ENSG00000187240

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

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gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000375735	ENSG00000187240	HEK293_OSMI2_6hA	HEK293_TMG_6hB	DYNC2H1	protein_coding	protein_coding	6.444873	3.632817	10.04675	0.6745798	0.3052614	1.465037	3.9790159	0.9406182	7.8002375	0.16665433	0.3396638	3.0384285	0.4822625	0.2612000	0.77660000	0.51540000	3.599918e-12	3.599918e-12	FALSE	TRUE
ENST00000528670	ENSG00000187240	HEK293_OSMI2_6hA	HEK293_TMG_6hB	DYNC2H1	protein_coding	nonsense_mediated_decay	6.444873	3.632817	10.04675	0.6745798	0.3052614	1.465037	1.8685104	2.1922379	1.6668633	0.51968365	0.3142859	-0.3932052	0.3927000	0.5899333	0.16486667	-0.42506667	3.061056e-06	3.599918e-12	TRUE	TRUE
ENST00000533197	ENSG00000187240	HEK293_OSMI2_6hA	HEK293_TMG_6hB	DYNC2H1	protein_coding	protein_coding	6.444873	3.632817	10.04675	0.6745798	0.3052614	1.465037	0.3435866	0.1936586	0.2461569	0.04168658	0.1246520	0.3308745	0.0747000	0.0550000	0.02523333	-0.02976667	6.789041e-01	3.599918e-12	FALSE	FALSE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_6hB	HEK293_OSMI2_6hA	log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB

ENSG00000187240	E001	0.3206185	0.0274424043	1.000000e+00		11	103109410	103109425	16	+	0.112	0.000	-9.421
ENSG00000187240	E002	2.4037535	0.0091520016	8.286718e-01	9.130521e-01	11	103109426	103109513	88	+	0.443	0.493	0.254
ENSG00000187240	E003	2.5817374	0.0091151935	9.231885e-01	9.638722e-01	11	103109514	103109521	8	+	0.466	0.493	0.138
ENSG00000187240	E004	25.8642364	0.0026937405	3.042330e-03	2.366732e-02	11	103109522	103109769	248	+	1.354	1.063	-1.031
ENSG00000187240	E005	31.2306602	0.0033828668	8.946175e-05	1.361472e-03	11	103113537	103113707	171	+	1.441	1.063	-1.335
ENSG00000187240	E006	27.5035605	0.0012867041	1.248156e-05	2.541553e-04	11	103114103	103114238	136	+	1.397	0.942	-1.626
ENSG00000187240	E007	21.6281622	0.0028766634	7.438595e-07	2.195801e-05	11	103115177	103115295	119	+	1.308	0.656	-2.456
ENSG00000187240	E008	24.3232264	0.0017570056	5.273270e-09	2.635440e-07	11	103116570	103116714	145	+	1.362	0.582	-2.963
ENSG00000187240	E009	33.7010891	0.0010706931	3.171875e-09	1.660473e-07	11	103117631	103117863	233	+	1.489	0.866	-2.234
ENSG00000187240	E010	20.6392055	0.0021401874	1.160853e-04	1.691974e-03	11	103120447	103120581	135	+	1.279	0.822	-1.677
ENSG00000187240	E011	19.1882311	0.0020808000	1.287765e-04	1.845659e-03	11	103120689	103120802	114	+	1.248	0.773	-1.758
ENSG00000187240	E012	19.0867292	0.0018373447	2.994122e-03	2.336514e-02	11	103120925	103121036	112	+	1.240	0.905	-1.218
ENSG00000187240	E013	22.0564047	0.0020076196	3.740883e-05	6.516442e-04	11	103121372	103121496	125	+	1.306	0.822	-1.770
ENSG00000187240	E014	27.8849663	0.0015673722	1.954092e-07	6.750402e-06	11	103122825	103123000	176	+	1.407	0.822	-2.122
ENSG00000187240	E015	27.0610595	0.0013771393	2.086400e-05	3.960196e-04	11	103125100	103125295	196	+	1.386	0.942	-1.591
ENSG00000187240	E016	19.7608235	0.0021422602	5.972156e-03	3.959590e-02	11	103128910	103129005	96	+	1.244	0.942	-1.095
ENSG00000187240	E017	24.4576920	0.0014045940	5.446373e-05	8.964832e-04	11	103133555	103133707	153	+	1.345	0.906	-1.583
ENSG00000187240	E018	18.3901098	0.0093921564	1.724263e-04	2.362020e-03	11	103134321	103134419	99	+	1.233	0.718	-1.930
ENSG00000187240	E019	19.4818373	0.0197248826	7.622415e-04	7.963956e-03	11	103135495	103135634	140	+	1.255	0.773	-1.787
