ENSG00000196911

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356348 ENSG00000196911 HEK293_OSMI2_6hA HEK293_TMG_6hB KPNA5 protein_coding protein_coding 8.40045 1.174331 17.99673 0.08961876 1.040554 3.926392 5.5332438 0.62572136 11.774174 0.13491962 1.0458506 4.212312 0.54187083 0.52093333 0.65190000 0.13096667 0.61477821 0.01005188 FALSE TRUE
ENST00000368564 ENSG00000196911 HEK293_OSMI2_6hA HEK293_TMG_6hB KPNA5 protein_coding protein_coding 8.40045 1.174331 17.99673 0.08961876 1.040554 3.926392 1.6324616 0.51539191 3.387433 0.01425531 0.1305775 2.692979 0.33334583 0.44613333 0.19016667 -0.25596667 0.01005188 0.01005188 FALSE TRUE
ENST00000413340 ENSG00000196911 HEK293_OSMI2_6hA HEK293_TMG_6hB KPNA5 protein_coding protein_coding 8.40045 1.174331 17.99673 0.08961876 1.040554 3.926392 0.6890558 0.00000000 1.321006 0.00000000 0.1747810 7.056373 0.05913333 0.00000000 0.07320000 0.07320000 0.01249428 0.01005188 FALSE FALSE
MSTRG.28862.1 ENSG00000196911 HEK293_OSMI2_6hA HEK293_TMG_6hB KPNA5 protein_coding   8.40045 1.174331 17.99673 0.08961876 1.040554 3.926392 0.5456893 0.03321775 1.514116 0.03321775 0.1045482 5.140205 0.06562083 0.03293333 0.08466667 0.05173333 0.44999849 0.01005188 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000196911 E001 2.281891 0.0512815677 2.576284e-01 4.963566e-01 6 116680941 116681186 246 + 0.368 0.001 -9.910
ENSG00000196911 E002 7.689340 0.0095654034 7.005488e-03 4.467043e-02 6 116681187 116681210 24 + 0.745 0.001 -11.676
ENSG00000196911 E003 45.889033 0.0093459964 2.869662e-02 1.234564e-01 6 116681211 116681338 128 + 1.428 1.213 -0.750
ENSG00000196911 E004 5.730877 0.0046341406 6.019559e-01 7.714468e-01 6 116681447 116681552 106 + 0.606 0.732 0.532
ENSG00000196911 E005 66.473799 0.0006812370 7.771388e-02 2.402141e-01 6 116689320 116689453 134 + 1.579 1.470 -0.371
ENSG00000196911 E006 57.615947 0.0108698526 6.574727e-01 8.083196e-01 6 116692055 116692156 102 + 1.513 1.501 -0.040
ENSG00000196911 E007 53.955067 0.0008521066 5.665460e-01 7.476732e-01 6 116692293 116692392 100 + 1.485 1.470 -0.051
ENSG00000196911 E008 55.352646 0.0009066500 7.299006e-01 8.541771e-01 6 116698704 116698798 95 + 1.496 1.501 0.018
ENSG00000196911 E009 62.014580 0.0011020356 4.349073e-01 6.549334e-01 6 116702019 116702150 132 + 1.545 1.516 -0.099
ENSG00000196911 E010 45.986169 0.0075324909 2.615923e-01 5.006749e-01 6 116705072 116705160 89 + 1.424 1.341 -0.288
ENSG00000196911 E011 2.772517 0.3668469807 4.206307e-01 6.441651e-01 6 116715212 116715292 81 + 0.369 0.640 1.330
ENSG00000196911 E012 52.756722 0.0011624859 2.694144e-01 5.092240e-01 6 116716219 116716318 100 + 1.482 1.419 -0.219
ENSG00000196911 E013 85.459556 0.0005392893 1.324996e-02 7.144234e-02 6 116722126 116722289 164 + 1.690 1.544 -0.496
ENSG00000196911 E014 58.053723 0.0006721672 1.074523e-01 2.947913e-01 6 116724297 116724375 79 + 1.523 1.419 -0.357
ENSG00000196911 E015 67.684461 0.0005988345 8.887824e-02 2.616971e-01 6 116725751 116725876 126 + 1.587 1.486 -0.345
ENSG00000196911 E016 68.566115 0.0005825224 8.190915e-02 2.485936e-01 6 116726495 116726622 128 + 1.590 1.486 -0.356
ENSG00000196911 E017 84.272903 0.0007220904 4.155365e-03 3.002368e-02 6 116729563 116729741 179 + 1.684 1.502 -0.621
ENSG00000196911 E018 107.302456 0.0021016827 3.734541e-01 6.068772e-01 6 116732136 116732368 233 + 1.768 1.853 0.287
ENSG00000196911 E019 364.813859 0.0057050853 4.434814e-06 1.037946e-04 6 116732369 116741505 9137 + 2.282 2.477 0.649
ENSG00000196911 E020 20.115417 0.0018846574 7.617870e-08 2.909783e-06 6 116741506 116741867 362 + 0.996 1.545 1.933