ENSG00000196352

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367063 ENSG00000196352 HEK293_OSMI2_6hA HEK293_TMG_6hB CD55 protein_coding protein_coding 22.83196 11.86459 33.17406 1.75252 1.117871 1.482612 1.642588 1.766563 0.7669797 0.3386355 0.2740513 -1.193140 0.0957000 0.1546000 0.02373333 -0.1308667 0.004446543 0.004446543 FALSE TRUE
ENST00000367064 ENSG00000196352 HEK293_OSMI2_6hA HEK293_TMG_6hB CD55 protein_coding protein_coding 22.83196 11.86459 33.17406 1.75252 1.117871 1.482612 7.048664 3.169933 12.2123958 0.5580327 0.1664403 1.942459 0.2882042 0.2646000 0.36870000 0.1041000 0.051512113 0.004446543 FALSE TRUE
MSTRG.2958.13 ENSG00000196352 HEK293_OSMI2_6hA HEK293_TMG_6hB CD55 protein_coding   22.83196 11.86459 33.17406 1.75252 1.117871 1.482612 11.062907 5.135266 14.7347368 0.7187537 0.6359328 1.518883 0.4868208 0.4340333 0.44383333 0.0098000 0.959864940 0.004446543 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000196352 E001 3.1826359 0.0075298584 1.014476e-01 2.844287e-01 1 207321519 207321519 1 + 0.670 0.388 -1.353
ENSG00000196352 E002 3.5032544 0.0074057870 6.070406e-02 2.043872e-01 1 207321520 207321529 10 + 0.709 0.388 -1.513
ENSG00000196352 E003 3.5032544 0.0074057870 6.070406e-02 2.043872e-01 1 207321530 207321531 2 + 0.709 0.388 -1.513
ENSG00000196352 E004 3.8370444 0.0066131108 1.116495e-01 3.018012e-01 1 207321532 207321537 6 + 0.727 0.466 -1.172
ENSG00000196352 E005 6.3546028 0.0049295797 6.792014e-02 2.204166e-01 1 207321538 207321581 44 + 0.899 0.640 -1.041
ENSG00000196352 E006 9.4431093 0.0159531305 4.531271e-01 6.680505e-01 1 207321582 207321642 61 + 1.013 0.916 -0.359
ENSG00000196352 E007 6.7215137 0.0891726507 9.250205e-01 9.648206e-01 1 207321643 207321660 18 + 0.860 0.840 -0.079
ENSG00000196352 E008 9.6853359 0.0071271182 2.598743e-02 1.152770e-01 1 207321661 207321677 17 + 0.899 1.146 0.907
ENSG00000196352 E009 13.7774073 0.0022865502 5.560430e-05 9.127974e-04 1 207321678 207321700 23 + 0.985 1.354 1.318
ENSG00000196352 E010 24.7334524 0.0013322830 2.235556e-05 4.203375e-04 1 207321701 207321747 47 + 1.263 1.563 1.036
ENSG00000196352 E011 33.5641062 0.0036538179 5.455690e-05 8.975990e-04 1 207321748 207321790 43 + 1.403 1.669 0.912
ENSG00000196352 E012 54.4049917 0.0008645365 1.548107e-03 1.394865e-02 1 207321791 207321865 75 + 1.655 1.815 0.541
ENSG00000196352 E013 0.2852693 0.2760193246 6.171943e-01   1 207322236 207322289 54 + 0.154 0.000 -11.335
ENSG00000196352 E014 90.1898397 0.0005677852 5.502553e-01 7.364739e-01 1 207322382 207322463 82 + 1.922 1.949 0.089
ENSG00000196352 E015 127.2048411 0.0004588127 2.691859e-01 5.089522e-01 1 207322464 207322567 104 + 2.091 2.056 -0.116
ENSG00000196352 E016 149.2999901 0.0028295082 6.461216e-01 8.009244e-01 1 207324559 207324657 99 + 2.142 2.164 0.074
ENSG00000196352 E017 158.4391245 0.0002885854 8.995694e-01 9.516746e-01 1 207324658 207324750 93 + 2.174 2.173 -0.003
ENSG00000196352 E018 92.7072405 0.0005830282 3.139790e-01 5.542039e-01 1 207325622 207325639 18 + 1.925 1.967 0.142
ENSG00000196352 E019 152.5572629 0.0011132568 5.029876e-01 7.028450e-01 1 207325640 207325721 82 + 2.159 2.139 -0.068
