ENSG00000196547

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360468 ENSG00000196547 HEK293_OSMI2_6hA HEK293_TMG_6hB MAN2A2 protein_coding protein_coding 28.10653 40.09219 26.40301 6.638039 1.670522 -0.6024323 4.260727 7.3584591 2.4781152 0.3454199 0.94910951 -1.5663096 0.15442083 0.190633333 0.09370000 -0.09693333 3.465125e-01 6.033177e-13 FALSE TRUE
ENST00000558374 ENSG00000196547 HEK293_OSMI2_6hA HEK293_TMG_6hB MAN2A2 protein_coding retained_intron 28.10653 40.09219 26.40301 6.638039 1.670522 -0.6024323 3.620655 5.0435561 4.6986801 0.5153020 0.30591894 -0.1019762 0.12742500 0.128400000 0.17846667 0.05006667 2.777271e-01 6.033177e-13 FALSE TRUE
ENST00000559374 ENSG00000196547 HEK293_OSMI2_6hA HEK293_TMG_6hB MAN2A2 protein_coding retained_intron 28.10653 40.09219 26.40301 6.638039 1.670522 -0.6024323 1.929694 2.5064402 2.0629352 1.1794823 0.11907293 -0.2797093 0.06692917 0.056600000 0.07916667 0.02256667 7.384065e-01 6.033177e-13 TRUE TRUE
ENST00000559717 ENSG00000196547 HEK293_OSMI2_6hA HEK293_TMG_6hB MAN2A2 protein_coding protein_coding 28.10653 40.09219 26.40301 6.638039 1.670522 -0.6024323 1.342276 0.1880294 3.3940900 0.1880294 0.84519321 4.1034823 0.05058750 0.003566667 0.13236667 0.12880000 1.125895e-02 6.033177e-13 FALSE TRUE
ENST00000561047 ENSG00000196547 HEK293_OSMI2_6hA HEK293_TMG_6hB MAN2A2 protein_coding retained_intron 28.10653 40.09219 26.40301 6.638039 1.670522 -0.6024323 2.262597 2.6942621 2.1961674 0.7308135 0.33059318 -0.2936927 0.08038750 0.065333333 0.08226667 0.01693333 7.520076e-01 6.033177e-13 FALSE TRUE
ENST00000561448 ENSG00000196547 HEK293_OSMI2_6hA HEK293_TMG_6hB MAN2A2 protein_coding nonsense_mediated_decay 28.10653 40.09219 26.40301 6.638039 1.670522 -0.6024323 3.657686 5.3239597 0.8343055 0.2709977 0.06335537 -2.6593699 0.13341667 0.137700000 0.03163333 -0.10606667 1.071919e-07 6.033177e-13 TRUE TRUE
MSTRG.11550.8 ENSG00000196547 HEK293_OSMI2_6hA HEK293_TMG_6hB MAN2A2 protein_coding   28.10653 40.09219 26.40301 6.638039 1.670522 -0.6024323 1.986209 4.4417071 0.0000000 0.4871644 0.00000000 -8.7982149 0.06880417 0.118533333 0.00000000 -0.11853333 6.033177e-13 6.033177e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000196547 E001 0.3807181 0.0265147240 5.785699e-01   15 90902218 90902274 57 + 0.165 0.089 -1.026
ENSG00000196547 E002 1.0293295 0.0172671820 9.399630e-01   15 90902275 90902376 102 + 0.284 0.280 -0.025
ENSG00000196547 E003 1.8146061 0.0106941599 3.532552e-01 5.901824e-01 15 90902377 90902427 51 + 0.519 0.372 -0.763
ENSG00000196547 E004 6.5061592 0.0055584046 2.820911e-01 5.224532e-01 15 90902428 90902526 99 + 0.923 0.808 -0.444
ENSG00000196547 E005 0.8203656 0.1520583893 1.525829e-01   15 90902695 90902812 118 + 0.000 0.329 11.752
ENSG00000196547 E006 0.5649788 0.0490483691 1.788808e-01   15 90902813 90902860 48 + 0.000 0.278 11.942
