ENSG00000196504

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000410080 ENSG00000196504 HEK293_OSMI2_6hA HEK293_TMG_6hB PRPF40A protein_coding protein_coding 51.77362 14.80996 95.9748 0.9734118 2.377256 2.695264 2.758459 0.7079345 5.7766399 0.1744208 0.46027230 3.010802 0.05180417 0.04710000 0.0605000 0.01340000 7.895148e-01 1.201704e-10 FALSE TRUE
ENST00000450303 ENSG00000196504 HEK293_OSMI2_6hA HEK293_TMG_6hB PRPF40A protein_coding retained_intron 51.77362 14.80996 95.9748 0.9734118 2.377256 2.695264 1.782955 3.0199149 0.9382095 0.9280624 0.05542905 -1.676000 0.10114583 0.20030000 0.0098000 -0.19050000 1.201704e-10 1.201704e-10   FALSE
ENST00000696381 ENSG00000196504 HEK293_OSMI2_6hA HEK293_TMG_6hB PRPF40A protein_coding protein_coding 51.77362 14.80996 95.9748 0.9734118 2.377256 2.695264 8.951747 3.0902898 15.9441337 0.2576893 0.95812110 2.363455 0.17071667 0.20816667 0.1658667 -0.04230000 3.750729e-01 1.201704e-10 FALSE TRUE
MSTRG.19358.5 ENSG00000196504 HEK293_OSMI2_6hA HEK293_TMG_6hB PRPF40A protein_coding   51.77362 14.80996 95.9748 0.9734118 2.377256 2.695264 7.398383 1.7898947 13.1435081 0.1142539 0.13543263 2.869463 0.14293333 0.12086667 0.1370333 0.01616667 7.697237e-01 1.201704e-10 FALSE TRUE
MSTRG.19358.6 ENSG00000196504 HEK293_OSMI2_6hA HEK293_TMG_6hB PRPF40A protein_coding   51.77362 14.80996 95.9748 0.9734118 2.377256 2.695264 20.033311 3.1977712 38.0719265 0.7701702 1.89035503 3.569463 0.30315833 0.21393333 0.3964333 0.18250000 8.852097e-02 1.201704e-10 FALSE TRUE
MSTRG.19358.7 ENSG00000196504 HEK293_OSMI2_6hA HEK293_TMG_6hB PRPF40A protein_coding   51.77362 14.80996 95.9748 0.9734118 2.377256 2.695264 4.779940 0.5111350 11.1162674 0.5111350 0.71100686 4.416169 0.06664167 0.03966667 0.1159333 0.07626667 2.976413e-01 1.201704e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000196504 E001 0.7860845 0.0170728411 5.447373e-01   2 152650919 152651045 127 - 0.216 0.000 -10.513
ENSG00000196504 E002 0.4820342 0.0213141399 1.000000e+00   2 152651593 152651731 139 - 0.142 0.000 -9.747
ENSG00000196504 E003 8.5510423 0.0035442262 1.837061e-02 9.025493e-02 2 152651732 152651882 151 - 0.780 1.090 1.171
ENSG00000196504 E004 9.5726375 0.0036438415 9.690411e-02 2.763066e-01 2 152651883 152651901 19 - 0.841 1.061 0.825
ENSG00000196504 E005 1198.2539537 0.0028703636 2.650455e-01 5.043851e-01 2 152651902 152656305 4404 - 2.917 2.947 0.100
ENSG00000196504 E006 373.7719638 0.0007021950 5.397658e-03 3.668347e-02 2 152656306 152656398 93 - 2.406 2.487 0.268
ENSG00000196504 E007 1.4762021 0.0138880869 1.426762e-01 3.514454e-01 2 152657885 152657888 4 - 0.249 0.535 1.651
ENSG00000196504 E008 346.1312444 0.0001984565 8.832251e-05 1.346789e-03 2 152657889 152657954 66 - 2.369 2.475 0.354
ENSG00000196504 E009 330.7403253 0.0003382701 1.293118e-06 3.551118e-05 2 152657955 152658020 66 - 2.344 2.478 0.446
ENSG00000196504 E010 291.3984612 0.0002177774 5.388543e-04 6.026730e-03 2 152658948 152659009 62 - 2.293 2.396 0.342
ENSG00000196504 E011 6.8962356 0.0673802792 3.006991e-01 5.411673e-01 2 152659010 152659092 83 - 0.730 0.920 0.740
ENSG00000196504 E012 330.5022741 0.0002137937 6.969112e-01 8.335501e-01 2 152659093 152659189 97 - 2.362 2.377 0.052
ENSG00000196504 E013 299.8384319 0.0001692244 8.421099e-01 9.206411e-01 2 152659270 152659356 87 - 2.320 2.331 0.035
ENSG00000196504 E014 0.1723744 0.0329352666 5.674435e-02   2 152659357 152659377 21 - 0.000 0.257 13.424
ENSG00000196504 E015 357.8632582 0.0001522499 1.614479e-01 3.789156e-01 2 152662603 152662698 96 - 2.392 2.434 0.138
ENSG00000196504 E016 375.5390497 0.0001845748 1.535922e-01 3.674456e-01 2 152663035 152663130 96 - 2.414 2.455 0.138
ENSG00000196504 E017 268.6921563 0.0001888503 8.577532e-01 9.292106e-01 2 152663131 152663172 42 - 2.274 2.284 0.034
ENSG00000196504 E018 381.0172715 0.0001783089 3.761741e-02 1.486236e-01 2 152663655 152663771 117 - 2.433 2.382 -0.170
