ENSG00000187240

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375735 ENSG00000187240 HEK293_OSMI2_6hA HEK293_TMG_6hB DYNC2H1 protein_coding protein_coding 6.444873 3.632817 10.04675 0.6745798 0.3052614 1.465037 3.9790159 0.9406182 7.8002375 0.16665433 0.3396638 3.0384285 0.4822625 0.2612000 0.77660000 0.51540000 3.599918e-12 3.599918e-12 FALSE TRUE
ENST00000528670 ENSG00000187240 HEK293_OSMI2_6hA HEK293_TMG_6hB DYNC2H1 protein_coding nonsense_mediated_decay 6.444873 3.632817 10.04675 0.6745798 0.3052614 1.465037 1.8685104 2.1922379 1.6668633 0.51968365 0.3142859 -0.3932052 0.3927000 0.5899333 0.16486667 -0.42506667 3.061056e-06 3.599918e-12 TRUE TRUE
ENST00000533197 ENSG00000187240 HEK293_OSMI2_6hA HEK293_TMG_6hB DYNC2H1 protein_coding protein_coding 6.444873 3.632817 10.04675 0.6745798 0.3052614 1.465037 0.3435866 0.1936586 0.2461569 0.04168658 0.1246520 0.3308745 0.0747000 0.0550000 0.02523333 -0.02976667 6.789041e-01 3.599918e-12 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000187240 E001 0.3206185 0.0274424043 1.000000e+00   11 103109410 103109425 16 + 0.112 0.000 -9.421
ENSG00000187240 E002 2.4037535 0.0091520016 8.286718e-01 9.130521e-01 11 103109426 103109513 88 + 0.443 0.493 0.254
ENSG00000187240 E003 2.5817374 0.0091151935 9.231885e-01 9.638722e-01 11 103109514 103109521 8 + 0.466 0.493 0.138
ENSG00000187240 E004 25.8642364 0.0026937405 3.042330e-03 2.366732e-02 11 103109522 103109769 248 + 1.354 1.063 -1.031
ENSG00000187240 E005 31.2306602 0.0033828668 8.946175e-05 1.361472e-03 11 103113537 103113707 171 + 1.441 1.063 -1.335
ENSG00000187240 E006 27.5035605 0.0012867041 1.248156e-05 2.541553e-04 11 103114103 103114238 136 + 1.397 0.942 -1.626
ENSG00000187240 E007 21.6281622 0.0028766634 7.438595e-07 2.195801e-05 11 103115177 103115295 119 + 1.308 0.656 -2.456
ENSG00000187240 E008 24.3232264 0.0017570056 5.273270e-09 2.635440e-07 11 103116570 103116714 145 + 1.362 0.582 -2.963
ENSG00000187240 E009 33.7010891 0.0010706931 3.171875e-09 1.660473e-07 11 103117631 103117863 233 + 1.489 0.866 -2.234
ENSG00000187240 E010 20.6392055 0.0021401874 1.160853e-04 1.691974e-03 11 103120447 103120581 135 + 1.279 0.822 -1.677
ENSG00000187240 E011 19.1882311 0.0020808000 1.287765e-04 1.845659e-03 11 103120689 103120802 114 + 1.248 0.773 -1.758
ENSG00000187240 E012 19.0867292 0.0018373447 2.994122e-03 2.336514e-02 11 103120925 103121036 112 + 1.240 0.905 -1.218
ENSG00000187240 E013 22.0564047 0.0020076196 3.740883e-05 6.516442e-04 11 103121372 103121496 125 + 1.306 0.822 -1.770
ENSG00000187240 E014 27.8849663 0.0015673722 1.954092e-07 6.750402e-06 11 103122825 103123000 176 + 1.407 0.822 -2.122
ENSG00000187240 E015 27.0610595 0.0013771393 2.086400e-05 3.960196e-04 11 103125100 103125295 196 + 1.386 0.942 -1.591
ENSG00000187240 E016 19.7608235 0.0021422602 5.972156e-03 3.959590e-02 11 103128910 103129005 96 + 1.244 0.942 -1.095
ENSG00000187240 E017 24.4576920 0.0014045940 5.446373e-05 8.964832e-04 11 103133555 103133707 153 + 1.345 0.906 -1.583
ENSG00000187240 E018 18.3901098 0.0093921564 1.724263e-04 2.362020e-03 11 103134321 103134419 99 + 1.233 0.718 -1.930
ENSG00000187240 E019 19.4818373 0.0197248826 7.622415e-04 7.963956e-03 11 103135495 103135634 140 + 1.255 0.773 -1.787
ENSG00000187240 E020 0.1779838 0.0353369076 1.000000e+00   11 103135702 103135719 18 + 0.060 0.000 -8.367
ENSG00000187240 E021 22.1624743 0.0256125320 9.104205e-03 5.428924e-02 11 103135720 103135866 147 + 1.299 0.942 -1.285
ENSG00000187240 E022 15.6971909 0.0146482367 6.219651e-02 2.077369e-01 11 103135867 103135948 82 + 1.149 0.906 -0.891
