ENSG00000188690

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368778 ENSG00000188690 HEK293_OSMI2_6hA HEK293_TMG_6hB UROS protein_coding protein_coding 116.3825 128.7825 65.04709 7.685504 2.963302 -0.9852704 6.031395 6.076307 3.910944 0.9583501 0.3416175 -0.6343660 0.05362917 0.04766667 0.05993333 0.012266667 0.76686059 0.02221807 FALSE TRUE
ENST00000368797 ENSG00000188690 HEK293_OSMI2_6hA HEK293_TMG_6hB UROS protein_coding protein_coding 116.3825 128.7825 65.04709 7.685504 2.963302 -0.9852704 64.322908 72.775621 29.356917 4.4703262 2.5639067 -1.3094617 0.54475417 0.56500000 0.44956667 -0.115433333 0.04017651 0.02221807 FALSE TRUE
ENST00000650587 ENSG00000188690 HEK293_OSMI2_6hA HEK293_TMG_6hB UROS protein_coding protein_coding 116.3825 128.7825 65.04709 7.685504 2.963302 -0.9852704 9.360799 9.382545 6.135951 1.3607389 1.5892845 -0.6118798 0.07860833 0.07243333 0.09466667 0.022233333 0.86775322 0.02221807 FALSE TRUE
MSTRG.4796.23 ENSG00000188690 HEK293_OSMI2_6hA HEK293_TMG_6hB UROS protein_coding   116.3825 128.7825 65.04709 7.685504 2.963302 -0.9852704 4.317571 2.181444 4.291202 2.1814437 0.1189182 0.9728584 0.04110000 0.01526667 0.06613333 0.050866667 0.18721672 0.02221807 FALSE TRUE
MSTRG.4796.4 ENSG00000188690 HEK293_OSMI2_6hA HEK293_TMG_6hB UROS protein_coding   116.3825 128.7825 65.04709 7.685504 2.963302 -0.9852704 8.190771 9.943873 4.938408 1.0327108 0.7718549 -1.0082933 0.06784583 0.07730000 0.07576667 -0.001533333 1.00000000 0.02221807 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000188690 E001 19.6974739 0.0242103106 5.511593e-04 6.141133e-03 10 125784980 125785260 281 - 1.498 1.137 -1.260
ENSG00000188690 E002 1.6234508 0.0126014254 1.960876e-01 4.246650e-01 10 125785517 125785839 323 - 0.539 0.313 -1.217
ENSG00000188690 E003 1.5435199 0.7836364582 5.429904e-01 7.312049e-01 10 125788577 125788581 5 - 0.620 0.212 -2.332
ENSG00000188690 E004 2.1803648 0.5170586949 8.658722e-01 9.336789e-01 10 125788582 125788582 1 - 0.616 0.391 -1.099
ENSG00000188690 E005 6.3582774 0.0865285681 7.481326e-01 8.655820e-01 10 125788583 125788585 3 - 0.876 0.801 -0.290
ENSG00000188690 E006 26.6829607 0.0169353832 6.660837e-01 8.137514e-01 10 125788586 125788589 4 - 1.374 1.421 0.163
ENSG00000188690 E007 74.0917206 0.0056659130 9.394031e-01 9.719339e-01 10 125788590 125788604 15 - 1.840 1.838 -0.006
ENSG00000188690 E008 360.1160770 0.0022313263 1.253135e-04 1.803637e-03 10 125788605 125788724 120 - 2.429 2.551 0.407
ENSG00000188690 E009 640.6920437 0.0013927151 1.019733e-07 3.774502e-06 10 125788725 125788914 190 - 2.673 2.801 0.427
ENSG00000188690 E010 481.0317341 0.0021263211 1.707519e-07 5.999916e-06 10 125788915 125789005 91 - 2.529 2.683 0.512
ENSG00000188690 E011 103.2942161 0.0039745661 2.633011e-01 5.025070e-01 10 125789283 125789363 81 - 1.937 1.996 0.196
ENSG00000188690 E012 90.8697210 0.0077868653 5.405518e-01 7.293889e-01 10 125789364 125789528 165 - 1.892 1.935 0.143
ENSG00000188690 E013 22.7856354 0.0335724287 5.333573e-02 1.875364e-01 10 125789529 125789568 40 - 1.139 1.395 0.900
ENSG00000188690 E014 92.6501151 0.0164865143 6.301137e-01 7.904489e-01 10 125791520 125791880 361 - 1.944 1.923 -0.071
ENSG00000188690 E015 62.3473650 0.0043003302 2.242939e-01 4.585487e-01 10 125791881 125792066 186 - 1.799 1.734 -0.220
ENSG00000188690 E016 99.9977859 0.0110672959 4.100057e-01 6.360069e-01 10 125792067 125792578 512 - 1.991 1.950 -0.138
ENSG00000188690 E017 74.5314365 0.0134118567 2.662377e-01 5.057471e-01 10 125792579 125792744 166 - 1.885 1.814 -0.239
