ENSG00000187790

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267430 ENSG00000187790 HEK293_OSMI2_6hA HEK293_TMG_6hB FANCM protein_coding protein_coding 5.120464 1.8268 10.10492 0.197432 0.7899111 2.461219 1.6591344 0.1201657 2.9487006 0.1201657 0.34518680 4.5065423 0.20632500 0.07330000 0.30076667 0.22746667 2.848734e-01 5.872702e-08 FALSE TRUE
ENST00000542564 ENSG00000187790 HEK293_OSMI2_6hA HEK293_TMG_6hB FANCM protein_coding protein_coding 5.120464 1.8268 10.10492 0.197432 0.7899111 2.461219 0.5864996 0.0000000 1.8227089 0.0000000 0.07388517 7.5178338 0.07885417 0.00000000 0.18163333 0.18163333 5.872702e-08 5.872702e-08 FALSE TRUE
ENST00000553551 ENSG00000187790 HEK293_OSMI2_6hA HEK293_TMG_6hB FANCM protein_coding retained_intron 5.120464 1.8268 10.10492 0.197432 0.7899111 2.461219 0.2744333 0.2425942 0.3775554 0.1381001 0.02714252 0.6175809 0.08032917 0.12083333 0.03793333 -0.08290000 4.038587e-01 5.872702e-08 FALSE FALSE
ENST00000696642 ENSG00000187790 HEK293_OSMI2_6hA HEK293_TMG_6hB FANCM protein_coding nonsense_mediated_decay 5.120464 1.8268 10.10492 0.197432 0.7899111 2.461219 0.1754671 0.0000000 0.5513168 0.0000000 0.28561740 5.8107433 0.02085000 0.00000000 0.05410000 0.05410000 5.898899e-01 5.872702e-08 FALSE TRUE
ENST00000696644 ENSG00000187790 HEK293_OSMI2_6hA HEK293_TMG_6hB FANCM protein_coding retained_intron 5.120464 1.8268 10.10492 0.197432 0.7899111 2.461219 0.5061204 0.1866971 1.2594401 0.1866971 0.68795669 2.6901445 0.07238750 0.08403333 0.11550000 0.03146667 8.586974e-01 5.872702e-08 FALSE FALSE
ENST00000696645 ENSG00000187790 HEK293_OSMI2_6hA HEK293_TMG_6hB FANCM protein_coding retained_intron 5.120464 1.8268 10.10492 0.197432 0.7899111 2.461219 0.2518795 0.4507149 0.1185506 0.1120571 0.06362768 -1.8415384 0.15000833 0.26416667 0.01090000 -0.25326667 1.596019e-03 5.872702e-08 FALSE TRUE
ENST00000696659 ENSG00000187790 HEK293_OSMI2_6hA HEK293_TMG_6hB FANCM protein_coding protein_coding 5.120464 1.8268 10.10492 0.197432 0.7899111 2.461219 0.1181678 0.2370469 0.1110886 0.1193906 0.11108857 -1.0287221 0.05083333 0.14553333 0.01110000 -0.13443333 4.801767e-01 5.872702e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000187790 E001 0.1426347 0.0323084261 8.349132e-01   14 45135930 45135931 2 + 0.051 0.000 -7.128
ENSG00000187790 E002 0.1426347 0.0323084261 8.349132e-01   14 45135932 45135939 8 + 0.051 0.000 -9.392
ENSG00000187790 E003 2.2159948 0.0865971496 5.218822e-01 7.162232e-01 14 45135940 45135952 13 + 0.416 0.264 -0.941
ENSG00000187790 E004 2.4127596 0.0385130715 4.391272e-01 6.580766e-01 14 45135953 45135953 1 + 0.437 0.265 -1.046
ENSG00000187790 E005 4.4138076 0.0253947792 1.043033e-01 2.893684e-01 14 45135954 45135970 17 + 0.626 0.265 -1.942
ENSG00000187790 E006 6.8510119 0.0042651291 6.349864e-02 2.105953e-01 14 45135971 45135992 22 + 0.783 0.429 -1.589
ENSG00000187790 E007 9.0456368 0.0032129386 1.276960e-02 6.951362e-02 14 45135993 45136002 10 + 0.892 0.429 -2.012
