ENSG00000187720

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261862 ENSG00000187720 HEK293_OSMI2_6hA HEK293_TMG_6hB THSD4 protein_coding protein_coding 0.8576356 0.9178158 0.6848799 0.0608188 0.005413841 -0.4170747 0.2100362 0.0000000 0.2833978 0.0000000 0.2037480 4.874786 0.2225208 0.0000 0.4173667 0.4173667 0.636538408 0.002786224 FALSE TRUE
ENST00000355327 ENSG00000187720 HEK293_OSMI2_6hA HEK293_TMG_6hB THSD4 protein_coding protein_coding 0.8576356 0.9178158 0.6848799 0.0608188 0.005413841 -0.4170747 0.4561552 0.5035155 0.3987517 0.1051871 0.2071764 -0.329183 0.5298083 0.5562 0.5786000 0.0224000 0.958539592 0.002786224 FALSE TRUE
ENST00000357769 ENSG00000187720 HEK293_OSMI2_6hA HEK293_TMG_6hB THSD4 protein_coding protein_coding 0.8576356 0.9178158 0.6848799 0.0608188 0.005413841 -0.4170747 0.1788181 0.4123189 0.0000000 0.1320565 0.0000000 -5.400261 0.2356083 0.4419 0.0000000 -0.4419000 0.002786224 0.002786224 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000187720 E001 0.0000000       15 71096952 71097006 55 +      
ENSG00000187720 E002 0.6058878 0.093344239 2.163733e-02   15 71115471 71115664 194 + 0.407 0.000 -11.356
ENSG00000187720 E003 0.6058878 0.093344239 2.163733e-02   15 71115665 71115698 34 + 0.407 0.000 -13.241
ENSG00000187720 E004 1.7083863 0.011903910 3.518392e-02 1.420615e-01 15 71141449 71141556 108 + 0.615 0.255 -1.967
ENSG00000187720 E005 1.3816108 0.013696863 1.237377e-01   15 71154863 71154932 70 + 0.524 0.255 -1.555
ENSG00000187720 E006 2.5869486 0.134346735 8.639445e-01 9.325768e-01 15 71215035 71215399 365 + 0.579 0.525 -0.247
ENSG00000187720 E007 9.8448462 0.004323152 7.543807e-02 2.357333e-01 15 71242649 71243096 448 + 1.130 0.941 -0.695
ENSG00000187720 E008 5.7710443 0.023404613 2.573113e-01 4.960567e-01 15 71256613 71256715 103 + 0.924 0.761 -0.635
ENSG00000187720 E009 7.8106479 0.006240595 8.274977e-03 5.059337e-02 15 71411687 71411823 137 + 1.104 0.800 -1.140
ENSG00000187720 E010 0.0000000       15 71547228 71547235 8 +      
ENSG00000187720 E011 0.0000000       15 71547236 71547481 246 +      
ENSG00000187720 E012 0.0000000       15 71660455 71660529 75 +      
ENSG00000187720 E013 10.8547060 0.002967094 2.036512e-01 4.341153e-01 15 71660530 71660734 205 + 1.143 1.014 -0.469
ENSG00000187720 E014 8.7853130 0.011875232 3.922128e-01 6.221761e-01 15 71728549 71728724 176 + 1.046 0.941 -0.389
ENSG00000187720 E015 0.0000000       15 71728725 71731120 2396 +      
ENSG00000187720 E016 6.7112153 0.039975616 8.750342e-01 9.387217e-01 15 71731121 71731217 97 + 0.860 0.875 0.059
ENSG00000187720 E017 0.0000000       15 71731218 71733932 2715 +      
ENSG00000187720 E018 9.4355804 0.004262893 4.749918e-01 6.835688e-01 15 71737732 71738007 276 + 1.048 0.967 -0.299
ENSG00000187720 E019 0.0000000       15 71738008 71738217 210 +      
ENSG00000187720 E020 4.1697458 0.067788495 5.474764e-01 7.344562e-01 15 71745106 71745235 130 + 0.760 0.651 -0.453
ENSG00000187720 E021 8.5029530 0.004699456 6.256295e-02 2.085264e-01 15 71746838 71747042 205 + 1.077 0.869 -0.775
ENSG00000187720 E022 8.2337745 0.004351986 4.564082e-02 1.691116e-01 15 71748421 71748594 174 + 1.077 0.853 -0.838
ENSG00000187720 E023 7.0152293 0.005210842 4.625924e-01 6.748809e-01 15 71757902 71758075 174 + 0.946 0.853 -0.353
ENSG00000187720 E024 7.6698549 0.004864255 8.177601e-01 9.068169e-01 15 71765020 71765199 180 + 0.905 0.928 0.085
ENSG00000187720 E025 0.0000000       15 71766699 71767651 953 +      
ENSG00000187720 E026 6.5437034 0.005679583 6.709613e-02 2.186072e-01 15 71771064 71771208 145 + 0.724 0.954 0.896
ENSG00000187720 E027 136.2189127 0.000501757 2.710717e-08 1.154318e-06 15 71777232 71783383 6152 + 2.055 2.169 0.381