ENSG00000196547 E007 2.3557917 0.0094385624 1.540386e-03 1.389014e-02 15 90902861 90902897 37 + 0.000 0.642 14.140
ENSG00000196547 E008 5.3141471 0.0072241984 2.707742e-02 1.185299e-01 15 90902898 90902925 28 + 0.519 0.877 1.505
ENSG00000196547 E009 13.7937873 0.0094318123 1.690975e-01 3.894153e-01 15 90902926 90902975 50 + 1.028 1.200 0.617
ENSG00000196547 E010 39.9076441 0.0018304851 5.218272e-01 7.161940e-01 15 90903231 90903301 71 + 1.599 1.583 -0.054
ENSG00000196547 E011 66.4799886 0.0006855576 8.790719e-02 2.598150e-01 15 90903302 90903432 131 + 1.840 1.784 -0.187
ENSG00000196547 E012 2.6607176 0.0357395873 3.516557e-01 5.887612e-01 15 90903433 90903681 249 + 0.625 0.484 -0.651
ENSG00000196547 E013 1.5705534 0.0114710249 7.071647e-02 2.261776e-01 15 90903682 90903734 53 + 0.576 0.279 -1.614
ENSG00000196547 E014 0.4514866 0.0230819918 2.212349e-01   15 90903735 90903741 7 + 0.284 0.088 -2.030
ENSG00000196547 E015 1.4394976 0.0122143028 1.482344e-01 3.597927e-01 15 90903744 90903845 102 + 0.519 0.280 -1.350
ENSG00000196547 E016 1.8313620 0.0109623645 1.253991e-01 3.244557e-01 15 90903846 90904034 189 + 0.576 0.329 -1.290
ENSG00000196547 E017 0.6370325 0.0205132354 7.812584e-01   15 90904035 90904189 155 + 0.165 0.225 0.557
ENSG00000196547 E018 92.2567233 0.0028963310 3.783350e-02 1.491792e-01 15 90904190 90904339 150 + 1.988 1.918 -0.236
ENSG00000196547 E019 107.1086657 0.0004440640 3.651639e-02 1.456428e-01 15 90905251 90905378 128 + 2.038 1.985 -0.179
ENSG00000196547 E020 110.0704311 0.0005094401 3.682253e-01 6.025780e-01 15 90905379 90905508 130 + 2.025 2.015 -0.033
ENSG00000196547 E021 117.3082674 0.0012326995 1.337947e-02 7.194989e-02 15 90905579 90905689 111 + 2.090 2.019 -0.239
ENSG00000196547 E022 80.4409222 0.0005154615 6.870391e-05 1.091747e-03 15 90905690 90905723 34 + 1.971 1.830 -0.473
ENSG00000196547 E023 97.3513535 0.0004441618 1.395853e-06 3.798236e-05 15 90905845 90905921 77 + 2.063 1.906 -0.528
ENSG00000196547 E024 82.7162543 0.0006145140 6.797842e-03 4.368869e-02 15 90905922 90905979 58 + 1.952 1.863 -0.300
ENSG00000196547 E025 74.7069948 0.0017078429 2.244713e-02 1.040688e-01 15 90905980 90906016 37 + 1.905 1.821 -0.281
ENSG00000196547 E026 99.7085045 0.0004568073 4.719484e-02 1.730043e-01 15 90906370 90906452 83 + 2.008 1.957 -0.173
ENSG00000196547 E027 83.6192234 0.0015788997 1.013210e-01 2.842147e-01 15 90906453 90906497 45 + 1.929 1.881 -0.160
ENSG00000196547 E028 114.7661239 0.0029167527 5.996539e-02 2.027455e-01 15 90906740 90906849 110 + 2.069 2.013 -0.188
ENSG00000196547 E029 103.5762601 0.0030151267 3.583776e-01 5.945016e-01 15 90906850 90906913 64 + 2.001 1.981 -0.066
ENSG00000196547 E030 6.2537524 0.1108405520 7.795663e-01 8.844606e-01 15 90907189 90907308 120 + 0.791 0.843 0.202
