ENSG00000196810

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357591 ENSG00000196810 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 9.012422 12.31657 6.776087 1.193823 0.4355605 -0.8611195 0.4736641 0.8208515 0.0000000 0.4507767 0.00000000 -6.3765187 0.0532000 0.07520000 0.0000000 -0.075200000 4.477939e-01 8.213932e-07 FALSE TRUE
ENST00000507044 ENSG00000196810 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 9.012422 12.31657 6.776087 1.193823 0.4355605 -0.8611195 1.1602578 1.0481080 0.8587993 0.5298184 0.25671949 -0.2843921 0.1295958 0.07810000 0.1300667 0.051966667 8.401019e-01 8.213932e-07   FALSE
ENST00000514984 ENSG00000196810 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 9.012422 12.31657 6.776087 1.193823 0.4355605 -0.8611195 2.4801583 3.4795025 2.6279244 0.6980334 0.41852674 -0.4036181 0.2676208 0.27646667 0.3837333 0.107266667 5.528307e-01 8.213932e-07 FALSE FALSE
ENST00000578730 ENSG00000196810 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 9.012422 12.31657 6.776087 1.193823 0.4355605 -0.8611195 1.5873913 2.1915685 1.0635500 0.1474649 0.11688547 -1.0361423 0.1771458 0.17906667 0.1591667 -0.019900000 8.972507e-01 8.213932e-07 TRUE TRUE
ENST00000581398 ENSG00000196810 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA lncRNA 9.012422 12.31657 6.776087 1.193823 0.4355605 -0.8611195 1.9546550 2.6067712 1.4366353 0.2881677 0.05733871 -0.8550866 0.2187375 0.21103333 0.2139000 0.002866667 1.000000e+00 8.213932e-07 FALSE TRUE
MSTRG.24436.1 ENSG00000196810 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA   9.012422 12.31657 6.776087 1.193823 0.4355605 -0.8611195 0.6095767 0.8811874 0.3328524 0.3125575 0.08602233 -1.3781413 0.0684625 0.07050000 0.0479000 -0.022600000 8.494326e-01 8.213932e-07 TRUE TRUE
MSTRG.24436.5 ENSG00000196810 HEK293_OSMI2_6hA HEK293_TMG_6hB   lncRNA   9.012422 12.31657 6.776087 1.193823 0.4355605 -0.8611195 0.2656408 0.6991018 0.0000000 0.0163315 0.00000000 -6.1479208 0.0296625 0.05773333 0.0000000 -0.057733333 8.213932e-07 8.213932e-07 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000196810 E001 0.9704473 0.0159730615 0.08628259   4 1249231 1249260 30 + 0.000 0.350 10.544
ENSG00000196810 E002 6.2717304 0.0203970655 0.02155122 0.10112810 4 1249261 1249299 39 + 0.546 0.921 1.545
ENSG00000196810 E003 10.7718591 0.0276207003 0.08597931 0.25638402 4 1249300 1249437 138 + 0.849 1.099 0.929
ENSG00000196810 E004 4.5477241 0.0369828718 0.09743880 0.27729114 4 1249438 1249450 13 + 0.480 0.785 1.335
ENSG00000196810 E005 4.0417474 0.0642055306 0.20970106 0.44152305 4 1249451 1249472 22 + 0.481 0.736 1.136
ENSG00000196810 E006 4.7622249 0.0118287931 0.13571142 0.34089548 4 1249473 1249542 70 + 0.546 0.789 1.031
ENSG00000196810 E007 8.4815113 0.0037633467 0.09647937 0.27559994 4 1249543 1249631 89 + 0.781 0.995 0.818
ENSG00000196810 E008 13.4972245 0.0054184708 0.11726943 0.31123096 4 1249632 1249702 71 + 1.002 1.171 0.609
ENSG00000196810 E009 9.4462317 0.0036474582 0.01247659 0.06834654 4 1249703 1249759 57 + 0.743 1.062 1.216
ENSG00000196810 E010 36.6307282 0.0102094045 0.32041311 0.56006906 4 1249760 1250109 350 + 1.485 1.557 0.247
ENSG00000196810 E011 12.5795366 0.0025543675 0.30079422 0.54125812 4 1250110 1250110 1 + 1.164 1.062 -0.367
ENSG00000196810 E012 54.3929127 0.0007637010 0.92636117 0.96529330 4 1250111 1250258 148 + 1.702 1.707 0.019
ENSG00000196810 E013 55.7206485 0.0009143472 0.80081129 0.89675127 4 1250259 1250350 92 + 1.727 1.716 -0.039
ENSG00000196810 E014 31.8810452 0.0011814767 0.01648173 0.08357649 4 1250351 1250373 23 + 1.583 1.432 -0.518
ENSG00000196810 E015 40.1777122 0.0010371162 0.03266674 0.13513078 4 1250374 1250525 152 + 1.661 1.540 -0.413
ENSG00000196810 E016 30.2693478 0.0014487307 0.79322456 0.89230538 4 1250526 1250638 113 + 1.442 1.461 0.064
ENSG00000196810 E017 43.5031589 0.0102985686 0.41244620 0.63794983 4 1250639 1250895 257 + 1.560 1.621 0.206
ENSG00000196810 E018 265.9520316 0.0010745851 0.59964332 0.76997639 4 1250896 1251822 927 + 2.393 2.380 -0.043
ENSG00000196810 E019 192.4022679 0.0006682966 0.38963285 0.62019518 4 1251823 1252990 1168 + 2.262 2.240 -0.073
ENSG00000196810 E020 16.2136934 0.0410579522 0.05684691 0.19565304 4 1252991 1254589 1599 + 1.349 1.103 -0.870
ENSG00000196810 E021 14.1868784 0.0022794518 0.71903029 0.84758292 4 1254590 1255910 1321 + 1.117 1.153 0.129
ENSG00000196810 E022 2.1190660 0.0096406597 0.25581756 0.49452141 4 1257357 1257434 78 + 0.303 0.515 1.174
ENSG00000196810 E023 6.5802676 0.0791058198 0.73303894 0.85601708 4 1265340 1266163 824 + 0.784 0.852 0.267
ENSG00000196810 E024 2.5416502 0.0106144824 0.03132214 0.13127716 4 1287605 1287723 119 + 0.177 0.591 2.527
ENSG00000196810 E025 1.6718989 0.2131262189 0.65207811 0.80480879 4 1288026 1288294 269 + 0.301 0.430 0.755