ENSG00000188917

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372936 ENSG00000188917 HEK293_OSMI2_6hA HEK293_TMG_6hB TRMT2B protein_coding protein_coding 12.35021 14.38234 6.767084 1.271682 0.2617043 -1.086565 0.7899652 1.1876100 0.4339593 0.1986409 0.05344943 -1.4316590 0.07008333 0.08170000 0.06396667 -0.017733333 7.807651e-01 4.240972e-07 FALSE TRUE
ENST00000372939 ENSG00000188917 HEK293_OSMI2_6hA HEK293_TMG_6hB TRMT2B protein_coding protein_coding 12.35021 14.38234 6.767084 1.271682 0.2617043 -1.086565 0.6861769 0.3944447 0.2235652 0.1987695 0.16639249 -0.7921174 0.05137500 0.02983333 0.03156667 0.001733333 1.000000e+00 4.240972e-07 FALSE TRUE
ENST00000545398 ENSG00000188917 HEK293_OSMI2_6hA HEK293_TMG_6hB TRMT2B protein_coding protein_coding 12.35021 14.38234 6.767084 1.271682 0.2617043 -1.086565 5.4718961 5.9346711 2.3127924 0.2455995 0.23733994 -1.3557368 0.43038333 0.41603333 0.34233333 -0.073700000 6.711416e-01 4.240972e-07 FALSE TRUE
MSTRG.34590.13 ENSG00000188917 HEK293_OSMI2_6hA HEK293_TMG_6hB TRMT2B protein_coding   12.35021 14.38234 6.767084 1.271682 0.2617043 -1.086565 1.3931707 1.5133223 1.1485895 0.4458014 0.19564715 -0.3948516 0.11614583 0.10210000 0.16893333 0.066833333 6.031170e-01 4.240972e-07 FALSE TRUE
MSTRG.34590.17 ENSG00000188917 HEK293_OSMI2_6hA HEK293_TMG_6hB TRMT2B protein_coding   12.35021 14.38234 6.767084 1.271682 0.2617043 -1.086565 0.6355504 0.7970203 0.6514475 0.3326343 0.28316721 -0.2869781 0.06499583 0.05243333 0.09896667 0.046533333 8.425067e-01 4.240972e-07 FALSE TRUE
MSTRG.34590.18 ENSG00000188917 HEK293_OSMI2_6hA HEK293_TMG_6hB TRMT2B protein_coding   12.35021 14.38234 6.767084 1.271682 0.2617043 -1.086565 0.1655694 0.0000000 0.4258309 0.0000000 0.11546718 5.4456966 0.01927083 0.00000000 0.06213333 0.062133333 4.240972e-07 4.240972e-07 FALSE TRUE
MSTRG.34590.6 ENSG00000188917 HEK293_OSMI2_6hA HEK293_TMG_6hB TRMT2B protein_coding   12.35021 14.38234 6.767084 1.271682 0.2617043 -1.086565 2.1407703 3.0650883 1.0068890 0.6097631 0.26373859 -1.5964657 0.15240000 0.20946667 0.14956667 -0.059900000 7.307023e-01 4.240972e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000188917 E001 0.2027342 0.0326383851 1.00000000   X 100973695 100973722 28 - 0.000 0.078 7.916
ENSG00000188917 E002 4.7480914 0.0053950480 0.04577467 0.1694516 X 101009346 101009349 4 - 0.896 0.618 -1.125
ENSG00000188917 E003 19.5971853 0.0020506737 0.40605783 0.6331112 X 101009350 101009414 65 - 1.313 1.244 -0.243
ENSG00000188917 E004 35.7474547 0.0010596192 0.83154774 0.9146998 X 101009415 101009492 78 - 1.515 1.502 -0.045
ENSG00000188917 E005 32.2318099 0.0012623706 0.91735569 0.9608999 X 101009493 101009541 49 - 1.455 1.462 0.027
ENSG00000188917 E006 26.2474167 0.0015887687 0.38582037 0.6171399 X 101009542 101009622 81 - 1.324 1.392 0.237
ENSG00000188917 E007 19.4113044 0.0019333979 0.17570855 0.3980700 X 101009623 101009639 17 - 1.153 1.278 0.441
ENSG00000188917 E008 214.9463719 0.0031054338 0.09593426 0.2746387 X 101009640 101010298 659 - 2.230 2.296 0.218
ENSG00000188917 E009 37.9747104 0.0116213644 0.27021643 0.5101770 X 101010299 101010317 19 - 1.454 1.555 0.345
