ENSG00000196365

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360614 ENSG00000196365 HEK293_OSMI2_6hA HEK293_TMG_6hB LONP1 protein_coding protein_coding 91.27259 135.0001 42.35228 23.75379 0.532404 -1.672215 46.98811 73.16009 15.899713 14.548450 0.2574146 -2.2013462 0.52454583 0.5362667 0.37566667 -0.16060000 7.551758e-04 3.910652e-05 FALSE TRUE
ENST00000585374 ENSG00000196365 HEK293_OSMI2_6hA HEK293_TMG_6hB LONP1 protein_coding protein_coding 91.27259 135.0001 42.35228 23.75379 0.532404 -1.672215 26.15958 30.29331 20.396213 5.821996 1.7413991 -0.5704671 0.29824583 0.2243667 0.48083333 0.25646667 3.910652e-05 3.910652e-05 FALSE TRUE
MSTRG.16253.8 ENSG00000196365 HEK293_OSMI2_6hA HEK293_TMG_6hB LONP1 protein_coding   91.27259 135.0001 42.35228 23.75379 0.532404 -1.672215 8.74050 17.54923 1.451106 4.095271 0.6567993 -3.5870962 0.07186667 0.1269000 0.03443333 -0.09246667 4.554506e-02 3.910652e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000196365 E001 1.9766714 2.042365e-01 3.491382e-01 5.865050e-01 19 5691834 5691834 1 - 0.207 0.444 1.546
ENSG00000196365 E002 301.5913015 2.396832e-01 8.608027e-02 2.565759e-01 19 5691835 5691954 120 - 2.098 2.448 1.170
ENSG00000196365 E003 432.7963713 3.419667e-01 1.123935e-01 3.031368e-01 19 5691955 5691992 38 - 2.244 2.605 1.204
ENSG00000196365 E004 1031.3390515 2.391420e-02 3.618614e-03 2.703343e-02 19 5691993 5692208 216 - 2.734 2.966 0.772
ENSG00000196365 E005 7.9985571 2.582598e-01 9.633348e-01 9.836125e-01 19 5692209 5692242 34 - 0.906 0.858 -0.181
ENSG00000196365 E006 910.2727794 1.319770e-03 2.075891e-07 7.130542e-06 19 5693298 5693462 165 - 2.757 2.901 0.479
ENSG00000196365 E007 988.0527746 1.207994e-03 2.259779e-04 2.957023e-03 19 5693552 5693769 218 - 2.825 2.930 0.347
ENSG00000196365 E008 910.3599898 2.023808e-04 3.640853e-03 2.715060e-02 19 5694387 5694552 166 - 2.820 2.891 0.235
ENSG00000196365 E009 734.9458897 9.833172e-05 4.483480e-02 1.672190e-01 19 5694761 5694901 141 - 2.738 2.796 0.194
ENSG00000196365 E010 755.5099551 1.215696e-04 7.230360e-01 8.499796e-01 19 5696054 5696170 117 - 2.772 2.803 0.102
ENSG00000196365 E011 801.6427022 1.179875e-04 5.428053e-01 7.310815e-01 19 5696249 5696371 123 - 2.809 2.824 0.051
ENSG00000196365 E012 27.5783330 5.148057e-02 1.788436e-01 4.024082e-01 19 5696372 5696669 298 - 1.499 1.329 -0.586
ENSG00000196365 E013 368.5577138 1.777378e-04 2.443084e-03 1.996689e-02 19 5696670 5696686 17 - 2.519 2.476 -0.143
ENSG00000196365 E014 542.4981581 2.183015e-04 4.389420e-03 3.131509e-02 19 5696687 5696757 71 - 2.675 2.645 -0.102
ENSG00000196365 E015 778.3994760 6.665813e-04 3.303183e-01 5.692644e-01 19 5699027 5699205 179 - 2.804 2.806 0.006
ENSG00000196365 E016 641.5309745 6.515857e-04 9.669735e-02 2.759583e-01 19 5700789 5700884 96 - 2.734 2.720 -0.045
ENSG00000196365 E017 440.6549463 3.442005e-03 1.279707e-01 3.286063e-01 19 5700885 5700908 24 - 2.588 2.551 -0.121
ENSG00000196365 E018 390.6694230 1.904864e-03 3.909203e-02 1.524279e-01 19 5700909 5700927 19 - 2.542 2.500 -0.139
