ENSG00000187676

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343307 ENSG00000187676 HEK293_OSMI2_6hA HEK293_TMG_6hB B3GLCT protein_coding protein_coding 7.887946 1.829273 12.33532 0.406317 0.8144403 2.746757 5.623559 1.811257 8.730784 0.4061705 0.7882801 2.262828 0.8165750 0.9902667 0.7063333 -0.2839333 4.674319e-07 9.752028e-09 FALSE TRUE
MSTRG.8557.4 ENSG00000187676 HEK293_OSMI2_6hA HEK293_TMG_6hB B3GLCT protein_coding   7.887946 1.829273 12.33532 0.406317 0.8144403 2.746757 2.090714 0.000000 3.485625 0.0000000 0.3806260 8.449407 0.1613792 0.0000000 0.2842333 0.2842333 9.752028e-09 9.752028e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000187676 E001 0.1426347 0.031506809 1.000000000   13 31199972 31199974 3 + 0.052 0.001 -6.385
ENSG00000187676 E002 1.2269724 0.014582975 0.618910985   13 31199975 31200021 47 + 0.244 0.423 1.126
ENSG00000187676 E003 8.4293927 0.004238824 0.167750675 0.38761188 13 31200022 31200154 133 + 0.848 0.774 -0.291
ENSG00000187676 E004 0.0000000       13 31200881 31200930 50 +      
ENSG00000187676 E005 15.7579268 0.013858237 0.017750713 0.08817318 13 31215051 31215100 50 + 1.091 0.926 -0.611
ENSG00000187676 E006 19.5828448 0.032399070 0.028265996 0.12206215 13 31222952 31222991 40 + 1.176 1.037 -0.502
ENSG00000187676 E007 29.2418459 0.041654921 0.041630404 0.15896479 13 31229185 31229294 110 + 1.333 1.244 -0.314
ENSG00000187676 E008 27.9447935 0.050328414 0.130071747 0.33196057 13 31247023 31247099 77 + 1.308 1.281 -0.096
ENSG00000187676 E009 35.0095509 0.045767052 0.001238461 0.01170610 13 31247855 31247966 112 + 1.425 1.154 -0.950
ENSG00000187676 E010 0.0000000       13 31260407 31260480 74 +      
ENSG00000187676 E011 45.9596332 0.047191100 0.005566756 0.03755913 13 31260946 31261082 137 + 1.531 1.353 -0.613
ENSG00000187676 E012 37.2752609 0.081480476 0.020667641 0.09824607 13 31269214 31269277 64 + 1.442 1.253 -0.660
ENSG00000187676 E013 46.8934462 0.087851101 0.019320542 0.09356451 13 31274509 31274628 120 + 1.537 1.374 -0.560
ENSG00000187676 E014 39.3014242 0.072429477 0.030830909 0.12984965 13 31276702 31276771 70 + 1.458 1.333 -0.433
ENSG00000187676 E015 1.0430191 0.015378759 0.818434801   13 31283069 31283306 238 + 0.245 0.261 0.123
ENSG00000187676 E016 52.5869425 0.071853460 0.151098174 0.36390375 13 31284648 31284761 114 + 1.566 1.561 -0.020
ENSG00000187676 E017 47.4236355 0.044469919 0.392961767 0.62276796 13 31286720 31286819 100 + 1.510 1.596 0.295
ENSG00000187676 E018 46.7899287 0.032349591 0.348736122 0.58618472 13 31317566 31317685 120 + 1.507 1.583 0.259
ENSG00000187676 E019 48.7334597 0.001268805 0.170863887 0.39168772 13 31323751 31323895 145 + 1.503 1.737 0.797
ENSG00000187676 E020 106.5487608 1.281529896 0.443297820 0.66093695 13 31329501 31330121 621 + 1.815 2.112 0.998
ENSG00000187676 E021 96.0032877 1.238720465 0.444731744 0.66193879 13 31330122 31331008 887 + 1.770 2.066 0.994
ENSG00000187676 E022 53.8398353 0.721818825 0.166401454 0.38575626 13 31331009 31331244 236 + 1.468 1.965 1.686
ENSG00000187676 E023 111.0570540 1.252039789 0.288189619 0.52892357 13 31331245 31332276 1032 + 1.790 2.244 1.526