ENSG00000187790 E008 9.3850363 0.0031316506 1.008249e-02 5.851405e-02 14 45136003 45136005 3 + 0.905 0.429 -2.064
ENSG00000187790 E009 10.0338354 0.0029321944 8.213959e-02 2.489949e-01 14 45136006 45136010 5 + 0.919 0.640 -1.114
ENSG00000187790 E010 22.4932260 0.0017210138 9.634070e-03 5.653961e-02 14 45136011 45136246 236 + 1.238 0.934 -1.105
ENSG00000187790 E011 30.9803693 0.0182476740 1.081800e-01 2.959939e-01 14 45136247 45136499 253 + 1.357 1.186 -0.599
ENSG00000187790 E012 18.6684870 0.0564538397 8.914527e-02 2.622114e-01 14 45136500 45136539 40 + 1.157 0.891 -0.979
ENSG00000187790 E013 6.7337696 0.2210810913 6.868262e-01 8.270736e-01 14 45136540 45137068 529 + 0.712 0.894 0.720
ENSG00000187790 E014 27.6416451 0.0015707018 1.751677e-03 1.538054e-02 14 45137069 45137241 173 + 1.323 0.974 -1.249
ENSG00000187790 E015 6.8928378 0.1028816888 3.786303e-02 1.492714e-01 14 45137242 45139329 2088 + 0.665 1.058 1.527
ENSG00000187790 E016 12.3567852 0.0027582512 4.646455e-01 6.763323e-01 14 45140632 45140709 78 + 0.979 0.889 -0.339
ENSG00000187790 E017 25.6008713 0.0015736407 4.803028e-03 3.354868e-02 14 45148837 45148995 159 + 1.291 0.974 -1.138
ENSG00000187790 E018 23.2163819 0.0151620333 1.151289e-01 3.076607e-01 14 45151397 45151528 132 + 1.241 1.047 -0.696
ENSG00000187790 E019 0.0000000       14 45151529 45152586 1058 +      
ENSG00000187790 E020 25.2987091 0.0087539803 4.184516e-01 6.424677e-01 14 45153920 45154052 133 + 1.265 1.186 -0.280
ENSG00000187790 E021 23.9084227 0.0075728609 1.131545e-01 3.044205e-01 14 45154697 45154822 126 + 1.253 1.078 -0.626
ENSG00000187790 E022 19.0118400 0.0017350432 2.477915e-02 1.115430e-01 14 45155373 45155459 87 + 1.168 0.889 -1.025
ENSG00000187790 E023 31.3035541 0.0012492947 6.772785e-05 1.078850e-03 14 45159096 45159280 185 + 1.380 0.934 -1.600
ENSG00000187790 E024 0.0000000       14 45159281 45159332 52 +      
ENSG00000187790 E025 38.0818082 0.0010235984 5.754937e-03 3.852000e-02 14 45164359 45164565 207 + 1.452 1.208 -0.850
ENSG00000187790 E026 1.1952074 0.1952660735 4.026779e-01   14 45164566 45165610 1045 + 0.294 0.000 -11.657
ENSG00000187790 E027 39.5585336 0.0011201483 2.730432e-03 2.174703e-02 14 45166950 45167163 214 + 1.472 1.208 -0.919
ENSG00000187790 E028 4.2056566 0.0343459402 1.153721e-01 3.081023e-01 14 45167164 45168394 1231 + 0.622 0.266 -1.920
ENSG00000187790 E029 2.4237023 0.0101177997 4.628534e-01 6.750533e-01 14 45170077 45170201 125 + 0.395 0.548 0.773
ENSG00000187790 E030 35.1133029 0.0011861334 1.979159e-02 9.518470e-02 14 45170589 45170746 158 + 1.416 1.208 -0.726
ENSG00000187790 E031 38.1781720 0.0009907202 3.613098e-02 1.445673e-01 14 45173055 45173210 156 + 1.446 1.272 -0.606
ENSG00000187790 E032 202.3592292 0.0002734349 1.738389e-03 1.528916e-02 14 45175071 45176976 1906 + 2.150 2.050 -0.334
ENSG00000187790 E033 1.1434572 0.0370504838 2.970212e-01   14 45178149 45178200 52 + 0.209 0.429 1.441
ENSG00000187790 E034 0.4576437 0.1744054717 3.454237e-01   14 45180471 45180622 152 + 0.095 0.266 1.793
