ENSG00000188559

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000202677 ENSG00000188559 HEK293_OSMI2_6hA HEK293_TMG_6hB RALGAPA2 protein_coding protein_coding 4.385892 6.295351 4.16271 0.4180462 0.2141452 -0.5955921 2.368413 2.732455 3.0536595 0.3820662 0.2740937 0.1597882 0.5414667 0.4298333 0.7308667 0.3010333 0.0018549555 0.0001869435 FALSE TRUE
ENST00000430436 ENSG00000188559 HEK293_OSMI2_6hA HEK293_TMG_6hB RALGAPA2 protein_coding protein_coding 4.385892 6.295351 4.16271 0.4180462 0.2141452 -0.5955921 1.801643 3.457412 0.8643139 0.1550637 0.1285788 -1.9876361 0.4084417 0.5519667 0.2100000 -0.3419667 0.0001869435 0.0001869435 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000188559 E001 0.0000000       20 20389530 20389551 22 -      
ENSG00000188559 E002 10.8351991 0.0029026790 2.220031e-04 2.915570e-03 20 20389552 20389690 139 - 0.671 1.233 2.128
ENSG00000188559 E003 35.4922148 0.1175176635 3.631197e-03 2.710021e-02 20 20389691 20389810 120 - 1.120 1.728 2.107
ENSG00000188559 E004 172.9907637 0.9861959603 1.844561e-01 4.097917e-01 20 20389811 20390522 712 - 1.838 2.397 1.874
ENSG00000188559 E005 47.6062600 0.3307491239 8.459209e-02 2.539318e-01 20 20390523 20390608 86 - 1.344 1.830 1.660
ENSG00000188559 E006 36.8241851 0.2242107718 3.740383e-02 1.480142e-01 20 20390609 20390645 37 - 1.197 1.731 1.840
ENSG00000188559 E007 250.0522580 1.1852390008 2.604522e-01 4.994102e-01 20 20390646 20391916 1271 - 2.044 2.546 1.677
ENSG00000188559 E008 169.5632414 1.0585682188 2.766791e-01 5.166869e-01 20 20391917 20392968 1052 - 1.909 2.370 1.542
ENSG00000188559 E009 60.6995003 0.5668228807 3.635414e-01 5.986319e-01 20 20392969 20393253 285 - 1.614 1.881 0.905
ENSG00000188559 E010 20.0597119 0.0056785866 9.720856e-01 9.879736e-01 20 20396695 20396734 40 - 1.244 1.377 0.464
ENSG00000188559 E011 38.0857384 0.0086211133 4.676483e-01 6.784680e-01 20 20412027 20412148 122 - 1.477 1.665 0.642
ENSG00000188559 E012 3.3020043 0.0506350496 6.849992e-01 8.259189e-01 20 20470933 20472828 1896 - 0.598 0.643 0.195
ENSG00000188559 E013 46.0261741 0.0023675943 4.470988e-01 6.635531e-01 20 20472829 20472956 128 - 1.556 1.738 0.621
ENSG00000188559 E014 49.6699695 0.0009265968 2.402627e-01 4.768722e-01 20 20495117 20495275 159 - 1.652 1.731 0.270
ENSG00000188559 E015 49.9884173 0.0007680597 3.775338e-01 6.102744e-01 20 20503351 20503506 156 - 1.645 1.740 0.324
ENSG00000188559 E016 37.9307170 0.0036788831 9.330008e-02 2.698932e-01 20 20505411 20505534 124 - 1.561 1.596 0.120
ENSG00000188559 E017 22.0283315 0.0028289890 3.566450e-01 5.930819e-01 20 20511254 20511325 72 - 1.313 1.379 0.230
ENSG00000188559 E018 52.5148766 0.0160758092 1.880044e-02 9.173833e-02 20 20512513 20512751 239 - 1.741 1.709 -0.109
ENSG00000188559 E019 75.7485808 0.0047556895 1.573165e-01 3.726906e-01 20 20512752 20513111 360 - 1.838 1.913 0.251
ENSG00000188559 E020 43.6161300 0.0058941657 2.070046e-02 9.831949e-02 20 20513112 20513284 173 - 1.648 1.645 -0.010
ENSG00000188559 E021 40.6456034 0.0042498419 2.583576e-03 2.086606e-02 20 20520917 20521100 184 - 1.641 1.598 -0.146
ENSG00000188559 E022 32.4159921 0.0167572035 1.758827e-02 8.759471e-02 20 20524406 20524543 138 - 1.552 1.497 -0.190
ENSG00000188559 E023 24.8069158 0.0307580336 1.355867e-01 3.407090e-01 20 20524830 20524898 69 - 1.412 1.397 -0.050
ENSG00000188559 E024 30.5683030 0.0134060376 3.357382e-01 5.742156e-01 20 20526252 20526362 111 - 1.456 1.519 0.216