ENSG00000196352 E020 146.6086128 0.0015553174 8.120800e-01 9.034591e-01 1 207326752 207326831 80 + 2.134 2.144 0.033
ENSG00000196352 E021 87.7221426 0.0006087210 2.625701e-01 5.017774e-01 1 207326832 207326837 6 + 1.901 1.949 0.161
ENSG00000196352 E022 2.6605005 0.0080169432 8.719106e-01 9.369651e-01 1 207326838 207327546 709 + 0.556 0.531 -0.115
ENSG00000196352 E023 219.9828423 0.0004091902 7.964975e-01 8.942929e-01 1 207331108 207331296 189 + 2.311 2.320 0.031
ENSG00000196352 E024 0.1779838 0.0355091439 1.000000e+00   1 207331297 207332223 927 + 0.085 0.000 -11.203
ENSG00000196352 E025 0.1779838 0.0355091439 1.000000e+00   1 207336578 207336692 115 + 0.085 0.000 -11.203
ENSG00000196352 E026 148.7913191 0.0005212642 6.246429e-01 7.871269e-01 1 207336693 207336753 61 + 2.139 2.156 0.058
ENSG00000196352 E027 174.5766674 0.0020514576 6.311306e-01 7.911390e-01 1 207336754 207336818 65 + 2.219 2.203 -0.053
ENSG00000196352 E028 16.7662880 0.0351037175 2.153118e-01 4.478796e-01 1 207336819 207337328 510 + 1.165 1.336 0.601
ENSG00000196352 E029 200.3374959 0.0003609966 5.508955e-01 7.369778e-01 1 207337329 207337409 81 + 2.277 2.264 -0.046
ENSG00000196352 E030 14.4314984 0.0024691486 4.280222e-02 1.620331e-01 1 207337410 207339396 1987 + 1.209 1.006 -0.733
ENSG00000196352 E031 129.1686846 0.0003525763 6.381327e-01 7.958131e-01 1 207339397 207339417 21 + 2.088 2.074 -0.044
ENSG00000196352 E032 8.0834107 0.0073601249 3.763263e-01 6.092767e-01 1 207339418 207340390 973 + 0.899 1.005 0.397
ENSG00000196352 E033 21.5267665 0.0403421789 1.656955e-03 1.472163e-02 1 207340391 207340508 118 + 1.169 1.535 1.274
ENSG00000196352 E034 10.4924434 0.0033333398 6.846549e-06 1.510787e-04 1 207340509 207340582 74 + 0.836 1.295 1.676
ENSG00000196352 E035 6.2035890 0.0366018655 6.190638e-05 9.995368e-04 1 207340583 207340766 184 + 0.557 1.152 2.340
ENSG00000196352 E036 0.3559677 0.4931294115 6.679583e-01   1 207347447 207347561 115 + 0.160 0.000 -11.153
ENSG00000196352 E037 0.2852693 0.2760193246 6.171943e-01   1 207354007 207354099 93 + 0.154 0.000 -11.335
ENSG00000196352 E038 0.8150164 0.0269759336 1.945630e-01   1 207358516 207358621 106 + 0.156 0.387 1.731
ENSG00000196352 E039 158.3229705 0.0002776123 1.428032e-04 2.013712e-03 1 207359546 207359642 97 + 2.206 2.091 -0.383
ENSG00000196352 E040 272.8586635 0.0003445867 4.809845e-08 1.924652e-06 1 207359643 207360966 1324 + 2.443 2.316 -0.425
ENSG00000196352 E041 2.1181295 0.1677334880 3.234034e-01 5.627488e-01 1 207362651 207362784 134 + 0.548 0.293 -1.396
ENSG00000196352 E042 0.3337900 0.0343699395 5.608056e-01   1 207365913 207365940 28 + 0.085 0.171 1.150
ENSG00000196352 E043 0.2027342 0.0357314021 2.181963e-01   1 207367370 207367487 118 + 0.000 0.171 12.045
ENSG00000196352 E044 0.0000000       1 207370709 207370834 126 +      
ENSG00000196352 E045 2.2073982 0.0095550430 5.049971e-02 1.808298e-01 1 207372769 207373252 484 + 0.362 0.685 1.562
ENSG00000196352 E046 0.0000000       1 207385222 207385406 185 +      
ENSG00000196352 E047 0.0000000       1 207386206 207386804 599 +