ENSG00000187792

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341976 ENSG00000187792 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF70 protein_coding protein_coding 4.092365 6.201844 2.853118 0.2092453 0.2421991 -1.117435 1.9615480 2.9511287 0.7247568 0.1955115 0.2410512 -2.0108085 0.45964583 0.47836667 0.2465000 -0.23186667 0.32592770 0.01584188 FALSE TRUE
MSTRG.21783.1 ENSG00000187792 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF70 protein_coding   4.092365 6.201844 2.853118 0.2092453 0.2421991 -1.117435 0.3626339 0.1845302 0.5388782 0.1845302 0.2414838 1.4964920 0.09844583 0.02920000 0.1811000 0.15190000 0.25250222 0.01584188 TRUE TRUE
MSTRG.21783.3 ENSG00000187792 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF70 protein_coding   4.092365 6.201844 2.853118 0.2092453 0.2421991 -1.117435 1.5037077 2.6611272 1.5894831 0.3301231 0.1156725 -0.7398429 0.38342083 0.42706667 0.5723667 0.14530000 0.66806384 0.01584188 TRUE TRUE
MSTRG.21783.5 ENSG00000187792 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF70 protein_coding   4.092365 6.201844 2.853118 0.2092453 0.2421991 -1.117435 0.2510735 0.4050582 0.0000000 0.1590863 0.0000000 -5.3752417 0.05459167 0.06536667 0.0000000 -0.06536667 0.01584188 0.01584188   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000187792 E001 1.106875 0.6301478291 0.2250310377   22 23731806 23731877 72 - 0.535 0.178 -2.257
ENSG00000187792 E002 67.580475 0.0032941558 0.0092374438 0.054856468 22 23738682 23739604 923 - 1.613 1.767 0.524
ENSG00000187792 E003 12.606798 0.0026617972 0.0817901307 0.248370026 22 23739605 23739708 104 - 0.867 1.083 0.805
ENSG00000187792 E004 14.292029 0.0082224753 0.0002986612 0.003715989 22 23739709 23740232 524 - 0.621 1.160 2.081
ENSG00000187792 E005 307.939229 0.0005934775 0.0007544759 0.007895450 22 23740233 23743257 3025 - 2.336 2.407 0.235
ENSG00000187792 E006 173.002413 0.0014127815 0.5100146565 0.707987382 22 23743258 23744439 1182 - 2.166 2.144 -0.076
ENSG00000187792 E007 28.925126 0.0027861485 0.3058209417 0.546487397 22 23744440 23744475 36 - 1.452 1.369 -0.288
ENSG00000187792 E008 36.491866 0.0012440166 0.0996725541 0.281164947 22 23744476 23744559 84 - 1.571 1.457 -0.391
ENSG00000187792 E009 60.622951 0.0006996586 0.0556070021 0.192721386 22 23744560 23744948 389 - 1.779 1.676 -0.348
ENSG00000187792 E010 17.717842 0.0019318484 0.0126993405 0.069238478 22 23744949 23744972 24 - 1.354 1.128 -0.798
ENSG00000187792 E011 27.818910 0.0012948368 0.0423823949 0.160942408 22 23744973 23745087 115 - 1.490 1.335 -0.536
ENSG00000187792 E012 21.015435 0.0075395954 0.0053794733 0.036590713 22 23745088 23745219 132 - 1.451 1.196 -0.889
ENSG00000187792 E013 2.339246 0.0350796569 0.2842667381 0.524788430 22 23745380 23745491 112 - 0.620 0.420 -0.957
ENSG00000187792 E014 10.523826 1.0321923770 0.2158481396 0.448467536 22 23750711 23750980 270 - 1.185 0.901 -1.040
ENSG00000187792 E015 1.713217 0.2681336839 1.0000000000 1.000000000 22 23750981 23751112 132 - 0.212 0.402 1.272