ENSG00000196236

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357137 ENSG00000196236 HEK293_OSMI2_6hA HEK293_TMG_6hB XPNPEP3 protein_coding protein_coding 11.57779 10.26008 13.96574 1.653287 0.3696156 0.4444773 3.5504968 2.439773 4.7967461 0.13944835 0.03930031 0.9724126 0.3060917 0.24826667 0.34390000 0.09563333 3.824251e-01 2.26665e-18 FALSE TRUE
ENST00000482652 ENSG00000196236 HEK293_OSMI2_6hA HEK293_TMG_6hB XPNPEP3 protein_coding processed_transcript 11.57779 10.26008 13.96574 1.653287 0.3696156 0.4444773 1.4312111 1.166724 1.3817005 0.05940926 0.07087004 0.2420734 0.1284750 0.12336667 0.09893333 -0.02443333 8.870502e-01 2.26665e-18   FALSE
MSTRG.22174.2 ENSG00000196236 HEK293_OSMI2_6hA HEK293_TMG_6hB XPNPEP3 protein_coding   11.57779 10.26008 13.96574 1.653287 0.3696156 0.4444773 0.8973428 0.600140 0.7142407 0.40849720 0.60648095 0.2473289 0.0777375 0.05893333 0.05013333 -0.00880000 9.472158e-01 2.26665e-18 FALSE TRUE
MSTRG.22174.3 ENSG00000196236 HEK293_OSMI2_6hA HEK293_TMG_6hB XPNPEP3 protein_coding   11.57779 10.26008 13.96574 1.653287 0.3696156 0.4444773 1.3051654 1.829765 1.3526295 0.37218178 0.42990288 -0.4331284 0.1058958 0.17523333 0.09563333 -0.07960000 3.756175e-01 2.26665e-18 FALSE TRUE
MSTRG.22174.5 ENSG00000196236 HEK293_OSMI2_6hA HEK293_TMG_6hB XPNPEP3 protein_coding   11.57779 10.26008 13.96574 1.653287 0.3696156 0.4444773 1.4021449 0.000000 3.7870745 0.00000000 0.37573678 8.5687445 0.1076500 0.00000000 0.27276667 0.27276667 2.266650e-18 2.26665e-18 FALSE TRUE
MSTRG.22174.6 ENSG00000196236 HEK293_OSMI2_6hA HEK293_TMG_6hB XPNPEP3 protein_coding   11.57779 10.26008 13.96574 1.653287 0.3696156 0.4444773 2.0554168 3.418604 1.0108352 0.77850402 0.53835328 -1.7478712 0.1944417 0.32480000 0.07253333 -0.25226667 4.211569e-01 2.26665e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000196236 E001 1.7920532 0.0140546938 1.401757e-02 7.440939e-02 22 40857077 40857089 13 + 0.202 0.619 2.414
ENSG00000196236 E002 3.0667385 0.0079451203 1.312386e-02 7.096521e-02 22 40857090 40857096 7 + 0.395 0.772 1.729
ENSG00000196236 E003 3.5735230 0.0080136652 3.258282e-02 1.349175e-01 22 40857097 40857102 6 + 0.488 0.797 1.344
ENSG00000196236 E004 21.7213291 0.0140113973 1.346508e-02 7.224377e-02 22 40857103 40857119 17 + 1.251 1.465 0.743
ENSG00000196236 E005 24.8651833 0.0083720011 5.011679e-03 3.468208e-02 22 40857120 40857130 11 + 1.306 1.520 0.739
ENSG00000196236 E006 32.8862474 0.0125092073 1.797381e-02 8.894618e-02 22 40857131 40857147 17 + 1.445 1.622 0.606
ENSG00000196236 E007 98.5294687 0.0015220663 4.286736e-09 2.184177e-07 22 40857148 40857245 98 + 1.889 2.101 0.712
ENSG00000196236 E008 0.3032425 0.0274424043 1.509677e-01   22 40860678 40860793 116 + 0.000 0.231 11.058
ENSG00000196236 E009 46.0997396 0.5230354382 4.282310e-02 1.620940e-01 22 40861618 40861835 218 + 1.309 1.891 1.989
ENSG00000196236 E010 19.7117151 0.1069808678 1.462058e-01 3.567144e-01 22 40861836 40862265 430 + 1.215 1.410 0.680
ENSG00000196236 E011 18.0085011 0.0382392749 6.207559e-01 7.843485e-01 22 40862266 40862679 414 + 1.254 1.297 0.149
ENSG00000196236 E012 2.6549205 0.1216610089 1.164644e-01 3.098886e-01 22 40862680 40862770 91 + 0.393 0.694 1.423
ENSG00000196236 E013 33.1734053 0.0019444958 5.728137e-01 7.522457e-01 22 40868999 40869018 20 + 1.549 1.499 -0.171
ENSG00000196236 E014 68.1425693 0.0022893675 4.419269e-02 1.655951e-01 22 40869019 40869115 97 + 1.884 1.775 -0.367
ENSG00000196236 E015 0.0000000       22 40869992 40870047 56 +      
ENSG00000196236 E016 4.1718118 0.0290345533 2.426767e-01 4.795784e-01 22 40870048 40870139 92 + 0.803 0.615 -0.779
ENSG00000196236 E017 0.0000000       22 40870140 40870343 204 +      
ENSG00000196236 E018 142.2747377 0.0045561469 1.239451e-01 3.219799e-01 22 40881770 40882177 408 + 2.188 2.114 -0.249
ENSG00000196236 E019 93.9678303 0.0031212024 3.117410e-01 5.521279e-01 22 40886313 40886515 203 + 1.962 1.995 0.109
ENSG00000196236 E020 40.0421812 0.0031483733 4.589863e-01 6.724797e-01 22 40907587 40907649 63 + 1.595 1.627 0.110
ENSG00000196236 E021 50.5106437 0.0177905477 5.339512e-01 7.248751e-01 22 40909122 40909235 114 + 1.734 1.682 -0.176
ENSG00000196236 E022 53.3983833 0.0039975049 2.716275e-01 5.114829e-01 22 40914239 40914324 86 + 1.766 1.693 -0.248
ENSG00000196236 E023 86.8724445 0.0009604847 5.446554e-01 7.323669e-01 22 40922333 40922513 181 + 1.957 1.920 -0.126
ENSG00000196236 E024 75.0258330 0.0026396502 4.683583e-01 6.789533e-01 22 40924362 40924482 121 + 1.870 1.888 0.060
ENSG00000196236 E025 82.6809076 0.0038510983 2.513960e-01 4.894673e-01 22 40926269 40926463 195 + 1.902 1.939 0.126
ENSG00000196236 E026 38.1626146 0.0010697574 2.973994e-01 5.379079e-01 22 40926464 40926517 54 + 1.623 1.549 -0.252
ENSG00000196236 E027 185.2055171 0.0015767407 2.556593e-02 1.139609e-01 22 40926518 40928469 1952 + 2.304 2.220 -0.280
ENSG00000196236 E028 399.6134977 0.0148576431 8.117377e-03 4.986678e-02 22 40928470 40932815 4346 + 2.665 2.514 -0.503
ENSG00000196236 E029 1.3867724 0.0131217151 1.989352e-01   22 40933218 40933282 65 + 0.276 0.492 1.241
ENSG00000196236 E030 1.0717634 0.0146939252 1.653670e-01   22 40933283 40933336 54 + 0.202 0.440 1.562
ENSG00000196236 E031 0.3559677 0.4797105430 3.906353e-01   22 40945674 40945707 34 + 0.207 0.000 -10.651