ENSG00000196547 E031 106.3213053 0.0012795379 3.581219e-01 5.943081e-01 15 90907309 90907387 79 + 2.010 1.996 -0.048
ENSG00000196547 E032 103.1388520 0.0057000343 4.967829e-01 6.987458e-01 15 90907388 90907495 108 + 1.952 2.007 0.184
ENSG00000196547 E033 0.9574634 0.0157345416 9.348954e-01   15 90907496 90907519 24 + 0.284 0.280 -0.028
ENSG00000196547 E034 146.6923818 0.0006723509 1.364303e-01 3.420187e-01 15 90909327 90909504 178 + 2.092 2.164 0.241
ENSG00000196547 E035 102.7823362 0.0013031110 8.313033e-01 9.145376e-01 15 90910090 90910154 65 + 1.981 1.995 0.044
ENSG00000196547 E036 88.3345623 0.0076903347 3.762524e-01 6.092196e-01 15 90910155 90910215 61 + 1.947 1.912 -0.118
ENSG00000196547 E037 103.4991219 0.0077891937 4.446423e-01 6.618749e-01 15 90910216 90910292 77 + 2.010 1.983 -0.091
ENSG00000196547 E038 121.9665345 0.0003494873 6.851413e-01 8.259795e-01 15 90910501 90910609 109 + 2.056 2.065 0.030
ENSG00000196547 E039 70.2521359 0.0005330098 3.735614e-01 6.070051e-01 15 90910610 90910619 10 + 1.837 1.820 -0.057
ENSG00000196547 E040 94.6827539 0.0012087736 2.129451e-01 4.452246e-01 15 90910620 90910683 64 + 1.975 1.948 -0.092
ENSG00000196547 E041 133.1241474 0.0003151338 3.498185e-01 5.870859e-01 15 90910847 90910961 115 + 2.105 2.097 -0.025
ENSG00000196547 E042 14.9360303 0.1092117182 1.896641e-01 4.165179e-01 15 90910962 90911170 209 + 1.262 1.122 -0.495
ENSG00000196547 E043 112.7065966 0.0003637238 2.097269e-01 4.415518e-01 15 90911171 90911238 68 + 2.042 2.021 -0.071
ENSG00000196547 E044 11.0600503 0.1085951276 3.130211e-01 5.533103e-01 15 90911239 90911366 128 + 1.147 1.002 -0.524
ENSG00000196547 E045 7.7018930 0.0640336081 1.034045e-01 2.879234e-01 15 90911367 90911384 18 + 1.050 0.825 -0.847
ENSG00000196547 E046 57.7434922 0.0032888288 1.826156e-01 4.074459e-01 15 90911385 90911395 11 + 1.778 1.729 -0.164
ENSG00000196547 E047 60.4946587 0.0047634588 4.100546e-01 6.360677e-01 15 90911396 90911415 20 + 1.781 1.757 -0.082
ENSG00000196547 E048 113.2716212 0.0005386777 6.724298e-01 8.178686e-01 15 90911416 90911550 135 + 2.027 2.035 0.027
ENSG00000196547 E049 2.1225777 0.0324239657 2.092101e-01 4.409400e-01 15 90911852 90912042 191 + 0.284 0.543 1.434
ENSG00000196547 E050 115.6928826 0.0009524416 7.182503e-01 8.471325e-01 15 90912043 90912182 140 + 2.035 2.046 0.037
ENSG00000196547 E051 109.6012874 0.0054665066 4.960911e-01 6.982614e-01 15 90912183 90912279 97 + 2.021 2.017 -0.014
ENSG00000196547 E052 31.8611365 0.0869362041 1.787233e-01 4.022755e-01 15 90912280 90912516 237 + 1.556 1.453 -0.352
ENSG00000196547 E053 26.3296611 0.0502698835 7.998290e-02 2.447993e-01 15 90912517 90912541 25 + 1.514 1.351 -0.559
ENSG00000196547 E054 126.5940914 0.0004497976 7.328875e-01 8.559179e-01 15 90912542 90912664 123 + 2.068 2.080 0.040
