ENSG00000196118

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000535476 ENSG00000196118 HEK293_OSMI2_6hA HEK293_TMG_6hB CFAP119 protein_coding protein_coding 20.41711 33.66982 7.989136 2.275764 0.2095318 -2.073968 0.5173140 0.7025204 0.8323130 0.1878107 0.4610640 0.2414251 0.04031250 0.02156667 0.1070000 0.08543333 8.016987e-01 6.132717e-05 FALSE FALSE
ENST00000537986 ENSG00000196118 HEK293_OSMI2_6hA HEK293_TMG_6hB CFAP119 protein_coding retained_intron 20.41711 33.66982 7.989136 2.275764 0.2095318 -2.073968 9.8193096 16.0312973 3.4354770 1.4245705 0.3166551 -2.2190152 0.45381667 0.47473333 0.4285667 -0.04616667 7.723262e-01 6.132717e-05   FALSE
ENST00000544613 ENSG00000196118 HEK293_OSMI2_6hA HEK293_TMG_6hB CFAP119 protein_coding protein_coding 20.41711 33.66982 7.989136 2.275764 0.2095318 -2.073968 0.6654196 1.7122898 0.0000000 0.3973606 0.0000000 -7.4281841 0.02889583 0.05240000 0.0000000 -0.05240000 6.132717e-05 6.132717e-05   FALSE
ENST00000544643 ENSG00000196118 HEK293_OSMI2_6hA HEK293_TMG_6hB CFAP119 protein_coding retained_intron 20.41711 33.66982 7.989136 2.275764 0.2095318 -2.073968 2.2424268 3.5720616 0.8275554 0.6149312 0.1366343 -2.0965335 0.11160000 0.10670000 0.1029000 -0.00380000 1.000000e+00 6.132717e-05   FALSE
ENST00000545825 ENSG00000196118 HEK293_OSMI2_6hA HEK293_TMG_6hB CFAP119 protein_coding protein_coding 20.41711 33.66982 7.989136 2.275764 0.2095318 -2.073968 4.3620037 7.2338988 1.6241729 0.7153829 0.1945785 -2.1482058 0.21876667 0.21456667 0.2024667 -0.01210000 9.570070e-01 6.132717e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000196118 E001 2.900469 0.0423859253 0.036535628 0.14567900 16 30757423 30757423 1 - 0.780 0.414 -1.656
ENSG00000196118 E002 3.275577 0.0095576713 0.047850639 0.17466270 16 30757424 30757424 1 - 0.780 0.456 -1.437
ENSG00000196118 E003 4.145516 0.0370050973 0.166840692 0.38633566 16 30757425 30757430 6 - 0.780 0.541 -1.023
ENSG00000196118 E004 4.317891 0.0117749527 0.166999362 0.38655434 16 30757431 30757434 4 - 0.780 0.557 -0.951
ENSG00000196118 E005 4.448759 0.0166829353 0.199932482 0.42959226 16 30757435 30757435 1 - 0.780 0.571 -0.885
ENSG00000196118 E006 21.114540 0.0051278228 1.000000000 1.00000000 16 30757436 30757466 31 - 1.183 1.186 0.009
ENSG00000196118 E007 110.836710 0.0031532200 0.246126821 0.48377309 16 30757467 30757654 188 - 1.826 1.885 0.198
ENSG00000196118 E008 6.551886 0.0054452937 0.042739228 0.16188270 16 30759012 30759101 90 - 0.972 0.686 -1.122
ENSG00000196118 E009 3.400284 0.0646291922 0.026943124 0.11813831 16 30759102 30759177 76 - 0.836 0.438 -1.748
ENSG00000196118 E010 30.048717 0.0398542399 0.268057075 0.50770858 16 30759178 30759247 70 - 1.439 1.299 -0.487
ENSG00000196118 E011 35.676325 0.0082757474 0.013210405 0.07129018 16 30759342 30759444 103 - 1.576 1.361 -0.741
ENSG00000196118 E012 18.126852 0.0022192335 0.095656593 0.27418123 16 30759445 30759458 14 - 1.269 1.098 -0.609
ENSG00000196118 E013 20.364395 0.0051131809 0.166855311 0.38635256 16 30759459 30759557 99 - 1.288 1.147 -0.499
ENSG00000196118 E014 12.316591 0.0035486456 0.002326024 0.01922482 16 30759558 30759653 96 - 1.249 0.907 -1.245
ENSG00000196118 E015 21.233825 0.0027756630 0.200426417 0.43026515 16 30759654 30759724 71 - 1.289 1.159 -0.458
ENSG00000196118 E016 6.391221 0.1512280127 0.022993265 0.10592408 16 30759725 30759809 85 - 1.068 0.641 -1.666
ENSG00000196118 E017 34.103968 0.0071874610 0.001882623 0.01628280 16 30760037 30760283 247 - 1.595 1.335 -0.895
ENSG00000196118 E018 73.825436 0.0006013862 0.913896348 0.95907940 16 30760284 30760292 9 - 1.703 1.706 0.011
ENSG00000196118 E019 164.836738 0.0024771640 0.486764298 0.69173348 16 30760293 30760453 161 - 2.026 2.050 0.080
ENSG00000196118 E020 63.395431 0.0200581046 0.604181236 0.77300950 16 30760454 30760605 152 - 1.667 1.635 -0.110
ENSG00000196118 E021 89.696620 0.0007719455 0.050701000 0.18133982 16 30760606 30760668 63 - 1.696 1.803 0.363
ENSG00000196118 E022 78.292657 0.0015987042 0.002792948 0.02214111 16 30761198 30761229 32 - 1.559 1.752 0.658
ENSG00000196118 E023 47.062889 0.0066009576 0.084444131 0.25360330 16 30761230 30761335 106 - 1.373 1.534 0.556
ENSG00000196118 E024 50.056418 0.0195859278 0.253058261 0.49131709 16 30761336 30761544 209 - 1.415 1.552 0.471
ENSG00000196118 E025 177.085974 0.0004066515 0.025792726 0.11464802 16 30761545 30762221 677 - 2.010 2.091 0.271