ENSG00000187240	E020	0.1779838	0.0353369076	1.000000e+00		11	103135702	103135719	18	+	0.060	0.000	-8.367
ENSG00000187240	E021	22.1624743	0.0256125320	9.104205e-03	5.428924e-02	11	103135720	103135866	147	+	1.299	0.942	-1.285
ENSG00000187240	E022	15.6971909	0.0146482367	6.219651e-02	2.077369e-01	11	103135867	103135948	82	+	1.149	0.906	-0.891
ENSG00000187240	E023	21.2283756	0.0107045764	4.147527e-03	2.997981e-02	11	103143268	103143395	128	+	1.284	0.942	-1.234
ENSG00000187240	E024	21.7567337	0.0027943915	1.236012e-03	1.168987e-02	11	103147772	103147887	116	+	1.295	0.942	-1.274
ENSG00000187240	E025	26.6816813	0.0012465488	2.253594e-04	2.951431e-03	11	103148490	103148617	128	+	1.376	1.007	-1.312
ENSG00000187240	E026	27.5022947	0.0117863024	9.826546e-05	1.473791e-03	11	103152136	103152285	150	+	1.396	0.942	-1.625
ENSG00000187240	E027	31.9932815	0.0342431562	4.988895e-04	5.664053e-03	11	103153303	103153508	206	+	1.460	0.976	-1.718
ENSG00000187240	E028	29.9712794	0.0017933535	4.563341e-07	1.428944e-05	11	103154451	103154606	156	+	1.438	0.906	-1.907
ENSG00000187240	E029	3.1095860	0.0291016286	7.978044e-01	8.951034e-01	11	103154607	103154694	88	+	0.526	0.581	0.255
ENSG00000187240	E030	28.7600856	0.0013914881	3.414544e-03	2.584830e-02	11	103154695	103154809	115	+	1.399	1.136	-0.924
ENSG00000187240	E031	34.4214097	0.0028185934	1.048190e-02	6.018417e-02	11	103155331	103155501	171	+	1.463	1.253	-0.730
ENSG00000187240	E032	2.2765741	0.1191364327	4.336637e-02	1.634945e-01	11	103155502	103156102	601	+	0.337	0.765	2.038
ENSG00000187240	E033	43.8783747	0.0010622182	2.741847e-04	3.468887e-03	11	103156388	103156770	383	+	1.574	1.302	-0.939
ENSG00000187240	E034	21.4056098	0.0022460400	7.661854e-04	7.995816e-03	11	103158677	103158809	133	+	1.283	0.906	-1.367
ENSG00000187240	E035	23.4137948	0.0017950440	4.746339e-04	5.446568e-03	11	103158910	103159027	118	+	1.318	0.942	-1.353
ENSG00000187240	E036	20.3614002	0.0099291538	7.215009e-03	4.564766e-02	11	103160932	103161044	113	+	1.262	0.942	-1.156
ENSG00000187240	E037	28.4800150	0.0070225572	3.771811e-02	1.488799e-01	11	103163028	103163147	120	+	1.389	1.197	-0.670
ENSG00000187240	E038	34.9891139	0.0227276406	1.832561e-02	9.010845e-02	11	103165898	103166048	151	+	1.482	1.231	-0.872
ENSG00000187240	E039	43.0784265	0.0009175722	2.301272e-03	1.906106e-02	11	103168755	103168960	206	+	1.563	1.345	-0.752
ENSG00000187240	E040	44.5170951	0.0028308512	2.260243e-03	1.880042e-02	11	103170108	103170290	183	+	1.573	1.345	-0.784
ENSG00000187240	E041	40.2682538	0.0008904664	5.714788e-03	3.831045e-02	11	103170886	103171068	183	+	1.533	1.331	-0.695
ENSG00000187240	E042	37.4057107	0.0016008934	6.384370e-02	2.113393e-01	11	103173082	103173305	224	+	1.491	1.359	-0.459
ENSG00000187240	E043	30.2697103	0.0012288425	3.315453e-02	1.364681e-01	11	103174055	103174170	116	+	1.409	1.236	-0.606
ENSG00000187240	E044	38.2254524	0.0009576445	8.930878e-04	9.038549e-03	11	103176235	103176434	200	+	1.515	1.253	-0.909
ENSG00000187240	E045	43.6785361	0.0248101411	1.180418e-01	3.126553e-01	11	103177556	103177820	265	+	1.563	1.396	-0.574
ENSG00000187240	E046	30.1164307	0.3594272124	8.173272e-01	9.065696e-01	11	103179026	103179233	208	+	1.389	1.341	-0.168
ENSG00000187240	E047	24.8460581	0.0243407514	4.831657e-01	6.892481e-01	11	103181757	103181886	130	+	1.316	1.235	-0.282
ENSG00000187240	E048	33.5622209	0.0010339157	6.871439e-01	8.272509e-01	11	103184896	103185051	156	+	1.426	1.409	-0.059
