ENSG00000188283

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000585441 ENSG00000188283 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF383 protein_coding processed_transcript 1.165455 0.5628046 2.376522 0.05755381 0.08045066 2.058795 0.06918332 0.00000000 0.39447886 0.00000000 0.07467302 5.3379924 0.03997500 0.00000000 0.167700000 0.16770000 0.02679536 0.02679536   FALSE
ENST00000586068 ENSG00000188283 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF383 protein_coding retained_intron 1.165455 0.5628046 2.376522 0.05755381 0.08045066 2.058795 0.16694392 0.02032108 0.27049008 0.02032108 0.01859506 3.2095569 0.12976667 0.03753333 0.113700000 0.07616667 0.57151211 0.02679536 FALSE TRUE
ENST00000586658 ENSG00000188283 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF383 protein_coding retained_intron 1.165455 0.5628046 2.376522 0.05755381 0.08045066 2.058795 0.12866433 0.21835605 0.20899689 0.04147250 0.10929066 -0.0603746 0.14485833 0.38113333 0.090366667 -0.29076667 0.24353965 0.02679536   FALSE
ENST00000588250 ENSG00000188283 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF383 protein_coding nonsense_mediated_decay 1.165455 0.5628046 2.376522 0.05755381 0.08045066 2.058795 0.01346298 0.10770385 0.00000000 0.10770385 0.00000000 -3.5570896 0.02831667 0.22653333 0.000000000 -0.22653333 0.76885351 0.02679536 FALSE TRUE
ENST00000589413 ENSG00000188283 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF383 protein_coding protein_coding 1.165455 0.5628046 2.376522 0.05755381 0.08045066 2.058795 0.19549271 0.03280904 0.25815696 0.03280904 0.02031788 2.6470903 0.20079583 0.06060000 0.108300000 0.04770000 0.76314003 0.02679536 FALSE TRUE
ENST00000590503 ENSG00000188283 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF383 protein_coding protein_coding 1.165455 0.5628046 2.376522 0.05755381 0.08045066 2.058795 0.01890443 0.04295623 0.01136602 0.02501314 0.01136602 -1.3094822 0.01877917 0.06900000 0.004633333 -0.06436667 0.11857714 0.02679536 FALSE TRUE
ENST00000684119 ENSG00000188283 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF383 protein_coding protein_coding 1.165455 0.5628046 2.376522 0.05755381 0.08045066 2.058795 0.19970067 0.02846493 0.33431637 0.02846493 0.04344906 3.1621193 0.14316667 0.04240000 0.140633333 0.09823333 0.55257356 0.02679536 FALSE TRUE
MSTRG.17060.3 ENSG00000188283 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF383 protein_coding   1.165455 0.5628046 2.376522 0.05755381 0.08045066 2.058795 0.23886629 0.08648876 0.71426990 0.04326541 0.15226796 2.9080947 0.17430833 0.14453333 0.297766667 0.15323333 0.62684821 0.02679536 FALSE TRUE
MSTRG.17060.6 ENSG00000188283 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF383 protein_coding   1.165455 0.5628046 2.376522 0.05755381 0.08045066 2.058795 0.10530108 0.00000000 0.11841453 0.00000000 0.11841453 3.6827366 0.08787917 0.00000000 0.048400000 0.04840000 1.00000000 0.02679536 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000188283 E001 0.9121510 0.016838606 0.22522852   19 37217926 37218182 257 + 0.259 0.000 -22.511
ENSG00000188283 E002 0.4654660 0.024441170 0.62964288   19 37218183 37218189 7 + 0.149 0.000 -21.511
ENSG00000188283 E003 1.8518288 0.011001993 0.27164289 0.5114835 19 37218190 37218213 24 + 0.397 0.247 -0.969
ENSG00000188283 E004 2.4764976 0.009391292 0.12197396 0.3190155 19 37218214 37218217 4 + 0.483 0.247 -1.416
ENSG00000188283 E005 7.5032617 0.005042793 0.02429109 0.1099932 19 37218218 37218274 57 + 0.844 0.608 -0.971
ENSG00000188283 E006 0.0000000       19 37218280 37218329 50 +      
ENSG00000188283 E007 1.4404930 0.013696863 0.47729170 0.6852188 19 37219276 37219490 215 + 0.320 0.247 -0.511
ENSG00000188283 E008 3.2201979 0.050563562 0.52423532 0.7179614 19 37219599 37219687 89 + 0.521 0.518 -0.013
ENSG00000188283 E009 2.4363263 0.028700007 0.96617423 0.9849795 19 37219688 37219749 62 + 0.421 0.518 0.487
ENSG00000188283 E010 6.5509598 0.004818130 0.01906519 0.0927026 19 37224818 37224939 122 + 0.800 0.517 -1.211
ENSG00000188283 E011 0.6682002 0.020601756 0.79799796   19 37224940 37225212 273 + 0.149 0.247 0.906
ENSG00000188283 E012 0.2735028 0.025987626 0.31304444   19 37226464 37226676 213 + 0.055 0.246 2.486
ENSG00000188283 E013 0.8545700 1.056755092 0.59883619   19 37227550 37227743 194 + 0.234 0.000 -22.314
ENSG00000188283 E014 6.3602345 0.006376343 0.06969696 0.2241652 19 37230409 37230411 3 + 0.789 0.608 -0.756
ENSG00000188283 E015 10.6511482 0.056133349 0.85187689 0.9261255 19 37230412 37230462 51 + 0.925 1.067 0.526
ENSG00000188283 E016 15.6073837 0.618729144 0.66956659 0.8160046 19 37235549 37235675 127 + 1.057 1.242 0.662
ENSG00000188283 E017 0.8745889 0.143103966 0.30517552   19 37235676 37235758 83 + 0.256 0.000 -22.484
ENSG00000188283 E018 1.5906897 0.061046394 0.49000868 0.6940056 19 37235759 37235978 220 + 0.290 0.519 1.279
ENSG00000188283 E019 14.1504685 0.645394574 0.69914370 0.8350575 19 37235979 37236074 96 + 1.001 1.259 0.926
ENSG00000188283 E020 123.1641842 0.128870057 0.30883183 0.5493345 19 37242469 37248740 6272 + 1.914 2.127 0.714