ENSG00000189042

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000536254 ENSG00000189042 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF567 protein_coding protein_coding 5.377666 1.749511 11.13991 0.1239813 0.6962117 2.663785 0.2925085 0.30550926 0.7206910 0.16100514 0.21810972 1.2115792 0.06423333 0.18616667 0.06326667 -0.12290000 8.746722e-01 4.863665e-07 FALSE TRUE
ENST00000588311 ENSG00000189042 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF567 protein_coding protein_coding 5.377666 1.749511 11.13991 0.1239813 0.6962117 2.663785 0.4106798 0.04779593 1.0116454 0.04779593 0.45574655 4.1437829 0.05280000 0.02586667 0.08636667 0.06050000 6.689652e-01 4.863665e-07 FALSE TRUE
ENST00000589264 ENSG00000189042 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF567 protein_coding protein_coding 5.377666 1.749511 11.13991 0.1239813 0.6962117 2.663785 0.7081474 0.65387936 0.4137009 0.13348407 0.27469471 -0.6478748 0.22102500 0.36780000 0.03510000 -0.33270000 3.533117e-02 4.863665e-07   FALSE
ENST00000590392 ENSG00000189042 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF567 protein_coding retained_intron 5.377666 1.749511 11.13991 0.1239813 0.6962117 2.663785 0.2667358 0.00000000 1.0121915 0.00000000 0.18611212 6.6755217 0.03288750 0.00000000 0.09093333 0.09093333 1.343550e-03 4.863665e-07   FALSE
MSTRG.17037.1 ENSG00000189042 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF567 protein_coding   5.377666 1.749511 11.13991 0.1239813 0.6962117 2.663785 1.4643006 0.24238020 3.4602727 0.12445376 0.10804704 3.7813784 0.23703333 0.12970000 0.31303333 0.18333333 5.308576e-01 4.863665e-07 FALSE TRUE
MSTRG.17037.2 ENSG00000189042 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF567 protein_coding   5.377666 1.749511 11.13991 0.1239813 0.6962117 2.663785 0.5529462 0.13396918 0.9188104 0.13396918 0.48425373 2.6896241 0.08432917 0.07253333 0.08726667 0.01473333 8.872952e-01 4.863665e-07 FALSE TRUE
MSTRG.17037.5 ENSG00000189042 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF567 protein_coding   5.377666 1.749511 11.13991 0.1239813 0.6962117 2.663785 0.9951307 0.00000000 2.9103249 0.00000000 0.48332540 8.1899851 0.11840000 0.00000000 0.26286667 0.26286667 4.863665e-07 4.863665e-07 FALSE TRUE
MSTRG.17037.6 ENSG00000189042 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF567 protein_coding   5.377666 1.749511 11.13991 0.1239813 0.6962117 2.663785 0.2629920 0.24424134 0.1565039 0.04329367 0.08062429 -0.6106426 0.08952083 0.14120000 0.01486667 -0.12633333 4.429682e-02 4.863665e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000189042 E001 0.8733510 0.4191581010 1.000000e+00   19 36687508 36687598 91 + 0.204 0.000 -9.443
ENSG00000189042 E002 0.5339515 0.8651599854 1.000000e+00   19 36687599 36687611 13 + 0.135 0.000 -10.074
ENSG00000189042 E003 0.5339515 0.8651599854 1.000000e+00   19 36687612 36687612 1 + 0.135 0.000 -10.074
ENSG00000189042 E004 1.1420522 0.0147502033 4.492567e-01   19 36687613 36687617 5 + 0.258 0.000 -12.131
ENSG00000189042 E005 2.5903676 0.0094411672 9.942555e-02 2.807293e-01 19 36687618 36687627 10 + 0.455 0.000 -13.077
ENSG00000189042 E006 11.7557556 0.0026708581 9.104426e-01 9.573569e-01 19 36687628 36687634 7 + 0.930 0.914 -0.060
ENSG00000189042 E007 0.6544085 0.0190110722 4.208964e-01   19 36687635 36687643 9 + 0.129 0.279 1.378
ENSG00000189042 E008 2.6286494 0.0988185248 1.571321e-01 3.724306e-01 19 36687644 36687686 43 + 0.377 0.669 1.411
ENSG00000189042 E009 1.3989868 0.0122097470 1.000000e+00 1.000000e+00 19 36689397 36689399 3 + 0.284 0.279 -0.038
ENSG00000189042 E010 1.2563522 0.0133134651 9.434729e-01   19 36689400 36689400 1 + 0.257 0.279 0.154
ENSG00000189042 E011 23.8007762 0.0033253369 4.708898e-01 6.807481e-01 19 36689401 36689497 97 + 1.215 1.134 -0.286
ENSG00000189042 E012 1.1740047 0.0231471567 8.131823e-01   19 36689624 36689721 98 + 0.229 0.279 0.375
ENSG00000189042 E013 15.1352762 0.0022616830 3.222176e-01 5.616417e-01 19 36694802 36694876 75 + 1.015 1.134 0.429
ENSG00000189042 E014 0.0000000       19 36703681 36703736 56 +      
ENSG00000189042 E015 0.6653672 0.0238511881 5.611481e-02   19 36711240 36712385 1146 + 0.090 0.448 2.965
ENSG00000189042 E016 24.9296726 0.0019527219 1.873417e-01 4.135245e-01 19 36712386 36712439 54 + 1.211 1.337 0.442
ENSG00000189042 E017 23.1145534 0.0026059311 1.537356e-01 3.676694e-01 19 36712440 36712481 42 + 1.179 1.319 0.494
ENSG00000189042 E018 24.1026499 0.0022271419 3.335500e-01 5.721015e-01 19 36712482 36712512 31 + 1.204 1.299 0.334
ENSG00000189042 E019 2.2525117 0.1219772085 6.677898e-01 8.148041e-01 19 36712513 36712732 220 + 0.397 0.281 -0.719
ENSG00000189042 E020 35.0538663 0.0012690224 6.475112e-01 8.018368e-01 19 36712781 36712867 87 + 1.365 1.404 0.134
ENSG00000189042 E021 110.4486613 0.0004442602 9.016431e-03 5.390591e-02 19 36718948 36719667 720 + 1.871 1.741 -0.439
ENSG00000189042 E022 34.0448965 0.0012285932 2.902137e-02 1.244182e-01 19 36719668 36719752 85 + 1.380 1.162 -0.767
ENSG00000189042 E023 123.5034209 0.0017506152 3.685710e-02 1.465496e-01 19 36719753 36720561 809 + 1.916 1.818 -0.332
ENSG00000189042 E024 39.4948479 0.0013938123 1.790775e-02 8.872921e-02 19 36720562 36721365 804 + 1.393 1.569 0.606
ENSG00000189042 E025 2.6100903 0.0108230209 1.556639e-06 4.180817e-05 19 36723189 36723252 64 + 0.229 1.001 3.701
ENSG00000189042 E026 1.8817904 0.0107989781 7.820639e-06 1.695550e-04 19 36723253 36723347 95 + 0.165 0.914 3.962
ENSG00000189042 E027 0.4986023 0.0402513928 1.000000e+00   19 36727093 36727214 122 + 0.129 0.000 -10.937
ENSG00000189042 E028 0.1308682 0.0339784851 4.107923e-02   19 36727523 36727701 179 + 0.000 0.278 12.704