ENSG00000196912

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000258459 ENSG00000196912 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD36B protein_coding protein_coding 1.275448 0.8236322 1.554068 0.1743488 0.1656446 0.9078206 0.34043791 0.05830800 0.58095958 0.05830800 0.08575877 3.1129330 0.3093250 0.05463333 0.3887667 0.334133333 0.13224788 0.03063705 FALSE TRUE
ENST00000359901 ENSG00000196912 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD36B protein_coding protein_coding 1.275448 0.8236322 1.554068 0.1743488 0.1656446 0.9078206 0.16962630 0.15766100 0.21112460 0.07984056 0.11291730 0.3993124 0.1226500 0.24106667 0.1284333 -0.112633333 0.93031385 0.03063705 FALSE TRUE
ENST00000419390 ENSG00000196912 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD36B protein_coding nonsense_mediated_decay 1.275448 0.8236322 1.554068 0.1743488 0.1656446 0.9078206 0.26366658 0.06742211 0.48203543 0.06742211 0.19321965 2.6679448 0.1734208 0.07346667 0.2924333 0.218966667 0.45501313 0.03063705 TRUE FALSE
ENST00000438709 ENSG00000196912 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD36B protein_coding nonsense_mediated_decay 1.275448 0.8236322 1.554068 0.1743488 0.1656446 0.9078206 0.16216390 0.31414546 0.05216595 0.07322339 0.05216595 -2.3824448 0.1416583 0.41900000 0.0282000 -0.390800000 0.03063705 0.03063705 TRUE TRUE
ENST00000443455 ENSG00000196912 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD36B protein_coding nonsense_mediated_decay 1.275448 0.8236322 1.554068 0.1743488 0.1656446 0.9078206 0.20396191 0.12006863 0.14081519 0.12006863 0.09155780 0.2135087 0.1289958 0.11246667 0.1054000 -0.007066667 0.96203192 0.03063705 TRUE FALSE
ENST00000488634 ENSG00000196912 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD36B protein_coding retained_intron 1.275448 0.8236322 1.554068 0.1743488 0.1656446 0.9078206 0.10794569 0.10602705 0.00000000 0.10602705 0.00000000 -3.5363893 0.0984375 0.09933333 0.0000000 -0.099333333 0.74765871 0.03063705 TRUE TRUE
ENST00000615794 ENSG00000196912 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD36B protein_coding retained_intron 1.275448 0.8236322 1.554068 0.1743488 0.1656446 0.9078206 0.02764565 0.00000000 0.08696761 0.00000000 0.08696761 3.2775030 0.0254875 0.00000000 0.0567000 0.056700000 0.92495331 0.03063705   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000196912 E001 0.0000000       2 97492663 97492665 3 -      
ENSG00000196912 E002 0.0000000       2 97492666 97492855 190 -      
ENSG00000196912 E003 0.0000000       2 97504798 97504800 3 -      
ENSG00000196912 E004 0.0000000       2 97504801 97506435 1635 -      
ENSG00000196912 E005 0.0000000       2 97506964 97507035 72 -      
ENSG00000196912 E006 0.0000000       2 97507036 97507065 30 -      
ENSG00000196912 E007 0.7320040 0.107126624 0.13083262   2 97507564 97507657 94 - 0.137 0.425 2.166
ENSG00000196912 E008 0.1308682 0.032649190 0.13906516   2 97507658 97507994 337 - 0.000 0.194 11.966
ENSG00000196912 E009 0.1779838 0.041263528 1.00000000   2 97507995 97508065 71 - 0.074 0.000 -9.564
ENSG00000196912 E010 0.9099878 0.193840927 0.29577412   2 97509581 97509733 153 - 0.193 0.421 1.549
ENSG00000196912 E011 1.0831700 0.016012249 0.79272301   2 97511138 97512052 915 - 0.284 0.328 0.290
ENSG00000196912 E012 3.1994955 0.223250279 0.68855280 0.82820142 2 97513180 97513363 184 - 0.569 0.636 0.297
ENSG00000196912 E013 2.7528105 0.154909991 0.47521920 0.68368393 2 97515732 97515945 214 - 0.503 0.637 0.614
ENSG00000196912 E014 0.9828494 0.017267182 0.15262570   2 97523326 97523467 142 - 0.324 0.000 -11.790
ENSG00000196912 E015 1.9682715 0.139567447 0.70457267 0.83848828 2 97532311 97532384 74 - 0.454 0.331 -0.687
ENSG00000196912 E016 3.3131281 0.031385065 0.31308311 0.55336233 2 97536300 97536372 73 - 0.634 0.431 -0.962