ENSG00000187240	E049	46.2698483	0.0008546336	1.534874e-01	3.673139e-01	11	103186242	103186501	260	+	1.570	1.486	-0.290
ENSG00000187240	E050	48.0002151	0.0007351633	2.148624e-03	1.806812e-02	11	103187340	103187586	247	+	1.605	1.397	-0.713
ENSG00000187240	E051	38.9637247	0.0009469316	1.837783e-02	9.028257e-02	11	103188497	103188648	152	+	1.515	1.345	-0.587
ENSG00000187240	E052	34.7889575	0.0011621541	7.111341e-01	8.425443e-01	11	103189672	103189816	145	+	1.445	1.432	-0.045
ENSG00000187240	E053	31.7104453	0.0037470976	6.789132e-01	8.220526e-01	11	103191517	103191619	103	+	1.405	1.384	-0.071
ENSG00000187240	E054	19.6612045	0.0023022165	6.437741e-01	7.993938e-01	11	103192097	103192117	21	+	1.210	1.178	-0.112
ENSG00000187240	E055	40.0017311	0.0048052491	6.929405e-01	8.310069e-01	11	103192118	103192264	147	+	1.502	1.485	-0.056
ENSG00000187240	E056	32.8163635	0.0014793178	2.275196e-01	4.623879e-01	11	103197933	103198063	131	+	1.429	1.345	-0.291
ENSG00000187240	E057	45.1246885	0.0074870866	8.249356e-02	2.497158e-01	11	103199228	103199476	249	+	1.569	1.442	-0.437
ENSG00000187240	E058	31.5934960	0.0136723570	3.765673e-02	1.487339e-01	11	103200046	103200154	109	+	1.427	1.217	-0.731
ENSG00000187240	E059	26.4153251	0.0015411700	9.351062e-01	9.697712e-01	11	103203663	103203776	114	+	1.324	1.345	0.074
ENSG00000187240	E060	20.5889657	0.0166392747	6.987116e-01	8.347858e-01	11	103204822	103204910	89	+	1.231	1.198	-0.118
ENSG00000187240	E061	19.7003111	0.0034159354	8.015204e-01	8.971980e-01	11	103204911	103204964	54	+	1.198	1.236	0.136
ENSG00000187240	E062	19.2379514	0.0021691795	2.760734e-01	5.160920e-01	11	103209876	103209960	85	+	1.214	1.113	-0.358
ENSG00000187240	E063	31.4523686	0.0014058677	3.256145e-01	5.648412e-01	11	103211789	103211943	155	+	1.412	1.345	-0.231
ENSG00000187240	E064	41.9219443	0.0011253214	4.392687e-01	6.581609e-01	11	103215721	103215858	138	+	1.527	1.486	-0.140
ENSG00000187240	E065	0.0000000				11	103215859	103215891	33	+
ENSG00000187240	E066	43.4103951	0.0010293464	8.186468e-01	9.072374e-01	11	103219915	103220028	114	+	1.534	1.533	-0.004
ENSG00000187240	E067	44.9875118	0.0029069346	9.819999e-01	9.927761e-01	11	103220623	103220783	161	+	1.544	1.559	0.052
ENSG00000187240	E068	35.6350623	0.0011138146	6.846054e-01	8.256816e-01	11	103222030	103222153	124	+	1.450	1.433	-0.059
ENSG00000187240	E069	28.7777884	0.0270721505	2.723795e-01	5.122347e-01	11	103222965	103223086	122	+	1.333	1.458	0.431
ENSG00000187240	E070	33.4277489	0.0027899878	4.675621e-01	6.784499e-01	11	103231260	103231346	87	+	1.407	1.476	0.240
ENSG00000187240	E071	38.7963813	0.0041900363	4.452215e-01	6.622274e-01	11	103234034	103234160	127	+	1.473	1.542	0.237
ENSG00000187240	E072	40.5707164	0.0021784761	8.439560e-02	2.535078e-01	11	103235672	103235813	142	+	1.482	1.614	0.451
ENSG00000187240	E073	43.7260697	0.0029204301	2.545743e-01	4.930840e-01	11	103236430	103236539	110	+	1.522	1.614	0.314
ENSG00000187240	E074	0.0000000				11	103241527	103241547	21	+
ENSG00000187240	E075	51.5444062	0.0007119722	9.532547e-01	9.785816e-01	11	103243693	103243791	99	+	1.603	1.622	0.063
ENSG00000187240	E076	53.9023705	0.0056800407	1.852786e-01	4.109362e-01	11	103245251	103245374	124	+	1.642	1.558	-0.286
ENSG00000187240	E077	56.6546296	0.0091469436	6.137598e-01	7.793869e-01	11	103253285	103253448	164	+	1.653	1.633	-0.068
