ENSG00000196781

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376463 ENSG00000196781 HEK293_OSMI2_6hA HEK293_TMG_6hB TLE1 protein_coding protein_coding 22.9569 30.31387 23.70935 4.244696 0.8677392 -0.3543892 6.462668 6.367419 8.975690 1.0241650 0.1515640 0.4946567 0.28407917 0.20886667 0.37913333 0.1702667 1.140544e-06 1.140544e-06 FALSE TRUE
ENST00000376499 ENSG00000196781 HEK293_OSMI2_6hA HEK293_TMG_6hB TLE1 protein_coding protein_coding 22.9569 30.31387 23.70935 4.244696 0.8677392 -0.3543892 9.236499 14.871228 7.848917 2.1965606 0.1862775 -0.9210912 0.39860417 0.49076667 0.33146667 -0.1593000 2.573660e-03 1.140544e-06 FALSE TRUE
MSTRG.32904.2 ENSG00000196781 HEK293_OSMI2_6hA HEK293_TMG_6hB TLE1 protein_coding   22.9569 30.31387 23.70935 4.244696 0.8677392 -0.3543892 4.166757 5.265536 4.878272 0.4677861 0.6878205 -0.1099932 0.18187500 0.17886667 0.20426667 0.0254000 8.871306e-01 1.140544e-06 FALSE TRUE
MSTRG.32904.3 ENSG00000196781 HEK293_OSMI2_6hA HEK293_TMG_6hB TLE1 protein_coding   22.9569 30.31387 23.70935 4.244696 0.8677392 -0.3543892 2.151099 2.543702 1.784999 0.7161953 0.1508578 -0.5086068 0.09347917 0.08003333 0.07543333 -0.0046000 9.949791e-01 1.140544e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000196781 E001 2.9179468 0.0083507637 2.304816e-01 4.656714e-01 9 81583683 81583696 14 - 0.435 0.642 0.972
ENSG00000196781 E002 23.4875504 0.0017224419 9.118959e-03 5.435050e-02 9 81583697 81583747 51 - 1.229 1.440 0.736
ENSG00000196781 E003 66.5909811 0.0027098607 3.160786e-02 1.320835e-01 9 81583748 81583753 6 - 1.733 1.853 0.406
ENSG00000196781 E004 80.9146975 0.0010548620 1.605864e-04 2.225317e-03 9 81583754 81583776 23 - 1.775 1.951 0.591
ENSG00000196781 E005 497.5455720 0.0001797020 1.781105e-03 1.557050e-02 9 81583777 81584305 529 - 2.641 2.700 0.195
ENSG00000196781 E006 155.4364325 0.0058439885 3.243543e-01 5.636339e-01 9 81584448 81584524 77 - 2.146 2.194 0.160
ENSG00000196781 E007 165.4446795 0.0009831385 3.006824e-02 1.275383e-01 9 81585505 81585655 151 - 2.156 2.232 0.255
ENSG00000196781 E008 188.0186283 0.0035741943 1.146762e-01 3.069076e-01 9 81587681 81587828 148 - 2.215 2.282 0.225
ENSG00000196781 E009 253.6931966 0.0006019386 1.533775e-01 3.671539e-01 9 81590805 81591052 248 - 2.362 2.403 0.136
ENSG00000196781 E010 226.7125229 0.0019969439 8.233972e-01 9.099002e-01 9 81593025 81593274 250 - 2.343 2.338 -0.015
ENSG00000196781 E011 0.8681014 0.0466856253 8.575682e-01   9 81599865 81600116 252 - 0.270 0.238 -0.241
ENSG00000196781 E012 107.3655769 0.0010124434 4.088412e-01 6.351178e-01 9 81610220 81610296 77 - 1.994 2.030 0.121
ENSG00000196781 E013 54.3479708 0.0013696967 2.017653e-01 4.318187e-01 9 81611769 81611805 37 - 1.677 1.749 0.244
ENSG00000196781 E014 67.8409473 0.0005604776 3.438790e-01 5.815374e-01 9 81611806 81611842 37 - 1.787 1.837 0.166
ENSG00000196781 E015 115.4861763 0.0038637282 3.611874e-02 1.445354e-01 9 81611843 81611956 114 - 1.980 2.082 0.341
ENSG00000196781 E016 46.5889067 0.0039229149 4.122240e-03 2.985166e-02 9 81611957 81611959 3 - 1.533 1.723 0.645
ENSG00000196781 E017 0.5470056 0.2658464650 6.019118e-01   9 81612292 81612393 102 - 0.267 0.167 -0.856
ENSG00000196781 E018 84.8530802 0.0042311379 3.585656e-02 1.438334e-01 9 81613377 81613421 45 - 1.843 1.957 0.381
ENSG00000196781 E019 135.2507371 0.0055910744 1.449527e-01 3.548735e-01 9 81613422 81613521 100 - 2.067 2.141 0.248
ENSG00000196781 E020 90.1500807 0.0074993926 3.109573e-01 5.513702e-01 9 81615982 81616020 39 - 1.898 1.965 0.224
ENSG00000196781 E021 160.3181186 0.0003597609 4.774338e-01 6.853292e-01 9 81616021 81616134 114 - 2.172 2.200 0.092
ENSG00000196781 E022 122.5247213 0.0003606441 6.597070e-01 8.098060e-01 9 81616646 81616699 54 - 2.079 2.071 -0.028
ENSG00000196781 E023 90.7949600 0.0004388127 6.765916e-03 4.354613e-02 9 81620441 81620453 13 - 2.006 1.909 -0.324
ENSG00000196781 E024 150.8492786 0.0002880484 2.349497e-01 4.708011e-01 9 81620454 81620557 104 - 2.182 2.153 -0.098
ENSG00000196781 E025 70.7266098 0.0006468001 2.501962e-01 4.881669e-01 9 81633348 81633364 17 - 1.865 1.821 -0.150
ENSG00000196781 E026 93.1104722 0.0004699827 5.171100e-13 5.586334e-11 9 81633469 81634096 628 - 2.107 1.847 -0.875
ENSG00000196781 E027 210.8051820 0.0004938781 1.844720e-04 2.500207e-03 9 81634097 81634301 205 - 2.365 2.274 -0.306
ENSG00000196781 E028 27.9522857 0.0035116117 6.414187e-02 2.119936e-01 9 81652184 81652213 30 - 1.517 1.389 -0.440
ENSG00000196781 E029 148.6392795 0.0004529691 1.408981e-04 1.990494e-03 9 81652214 81652288 75 - 2.222 2.112 -0.368
ENSG00000196781 E030 138.9959332 0.0003911125 2.191573e-08 9.530847e-07 9 81653974 81654036 63 - 2.227 2.060 -0.558
ENSG00000196781 E031 1.3914542 0.1110077856 4.929098e-01 6.958859e-01 9 81673882 81673991 110 - 0.435 0.298 -0.805
ENSG00000196781 E032 108.8922602 0.0006211286 8.091747e-07 2.363951e-05 9 81685676 81685720 45 - 2.122 1.953 -0.567
ENSG00000196781 E033 133.3236134 0.0018956469 1.080232e-04 1.594417e-03 9 81685833 81685896 64 - 2.194 2.056 -0.462
ENSG00000196781 E034 135.2761891 0.0009706620 4.303044e-02 1.626468e-01 9 81687334 81687434 101 - 2.158 2.097 -0.206
ENSG00000196781 E035 456.0873038 0.0012613141 3.323366e-02 1.366765e-01 9 81688217 81689626 1410 - 2.605 2.660 0.182