ENSG00000196950

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359634 ENSG00000196950 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC39A10 protein_coding protein_coding 12.46566 2.144559 24.41329 0.3459795 0.8898774 3.502793 10.4637862 0.7380431 22.47966056 0.23463480 0.72999377 4.9099966 0.5847792 0.3272 0.92106667 0.5938667 3.463249e-12 1.383941e-17 FALSE TRUE
ENST00000464301 ENSG00000196950 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC39A10 protein_coding processed_transcript 12.46566 2.144559 24.41329 0.3459795 0.8898774 3.502793 0.5197443 0.5808767 0.41024160 0.07789656 0.22914365 -0.4916382 0.1155333 0.3030 0.01613333 -0.2868667 3.108244e-02 1.383941e-17   FALSE
MSTRG.19692.11 ENSG00000196950 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC39A10 protein_coding   12.46566 2.144559 24.41329 0.3459795 0.8898774 3.502793 0.5710787 0.7683193 0.03404279 0.20347932 0.03404279 -4.1433842 0.2451833 0.3476 0.00140000 -0.3462000 1.383941e-17 1.383941e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000196950 E001 0.0000000       2 195575977 195576082 106 +      
ENSG00000196950 E002 0.0000000       2 195606136 195606233 98 +      
ENSG00000196950 E003 0.0000000       2 195656747 195656910 164 +      
ENSG00000196950 E004 0.8627522 0.020395980 3.200634e-01   2 195656911 195657010 100 + 0.112 0.384 2.277
ENSG00000196950 E005 1.2493376 0.013685208 8.642869e-01   2 195657128 195657135 8 + 0.200 0.001 -8.167
ENSG00000196950 E006 6.2204962 0.004744795 2.105945e-01 4.425225e-01 2 195657136 195657225 90 + 0.578 0.384 -0.971
ENSG00000196950 E007 8.7157208 0.050905581 9.198322e-02 2.673936e-01 2 195657226 195657234 9 + 0.690 0.385 -1.451
ENSG00000196950 E008 33.7274398 0.017748594 1.740975e-01 3.959999e-01 2 195657235 195657281 47 + 1.197 1.183 -0.050
ENSG00000196950 E009 2.1366999 0.021006655 1.704517e-06 4.537088e-05 2 195657449 195657609 161 + 0.158 1.091 4.692
ENSG00000196950 E010 8.5221463 0.377085509 7.596984e-05 1.188414e-03 2 195658064 195658422 359 + 0.404 1.669 4.898
ENSG00000196950 E011 5.7514394 0.042026588 4.398146e-12 4.057069e-10 2 195658423 195658587 165 + 0.334 1.487 4.677
ENSG00000196950 E012 0.8274031 0.017277064 3.166028e-01   2 195671657 195671720 64 + 0.112 0.384 2.279
ENSG00000196950 E013 38.2272127 0.025566398 3.054759e-01 5.461122e-01 2 195680032 195680048 17 + 1.245 1.288 0.151
ENSG00000196950 E014 154.5135940 0.013689935 3.580218e-05 6.271956e-04 2 195680049 195680476 428 + 1.844 1.664 -0.607
ENSG00000196950 E015 191.8263475 0.026846311 1.800045e-04 2.448686e-03 2 195680477 195680892 416 + 1.936 1.756 -0.606
ENSG00000196950 E016 90.2281556 0.023059543 1.140500e-02 6.400779e-02 2 195680893 195681050 158 + 1.612 1.509 -0.352
ENSG00000196950 E017 103.3333997 0.030209803 1.890861e-02 9.212258e-02 2 195683699 195683906 208 + 1.668 1.594 -0.250
ENSG00000196950 E018 0.1614157 0.034398469 4.620873e-01   2 195684445 195684492 48 + 0.031 0.001 -5.168
ENSG00000196950 E019 86.8517526 0.046448936 2.273112e-01 4.621800e-01 2 195706616 195706785 170 + 1.588 1.614 0.089
ENSG00000196950 E020 122.9080297 0.038196215 9.492580e-02 2.728519e-01 2 195708656 195708844 189 + 1.738 1.739 0.004
ENSG00000196950 E021 97.7358729 0.016345326 5.360678e-02 1.881272e-01 2 195713433 195713553 121 + 1.640 1.640 -0.002
ENSG00000196950 E022 170.6079160 0.015435486 2.992281e-02 1.271063e-01 2 195716637 195717005 369 + 1.878 1.895 0.059
ENSG00000196950 E023 0.0000000       2 195717006 195717383 378 +      
ENSG00000196950 E024 73.0024115 0.024939336 1.710450e-02 8.583993e-02 2 195718252 195718332 81 + 1.524 1.419 -0.360
ENSG00000196950 E025 97.6768063 0.000552719 6.050213e-02 2.039431e-01 2 195728159 195728349 191 + 1.645 1.680 0.118
ENSG00000196950 E026 509.7845980 0.696144638 1.472386e-01 3.583667e-01 2 195734883 195737702 2820 + 2.312 2.763 1.503