ENSG00000187240	E078	48.1607199	0.0009363977	5.713093e-01	7.512658e-01	11	103255415	103255534	120	+	1.581	1.559	-0.074
ENSG00000187240	E079	51.2056395	0.0074489571	1.305229e-01	3.326448e-01	11	103256106	103256240	135	+	1.577	1.702	0.425
ENSG00000187240	E080	52.0305582	0.0106199906	1.344145e-02	7.215801e-02	11	103257608	103257751	144	+	1.568	1.772	0.690
ENSG00000187240	E081	38.6144782	0.0013981334	1.189906e-01	3.142079e-01	11	103259888	103259977	90	+	1.461	1.584	0.421
ENSG00000187240	E082	32.0958465	0.0012545047	1.676337e-01	3.874101e-01	11	103280348	103280413	66	+	1.386	1.505	0.409
ENSG00000187240	E083	0.3447487	0.7160352720	7.273602e-02		11	103282157	103282178	22	+	0.000	0.388	13.874
ENSG00000187240	E084	36.5860820	0.0010904824	4.125131e-01	6.379759e-01	11	103282179	103282229	51	+	1.450	1.524	0.254
ENSG00000187240	E085	19.3566757	0.0633645339	7.327288e-01	8.558199e-01	11	103283008	103283016	9	+	1.183	1.286	0.365
ENSG00000187240	E086	28.5845485	0.0082336939	2.933800e-01	5.340795e-01	11	103283017	103283085	69	+	1.339	1.452	0.392
ENSG00000187240	E087	38.6444035	0.0011316385	1.467089e-02	7.685450e-02	11	103286255	103286386	132	+	1.450	1.629	0.612
ENSG00000187240	E088	35.3184566	0.0010761554	1.773266e-05	3.451872e-04	11	103287533	103287605	73	+	1.376	1.677	1.031
ENSG00000187240	E089	0.1779838	0.0353369076	1.000000e+00		11	103287606	103287744	139	+	0.060	0.000	-8.367
ENSG00000187240	E090	54.3647358	0.0039664307	1.132403e-05	2.333553e-04	11	103303093	103303253	161	+	1.567	1.848	0.955
ENSG00000187240	E091	57.6744923	0.0007290108	1.065208e-03	1.041351e-02	11	103304595	103304720	126	+	1.615	1.809	0.658
ENSG00000187240	E092	54.0367381	0.0139464860	1.428274e-02	7.546317e-02	11	103307721	103307831	111	+	1.582	1.786	0.690
ENSG00000187240	E093	65.9843815	0.0006838670	1.822304e-03	1.585639e-02	11	103311878	103312033	156	+	1.673	1.850	0.598
ENSG00000187240	E094	45.8575956	0.0070883283	3.159247e-03	2.436590e-02	11	103316545	103316620	76	+	1.506	1.727	0.752
ENSG00000187240	E095	65.4768207	0.0228871760	1.027234e-03	1.012349e-02	11	103321029	103321237	209	+	1.637	1.929	0.987
ENSG00000187240	E096	0.1614157	0.0332174455	1.000000e+00		11	103321238	103321241	4	+	0.060	0.000	-8.365
ENSG00000187240	E097	50.3582488	0.0053212303	1.849345e-06	4.865534e-05	11	103323886	103323990	105	+	1.516	1.834	1.082
ENSG00000187240	E098	56.4647463	0.0088055959	2.305699e-08	9.970989e-07	11	103358243	103358359	117	+	1.540	1.928	1.315
ENSG00000187240	E099	78.4243961	0.0044503781	6.328346e-11	4.668544e-09	11	103399663	103399872	210	+	1.690	2.054	1.228
ENSG00000187240	E100	54.5061838	0.0060572153	1.190132e-04	1.726861e-03	11	103435943	103436032	90	+	1.565	1.833	0.909
ENSG00000187240	E101	0.7282998	0.5322562118	2.630202e-01		11	103454999	103455185	187	+	0.113	0.398	2.336
ENSG00000187240	E102	64.2166489	0.0022344373	1.633839e-07	5.761285e-06	11	103455186	103455295	110	+	1.626	1.922	1.000
ENSG00000187240	E103	58.5491611	0.0007444138	8.425682e-10	4.994327e-08	11	103456275	103456356	82	+	1.577	1.910	1.128
ENSG00000187240	E104	0.7485721	0.5502125858	2.091079e-01		11	103468389	103468588	200	+	0.115	0.472	2.690
ENSG00000187240	E105	67.3746614	0.0007632611	2.481939e-12	2.388047e-10	11	103468589	103468705	117	+	1.629	1.983	1.196
ENSG00000187240	E106	90.2971889	0.0117737213	5.507549e-06	1.253933e-04	11	103479095	103479863	769	+	1.766	2.082	1.062

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000187240

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3