ENSG00000188917 E010 46.5832795 0.0024524003 0.13170953 0.3345044 X 101010318 101010373 56 - 1.542 1.639 0.331
ENSG00000188917 E011 35.9401719 0.0010017488 0.23056405 0.4657936 X 101010374 101010400 27 - 1.447 1.528 0.279
ENSG00000188917 E012 32.7749967 0.0123407321 0.29782078 0.5382803 X 101010401 101010438 38 - 1.393 1.492 0.341
ENSG00000188917 E013 29.6887142 0.0109245753 0.09349775 0.2701960 X 101010439 101010449 11 - 1.302 1.461 0.551
ENSG00000188917 E014 86.1301039 0.0007388877 0.02650863 0.1167927 X 101010450 101010609 160 - 1.802 1.903 0.340
ENSG00000188917 E015 78.6917729 0.0005243333 0.04490759 0.1673728 X 101010610 101010707 98 - 1.776 1.868 0.312
ENSG00000188917 E016 83.0856708 0.0089557205 0.89192954 0.9475646 X 101018971 101019070 100 - 1.861 1.874 0.044
ENSG00000188917 E017 88.3518608 0.0047498566 0.15281976 0.3663797 X 101019284 101019403 120 - 1.948 1.879 -0.233
ENSG00000188917 E018 87.0809117 0.0026227386 0.02028527 0.0968813 X 101020487 101020588 102 - 1.966 1.861 -0.353
ENSG00000188917 E019 122.3194896 0.0004492125 0.38982753 0.6203200 X 101021101 101021315 215 - 2.053 2.024 -0.099
ENSG00000188917 E020 63.5395993 0.0020818347 0.38116361 0.6131858 X 101021968 101022062 95 - 1.714 1.763 0.165
ENSG00000188917 E021 83.3727913 0.0004939553 0.78348268 0.8866797 X 101023470 101023585 116 - 1.875 1.864 -0.037
ENSG00000188917 E022 50.7610739 0.0007473896 0.37050315 0.6043706 X 101023586 101023616 31 - 1.691 1.643 -0.163
ENSG00000188917 E023 42.9822239 0.0012740166 0.54173078 0.7303253 X 101035613 101035622 10 - 1.614 1.578 -0.124
ENSG00000188917 E024 64.5788624 0.0006549536 0.38847824 0.6192298 X 101035623 101035683 61 - 1.791 1.750 -0.140
ENSG00000188917 E025 80.8812725 0.0004867080 0.53255784 0.7239242 X 101036974 101037073 100 - 1.875 1.849 -0.089
ENSG00000188917 E026 2.0104905 0.1869917952 0.56539851 0.7469809 X 101037074 101037539 466 - 0.315 0.476 0.905
ENSG00000188917 E027 76.4243109 0.0005840405 0.37857808 0.6110408 X 101037917 101038051 135 - 1.860 1.821 -0.130
ENSG00000188917 E028 47.6475852 0.0010666992 0.04539016 0.1685425 X 101041317 101041371 55 - 1.714 1.604 -0.373
ENSG00000188917 E029 54.5432497 0.0088182034 0.11562508 0.3085207 X 101042042 101042210 169 - 1.769 1.662 -0.364
ENSG00000188917 E030 24.5161394 0.0013976557 0.24345813 0.4804796 X 101042211 101042232 22 - 1.412 1.324 -0.306
ENSG00000188917 E031 45.5113586 0.0009300473 0.60447967 0.7731874 X 101042233 101042312 80 - 1.592 1.623 0.106
ENSG00000188917 E032 15.5308437 0.0023186917 0.35289740 0.5899444 X 101051251 101051362 112 - 1.227 1.140 -0.307
ENSG00000188917 E033 7.0318362 0.0068749017 0.20188332 0.4319847 X 101051363 101051366 4 - 0.975 0.814 -0.616
ENSG00000188917 E034 8.2398488 0.0036925401 0.41405400 0.6390379 X 101051367 101051638 272 - 0.833 0.939 0.402
ENSG00000188917 E035 1.6248558 0.0109829651 0.84075229 0.9198669 X 101051639 101051643 5 - 0.413 0.376 -0.203
ENSG00000188917 E036 8.3093298 0.0035580597 0.89087884 0.9470988 X 101051644 101051733 90 - 0.924 0.908 -0.061
ENSG00000188917 E037 23.3265051 0.0024857072 0.95851612 0.9811346 X 101051784 101051816 33 - 1.335 1.339 0.016
ENSG00000188917 E038 58.1426839 0.0008398122 0.70358650 0.8378985 X 101051817 101052121 305 - 1.731 1.713 -0.063