ENSG00000196365 E019 9.4518323 3.078738e-03 1.643974e-03 1.462620e-02 19 5704109 5704258 150 - 1.180 0.851 -1.214
ENSG00000196365 E020 714.2186014 1.317297e-03 2.254286e-02 1.043733e-01 19 5705772 5705910 139 - 2.796 2.763 -0.110
ENSG00000196365 E021 376.2053244 6.791530e-04 1.772226e-02 8.808380e-02 19 5705911 5705947 37 - 2.522 2.487 -0.118
ENSG00000196365 E022 385.6323804 2.228099e-04 1.567080e-02 8.062478e-02 19 5705948 5705992 45 - 2.529 2.499 -0.097
ENSG00000196365 E023 431.3860345 4.357044e-04 2.488411e-02 1.118740e-01 19 5707060 5707143 84 - 2.575 2.548 -0.089
ENSG00000196365 E024 494.0664581 2.342969e-03 3.486714e-02 1.412645e-01 19 5707697 5707811 115 - 2.644 2.601 -0.142
ENSG00000196365 E025 243.3041017 2.725980e-03 3.215374e-03 2.469784e-02 19 5707812 5707826 15 - 2.370 2.287 -0.276
ENSG00000196365 E026 15.0585811 1.393155e-01 9.875514e-01 9.956185e-01 19 5707827 5708032 206 - 1.098 1.134 0.129
ENSG00000196365 E027 440.5245246 1.489285e-04 1.155585e-06 3.220297e-05 19 5708342 5708403 62 - 2.620 2.547 -0.243
ENSG00000196365 E028 29.9187193 5.432743e-02 2.730595e-01 5.129111e-01 19 5708404 5708958 555 - 1.504 1.374 -0.449
ENSG00000196365 E029 404.0912458 1.620993e-04 3.485535e-06 8.458475e-05 19 5711771 5711818 48 - 2.583 2.510 -0.241
ENSG00000196365 E030 596.2794992 1.342712e-04 9.267308e-07 2.657103e-05 19 5711819 5711950 132 - 2.742 2.681 -0.202
ENSG00000196365 E031 427.0199725 1.746229e-04 3.918498e-10 2.448312e-08 19 5711951 5712002 52 - 2.627 2.524 -0.343
ENSG00000196365 E032 1.6894674 1.162734e-02 2.315827e-01 4.669554e-01 19 5712003 5712070 68 - 0.539 0.339 -1.057
ENSG00000196365 E033 2.8884968 1.950421e-02 3.497846e-01 5.870733e-01 19 5712463 5712468 6 - 0.348 0.550 1.050
ENSG00000196365 E034 577.6948538 2.123332e-03 3.839160e-06 9.167290e-05 19 5713134 5713253 120 - 2.758 2.650 -0.359
ENSG00000196365 E035 429.7123684 1.218370e-03 1.021809e-06 2.893558e-05 19 5714183 5714271 89 - 2.628 2.523 -0.348
ENSG00000196365 E036 0.9161448 1.586464e-02 1.146462e-01   19 5714903 5715040 138 - 0.454 0.178 -1.862
ENSG00000196365 E037 5.7727390 4.576120e-03 1.449860e-02 7.623367e-02 19 5717355 5717616 262 - 0.982 0.674 -1.208
ENSG00000196365 E038 320.7583457 1.899118e-03 3.408751e-03 2.581424e-02 19 5719704 5719816 113 - 2.475 2.404 -0.237
ENSG00000196365 E039 95.8997037 4.658713e-04 6.597596e-01 8.098354e-01 19 5719817 5719833 17 - 1.866 1.911 0.151
ENSG00000196365 E040 152.2156384 3.047467e-04 2.353477e-05 4.389133e-04 19 5719834 5719932 99 - 1.949 2.136 0.628
ENSG00000196365 E041 186.3259809 1.269360e-03 2.484647e-05 4.591906e-04 19 5719933 5720008 76 - 2.036 2.224 0.631
ENSG00000196365 E042 151.9591132 1.173821e-03 1.426024e-03 1.308328e-02 19 5720009 5720042 34 - 1.975 2.131 0.524
ENSG00000196365 E043 174.6018236 3.494397e-04 8.575425e-07 2.485585e-05 19 5720043 5720165 123 - 1.994 2.199 0.687
ENSG00000196365 E044 25.1893271 1.707274e-03 8.514311e-01 9.258428e-01 19 5720219 5720572 354 - 1.302 1.342 0.139