ENSG00000197050

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000304239 ENSG00000197050 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF420 protein_coding protein_coding 3.979252 1.031335 7.365003 0.2462575 0.3225226 2.824209 0.1257139 0.00000000 0.71439915 0.00000000 0.07003250 6.1787129 0.02207500 0.00000000 0.09733333 0.09733333 0.008638307 0.008638307 FALSE TRUE
ENST00000337995 ENSG00000197050 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF420 protein_coding protein_coding 3.979252 1.031335 7.365003 0.2462575 0.3225226 2.824209 2.4685758 0.85092824 5.36527983 0.14379038 0.33842696 2.6423750 0.61281667 0.85973333 0.73510000 -0.12463333 0.761961542 0.008638307 FALSE TRUE
ENST00000585862 ENSG00000197050 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF420 protein_coding protein_coding 3.979252 1.031335 7.365003 0.2462575 0.3225226 2.824209 0.2118607 0.06181369 0.13157879 0.06181369 0.13157879 0.9792743 0.07020833 0.05773333 0.01643333 -0.04130000 0.871967662 0.008638307 FALSE TRUE
ENST00000586540 ENSG00000197050 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF420 protein_coding processed_transcript 3.979252 1.031335 7.365003 0.2462575 0.3225226 2.824209 0.4426947 0.04311277 0.61953907 0.04311277 0.23482646 3.5671653 0.10213750 0.03000000 0.08210000 0.05210000 0.791015729 0.008638307 FALSE FALSE
ENST00000589245 ENSG00000197050 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF420 protein_coding protein_coding 3.979252 1.031335 7.365003 0.2462575 0.3225226 2.824209 0.3519266 0.02222876 0.39386310 0.02222876 0.39386310 3.6474456 0.05912917 0.01546667 0.04923333 0.03376667 0.899780163 0.008638307 FALSE TRUE
MSTRG.17053.7 ENSG00000197050 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF420 protein_coding   3.979252 1.031335 7.365003 0.2462575 0.3225226 2.824209 0.2054464 0.00000000 0.09853232 0.00000000 0.05043626 3.4400529 0.08677500 0.00000000 0.01396667 0.01396667 0.847697108 0.008638307   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000197050 E001 0.0000000       19 37007857 37007858 2 +      
ENSG00000197050 E002 0.0000000       19 37007859 37008082 224 +      
ENSG00000197050 E003 1.1964248 0.051505606 0.174201308   19 37078418 37078432 15 + 0.232 0.503 1.629
ENSG00000197050 E004 1.0537902 0.016256286 0.107984588   19 37078433 37078434 2 + 0.195 0.504 1.947
ENSG00000197050 E005 1.6728495 0.021853883 0.122144863 0.31925580 19 37078435 37078445 11 + 0.299 0.594 1.558
ENSG00000197050 E006 8.8985289 0.437362436 0.354374090 0.59117299 19 37078446 37078570 125 + 0.850 1.034 0.688
ENSG00000197050 E007 8.2404477 0.087866905 0.662030514 0.81111041 19 37080345 37080388 44 + 0.877 0.781 -0.375
ENSG00000197050 E008 14.5374171 0.002529724 0.670295243 0.81648841 19 37089039 37089127 89 + 1.088 1.050 -0.135
ENSG00000197050 E009 21.3649278 0.002136970 0.740000820 0.86044121 19 37090995 37091121 127 + 1.233 1.213 -0.068
ENSG00000197050 E010 0.4702677 0.024441170 0.457561571   19 37096031 37096115 85 + 0.109 0.238 1.357
ENSG00000197050 E011 0.1308682 0.032649190 0.077842997   19 37111600 37111711 112 + 0.000 0.238 10.498
ENSG00000197050 E012 119.7441456 0.006218833 0.001289396 0.01208172 19 37127128 37128166 1039 + 1.976 1.834 -0.479
ENSG00000197050 E013 44.1199712 0.001102173 0.097149421 0.27677101 19 37128167 37128402 236 + 1.551 1.448 -0.354
ENSG00000197050 E014 28.4773644 0.015736395 0.618922864 0.78305468 19 37128403 37128612 210 + 1.359 1.316 -0.149
ENSG00000197050 E015 33.8702470 0.150485807 0.334679794 0.57326331 19 37128613 37128906 294 + 1.396 1.520 0.425
ENSG00000197050 E016 78.7533858 0.007547047 0.063807271 0.21125989 19 37128907 37130036 1130 + 1.756 1.872 0.390
ENSG00000197050 E017 18.5310664 0.023919357 0.170695510 0.39140740 19 37130037 37130143 107 + 1.134 1.302 0.593
ENSG00000197050 E018 16.4912929 0.021112317 0.126295662 0.32595090 19 37130144 37130368 225 + 1.085 1.282 0.699