ENSG00000196214

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000439461 ENSG00000196214 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF766 protein_coding protein_coding 2.642009 1.269187 5.336547 0.1409018 0.3617325 2.063381 0.6915161 0.39355752 1.153156 0.05614110 0.11899544 1.527199 0.3514375 0.31563333 0.21610000 -0.099533333 6.270109e-01 4.734179e-07 FALSE TRUE
ENST00000593703 ENSG00000196214 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF766 protein_coding protein_coding 2.642009 1.269187 5.336547 0.1409018 0.3617325 2.063381 0.4945625 0.00000000 1.467869 0.00000000 0.25612273 7.207375 0.1145167 0.00000000 0.27133333 0.271333333 4.734179e-07 4.734179e-07 FALSE TRUE
ENST00000599581 ENSG00000196214 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF766 protein_coding protein_coding 2.642009 1.269187 5.336547 0.1409018 0.3617325 2.063381 1.1667868 0.73228712 2.223585 0.06331787 0.13974633 1.589312 0.4209167 0.58416667 0.41936667 -0.164800000 4.101430e-01 4.734179e-07 FALSE TRUE
ENST00000601711 ENSG00000196214 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF766 protein_coding protein_coding 2.642009 1.269187 5.336547 0.1409018 0.3617325 2.063381 0.1438273 0.08286251 0.340412 0.08286251 0.05182713 1.915884 0.0652875 0.05676667 0.06563333 0.008866667 8.545854e-01 4.734179e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000196214 E001 0.5173834 0.0580751290 0.4152098051   19 52269587 52269592 6 + 0.197 0.000 -10.938
ENSG00000196214 E002 7.2670065 0.0050602227 0.0137017895 0.073163093 19 52269593 52269631 39 + 0.936 0.571 -1.485
ENSG00000196214 E003 0.1723744 0.0327609115 0.1624837828   19 52274462 52274474 13 + 0.000 0.189 12.518
ENSG00000196214 E004 0.0000000       19 52274475 52274513 39 +      
ENSG00000196214 E005 0.1723744 0.0327609115 0.1624837828   19 52274514 52274582 69 + 0.000 0.189 12.518
ENSG00000196214 E006 0.1723744 0.0327609115 0.1624837828   19 52274583 52274669 87 + 0.000 0.189 12.518
ENSG00000196214 E007 0.0000000       19 52275578 52275607 30 +      
ENSG00000196214 E008 0.9825891 0.3026612930 0.3739550830   19 52277154 52277541 388 + 0.196 0.426 1.550
ENSG00000196214 E009 13.9490185 0.0484095656 0.0377596700 0.148986862 19 52282111 52282237 127 + 1.184 0.881 -1.111
ENSG00000196214 E010 0.0000000       19 52282238 52282574 337 +      
ENSG00000196214 E011 18.7491918 0.0042148382 0.0006204633 0.006755285 19 52283285 52283413 129 + 1.311 0.964 -1.246
ENSG00000196214 E012 0.5530924 0.0232913230 0.1433954547   19 52288042 52288115 74 + 0.076 0.321 2.518
ENSG00000196214 E013 89.7649459 0.0005845005 0.0513037670 0.182856415 19 52290066 52291124 1059 + 1.920 1.853 -0.225
ENSG00000196214 E014 78.2226471 0.0026758039 0.0107822918 0.061464239 19 52291125 52292148 1024 + 1.817 1.922 0.355
ENSG00000196214 E015 66.2767441 0.0018714944 0.0112152413 0.063254992 19 52292149 52296046 3898 + 1.747 1.859 0.378