ENSG00000196914

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356641 ENSG00000196914 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGEF12 protein_coding protein_coding 13.85412 8.718195 20.76188 1.961269 0.6886794 1.250877 9.1088069 5.4075848 15.0086099 0.8558092 0.6410514 1.471030 0.66930417 0.64373333 0.7227000 0.07896667 0.70688718 0.00146554 FALSE TRUE
ENST00000397843 ENSG00000196914 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGEF12 protein_coding protein_coding 13.85412 8.718195 20.76188 1.961269 0.6886794 1.250877 1.2462451 1.6960861 0.2001479 0.5966667 0.2001479 -3.021214 0.11232917 0.19520000 0.0102000 -0.18500000 0.04542367 0.00146554 FALSE TRUE
ENST00000532993 ENSG00000196914 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGEF12 protein_coding protein_coding 13.85412 8.718195 20.76188 1.961269 0.6886794 1.250877 0.3181259 0.9108255 0.0000000 0.9108255 0.0000000 -6.524856 0.04077917 0.07733333 0.0000000 -0.07733333 0.79846589 0.00146554 FALSE TRUE
MSTRG.6464.1 ENSG00000196914 HEK293_OSMI2_6hA HEK293_TMG_6hB ARHGEF12 protein_coding   13.85412 8.718195 20.76188 1.961269 0.6886794 1.250877 2.2011602 0.1816319 4.3725347 0.1141513 0.1613686 4.515356 0.11317500 0.01836667 0.2105667 0.19220000 0.00146554 0.00146554 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000196914 E001 1.6195066 0.0121036785 2.757661e-01 5.158671e-01 11 120336342 120336412 71 + 0.317 0.534 1.175
ENSG00000196914 E002 5.7263813 0.1246398004 1.926998e-01 4.203835e-01 11 120336413 120336463 51 + 0.674 0.996 1.260
ENSG00000196914 E003 17.5200005 0.0200125591 6.278812e-02 2.090144e-01 11 120336464 120336649 186 + 1.150 1.395 0.860
ENSG00000196914 E004 33.1621074 0.0319907246 6.198589e-01 7.837388e-01 11 120336650 120336913 264 + 1.471 1.576 0.360
ENSG00000196914 E005 108.8207232 0.0180628652 1.533269e-03 1.383772e-02 11 120336914 120337275 362 + 2.063 1.865 -0.664
ENSG00000196914 E006 0.0000000       11 120385294 120385320 27 +      
ENSG00000196914 E007 0.0000000       11 120385321 120385486 166 +      
ENSG00000196914 E008 0.8096672 0.0312201949 5.356081e-01   11 120405933 120406117 185 + 0.270 0.171 -0.830
ENSG00000196914 E009 46.0795631 0.0103715083 2.216735e-05 4.171221e-04 11 120406118 120406141 24 + 1.715 1.411 -1.038
ENSG00000196914 E010 64.1805650 0.0086838662 1.545970e-04 2.153567e-03 11 120407738 120407823 86 + 1.840 1.615 -0.761
ENSG00000196914 E011 0.0000000       11 120407824 120409393 1570 +      
ENSG00000196914 E012 16.8957813 0.0142150286 1.174494e-01 3.115604e-01 11 120409394 120409450 57 + 1.256 1.132 -0.443
ENSG00000196914 E013 0.4820342 0.0213096117 2.705533e-01   11 120409451 120411837 2387 + 0.216 0.000 -12.420
ENSG00000196914 E014 2.2457184 0.0579496046 4.337679e-01 6.540587e-01 11 120417529 120417657 129 + 0.525 0.392 -0.680
ENSG00000196914 E015 70.4160659 0.0007419682 1.928842e-08 8.483859e-07 11 120420753 120420851 99 + 1.882 1.645 -0.799