ENSG00000188559 E025 31.9000166 0.0011765781 3.587044e-01 5.947477e-01 20 20531687 20531795 109 - 1.468 1.550 0.280
ENSG00000188559 E026 24.8901249 0.0015228977 8.569940e-02 2.558638e-01 20 20535745 20535803 59 - 1.403 1.422 0.063
ENSG00000188559 E027 34.6595604 0.0117923487 1.148803e-01 3.072574e-01 20 20536656 20536784 129 - 1.538 1.563 0.084
ENSG00000188559 E028 31.1375952 0.0166114210 3.637590e-01 5.988627e-01 20 20546704 20546832 129 - 1.464 1.532 0.234
ENSG00000188559 E029 34.3378226 0.0127261071 8.805899e-03 5.296403e-02 20 20571458 20571613 156 - 1.579 1.521 -0.198
ENSG00000188559 E030 30.1865902 0.0015503408 1.707423e-03 1.506832e-02 20 20571848 20571946 99 - 1.524 1.462 -0.214
ENSG00000188559 E031 37.0458823 0.0013516480 4.583157e-04 5.297975e-03 20 20572875 20573068 194 - 1.611 1.546 -0.220
ENSG00000188559 E032 34.2534729 0.0084780829 3.663445e-03 2.727715e-02 20 20583050 20583226 177 - 1.586 1.521 -0.221
ENSG00000188559 E033 25.5291626 0.0221427713 1.194418e-01 3.149562e-01 20 20584865 20584955 91 - 1.427 1.422 -0.017
ENSG00000188559 E034 31.2387248 0.0064838409 1.149941e-02 6.438721e-02 20 20589268 20589365 98 - 1.529 1.492 -0.125
ENSG00000188559 E035 30.7424234 0.0101635858 1.747791e-02 8.721647e-02 20 20591177 20591314 138 - 1.528 1.489 -0.132
ENSG00000188559 E036 0.1723744 0.0350618355 8.670797e-01   20 20598679 20598819 141 - 0.000 0.108 10.118
ENSG00000188559 E037 33.5485968 0.0035933271 1.001742e-02 5.823195e-02 20 20601682 20601846 165 - 1.556 1.531 -0.087
ENSG00000188559 E038 44.9260045 0.0049869930 1.731701e-02 8.661463e-02 20 20605175 20605412 238 - 1.656 1.652 -0.012
ENSG00000188559 E039 32.3503287 0.0103570277 5.731599e-04 6.336962e-03 20 20611315 20611426 112 - 1.578 1.457 -0.417
ENSG00000188559 E040 26.9423056 0.0069402010 2.804106e-04 3.533702e-03 20 20616043 20616191 149 - 1.510 1.374 -0.466
ENSG00000188559 E041 28.5273992 0.0209840734 2.726087e-03 2.171955e-02 20 20619277 20619414 138 - 1.536 1.403 -0.458
ENSG00000188559 E042 34.9259251 0.0059390183 4.240137e-05 7.230372e-04 20 20620463 20620630 168 - 1.622 1.487 -0.462
ENSG00000188559 E043 38.7384499 0.0230227390 8.316026e-03 5.077908e-02 20 20629363 20629590 228 - 1.643 1.551 -0.312
ENSG00000188559 E044 0.3447487 0.4849258826 5.588346e-01   20 20635351 20635417 67 - 0.000 0.198 11.145
ENSG00000188559 E045 39.4080058 0.0401022054 7.191546e-03 4.553993e-02 20 20635418 20635617 200 - 1.681 1.531 -0.512
ENSG00000188559 E046 27.5299980 0.0018547419 1.761290e-06 4.661900e-05 20 20637363 20637501 139 - 1.547 1.367 -0.620
ENSG00000188559 E047 23.0864955 0.0015595129 1.339213e-02 7.199630e-02 20 20639785 20639900 116 - 1.403 1.362 -0.142
ENSG00000188559 E048 28.1183171 0.0015189795 7.174253e-05 1.133322e-03 20 20640701 20640878 178 - 1.524 1.399 -0.431
ENSG00000188559 E049 13.5655491 0.0512245132 2.948617e-02 1.258306e-01 20 20643506 20643549 44 - 1.241 1.072 -0.605
ENSG00000188559 E050 15.2075817 0.0022078663 2.702667e-06 6.783248e-05 20 20653530 20653587 58 - 1.342 1.070 -0.967
ENSG00000188559 E051 9.3971203 0.0036868564 9.413945e-03 5.559744e-02 20 20676236 20676288 53 - 1.094 0.950 -0.531
ENSG00000188559 E052 9.5900426 0.0710733757 3.085667e-03 2.393210e-02 20 20680691 20680801 111 - 1.179 0.863 -1.164
ENSG00000188559 E053 8.5435094 0.0590183409 1.524525e-02 7.899960e-02 20 20712375 20712644 270 - 1.095 0.880 -0.800