ENSG00000196547 E055 65.9005742 0.0005872520 3.597372e-01 5.955862e-01 15 90912877 90912879 3 + 1.750 1.817 0.226
ENSG00000196547 E056 70.0683674 0.0006918779 8.685992e-01 9.351489e-01 15 90912880 90912887 8 + 1.801 1.832 0.105
ENSG00000196547 E057 137.8136428 0.0004301404 8.282322e-01 9.127614e-01 15 90912888 90912991 104 + 2.102 2.118 0.055
ENSG00000196547 E058 153.0991942 0.0003922743 3.928546e-01 6.226795e-01 15 90913273 90913374 102 + 2.161 2.157 -0.012
ENSG00000196547 E059 86.7078738 0.0004500125 3.594176e-01 5.953728e-01 15 90913375 90913406 32 + 1.924 1.910 -0.047
ENSG00000196547 E060 46.8236548 0.0411942500 1.020057e-01 2.853669e-01 15 90913407 90913613 207 + 1.738 1.599 -0.471
ENSG00000196547 E061 165.7740404 0.0015054955 4.704835e-01 6.804077e-01 15 90913614 90913755 142 + 2.159 2.206 0.158
ENSG00000196547 E062 5.2405113 0.0064684182 8.766243e-01 9.395051e-01 15 90915418 90915496 79 + 0.749 0.792 0.173
ENSG00000196547 E063 2.7239011 0.0855194696 9.734115e-01 9.886348e-01 15 90915995 90916067 73 + 0.520 0.568 0.224
ENSG00000196547 E064 1.9336352 0.0123168226 2.463871e-01 4.840270e-01 15 90916068 90916100 33 + 0.283 0.513 1.296
ENSG00000196547 E065 2.6549205 0.0217578266 9.593654e-01 9.816091e-01 15 90916101 90916122 22 + 0.518 0.544 0.120
ENSG00000196547 E066 145.6241958 0.0011649020 2.404553e-02 1.092191e-01 15 90916123 90916256 134 + 2.063 2.166 0.343
ENSG00000196547 E067 6.5200813 0.2249853824 1.415543e-01 3.498082e-01 15 90916527 90916585 59 + 0.995 0.760 -0.903
ENSG00000196547 E068 9.4076186 0.0232338129 6.808389e-02 2.207793e-01 15 90916586 90916660 75 + 1.113 0.917 -0.723
ENSG00000196547 E069 9.0561880 0.1339212520 8.039193e-01 8.985935e-01 15 90917652 90917843 192 + 0.965 0.981 0.060
ENSG00000196547 E070 96.5733539 0.0028013796 8.120580e-02 2.472593e-01 15 90918194 90918234 41 + 1.885 1.989 0.351
ENSG00000196547 E071 183.7868514 0.0003550903 3.294977e-02 1.359267e-01 15 90918235 90918388 154 + 2.178 2.264 0.286
ENSG00000196547 E072 5.2226555 0.0263794912 4.958350e-01 6.980879e-01 15 90918389 90918644 256 + 0.816 0.742 -0.292
ENSG00000196547 E073 166.8413464 0.0017413267 3.157429e-01 5.557525e-01 15 90918645 90918733 89 + 2.156 2.215 0.199
ENSG00000196547 E074 117.3689412 0.0004190392 2.244475e-01 4.587467e-01 15 90918734 90918755 22 + 2.058 2.039 -0.064
ENSG00000196547 E075 286.0816544 0.0002056181 8.495416e-01 9.246941e-01 15 90919635 90919865 231 + 2.411 2.439 0.093
ENSG00000196547 E076 295.6486854 0.0001936206 2.184620e-02 1.020627e-01 15 90919866 90920110 245 + 2.393 2.468 0.250
ENSG00000196547 E077 622.0060958 0.1501381902 1.248459e-01 3.234827e-01 15 90920111 90920998 888 + 2.594 2.829 0.781
ENSG00000196547 E078 218.1218927 0.0523375660 1.426088e-01 3.513457e-01 15 90920999 90922584 1586 + 2.197 2.359 0.539