ENSG00000196247

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344930 ENSG00000196247 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF107 protein_coding protein_coding 5.783213 3.056711 9.706984 0.2650449 0.2957138 1.663816 0.44172411 0.1243606 0.8814262 0.12436060 0.28449972 2.73000515 0.05359167 0.04920000 0.08986667 0.0406666667 0.5599064016 0.0006591426 FALSE TRUE
ENST00000360117 ENSG00000196247 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF107 protein_coding nonsense_mediated_decay 5.783213 3.056711 9.706984 0.2650449 0.2957138 1.663816 0.03187807 0.2045048 0.0000000 0.20450480 0.00000000 -4.42293805 0.01009583 0.06220000 0.00000000 -0.0622000000 0.7260820529 0.0006591426 FALSE TRUE
ENST00000613690 ENSG00000196247 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF107 protein_coding protein_coding 5.783213 3.056711 9.706984 0.2650449 0.2957138 1.663816 0.07059191 0.3397260 0.0000000 0.33972605 0.00000000 -5.12815335 0.01613333 0.10333333 0.00000000 -0.1033333333 0.7483336436 0.0006591426 FALSE TRUE
ENST00000620827 ENSG00000196247 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF107 protein_coding protein_coding 5.783213 3.056711 9.706984 0.2650449 0.2957138 1.663816 2.87314752 0.5137057 6.0151552 0.33562272 0.54488987 3.52417029 0.41354167 0.16600000 0.61966667 0.4536666667 0.3015240361 0.0006591426 FALSE TRUE
ENST00000682671 ENSG00000196247 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF107 protein_coding processed_transcript 5.783213 3.056711 9.706984 0.2650449 0.2957138 1.663816 0.28191282 0.3181726 0.3025076 0.15197943 0.07308715 -0.07056339 0.05938750 0.09933333 0.03166667 -0.0676666667 0.4348012782 0.0006591426 FALSE TRUE
ENST00000683053 ENSG00000196247 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF107 protein_coding processed_transcript 5.783213 3.056711 9.706984 0.2650449 0.2957138 1.663816 0.31338853 0.1259508 0.2253595 0.12595084 0.12035517 0.79178122 0.05835000 0.03753333 0.02270000 -0.0148333333 0.9588520219 0.0006591426 FALSE TRUE
ENST00000683656 ENSG00000196247 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF107 protein_coding processed_transcript 5.783213 3.056711 9.706984 0.2650449 0.2957138 1.663816 0.48739358 0.6667389 0.1009637 0.12679702 0.05404333 -2.60851140 0.14949583 0.22903333 0.01060000 -0.2184333333 0.0006591426 0.0006591426 FALSE TRUE
ENST00000684016 ENSG00000196247 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF107 protein_coding processed_transcript 5.783213 3.056711 9.706984 0.2650449 0.2957138 1.663816 0.26127853 0.2504139 0.4203373 0.02895748 0.02099545 0.72466132 0.05818750 0.08366667 0.04330000 -0.0403666667 0.4709660905 0.0006591426   FALSE
MSTRG.29912.6 ENSG00000196247 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF107 protein_coding   5.783213 3.056711 9.706984 0.2650449 0.2957138 1.663816 0.31185665 0.1709389 0.5130110 0.17093892 0.26080125 1.53133862 0.05063750 0.05200000 0.05283333 0.0008333333 0.8772892717 0.0006591426 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000196247 E001 1.8891330 0.2436434224 7.754878e-01 8.820402e-01 7 64666099 64666129 31 + 0.414 0.349 -0.374
ENSG00000196247 E002 3.5449843 0.2514288124 7.910294e-01 8.910933e-01 7 64666130 64666132 3 + 0.606 0.539 -0.304
ENSG00000196247 E003 4.0104503 0.2196648064 6.311344e-01 7.911390e-01 7 64666133 64666133 1 + 0.658 0.538 -0.535
ENSG00000196247 E004 16.6834465 0.0023419604 2.976737e-01 5.381836e-01 7 64666134 64666163 30 + 1.190 1.111 -0.282
ENSG00000196247 E005 20.5227198 0.0019733563 1.281172e-01 3.288084e-01 7 64666164 64666180 17 + 1.283 1.168 -0.407
ENSG00000196247 E006 23.8851746 0.0015309935 2.932209e-01 5.339284e-01 7 64666181 64666197 17 + 1.338 1.276 -0.217
ENSG00000196247 E007 27.5764774 0.0013971462 5.132937e-01 7.104476e-01 7 64666198 64666220 23 + 1.387 1.363 -0.085
ENSG00000196247 E008 33.2186109 0.0014889523 4.000828e-01 6.283189e-01 7 64666221 64666285 65 + 1.469 1.435 -0.117
ENSG00000196247 E009 3.8141652 0.1138343052 2.354819e-01 4.713976e-01 7 64669037 64669178 142 + 0.558 0.801 1.024
ENSG00000196247 E010 22.4012787 0.0025567810 2.158552e-03 1.813006e-02 7 64679177 64679336 160 + 1.223 1.489 0.924
ENSG00000196247 E011 0.7962354 0.0172671820 8.943872e-02   7 64681133 64681145 13 + 0.130 0.445 2.355
ENSG00000196247 E012 1.1409841 0.0973184102 1.898460e-02   7 64681146 64681222 77 + 0.130 0.601 3.097
ENSG00000196247 E013 3.1530047 0.1066327403 2.593191e-05 4.758844e-04 7 64683946 64684086 141 + 0.184 1.010 4.132
ENSG00000196247 E014 5.0812612 0.0053141134 6.764664e-05 1.077973e-03 7 64684087 64684205 119 + 0.515 1.069 2.240
ENSG00000196247 E015 61.4483667 0.0058298530 1.596397e-55 6.951408e-52 7 64684335 64686886 2552 + 1.310 2.211 3.058
ENSG00000196247 E016 11.7301153 0.1140737141 7.514860e-03 4.709558e-02 7 64689355 64690398 1044 + 0.827 1.388 2.038
ENSG00000196247 E017 4.6976310 0.0141114860 2.692634e-01 5.090577e-01 7 64690399 64690525 127 + 0.652 0.842 0.770
ENSG00000196247 E018 0.2735028 0.0262573492 3.929978e-01   7 64691145 64691247 103 + 0.070 0.203 1.769
ENSG00000196247 E019 33.6829026 0.0106722298 1.967954e-04 2.638590e-03 7 64691248 64691374 127 + 1.527 1.201 -1.133
ENSG00000196247 E020 26.8406854 0.0019071263 6.176772e-05 9.977723e-04 7 64691865 64691960 96 + 1.429 1.091 -1.192
ENSG00000196247 E021 3.1944815 0.0082923731 8.007748e-03 4.934683e-02 7 64697374 64698545 1172 + 0.410 0.843 1.925
ENSG00000196247 E022 636.6780412 0.0002995435 4.980182e-29 3.677172e-26 7 64706324 64711577 5254 + 2.751 2.660 -0.302