ENSG00000189091

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000563739 ENSG00000189091 HEK293_OSMI2_6hA HEK293_TMG_6hB SF3B3 protein_coding retained_intron 234.1112 252.7591 255.7426 44.35271 9.663528 0.01692914 41.15778 49.106554 38.52936 6.968934 1.346561 -0.349876773 0.17844167 0.19703333 0.15066667 -0.046366667 0.081506731 1.341567e-06 FALSE TRUE
ENST00000567635 ENSG00000189091 HEK293_OSMI2_6hA HEK293_TMG_6hB SF3B3 protein_coding nonsense_mediated_decay 234.1112 252.7591 255.7426 44.35271 9.663528 0.01692914 30.01250 30.254980 36.55005 3.498524 2.075223 0.272618815 0.12690417 0.12313333 0.14293333 0.019800000 0.768395560 1.341567e-06   FALSE
ENST00000567654 ENSG00000189091 HEK293_OSMI2_6hA HEK293_TMG_6hB SF3B3 protein_coding protein_coding 234.1112 252.7591 255.7426 44.35271 9.663528 0.01692914 11.35389 4.636403 29.66825 4.636403 2.296359 2.675219740 0.04557917 0.01440000 0.11630000 0.101900000 0.116909178 1.341567e-06 FALSE FALSE
ENST00000568539 ENSG00000189091 HEK293_OSMI2_6hA HEK293_TMG_6hB SF3B3 protein_coding retained_intron 234.1112 252.7591 255.7426 44.35271 9.663528 0.01692914 43.34653 48.876248 48.65905 9.660738 3.590829 -0.006424079 0.18475833 0.19150000 0.18976667 -0.001733333 1.000000000 1.341567e-06 FALSE FALSE
ENST00000572365 ENSG00000189091 HEK293_OSMI2_6hA HEK293_TMG_6hB SF3B3 protein_coding retained_intron 234.1112 252.7591 255.7426 44.35271 9.663528 0.01692914 21.75258 22.873279 26.37839 7.055284 1.943229 0.205609524 0.09065000 0.08576667 0.10296667 0.017200000 0.795858357 1.341567e-06 FALSE FALSE
MSTRG.12933.3 ENSG00000189091 HEK293_OSMI2_6hA HEK293_TMG_6hB SF3B3 protein_coding   234.1112 252.7591 255.7426 44.35271 9.663528 0.01692914 46.45074 58.361268 35.47529 11.998859 2.690874 -0.718037411 0.20096250 0.22810000 0.13893333 -0.089166667 0.008233961 1.341567e-06 TRUE TRUE
MSTRG.12933.5 ENSG00000189091 HEK293_OSMI2_6hA HEK293_TMG_6hB SF3B3 protein_coding   234.1112 252.7591 255.7426 44.35271 9.663528 0.01692914 16.00716 15.479110 21.19404 1.933921 1.793507 0.453084738 0.06805833 0.06253333 0.08293333 0.020400000 0.467325065 1.341567e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000189091 E001 0.5845677 3.831127e-01 6.857743e-01   16 70523670 70523790 121 + 0.260 0.173 -0.746
ENSG00000189091 E002 0.5845677 3.831127e-01 6.857743e-01   16 70523791 70523797 7 + 0.260 0.173 -0.746
ENSG00000189091 E003 0.8995767 1.931215e-02 5.699972e-01   16 70523798 70523798 1 + 0.347 0.246 -0.682
ENSG00000189091 E004 12.8051661 7.735387e-03 3.150894e-02 1.317901e-01 16 70523799 70523804 6 + 1.239 1.029 -0.753
ENSG00000189091 E005 30.9191088 5.005916e-03 2.907272e-04 3.635694e-03 16 70523805 70523812 8 + 1.623 1.371 -0.864
ENSG00000189091 E006 32.0793064 4.566121e-03 4.720992e-04 5.422610e-03 16 70523813 70523815 3 + 1.631 1.394 -0.813