ENSG00000196914 E016 54.1833406 0.0007171898 1.163544e-07 4.249388e-06 11 120421803 120421852 50 + 1.774 1.519 -0.867
ENSG00000196914 E017 48.9910150 0.0022583636 3.966710e-05 6.827880e-04 11 120424358 120424415 58 + 1.723 1.513 -0.717
ENSG00000196914 E018 94.4939747 0.0028988413 5.784097e-04 6.385821e-03 11 120428069 120428247 179 + 1.985 1.864 -0.407
ENSG00000196914 E019 66.9194568 0.0137959843 2.884365e-02 1.239139e-01 11 120429440 120429517 78 + 1.836 1.723 -0.381
ENSG00000196914 E020 55.5847081 0.0154718059 1.612561e-01 3.786446e-01 11 120429712 120429831 120 + 1.743 1.682 -0.209
ENSG00000196914 E021 84.9866438 0.0005315349 9.553379e-02 2.739819e-01 11 120431771 120431911 141 + 1.911 1.884 -0.090
ENSG00000196914 E022 74.5999266 0.0005420612 1.633137e-02 8.301170e-02 11 120437308 120437382 75 + 1.863 1.797 -0.223
ENSG00000196914 E023 1.4866132 0.0128829809 9.731280e-01 9.885256e-01 11 120438448 120440128 1681 + 0.359 0.390 0.176
ENSG00000196914 E024 71.1783642 0.0006312108 2.478758e-02 1.115661e-01 11 120440129 120440221 93 + 1.844 1.783 -0.206
ENSG00000196914 E025 71.4734204 0.0005782326 5.343851e-01 7.251833e-01 11 120441707 120441817 111 + 1.824 1.838 0.049
ENSG00000196914 E026 78.9627331 0.0009102396 7.314375e-02 2.311147e-01 11 120442104 120442202 99 + 1.881 1.844 -0.125
ENSG00000196914 E027 59.8481886 0.0022124962 3.378438e-02 1.382931e-01 11 120445422 120445464 43 + 1.772 1.699 -0.247
ENSG00000196914 E028 96.3648552 0.0007669608 1.408308e-04 1.989709e-03 11 120446403 120446508 106 + 1.986 1.871 -0.386
ENSG00000196914 E029 105.3820164 0.0003983783 3.368140e-04 4.107631e-03 11 120446948 120447085 138 + 2.021 1.926 -0.317
ENSG00000196914 E030 0.7254668 0.1896105825 1.127077e-01   11 120447086 120447266 181 + 0.085 0.396 2.782
ENSG00000196914 E031 57.8302619 0.0007712586 2.928146e-01 5.335250e-01 11 120447874 120447906 33 + 1.738 1.727 -0.035
ENSG00000196914 E032 81.8016887 0.0014039618 8.149201e-02 2.478192e-01 11 120448234 120448348 115 + 1.898 1.864 -0.115
ENSG00000196914 E033 0.3150090 0.0380194623 5.931692e-01   11 120448494 120449108 615 + 0.084 0.172 1.180
ENSG00000196914 E034 78.7960925 0.0029830375 3.730804e-02 1.477654e-01 11 120449109 120449214 106 + 1.890 1.830 -0.202
ENSG00000196914 E035 0.1308682 0.0326491905 2.368036e-01   11 120449275 120451511 2237 + 0.000 0.171 11.257
ENSG00000196914 E036 128.6462652 0.0003439666 2.298605e-03 1.904362e-02 11 120451512 120451724 213 + 2.099 2.038 -0.206
ENSG00000196914 E037 0.1614157 0.0340063417 1.000000e+00   11 120457051 120457117 67 + 0.084 0.000 -10.649
ENSG00000196914 E038 124.7953376 0.0032727192 4.830233e-04 5.521199e-03 11 120457118 120457250 133 + 2.097 1.985 -0.377
ENSG00000196914 E039 0.9915952 0.1228634688 4.419361e-01   11 120457251 120457717 467 + 0.318 0.172 -1.146
ENSG00000196914 E040 0.4632531 0.0264986057 2.726000e-01   11 120457718 120457720 3 + 0.216 0.000 -12.329
ENSG00000196914 E041 80.4531959 0.0051572954 9.045572e-04 9.131141e-03 11 120457721 120457756 36 + 1.917 1.769 -0.499
