ENSG00000196975

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394295 ENSG00000196975 HEK293_OSMI2_6hA HEK293_TMG_6hB ANXA4 protein_coding protein_coding 7.706527 4.32465 7.957507 0.5701571 0.4046723 0.8782127 2.5537055 1.2809098 2.5630019 0.27475243 0.37106439 0.9950643 0.36025833 0.3168333 0.32300000 0.006166667 0.9977506984 0.0002050668 FALSE TRUE
ENST00000409920 ENSG00000196975 HEK293_OSMI2_6hA HEK293_TMG_6hB ANXA4 protein_coding protein_coding 7.706527 4.32465 7.957507 0.5701571 0.4046723 0.8782127 1.2736575 0.7518954 1.4694644 0.15224501 0.14962518 0.9574101 0.16447083 0.1794333 0.18380000 0.004366667 0.9854439775 0.0002050668 FALSE TRUE
ENST00000418066 ENSG00000196975 HEK293_OSMI2_6hA HEK293_TMG_6hB ANXA4 protein_coding processed_transcript 7.706527 4.32465 7.957507 0.5701571 0.4046723 0.8782127 0.4832694 0.6774240 0.2425358 0.06635147 0.03473699 -1.4447123 0.07040833 0.1618000 0.03073333 -0.131066667 0.0002050668 0.0002050668   FALSE
ENST00000460439 ENSG00000196975 HEK293_OSMI2_6hA HEK293_TMG_6hB ANXA4 protein_coding processed_transcript 7.706527 4.32465 7.957507 0.5701571 0.4046723 0.8782127 3.0558050 1.3988523 3.4544361 0.70119773 0.57174953 1.2981002 0.35762500 0.2929667 0.43280000 0.139833333 0.8579486919 0.0002050668 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000196975 E001 6.2547348 0.0043318205 4.855740e-07 1.508628e-05 2 69644425 69644905 481 + 0.485 1.132 2.608
ENSG00000196975 E002 4.8970477 0.0827633025 2.705176e-02 1.184664e-01 2 69652998 69653282 285 + 0.553 0.961 1.659
ENSG00000196975 E003 2.1826773 0.1410751061 1.193428e-03 1.138239e-02 2 69720774 69720790 17 + 0.100 0.772 4.248
ENSG00000196975 E004 1.9153315 0.3891421758 3.956039e-03 2.890073e-02 2 69720791 69720871 81 + 0.000 0.752 15.435
ENSG00000196975 E005 10.3199224 0.0031960219 6.257490e-01 7.877141e-01 2 69741974 69742101 128 + 1.022 1.077 0.202
ENSG00000196975 E006 6.8806978 0.0041833917 7.888421e-01 8.897998e-01 2 69742102 69742104 3 + 0.900 0.874 -0.101
ENSG00000196975 E007 11.3553973 0.0033022595 5.338828e-01 7.248244e-01 2 69742105 69742131 27 + 1.116 1.061 -0.201
ENSG00000196975 E008 9.8583188 0.0045216785 4.855678e-01 6.909613e-01 2 69742132 69742132 1 + 1.062 0.995 -0.246
ENSG00000196975 E009 9.8583188 0.0045216785 4.855678e-01 6.909613e-01 2 69742133 69742133 1 + 1.062 0.995 -0.246
ENSG00000196975 E010 21.2184770 0.0020446598 8.124452e-01 9.036674e-01 2 69742134 69742175 42 + 1.334 1.358 0.086
ENSG00000196975 E011 0.3393995 0.0264390880 3.518029e-01   2 69781162 69781299 138 + 0.180 0.000 -11.640
ENSG00000196975 E012 0.1308682 0.0326491905 3.203596e-01   2 69781494 69781519 26 + 0.000 0.147 11.910
ENSG00000196975 E013 27.5045891 0.0015128977 6.808109e-01 8.231863e-01 2 69781520 69781574 55 + 1.463 1.442 -0.071
ENSG00000196975 E014 40.3836688 0.0010892938 4.888079e-01 6.931851e-01 2 69788054 69788141 88 + 1.594 1.638 0.149
ENSG00000196975 E015 0.2027342 0.0382916595 3.182036e-01   2 69803393 69803515 123 + 0.000 0.148 11.917
ENSG00000196975 E016 51.7197124 0.0011745293 7.466114e-01 8.647332e-01 2 69804533 69804627 95 + 1.708 1.729 0.071
ENSG00000196975 E017 42.6576111 0.0009136164 9.490798e-01 9.766487e-01 2 69806385 69806432 48 + 1.635 1.638 0.011
ENSG00000196975 E018 35.7904660 0.0018923425 8.167713e-01 9.063240e-01 2 69806433 69806498 66 + 1.562 1.554 -0.027
ENSG00000196975 E019 39.8895381 0.0009460893 6.681650e-01 8.150043e-01 2 69807906 69807977 72 + 1.614 1.596 -0.061
ENSG00000196975 E020 24.0950436 0.0014666956 8.120596e-02 2.472593e-01 2 69807978 69807981 4 + 1.439 1.319 -0.417
ENSG00000196975 E021 24.2518299 0.0017701102 1.477426e-01 3.590558e-01 2 69807982 69807996 15 + 1.435 1.335 -0.344
ENSG00000196975 E022 0.7437705 0.0172671820 9.781766e-01   2 69807997 69808189 193 + 0.248 0.257 0.066
ENSG00000196975 E023 3.5450975 0.1261384919 6.813391e-01 8.234849e-01 2 69808190 69810593 2404 + 0.609 0.707 0.417
ENSG00000196975 E024 37.8932930 0.0010292512 4.895120e-01 6.936757e-01 2 69810594 69810673 80 + 1.597 1.564 -0.114
ENSG00000196975 E025 1.7395311 0.3650720929 4.919136e-01 6.952597e-01 2 69810674 69811336 663 + 0.358 0.533 0.910
ENSG00000196975 E026 1.2629188 0.0148008534 4.387985e-02   2 69811337 69811456 120 + 0.180 0.535 2.238
ENSG00000196975 E027 38.1145569 0.0014324205 3.510569e-01 5.881819e-01 2 69812653 69812709 57 + 1.559 1.618 0.201
ENSG00000196975 E028 0.6426420 0.0203803411 6.693689e-01   2 69814787 69816100 1314 + 0.180 0.257 0.652
ENSG00000196975 E029 47.4500257 0.0007962551 6.183158e-01 7.826442e-01 2 69816101 69816194 94 + 1.667 1.699 0.106
ENSG00000196975 E030 3.4690996 0.0074779862 3.176039e-01 5.575634e-01 2 69816195 69818598 2404 + 0.583 0.736 0.653
ENSG00000196975 E031 41.6991095 0.0009942456 4.488549e-01 6.649001e-01 2 69818599 69818694 96 + 1.640 1.605 -0.120
ENSG00000196975 E032 32.6483489 0.0026817528 9.425012e-01 9.735319e-01 2 69819280 69819338 59 + 1.523 1.523 0.001
ENSG00000196975 E033 48.1753114 0.0007900257 4.688069e-01 6.792556e-01 2 69820699 69820821 123 + 1.700 1.669 -0.103
ENSG00000196975 E034 61.0992142 0.0007459872 1.065382e-01 2.932261e-01 2 69825456 69827112 1657 + 1.809 1.742 -0.227