ENSG00000189091 E007 454.1627470 8.717890e-04 6.506901e-08 2.530390e-06 16 70523816 70523892 77 + 2.712 2.596 -0.385
ENSG00000189091 E008 567.9313583 3.450558e-04 9.724808e-07 2.772828e-05 16 70523893 70523928 36 + 2.790 2.707 -0.277
ENSG00000189091 E009 7.2254033 7.608907e-02 6.909602e-01 8.296808e-01 16 70523929 70524055 127 + 0.941 0.874 -0.252
ENSG00000189091 E010 5.6238747 6.160151e-03 4.032674e-01 6.309222e-01 16 70524550 70524863 314 + 0.740 0.852 0.445
ENSG00000189091 E011 5.5884235 9.656655e-02 7.893901e-01 8.901224e-01 16 70524864 70524866 3 + 0.849 0.796 -0.207
ENSG00000189091 E012 20.8903224 4.177217e-02 7.286979e-01 8.534224e-01 16 70524867 70525017 151 + 1.305 1.348 0.149
ENSG00000189091 E013 1014.0108147 1.157524e-04 1.042009e-16 1.987010e-14 16 70526587 70526726 140 + 3.050 2.950 -0.331
ENSG00000189091 E014 0.3337900 3.113866e-02 7.329444e-01   16 70526901 70527014 114 + 0.149 0.099 -0.679
ENSG00000189091 E015 1776.6217598 7.469358e-05 1.333241e-29 1.024503e-26 16 70528873 70529199 327 + 3.294 3.192 -0.340
ENSG00000189091 E016 1242.6781637 6.924568e-05 1.886188e-28 1.351553e-25 16 70530745 70530917 173 + 3.147 3.031 -0.388
ENSG00000189091 E017 1111.8091126 8.565289e-05 5.258263e-20 1.566621e-17 16 70532479 70532620 142 + 3.092 2.989 -0.342
ENSG00000189091 E018 956.0434432 7.770724e-05 6.486908e-07 1.949436e-05 16 70535308 70535420 113 + 3.001 2.942 -0.196
ENSG00000189091 E019 772.6474147 6.287753e-04 1.716769e-03 1.513597e-02 16 70538323 70538394 72 + 2.905 2.853 -0.173
ENSG00000189091 E020 772.0162372 9.705326e-05 1.875424e-05 3.618385e-04 16 70538395 70538460 66 + 2.907 2.851 -0.188
ENSG00000189091 E021 895.2113364 8.974809e-05 5.363342e-02 1.881864e-01 16 70539104 70539207 104 + 2.951 2.928 -0.076
ENSG00000189091 E022 805.8534271 3.656025e-04 9.584103e-03 5.632865e-02 16 70541669 70541738 70 + 2.913 2.875 -0.124
ENSG00000189091 E023 1061.4811191 1.204323e-04 6.179964e-03 4.060534e-02 16 70541739 70541834 96 + 3.028 2.998 -0.103
ENSG00000189091 E024 1106.6525142 1.890650e-04 9.651000e-06 2.032191e-04 16 70544438 70544533 96 + 3.060 3.008 -0.175
ENSG00000189091 E025 1041.7956596 1.074380e-04 3.021951e-09 1.590322e-07 16 70548370 70548442 73 + 3.044 2.974 -0.231
ENSG00000189091 E026 4.1463060 6.189885e-03 2.007787e-02 9.616276e-02 16 70548443 70548512 70 + 0.877 0.550 -1.359
ENSG00000189091 E027 11.1005618 5.052054e-02 6.377294e-05 1.025676e-03 16 70550203 70550649 447 + 1.335 0.748 -2.166
ENSG00000189091 E028 20.8116205 5.226692e-02 1.077400e-02 6.142906e-02 16 70550650 70550678 29 + 1.505 1.167 -1.178
ENSG00000189091 E029 6.5259197 1.344703e-01 6.551401e-01 8.067946e-01 16 70554106 70554445 340 + 0.921 0.825 -0.371
ENSG00000189091 E030 1444.7932300 3.802581e-04 9.570699e-06 2.018285e-04 16 70554446 70554597 152 + 3.179 3.123 -0.186