ENSG00000196914 E042 0.1614157 0.0340063417 1.000000e+00   11 120457757 120458079 323 + 0.084 0.000 -10.649
ENSG00000196914 E043 128.2558105 0.0003524236 5.313005e-08 2.106632e-06 11 120458080 120458234 155 + 2.119 1.969 -0.502
ENSG00000196914 E044 0.1779838 0.0366219551 1.000000e+00   11 120458235 120459173 939 + 0.085 0.000 -10.616
ENSG00000196914 E045 112.0446757 0.0004058481 3.823125e-03 2.815745e-02 11 120459174 120459320 147 + 2.040 1.976 -0.214
ENSG00000196914 E046 0.0000000       11 120459321 120459339 19 +      
ENSG00000196914 E047 86.1216595 0.0008264185 1.103734e-01 2.996377e-01 11 120460672 120460757 86 + 1.918 1.893 -0.084
ENSG00000196914 E048 0.4466850 0.0243998070 2.726249e-01   11 120462549 120465236 2688 + 0.216 0.000 -12.363
ENSG00000196914 E049 102.1298811 0.0004488168 7.053113e-01 8.388925e-01 11 120465237 120465362 126 + 1.962 2.018 0.191
ENSG00000196914 E050 97.5339747 0.0004501545 4.681899e-01 6.788540e-01 11 120467194 120467308 115 + 1.954 1.969 0.050
ENSG00000196914 E051 98.3797643 0.0053330967 4.416101e-01 6.598128e-01 11 120469288 120469388 101 + 1.961 1.970 0.029
ENSG00000196914 E052 80.2362796 0.0005642125 3.051088e-02 1.288725e-01 11 120473050 120473127 78 + 1.895 1.844 -0.170
ENSG00000196914 E053 76.1230121 0.0004992823 2.761144e-01 5.161242e-01 11 120474560 120474635 76 + 1.855 1.850 -0.016
ENSG00000196914 E054 114.6601773 0.0006300251 7.509451e-01 8.673410e-01 11 120475340 120475507 168 + 2.017 2.048 0.103
ENSG00000196914 E055 0.9888187 0.0154230098 3.823584e-01   11 120475975 120476660 686 + 0.316 0.172 -1.143
ENSG00000196914 E056 95.7927850 0.0052628639 5.821200e-01 7.584459e-01 11 120476661 120476748 88 + 1.947 1.959 0.040
ENSG00000196914 E057 0.2027342 0.0322611321 2.354600e-01   11 120477000 120477218 219 + 0.000 0.172 11.268
ENSG00000196914 E058 95.6484171 0.0030224126 3.521435e-01 5.891830e-01 11 120477219 120477305 87 + 1.953 1.949 -0.013
ENSG00000196914 E059 87.8093461 0.0064166841 8.207565e-01 9.084856e-01 11 120477447 120477526 80 + 1.908 1.933 0.086
ENSG00000196914 E060 4.4733754 0.0099666415 4.953978e-01 6.977269e-01 11 120477527 120477646 120 + 0.667 0.801 0.546
ENSG00000196914 E061 44.8816719 0.0007909896 7.952773e-01 8.935314e-01 11 120478156 120478159 4 + 1.612 1.668 0.192
ENSG00000196914 E062 87.4240684 0.0004660811 8.316511e-01 9.147780e-01 11 120478160 120478233 74 + 1.897 1.948 0.172
ENSG00000196914 E063 129.5664182 0.0003069607 7.627994e-01 8.742574e-01 11 120478234 120478389 156 + 2.065 2.117 0.176
ENSG00000196914 E064 268.0739848 0.0002040769 1.119095e-01 3.022681e-01 11 120479960 120480430 471 + 2.370 2.449 0.264
ENSG00000196914 E065 198.3841851 0.0011557151 1.501317e-02 7.813371e-02 11 120481260 120481576 317 + 2.224 2.339 0.385
ENSG00000196914 E066 95.6301919 0.0006902987 8.610305e-02 2.566212e-01 11 120484438 120484507 70 + 1.911 2.021 0.368
ENSG00000196914 E067 1492.2734253 0.0020219446 2.324543e-23 1.004481e-20 11 120485067 120489937 4871 + 3.057 3.281 0.742