ENSG00000187446

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334660 ENSG00000187446 HEK293_OSMI2_6hA HEK293_TMG_6hB CHP1 protein_coding protein_coding 24.24351 28.51875 19.63214 6.429845 0.765833 -0.5384647 18.4952250 21.3061069 14.934643 4.5421052 0.7379273 -0.5123155 0.75307500 0.753033333 0.7606333 0.00760000 0.980868471 0.008280702 FALSE TRUE
ENST00000560411 ENSG00000187446 HEK293_OSMI2_6hA HEK293_TMG_6hB CHP1 protein_coding nonsense_mediated_decay 24.24351 28.51875 19.63214 6.429845 0.765833 -0.5384647 1.9257902 2.6224323 2.379862 0.2999891 0.3296934 -0.1394693 0.08780000 0.102200000 0.1205667 0.01836667 0.873698149 0.008280702 FALSE FALSE
ENST00000560784 ENSG00000187446 HEK293_OSMI2_6hA HEK293_TMG_6hB CHP1 protein_coding nonsense_mediated_decay 24.24351 28.51875 19.63214 6.429845 0.765833 -0.5384647 0.9070799 0.1065712 1.350283 0.1065712 0.1574828 3.5446237 0.04424583 0.002733333 0.0690000 0.06626667 0.008280702 0.008280702 TRUE TRUE
MSTRG.10595.7 ENSG00000187446 HEK293_OSMI2_6hA HEK293_TMG_6hB CHP1 protein_coding   24.24351 28.51875 19.63214 6.429845 0.765833 -0.5384647 1.2576814 1.8938997 0.000000 1.0119632 0.0000000 -7.5728137 0.04511250 0.054433333 0.0000000 -0.05443333 0.302779644 0.008280702 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000187446 E001 1.493628 0.0247435618 2.422857e-01 4.791091e-01 15 41230839 41230966 128 + 0.496 0.296 -1.125
ENSG00000187446 E002 21.055525 0.0578857818 5.370096e-01 7.270193e-01 15 41231140 41231163 24 + 1.273 1.353 0.277
ENSG00000187446 E003 29.006812 0.0415846299 2.773543e-01 5.173960e-01 15 41231164 41231221 58 + 1.377 1.502 0.434
ENSG00000187446 E004 32.222442 0.0354588555 2.002711e-01 4.300734e-01 15 41231222 41231238 17 + 1.407 1.549 0.487
ENSG00000187446 E005 30.720568 0.0081802650 1.378496e-01 3.442248e-01 15 41231239 41231267 29 + 1.395 1.521 0.433
ENSG00000187446 E006 43.558882 0.0048553524 2.414194e-01 4.781954e-01 15 41231268 41231292 25 + 1.570 1.656 0.292
ENSG00000187446 E007 155.038513 0.0010036473 5.683190e-01 7.490445e-01 15 41231293 41231449 157 + 2.177 2.171 -0.019
ENSG00000187446 E008 0.423152 0.0919159536 9.818468e-01   15 41234139 41234234 96 + 0.154 0.171 0.184
ENSG00000187446 E009 127.827496 0.0004762064 1.902461e-01 4.172741e-01 15 41243667 41243739 73 + 2.111 2.082 -0.097
ENSG00000187446 E010 0.000000       15 41256684 41256810 127 +      
ENSG00000187446 E011 129.444545 0.0010227161 1.110565e-02 6.281625e-02 15 41256910 41256990 81 + 2.142 2.071 -0.240
ENSG00000187446 E012 152.795872 0.0010582736 1.034864e-04 1.539046e-03 15 41262756 41262883 128 + 2.232 2.125 -0.358
ENSG00000187446 E013 2.964363 0.0081999890 4.791405e-03 3.348215e-02 15 41264165 41264235 71 + 0.815 0.392 -1.913
ENSG00000187446 E014 102.357255 0.0004589092 1.875857e-03 1.623577e-02 15 41270557 41270618 62 + 2.053 1.955 -0.328
ENSG00000187446 E015 1.988630 0.0249797413 1.656116e-01 3.846819e-01 15 41272180 41272375 196 + 0.267 0.538 1.526
ENSG00000187446 E016 133.584909 0.0003659536 1.071640e-02 6.117693e-02 15 41278767 41278889 123 + 2.149 2.083 -0.221
ENSG00000187446 E017 697.928911 0.0001479334 1.139259e-04 1.665569e-03 15 41279336 41280654 1319 + 2.845 2.811 -0.114
ENSG00000187446 E018 98.370703 0.0007343166 1.688425e-01 3.890397e-01 15 41280655 41280788 134 + 1.928 1.996 0.227
ENSG00000187446 E019 274.323454 0.0006691493 3.129020e-03 2.418439e-02 15 41280789 41281136 348 + 2.359 2.445 0.288
ENSG00000187446 E020 536.458892 0.0021758094 3.388878e-06 8.248667e-05 15 41281137 41281887 751 + 2.621 2.754 0.441