136 E021 112.1574513 0.0003533734 8.085991e-01 9.013432e-01 11 65619537 65619660 124 + 2.030 2.025 -0.015
ENSG00000197136 E022 40.3214581 0.0011972635 3.821881e-01 6.140081e-01 11 65619754 65619756 3 + 1.555 1.612 0.195
ENSG00000197136 E023 102.6635789 0.0005421045 1.362658e-01 3.417778e-01 11 65619757 65619857 101 + 1.949 2.011 0.208
ENSG00000197136 E024 98.4163883 0.0004049275 9.107134e-01 9.574816e-01 11 65619858 65619932 75 + 1.969 1.969 0.000
ENSG00000197136 E025 138.1528996 0.0003510686 1.547435e-01 3.690354e-01 11 65620339 65620429 91 + 2.144 2.102 -0.139
ENSG00000197136 E026 177.6076785 0.0002352407 1.664614e-01 3.858156e-01 11 65620831 65620966 136 + 2.248 2.213 -0.117
ENSG00000197136 E027 33.4284252 0.0012189361 8.380619e-01 9.183487e-01 11 65622206 65622223 18 + 1.495 1.512 0.060
ENSG00000197136 E028 43.5110132 0.0008685967 5.640826e-01 7.461944e-01 11 65622224 65622244 21 + 1.637 1.608 -0.098
ENSG00000197136 E029 144.5381985 0.0003317641 5.390942e-01 7.283814e-01 11 65622245 65622366 122 + 2.145 2.130 -0.051
ENSG00000197136 E030 155.1365264 0.0003512281 9.400560e-02 2.711632e-01 11 65623491 65623644 154 + 2.199 2.153 -0.156
ENSG00000197136 E031 89.6935387 0.0005507285 4.888314e-02 1.769661e-01 11 65623929 65623961 33 + 1.980 1.906 -0.248
ENSG00000197136 E032 225.7058919 0.0008683186 1.785352e-02 8.854960e-02 11 65624195 65624366 172 + 2.369 2.306 -0.209
ENSG00000197136 E033 189.0248172 0.0009428476 1.193488e-01 3.147965e-01 11 65624471 65624581 111 + 2.279 2.235 -0.148
ENSG00000197136 E034 151.1627246 0.0005483648 1.431875e-01 3.522664e-01 11 65624925 65625016 92 + 2.181 2.139 -0.142
ENSG00000197136 E035 1.8100942 0.1725268172 8.932223e-01 9.482799e-01 11 65625127 65625170 44 + 0.380 0.422 0.233
ENSG00000197136 E036 146.6811307 0.0002956420 3.538051e-01 5.906478e-01 11 65625171 65625280 110 + 2.118 2.152 0.112
ENSG00000197136 E037 145.1978982 0.0005366358 6.738053e-02 2.191849e-01 11 65625405 65625510 106 + 2.091 2.156 0.216
ENSG00000197136 E038 143.6860109 0.0004302092 7.584032e-01 8.716098e-01 11 65625652 65625744 93 + 2.123 2.136 0.046
ENSG00000197136 E039 183.1991440 0.0017448974 4.347132e-01 6.547746e-01 11 65625904 65626054 151 + 2.254 2.229 -0.083
ENSG00000197136 E040 34.4572936 0.0423518681 5.784240e-03 3.866855e-02 11 65626055 65626779 725 + 1.697 1.403 -1.005
ENSG00000197136 E041 12.3492794 0.1223183171 4.599486e-01 6.731054e-01 11 65626853 65626903 51 + 1.167 1.061 -0.382
ENSG00000197136 E042 170.1416192 0.0002570000 6.372291e-01 7.951914e-01 11 65626904 65627048 145 + 2.194 2.212 0.060
ENSG00000197136 E043 176.9801180 0.0002366550 6.732829e-01 8.184487e-01 11 65627405 65627582 178 + 2.228 2.220 -0.026
ENSG00000197136 E044 190.3625134 0.0002636070 1.089726e-02 6.193044e-02 11 65628595 65628703 109 + 2.298 2.233 -0.218
ENSG00000197136 E045 258.9816714 0.0002334871 2.122358e-02 1.000625e-01 11 65628819 65628948 130 + 2.422 2.372 -0.167
ENSG00000197136 E046 207.7787767 0.0003223258 7.328753e-03 4.621406e-02 11 65629357 65629415 59 + 2.337 2.271 -0.222
ENSG00000197136 E047 359.8134467 0.0011223169 6.670829e-03 4.305325e-02 11 65629520 65629735 216 + 2.571 2.508 -0.211
ENSG00000197136 E048 226.4035189 0.0002070620 2.245173e-03 1.869763e-02 11 65630351 65630410 60 + 2.377 2.306 -0.239
ENSG00000197136 E049 294.3469869 0.0002366665 5.549204e-01 7.397327e-01 11 65630411 65630604 194 + 2.448 2.438 -0.031
ENSG00000197136 E050 7.6506235 0.0817528798 6.335341e-01 7.926781e-01 11 65634079 65634125 47 + 0.844 0.940 0.365
ENSG00000197136 E051 295.2915331 0.0004740664 1.575597e-01 3.730535e-01 11 65634126 65634356 231 + 2.417 2.454 0.123
ENSG00000197136 E052 210.9158143 0.0002570563 4.611556e-02 1.702903e-01 11 65634538 65634641 104 + 2.258 2.315 0.192
ENSG00000197136 E053 232.1965755 0.0010035094 3.452164e-05 6.081502e-04 11 65634973 65635120 148 + 2.251 2.376 0.418
ENSG00000197136 E054 309.0613431 0.0001711642 3.507696e-07 1.132270e-05 11 65635218 65635448 231 + 2.379 2.497 0.395
ENSG00000197136 E055 302.4958631 0.0001618100 3.479811e-06 8.446998e-05 11 65635529 65635803 275 + 2.378 2.487 0.363
ENSG00000197136 E056 39.7664778 0.0153329209 8.689773e-01 9.354052e-01 11 65635951 65636031 81 + 1.590 1.577 -0.045
ENSG00000197136 E057 226.9888138 0.0006128436 3.473226e-08 1.437917e-06 11 65636174 65636307 134 + 2.216 2.377 0.537
ENSG00000197136 E058 404.1970070 0.0004131677 1.435933e-15 2.356082e-13 11 65636391 65636689 299 + 2.453 2.628 0.585
ENSG00000197136 E059 788.2429148 0.0022202660 4.846582e-05 8.097010e-04 11 65636766 65637590 825 + 2.794 2.899 0.346