ENSG00000188191

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000403562 ENSG00000188191 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKAR1B protein_coding protein_coding 26.02378 38.2992 10.89129 8.088487 0.4336285 -1.813193 9.0815718 13.43470 3.460578 2.186559 0.3841286 -1.953789 0.3493333 0.3610000 0.3209333 -0.04006667 8.753386e-01 6.064332e-20 FALSE TRUE
ENST00000430040 ENSG00000188191 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKAR1B protein_coding protein_coding 26.02378 38.2992 10.89129 8.088487 0.4336285 -1.813193 0.7374598 0.00000 1.778167 0.000000 0.3496191 7.482338 0.0538750 0.0000000 0.1617333 0.16173333 6.064332e-20 6.064332e-20 FALSE TRUE
ENST00000537384 ENSG00000188191 HEK293_OSMI2_6hA HEK293_TMG_6hB PRKAR1B protein_coding protein_coding 26.02378 38.2992 10.89129 8.088487 0.4336285 -1.813193 14.4557751 23.44581 4.795222 6.097580 0.3093261 -2.287270 0.5253667 0.5949667 0.4420667 -0.15290000 3.116746e-01 6.064332e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000188191 E001 0.3751086 0.0338699033 1.000000e+00   7 549197 549197 1 - 0.000 0.111 8.592
ENSG00000188191 E002 79.0376784 0.0093540429 4.026725e-01 6.305027e-01 7 549198 549408 211 - 1.720 1.790 0.238
ENSG00000188191 E003 154.6992683 0.0004319036 7.997698e-03 4.929383e-02 7 549409 549536 128 - 1.980 2.087 0.357
ENSG00000188191 E004 199.8142611 0.0010632749 5.591021e-03 3.768541e-02 7 549537 549739 203 - 2.091 2.196 0.350
ENSG00000188191 E005 70.8043348 0.0029090242 3.839125e-02 1.505986e-01 7 549740 549741 2 - 1.614 1.750 0.461
ENSG00000188191 E006 77.5065289 0.0026777954 1.364513e-02 7.295451e-02 7 549742 549749 8 - 1.636 1.792 0.529
ENSG00000188191 E007 337.6208390 0.0007409063 2.089240e-03 1.766498e-02 7 549750 550269 520 - 2.332 2.419 0.290
ENSG00000188191 E008 209.6086483 0.0009095966 1.336513e-02 7.190125e-02 7 550270 550602 333 - 2.128 2.214 0.289
ENSG00000188191 E009 115.6514309 0.0003558368 7.044247e-01 8.383970e-01 7 551389 551470 82 - 1.957 1.941 -0.052
ENSG00000188191 E010 203.0450206 0.0008699330 3.311031e-02 1.363555e-01 7 579256 579377 122 - 2.242 2.170 -0.239
ENSG00000188191 E011 206.0108887 0.0014869841 1.830639e-03 1.591912e-02 7 584508 584568 61 - 2.278 2.166 -0.371
ENSG00000188191 E012 169.7072318 0.0047567571 4.895058e-02 1.771272e-01 7 596146 596179 34 - 2.182 2.084 -0.328
ENSG00000188191 E013 299.2774361 0.0001956752 6.159945e-03 4.051520e-02 7 596180 596304 125 - 2.409 2.340 -0.232
ENSG00000188191 E014 0.0000000       7 602553 602683 131 -      
ENSG00000188191 E015 216.5859485 0.0002369658 2.373198e-01 4.734575e-01 7 606193 606239 47 - 2.243 2.207 -0.120
ENSG00000188191 E016 138.7101987 0.0003861436 3.124317e-01 5.527402e-01 7 607391 607395 5 - 2.052 2.013 -0.132
ENSG00000188191 E017 205.4079011 0.0002372986 9.377752e-02 2.707741e-01 7 607396 607452 57 - 2.234 2.182 -0.173
ENSG00000188191 E018 211.4262193 0.0003183319 1.052178e-02 6.034993e-02 7 677229 677320 92 - 2.269 2.191 -0.260
ENSG00000188191 E019 204.6363857 0.0011674750 9.288668e-01 9.664674e-01 7 680556 680726 171 - 2.192 2.185 -0.024
ENSG00000188191 E020 0.0000000       7 691540 691794 255 -      
ENSG00000188191 E021 1.3556047 0.2778477561 7.010671e-01   7 696713 697102 390 - 0.233 0.328 0.672
ENSG00000188191 E022 155.3645454 0.0003410494 1.629918e-01 3.812056e-01 7 711329 711527 199 - 2.026 2.080 0.179
ENSG00000188191 E023 0.0000000       7 712414 712572 159 -      
ENSG00000188191 E024 0.7788594 0.2889427368 4.537754e-01   7 712848 712921 74 - 0.000 0.235 11.102
ENSG00000188191 E025 0.8203656 0.6466154991 6.179537e-01   7 712922 713054 133 - 0.000 0.239 10.816
ENSG00000188191 E026 0.9630002 0.5460642864 1.000000e+00   7 713055 713207 153 - 0.232 0.239 0.057
ENSG00000188191 E027 1.6545955 0.0120228256 8.025124e-01 8.977331e-01 7 716619 716683 65 - 0.386 0.335 -0.301
ENSG00000188191 E028 6.0271800 0.0234748197 5.122323e-01 7.096436e-01 7 716684 716846 163 - 0.829 0.716 -0.451
ENSG00000188191 E029 1.3624993 0.2372428548 6.558182e-01   7 725237 725297 61 - 0.388 0.276 -0.703
ENSG00000188191 E030 1.3522807 0.0425870644 6.689213e-01   7 726604 727209 606 - 0.386 0.303 -0.508
ENSG00000188191 E031 30.2791937 0.0014769861 1.253990e-07 4.550348e-06 7 727210 727341 132 - 0.828 1.436 2.197
ENSG00000188191 E032 32.9066541 0.0013008768 8.223040e-01 9.092848e-01 7 727590 727650 61 - 1.392 1.410 0.063