ENSG00000196912 E017 2.3524564 0.010431635 0.30722758 0.54783656 2 97536468 97536496 29 - 0.530 0.328 -1.082
ENSG00000196912 E018 2.0296250 0.016206550 0.45453100 0.66914437 2 97538168 97538240 73 - 0.480 0.328 -0.840
ENSG00000196912 E019 1.7907338 0.077405401 0.94047317 0.97253640 2 97538335 97538363 29 - 0.422 0.428 0.035
ENSG00000196912 E020 3.4218346 0.007154686 0.50223047 0.70231661 2 97540034 97540106 73 - 0.635 0.513 -0.555
ENSG00000196912 E021 2.5943614 0.014644221 0.60789138 0.77545455 2 97540201 97540229 29 - 0.532 0.430 -0.505
ENSG00000196912 E022 3.7120231 0.007905190 0.43549235 0.65535908 2 97541911 97541983 73 - 0.654 0.513 -0.634
ENSG00000196912 E023 2.7325703 0.152108731 0.61888918 0.78305344 2 97542079 97542107 29 - 0.557 0.426 -0.644
ENSG00000196912 E024 3.1992040 0.018526778 0.33525710 0.57382524 2 97543790 97543862 73 - 0.616 0.431 -0.884
ENSG00000196912 E025 2.7608889 0.009501832 0.52889830 0.72122419 2 97543957 97543985 29 - 0.554 0.431 -0.603
ENSG00000196912 E026 3.4448495 0.008718208 0.63212106 0.79175631 2 97545666 97545738 73 - 0.576 0.643 0.297
ENSG00000196912 E027 1.9580486 0.012249031 0.46681075 0.67786986 2 97545833 97545861 29 - 0.393 0.514 0.620
ENSG00000196912 E028 1.5525802 0.012462843 0.75975461 0.87243681 2 97547536 97547564 29 - 0.393 0.328 -0.383
ENSG00000196912 E029 2.0567920 0.015046453 0.12678140 0.32666702 2 97547565 97547608 44 - 0.507 0.194 -1.970
ENSG00000196912 E030 2.2841044 0.010777460 0.01135809 0.06384223 2 97547703 97547731 29 - 0.554 0.000 -12.839
ENSG00000196912 E031 3.7837015 0.009111379 0.79781210 0.89510340 2 97549419 97549491 73 - 0.636 0.583 -0.233
ENSG00000196912 E032 3.1534232 0.009011808 0.45864065 0.67225303 2 97549586 97549614 29 - 0.531 0.643 0.500
ENSG00000196912 E033 2.1045049 0.016345325 0.59877255 0.76941095 2 97551289 97551311 23 - 0.425 0.513 0.442
ENSG00000196912 E034 2.4570759 0.032098882 0.45302987 0.66795937 2 97551312 97551361 50 - 0.455 0.582 0.607
ENSG00000196912 E035 1.9762095 0.011419845 0.18340458 0.40832097 2 97551452 97551480 29 - 0.360 0.583 1.132
ENSG00000196912 E036 4.2494548 0.032082989 0.25329031 0.49151148 2 97553168 97553240 73 - 0.616 0.787 0.712
ENSG00000196912 E037 3.0837203 0.008259607 0.38318961 0.61487824 2 97553343 97553371 29 - 0.596 0.431 -0.796
ENSG00000196912 E038 3.8632718 0.092025770 0.11770790 0.31203810 2 97555060 97555132 73 - 0.703 0.330 -1.828
ENSG00000196912 E039 2.5813614 0.136948612 0.37237611 0.60596621 2 97555226 97555254 29 - 0.554 0.330 -1.183
ENSG00000196912 E040 1.6864690 0.014971903 0.20863291 0.44021574 2 97556937 97557009 73 - 0.453 0.194 -1.705
ENSG00000196912 E041 1.1974700 0.018063526 0.41119591   2 97557104 97557132 29 - 0.284 0.430 0.874
ENSG00000196912 E042 2.6183742 0.008605534 0.30928562 0.54977814 2 97558799 97558871 73 - 0.481 0.642 0.740
ENSG00000196912 E043 2.3675965 0.009448730 0.42662504 0.64850680 2 97558966 97558994 29 - 0.454 0.582 0.616
ENSG00000196912 E044 3.1177843 0.007647259 0.65928018 0.80953623 2 97560665 97560737 73 - 0.596 0.513 -0.385
ENSG00000196912 E045 2.6301407 0.008494475 0.62285950 0.78575807 2 97560832 97560860 29 - 0.506 0.582 0.352
ENSG00000196912 E046 0.8571428 0.017978125 0.42945572   2 97576379 97576446 68 - 0.191 0.329 1.034
ENSG00000196912 E047 3.1365653 0.007517911 0.65960710 0.80976126 2 97578906 97579043 138 - 0.596 0.513 -0.386
ENSG00000196912 E048 4.0194700 0.018996212 0.13703224 0.34300071 2 97580462 97580568 107 - 0.704 0.430 -1.265
ENSG00000196912 E049 8.0588497 0.004561478 0.98776136 0.99572735 2 97584944 97585117 174 - 0.903 0.891 -0.047
ENSG00000196912 E050 6.8631496 0.004566367 0.11042280 0.29969684 2 97585284 97585398 115 - 0.790 0.976 0.714
ENSG00000196912 E051 11.4264008 0.003351384 0.07050910 0.22573840 2 97589525 97589877 353 - 0.993 1.163 0.615