ENSG00000188312

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375587 ENSG00000188312 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPP protein_coding protein_coding 8.696802 5.574819 11.7125 1.888739 0.9137391 1.069698 1.8872260 2.312811 1.694313 0.3684645 0.1571517 -0.4466811 0.2811958 0.4799667 0.14713333 -0.33283333 0.0389118166 0.0001137665 FALSE TRUE
ENST00000618653 ENSG00000188312 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPP protein_coding protein_coding 8.696802 5.574819 11.7125 1.888739 0.9137391 1.069698 5.6724192 2.490568 8.315188 1.5778535 0.8191246 1.7352270 0.5847208 0.3587667 0.70750000 0.34873333 0.1756711857 0.0001137665 FALSE FALSE
MSTRG.32989.2 ENSG00000188312 HEK293_OSMI2_6hA HEK293_TMG_6hB CENPP protein_coding   8.696802 5.574819 11.7125 1.888739 0.9137391 1.069698 0.1871476 0.000000 0.635014 0.0000000 0.1670080 6.0112585 0.0151125 0.0000000 0.05363333 0.05363333 0.0001137665 0.0001137665 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000188312 E001 5.4854966 0.0278195013 2.418797e-02 0.1096608009 9 92325930 92325951 22 + 0.597 0.943 1.398
ENSG00000188312 E002 5.4245892 0.0761013055 3.833593e-02 0.1504720334 9 92325952 92325952 1 + 0.554 0.948 1.609
ENSG00000188312 E003 16.1630745 0.0522052278 2.451845e-01 0.4825352899 9 92325953 92325998 46 + 1.141 1.299 0.559
ENSG00000188312 E004 30.5574243 0.0612846414 2.290076e-01 0.4639739312 9 92325999 92326105 107 + 1.571 1.438 -0.456
ENSG00000188312 E005 67.2129495 0.0400561409 1.371333e-03 0.0126974495 9 92332170 92332351 182 + 1.981 1.672 -1.042
ENSG00000188312 E006 57.5236729 0.0519869700 2.237617e-03 0.0186447577 9 92337541 92337629 89 + 1.921 1.595 -1.102
ENSG00000188312 E007 54.0359257 0.0119307529 2.552094e-05 0.0004695604 9 92345699 92345787 89 + 1.879 1.596 -0.958
ENSG00000188312 E008 45.0269209 0.0014539451 3.524600e-01 0.5895265381 9 92379763 92379859 97 + 1.699 1.642 -0.195
ENSG00000188312 E009 0.2922838 0.0252708632 8.587308e-01   9 92379860 92379865 6 + 0.136 0.108 -0.387
ENSG00000188312 E010 0.0000000       9 92600257 92600508 252 +      
ENSG00000188312 E011 5.7959186 0.0946492517 3.269039e-02 0.1351942832 9 92610544 92611313 770 + 0.556 0.953 1.617
ENSG00000188312 E012 40.8281730 0.1616113329 5.965374e-01 0.7680141894 9 92611314 92611393 80 + 1.618 1.619 0.003
ENSG00000188312 E013 52.3610002 0.0098153765 5.800741e-01 0.7572201148 9 92612523 92612614 92 + 1.753 1.705 -0.161
ENSG00000188312 E014 262.0563195 0.0750159498 3.668616e-01 0.6013662341 9 92613019 92617081 4063 + 2.397 2.430 0.111
ENSG00000188312 E015 61.2796910 0.0179508831 5.843175e-02 0.1992741447 9 92617082 92618314 1233 + 1.705 1.841 0.459
ENSG00000188312 E016 18.0565480 0.0080828608 3.078290e-01 0.5484539861 9 92618315 92618432 118 + 1.226 1.306 0.281
ENSG00000188312 E017 93.7226713 0.0007075935 5.500789e-06 0.0001252562 9 92618433 92619858 1426 + 1.880 2.035 0.524
ENSG00000188312 E018 52.3489669 0.4231247696 7.918090e-02 0.2431862147 9 92619859 92620602 744 + 1.476 1.845 1.255
ENSG00000188312 E019 1.7191574 0.0121576472 4.974309e-01 0.6991359960 9 92621539 92621645 107 + 0.506 0.382 -0.646
ENSG00000188312 E020 2.2487168 0.0096993547 5.394110e-01 0.7285571129 9 92631586 92632023 438 + 0.454 0.549 0.463
ENSG00000188312 E021 3.6629164 0.1393523787 4.973397e-01 0.6991262581 9 92632565 92632873 309 + 0.740 0.605 -0.569
ENSG00000188312 E022 1.5665054 1.0532362081 1.277211e-01 0.3282431638 9 92634656 92634842 187 + 0.658 0.000 -12.477