ENSG00000189091 E031 1502.0441743 1.037178e-04 6.790887e-03 4.365885e-02 16 70555051 70555206 156 + 3.177 3.151 -0.088
ENSG00000189091 E032 1625.4310713 5.595467e-04 9.707228e-02 2.766468e-01 16 70556179 70556334 156 + 3.210 3.189 -0.072
ENSG00000189091 E033 11.9775220 1.770051e-01 1.842961e-01 4.095741e-01 16 70556335 70556597 263 + 1.228 0.993 -0.849
ENSG00000189091 E034 1502.8305818 4.799587e-04 4.935694e-01 6.963193e-01 16 70556886 70557029 144 + 3.155 3.168 0.042
ENSG00000189091 E035 7.6517845 4.750158e-03 1.920388e-01 4.194160e-01 16 70560350 70560468 119 + 1.017 0.867 -0.563
ENSG00000189091 E036 1374.6482952 2.200270e-04 8.324981e-03 5.081424e-02 16 70560469 70560591 123 + 3.102 3.136 0.116
ENSG00000189091 E037 1.6384026 9.156389e-01 9.147590e-01 9.594955e-01 16 70561349 70561629 281 + 0.423 0.407 -0.088
ENSG00000189091 E038 1573.3604919 1.882854e-04 1.067074e-01 2.935156e-01 16 70561630 70561784 155 + 3.169 3.190 0.070
ENSG00000189091 E039 2.4765767 5.220894e-02 9.387232e-01 9.716744e-01 16 70563729 70563875 147 + 0.538 0.520 -0.084
ENSG00000189091 E040 1653.7349299 5.918045e-05 3.136145e-02 1.313901e-01 16 70563876 70564050 175 + 3.189 3.211 0.073
ENSG00000189091 E041 1742.9747047 1.553951e-04 2.420625e-03 1.981767e-02 16 70565065 70565270 206 + 3.204 3.238 0.111
ENSG00000189091 E042 1808.1780462 5.401126e-05 6.615004e-02 2.164133e-01 16 70565368 70565524 157 + 3.230 3.248 0.061
ENSG00000189091 E043 2.5283064 1.010732e-02 6.888140e-01 8.283329e-01 16 70565525 70565720 196 + 0.483 0.551 0.321
ENSG00000189091 E044 1562.4302588 6.874082e-05 1.100661e-07 4.043209e-06 16 70567411 70567536 126 + 3.143 3.197 0.181
ENSG00000189091 E045 1.0230998 2.106806e-01 5.835915e-02   16 70567537 70567541 5 + 0.000 0.407 11.299
ENSG00000189091 E046 2098.0736335 6.309511e-05 1.204561e-06 3.337066e-05 16 70568283 70568495 213 + 3.277 3.322 0.146
ENSG00000189091 E047 1554.3216352 7.070953e-05 1.046761e-06 2.957312e-05 16 70569043 70569141 99 + 3.143 3.193 0.168
ENSG00000189091 E048 10.7586326 1.451007e-01 7.884518e-01 8.896117e-01 16 70569915 70570005 91 + 1.027 1.074 0.172
ENSG00000189091 E049 1730.3608770 9.022026e-05 4.591565e-17 9.206061e-15 16 70570006 70570149 144 + 3.168 3.252 0.281
ENSG00000189091 E050 1440.0712838 9.293039e-04 1.143771e-08 5.291165e-07 16 70571095 70571199 105 + 3.074 3.181 0.358
ENSG00000189091 E051 4168.7963576 5.072147e-05 8.709529e-63 6.162827e-59 16 70571673 70576300 4628 + 3.534 3.642 0.359
ENSG00000189091 E052 16.6349741 2.197154e-03 3.296949e-03 2.517638e-02 16 70576301 70576348 48 + 1.049 1.320 0.962
ENSG00000189091 E053 264.7686595 3.321185e-03 1.191092e-12 1.199617e-10 16 70576349 70577317 969 + 2.227 2.493 0.888
ENSG00000189091 E054 115.7451192 4.827535e-03 2.968933e-11 2.351180e-09 16 70577318 70577670 353 + 1.814 2.152 1.134