ENSG00000189410

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375031 ENSG00000189410 HEK293_OSMI2_6hA HEK293_TMG_6hB SH2D5 protein_coding protein_coding 5.262682 7.91756 2.000354 0.7831106 0.003109345 -1.979427 0.3497048 0.5459283 0.3365613 0.20459522 0.17921151 -0.6817883 0.07437500 0.07530000 0.1682000 0.09290000 0.89744716 0.01167433 FALSE  
ENST00000444387 ENSG00000189410 HEK293_OSMI2_6hA HEK293_TMG_6hB SH2D5 protein_coding protein_coding 5.262682 7.91756 2.000354 0.7831106 0.003109345 -1.979427 0.5014831 0.8405280 0.2942228 0.43330508 0.29422283 -1.4832303 0.10912917 0.09816667 0.1473000 0.04913333 0.77771689 0.01167433 FALSE  
ENST00000460804 ENSG00000189410 HEK293_OSMI2_6hA HEK293_TMG_6hB SH2D5 protein_coding processed_transcript 5.262682 7.91756 2.000354 0.7831106 0.003109345 -1.979427 3.4025176 4.7869129 1.0188712 0.41565508 0.04965404 -2.2210438 0.62188750 0.60600000 0.5092667 -0.09673333 0.55573960 0.01167433 FALSE  
MSTRG.476.5 ENSG00000189410 HEK293_OSMI2_6hA HEK293_TMG_6hB SH2D5 protein_coding   5.262682 7.91756 2.000354 0.7831106 0.003109345 -1.979427 0.2810044 0.4315329 0.0000000 0.06362111 0.00000000 -5.4644489 0.05042083 0.05500000 0.0000000 -0.05500000 0.01167433 0.01167433 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000189410 E001 0.6368449 1.7365266511 0.75088292   1 20719731 20719731 1 - 0.001 0.178 8.239
ENSG00000189410 E002 151.5912656 0.0003511078 0.01411068 0.07478676 1 20719732 20720709 978 - 1.946 2.039 0.311
ENSG00000189410 E003 65.9010303 0.0070754563 0.06037894 0.20366529 1 20720710 20721106 397 - 1.542 1.688 0.495
ENSG00000189410 E004 84.7059004 0.0011369880 0.02188507 0.10219389 1 20721107 20721650 544 - 1.872 1.756 -0.390
ENSG00000189410 E005 10.3202263 0.0706784154 0.68152855 0.82360849 1 20721651 20721656 6 - 0.954 0.897 -0.217
ENSG00000189410 E006 9.7423834 0.0658107748 0.57327446 0.75251438 1 20721657 20721657 1 - 0.954 0.872 -0.310
ENSG00000189410 E007 12.5036436 0.0255952640 1.00000000 1.00000000 1 20721658 20721664 7 - 0.957 0.984 0.100
ENSG00000189410 E008 45.4532173 0.0043658853 0.51805612 0.71366403 1 20721665 20721995 331 - 1.466 1.520 0.185
ENSG00000189410 E009 11.7871777 0.0080826000 0.55862565 0.74227142 1 20722756 20722773 18 - 0.873 0.981 0.407
ENSG00000189410 E010 30.1677159 0.0042191580 0.74664734 0.86475077 1 20722774 20722915 142 - 1.309 1.343 0.119
ENSG00000189410 E011 28.1160415 0.0014302513 0.48095083 0.68773994 1 20723626 20723734 109 - 1.255 1.326 0.249
ENSG00000189410 E012 31.7414092 0.0013009529 0.80261924 0.89781747 1 20724083 20724251 169 - 1.343 1.368 0.090
ENSG00000189410 E013 2.5917866 0.1928261941 0.26891313 0.50866718 1 20724349 20724395 47 - 0.626 0.393 -1.131
ENSG00000189410 E014 29.2848871 0.0016848481 0.59397771 0.76631702 1 20724396 20724600 205 - 1.373 1.330 -0.150
ENSG00000189410 E015 13.6984630 0.0027511890 1.00000000 1.00000000 1 20724601 20724630 30 - 1.029 1.027 -0.011
ENSG00000189410 E016 10.9643496 0.0029067848 0.86163187 0.93120564 1 20724631 20724635 5 - 0.958 0.934 -0.092
ENSG00000189410 E017 9.0655814 0.0035984712 0.22265500 0.45664426 1 20725920 20725931 12 - 0.995 0.840 -0.588
ENSG00000189410 E018 17.6927326 0.0019158620 0.19364596 0.42164731 1 20725932 20726066 135 - 1.235 1.104 -0.466
ENSG00000189410 E019 7.7319167 0.0283923629 0.37984185 0.61205673 1 20727001 20727031 31 - 0.916 0.799 -0.454
ENSG00000189410 E020 9.2761606 0.0357670504 0.12248756 0.31973815 1 20727032 20727075 44 - 1.060 0.846 -0.801
ENSG00000189410 E021 1.3568898 1.1345233077 0.56507185   1 20727469 20727522 54 - 0.258 0.287 0.201
ENSG00000189410 E022 11.0965437 0.0029628172 0.01913495 0.09291967 1 20727523 20727603 81 - 1.168 0.900 -0.986
ENSG00000189410 E023 9.3659772 0.0038549783 0.42313069 0.64594336 1 20727958 20728086 129 - 0.958 0.856 -0.389
ENSG00000189410 E024 3.1485105 0.1549181477 0.84328985 0.92128241 1 20730746 20730851 106 - 0.534 0.490 -0.211
ENSG00000189410 E025 7.8381946 0.0934586801 0.18694500 0.41297103 1 20731012 20731447 436 - 0.990 0.766 -0.862
ENSG00000189410 E026 3.2006857 0.3136744622 0.23581772 0.47179380 1 20731448 20731591 144 - 0.696 0.468 -1.033
ENSG00000189410 E027 6.9698248 0.0048388458 0.09903615 0.28007837 1 20732004 20732180 177 - 0.418 0.798 1.706
ENSG00000189410 E028 0.3336024 3.0946131944 0.64496754   1 20732181 20732703 523 - 0.000 0.100 8.842
ENSG00000189410 E029 0.3150090 2.7946943769 0.23575848   1 20732764 20732968 205 - 0.248 0.054 -2.527