ENSG00000187790 E035 0.4576437 0.1744054717 3.454237e-01   14 45180623 45180736 114 + 0.095 0.266 1.793
ENSG00000187790 E036 0.6190593 0.0213851721 4.998476e-01   14 45180737 45180834 98 + 0.137 0.266 1.188
ENSG00000187790 E037 0.4764247 0.0217681645 3.345439e-01   14 45180835 45180889 55 + 0.096 0.266 1.772
ENSG00000187790 E038 0.3337900 0.0270659833 1.705888e-01   14 45180890 45181429 540 + 0.051 0.266 2.771
ENSG00000187790 E039 35.1319453 0.0013845583 3.548427e-02 1.428548e-01 14 45181430 45181524 95 + 1.414 1.230 -0.642
ENSG00000187790 E040 0.3228314 0.3988679196 1.000000e+00   14 45181584 45181636 53 + 0.096 0.000 -9.537
ENSG00000187790 E041 28.2881178 0.0032560496 9.102986e-01 9.573112e-01 14 45181637 45181705 69 + 1.307 1.309 0.008
ENSG00000187790 E042 0.4820342 0.0213186909 1.000000e+00   14 45181706 45181720 15 + 0.137 0.000 -10.975
ENSG00000187790 E043 0.8567829 0.1282526717 6.245232e-01   14 45183498 45183773 276 + 0.211 0.000 -11.211
ENSG00000187790 E044 37.1558831 0.0019964187 1.281592e-01 3.288743e-01 14 45183774 45183902 129 + 1.431 1.309 -0.423
ENSG00000187790 E045 43.5139004 0.0011496348 1.656868e-02 8.386216e-02 14 45185217 45185373 157 + 1.501 1.309 -0.662
ENSG00000187790 E046 43.0885266 0.0010241513 9.872956e-01 9.954986e-01 14 45187781 45187887 107 + 1.472 1.484 0.040
ENSG00000187790 E047 74.3032662 0.0050309388 8.859031e-04 8.980822e-03 14 45188802 45189173 372 + 1.676 1.888 0.716
ENSG00000187790 E048 52.0475020 0.0041768994 1.418371e-02 7.507309e-02 14 45189174 45189362 189 + 1.532 1.712 0.611
ENSG00000187790 E049 2.8945901 0.0085695870 6.679860e-01 8.149147e-01 14 45189363 45189949 587 + 0.455 0.548 0.450
ENSG00000187790 E050 5.0047339 0.0063380791 1.362509e-03 1.263021e-02 14 45194392 45195480 1089 + 0.525 1.012 1.983
ENSG00000187790 E051 2.1078854 0.0099264755 1.026989e-01 2.866029e-01 14 45195481 45195585 105 + 0.325 0.641 1.601
ENSG00000187790 E052 6.5005721 0.0236779033 3.424800e-05 6.040817e-04 14 45195586 45196171 586 + 0.584 1.187 2.341
ENSG00000187790 E053 82.3480179 0.0004572823 2.028476e-03 1.724911e-02 14 45196172 45196547 376 + 1.726 1.895 0.568
ENSG00000187790 E054 0.6951069 0.4512677553 4.760548e-02   14 45196548 45196551 4 + 0.051 0.555 4.368
ENSG00000187790 E055 15.4679074 0.2392593799 8.585116e-02 2.561582e-01 14 45196728 45198643 1916 + 0.916 1.508 2.107
ENSG00000187790 E056 19.9704458 0.0019490009 4.625985e-03 3.261234e-02 14 45198644 45198646 3 + 1.109 1.391 0.991
ENSG00000187790 E057 33.9520714 0.0010547196 2.979215e-04 3.709374e-03 14 45198647 45198731 85 + 1.328 1.609 0.967
ENSG00000187790 E058 34.4410847 0.0016877077 1.453417e-04 2.043411e-03 14 45198732 45198835 104 + 1.333 1.626 1.009
ENSG00000187790 E059 35.4393656 0.0010269412 3.487781e-06 8.461505e-05 14 45198836 45198935 100 + 1.335 1.675 1.167
ENSG00000187790 E060 0.6424544 0.0238630907 5.184845e-03   14 45198936 45199088 153 + 0.051 0.547 4.351
ENSG00000187790 E061 39.0553610 0.0010171704 2.466243e-05 4.563356e-04 14 45199870 45200890 1021 + 1.380 1.683 1.038