ENSG00000196504 E019 1.1176617 0.0153787590 1.000000e+00   2 152663772 152663855 84 - 0.249 0.257 0.064
ENSG00000196504 E020 376.2435647 0.0025249212 1.497162e-01 3.618735e-01 2 152663876 152663967 92 - 2.425 2.374 -0.171
ENSG00000196504 E021 63.9405748 0.0165955943 4.093936e-01 6.355882e-01 2 152663968 152663979 12 - 1.666 1.591 -0.252
ENSG00000196504 E022 339.4981762 0.0030733358 7.306627e-01 8.545861e-01 2 152664138 152664252 115 - 2.372 2.385 0.044
ENSG00000196504 E023 428.6213157 0.0002100642 4.777291e-02 1.744831e-01 2 152669137 152669270 134 - 2.482 2.436 -0.152
ENSG00000196504 E024 502.8979696 0.0010511390 1.047322e-02 6.015626e-02 2 152670231 152670381 151 - 2.554 2.489 -0.218
ENSG00000196504 E025 401.9736742 0.0030816075 1.968769e-02 9.486174e-02 2 152671273 152671381 109 - 2.459 2.379 -0.268
ENSG00000196504 E026 342.9416323 0.0021539221 2.584213e-03 2.086794e-02 2 152672459 152672547 89 - 2.393 2.289 -0.348
ENSG00000196504 E027 270.0645756 0.0004140039 2.028624e-03 1.724950e-02 2 152672548 152672623 76 - 2.289 2.191 -0.328
ENSG00000196504 E028 242.4181759 0.0002436350 4.782024e-02 1.745846e-01 2 152672978 152673042 65 - 2.237 2.175 -0.208
ENSG00000196504 E029 267.7286680 0.0002123280 3.291674e-03 2.514176e-02 2 152673598 152673706 109 - 2.284 2.193 -0.304
ENSG00000196504 E030 512.7175403 0.0001890223 3.925040e-06 9.351319e-05 2 152676405 152676779 375 - 2.568 2.462 -0.353
ENSG00000196504 E031 182.2270797 0.0025419446 7.577560e-03 4.738394e-02 2 152677451 152677475 25 - 2.124 2.003 -0.404
ENSG00000196504 E032 179.3885502 0.0038601960 4.811077e-02 1.752459e-01 2 152679056 152679109 54 - 2.114 2.020 -0.316
ENSG00000196504 E033 5.4607167 0.1501676817 9.893171e-02 2.799214e-01 2 152679129 152679351 223 - 0.719 0.255 -2.406
ENSG00000196504 E034 316.5335623 0.0001735449 7.482224e-06 1.630297e-04 2 152679352 152679472 121 - 2.362 2.230 -0.442
ENSG00000196504 E035 302.2916851 0.0002156760 1.603145e-07 5.664811e-06 2 152681226 152681336 111 - 2.345 2.182 -0.546
ENSG00000196504 E036 149.5103245 0.0003474303 2.976461e-06 7.386696e-05 2 152690962 152690978 17 - 2.047 1.833 -0.719
ENSG00000196504 E037 191.9151867 0.0003786382 7.612651e-08 2.908444e-06 2 152693038 152693068 31 - 2.154 1.933 -0.739
ENSG00000196504 E038 2.9009508 0.0111140695 2.617090e-01 5.007798e-01 2 152693069 152693111 43 - 0.504 0.257 -1.440
ENSG00000196504 E039 7.2317594 0.0046524654 4.327186e-01 6.532861e-01 2 152693158 152693476 319 - 0.751 0.873 0.479
ENSG00000196504 E040 10.3218267 0.0035145585 1.006347e-01 2.829298e-01 2 152694063 152694436 374 - 0.879 1.090 0.783
ENSG00000196504 E041 16.1057109 0.0189285059 1.868420e-17 3.922134e-15 2 152694437 152694541 105 - 0.789 1.682 3.191
ENSG00000196504 E042 320.0911424 0.0011640525 7.904002e-02 2.429039e-01 2 152694542 152694622 81 - 2.341 2.398 0.191
ENSG00000196504 E043 7.7633923 0.0498690139 2.156792e-09 1.180003e-07 2 152714550 152714629 80 - 0.506 1.394 3.432
ENSG00000196504 E044 333.0526202 0.0002236245 4.538771e-08 1.827810e-06 2 152715995 152716126 132 - 2.342 2.488 0.488
ENSG00000196504 E045 1.8459615 0.0108451244 2.486427e-01 4.863932e-01 2 152716127 152716130 4 - 0.308 0.535 1.236
ENSG00000196504 E046 65.7124686 0.0005949326 9.839371e-02 2.789504e-01 2 152717230 152717355 126 - 1.653 1.754 0.343
ENSG00000196504 E047 195.0549020 0.0002167220 3.884500e-09 1.994791e-07 2 152717356 152717431 76 - 2.103 2.300 0.659
ENSG00000196504 E048 68.8094895 0.0029111962 2.637964e-11 2.109166e-09 2 152717432 152717625 194 - 1.616 1.989 1.260
ENSG00000196504 E049 23.4571545 0.3730104038 3.308572e-01 5.697628e-01 2 152717626 152717830 205 - 1.206 1.406 0.700
ENSG00000196504 E050 24.3442370 0.7036081074 9.918545e-02 2.803292e-01 2 152717831 152717992 162 - 1.124 1.667 1.886
ENSG00000196504 E051 12.0714390 0.5640185815 1.205754e-01 3.167478e-01 2 152717993 152718412 420 - 0.857 1.368 1.852