ENSG00000188690 E018 148.2329324 0.0079573969 6.822830e-02 2.210914e-01 10 125792745 125793857 1113 - 2.192 2.105 -0.293
ENSG00000188690 E019 50.4333865 0.0136559678 2.591274e-03 2.090636e-02 10 125793858 125794021 164 - 1.817 1.593 -0.757
ENSG00000188690 E020 103.4453967 0.0200371473 2.251020e-02 1.042616e-01 10 125794022 125794388 367 - 2.087 1.923 -0.551
ENSG00000188690 E021 353.9518071 0.0017330519 3.277387e-01 5.668124e-01 10 125794880 125794899 20 - 2.488 2.519 0.105
ENSG00000188690 E022 328.4911591 0.0016973760 4.979172e-01 6.994321e-01 10 125794900 125794901 2 - 2.461 2.484 0.078
ENSG00000188690 E023 603.2467320 0.0007444216 4.666726e-01 6.778345e-01 10 125794902 125794978 77 - 2.728 2.746 0.059
ENSG00000188690 E024 5.2931054 0.0053293942 4.432350e-01 6.609024e-01 10 125794979 125795061 83 - 0.839 0.736 -0.411
ENSG00000188690 E025 4.7905547 0.0055641290 4.902311e-01 6.941619e-01 10 125795062 125795158 97 - 0.648 0.753 0.435
ENSG00000188690 E026 2.8873944 0.0537296180 5.871111e-01 7.616939e-01 10 125795159 125795227 69 - 0.472 0.579 0.509
ENSG00000188690 E027 608.7806591 0.0015541837 8.836787e-01 9.432140e-01 10 125796103 125796188 86 - 2.743 2.744 0.004
ENSG00000188690 E028 12.5879943 0.0507241057 4.990139e-01 7.001036e-01 10 125796189 125796190 2 - 1.013 1.127 0.415
ENSG00000188690 E029 22.5386408 0.0281980200 9.481864e-01 9.763872e-01 10 125796790 125796861 72 - 1.319 1.335 0.057
ENSG00000188690 E030 7.9841835 0.0040431163 6.968360e-01 8.335185e-01 10 125797412 125797425 14 - 0.948 0.902 -0.173
ENSG00000188690 E031 15.2940545 0.0165980501 8.561517e-01 9.283543e-01 10 125797426 125797502 77 - 1.156 1.177 0.075
ENSG00000188690 E032 19.2317404 0.0020895068 6.168625e-01 7.816521e-01 10 125797503 125797641 139 - 1.294 1.254 -0.143
ENSG00000188690 E033 561.2096535 0.0018086167 9.422819e-01 9.734060e-01 10 125798065 125798145 81 - 2.703 2.710 0.024
ENSG00000188690 E034 87.0246494 0.0478329144 9.270502e-01 9.655909e-01 10 125798146 125800695 2550 - 1.871 1.918 0.155
ENSG00000188690 E035 124.1542464 0.0209241707 2.262876e-01 4.609819e-01 10 125802057 125802949 893 - 2.108 2.033 -0.254
ENSG00000188690 E036 27.6654393 0.0139120766 7.088312e-01 8.410422e-01 10 125802950 125802988 39 - 1.432 1.403 -0.100
ENSG00000188690 E037 29.5196757 0.0151487481 7.667581e-01 8.766686e-01 10 125802989 125803024 36 - 1.416 1.449 0.116
ENSG00000188690 E038 7.0051892 0.0929923511 1.035909e-01 2.881716e-01 10 125807150 125807412 263 - 1.037 0.761 -1.053
ENSG00000188690 E039 636.4642077 0.0014645337 9.940101e-02 2.807046e-01 10 125807413 125807487 75 - 2.785 2.752 -0.109
ENSG00000188690 E040 700.4180621 0.0012780631 2.189465e-04 2.880997e-03 10 125812214 125812288 75 - 2.854 2.781 -0.245
ENSG00000188690 E041 744.9214150 0.0003395023 1.485384e-07 5.293860e-06 10 125815034 125815130 97 - 2.884 2.805 -0.263
ENSG00000188690 E042 585.6554558 0.0001702324 1.833976e-06 4.832448e-05 10 125816177 125816260 84 - 2.776 2.701 -0.250
ENSG00000188690 E043 540.6644138 0.0005740500 4.779256e-01 6.857396e-01 10 125816437 125816525 89 - 2.679 2.697 0.057
ENSG00000188690 E044 9.7878368 0.0643501725 4.309204e-01 6.518349e-01 10 125816526 125816632 107 - 0.898 1.028 0.486
ENSG00000188690 E045 0.8217936 0.0175814988 1.731629e-01   10 125822212 125822255 44 - 0.394 0.153 -1.799
ENSG00000188690 E046 378.8715697 0.0029005450 1.014373e-04 1.513720e-03 10 125823029 125823273 245 - 2.443 2.575 0.440