ENSG00000187240 E023 21.2283756 0.0107045764 4.147527e-03 2.997981e-02 11 103143268 103143395 128 + 1.284 0.942 -1.234
ENSG00000187240 E024 21.7567337 0.0027943915 1.236012e-03 1.168987e-02 11 103147772 103147887 116 + 1.295 0.942 -1.274
ENSG00000187240 E025 26.6816813 0.0012465488 2.253594e-04 2.951431e-03 11 103148490 103148617 128 + 1.376 1.007 -1.312
ENSG00000187240 E026 27.5022947 0.0117863024 9.826546e-05 1.473791e-03 11 103152136 103152285 150 + 1.396 0.942 -1.625
ENSG00000187240 E027 31.9932815 0.0342431562 4.988895e-04 5.664053e-03 11 103153303 103153508 206 + 1.460 0.976 -1.718
ENSG00000187240 E028 29.9712794 0.0017933535 4.563341e-07 1.428944e-05 11 103154451 103154606 156 + 1.438 0.906 -1.907
ENSG00000187240 E029 3.1095860 0.0291016286 7.978044e-01 8.951034e-01 11 103154607 103154694 88 + 0.526 0.581 0.255
ENSG00000187240 E030 28.7600856 0.0013914881 3.414544e-03 2.584830e-02 11 103154695 103154809 115 + 1.399 1.136 -0.924
ENSG00000187240 E031 34.4214097 0.0028185934 1.048190e-02 6.018417e-02 11 103155331 103155501 171 + 1.463 1.253 -0.730
ENSG00000187240 E032 2.2765741 0.1191364327 4.336637e-02 1.634945e-01 11 103155502 103156102 601 + 0.337 0.765 2.038
ENSG00000187240 E033 43.8783747 0.0010622182 2.741847e-04 3.468887e-03 11 103156388 103156770 383 + 1.574 1.302 -0.939
ENSG00000187240 E034 21.4056098 0.0022460400 7.661854e-04 7.995816e-03 11 103158677 103158809 133 + 1.283 0.906 -1.367
ENSG00000187240 E035 23.4137948 0.0017950440 4.746339e-04 5.446568e-03 11 103158910 103159027 118 + 1.318 0.942 -1.353
ENSG00000187240 E036 20.3614002 0.0099291538 7.215009e-03 4.564766e-02 11 103160932 103161044 113 + 1.262 0.942 -1.156
ENSG00000187240 E037 28.4800150 0.0070225572 3.771811e-02 1.488799e-01 11 103163028 103163147 120 + 1.389 1.197 -0.670
ENSG00000187240 E038 34.9891139 0.0227276406 1.832561e-02 9.010845e-02 11 103165898 103166048 151 + 1.482 1.231 -0.872
ENSG00000187240 E039 43.0784265 0.0009175722 2.301272e-03 1.906106e-02 11 103168755 103168960 206 + 1.563 1.345 -0.752
ENSG00000187240 E040 44.5170951 0.0028308512 2.260243e-03 1.880042e-02 11 103170108 103170290 183 + 1.573 1.345 -0.784
ENSG00000187240 E041 40.2682538 0.0008904664 5.714788e-03 3.831045e-02 11 103170886 103171068 183 + 1.533 1.331 -0.695
ENSG00000187240 E042 37.4057107 0.0016008934 6.384370e-02 2.113393e-01 11 103173082 103173305 224 + 1.491 1.359 -0.459
ENSG00000187240 E043 30.2697103 0.0012288425 3.315453e-02 1.364681e-01 11 103174055 103174170 116 + 1.409 1.236 -0.606
ENSG00000187240 E044 38.2254524 0.0009576445 8.930878e-04 9.038549e-03 11 103176235 103176434 200 + 1.515 1.253 -0.909
ENSG00000187240 E045 43.6785361 0.0248101411 1.180418e-01 3.126553e-01 11 103177556 103177820 265 + 1.563 1.396 -0.574
ENSG00000187240 E046 30.1164307 0.3594272124 8.173272e-01 9.065696e-01 11 103179026 103179233 208 + 1.389 1.341 -0.168
ENSG00000187240 E047 24.8460581 0.0243407514 4.831657e-01 6.892481e-01 11 103181757 103181886 130 + 1.316 1.235 -0.282
ENSG00000187240 E048 33.5622209 0.0010339157 6.871439e-01 8.272509e-01 11 103184896 103185051 156 + 1.426 1.409 -0.059
ENSG00000187240 E049 46.2698483 0.0008546336 1.534874e-01 3.673139e-01 11 103186242 103186501 260 + 1.570 1.486 -0.290
ENSG00000187240 E050 48.0002151 0.0007351633 2.148624e-03 1.806812e-02 11 103187340 103187586 247 + 1.605 1.397 -0.713
ENSG00000187240 E051 38.9637247 0.0009469316 1.837783e-02 9.028257e-02 11 103188497 103188648 152 + 1.515 1.345 -0.587
ENSG00000187240 E052 34.7889575 0.0011621541 7.111341e-01 8.425443e-01 11 103189672 103189816 145 + 1.445 1.432 -0.045
ENSG00000187240 E053 31.7104453 0.0037470976 6.789132e-01 8.220526e-01 11 103191517 103191619 103 + 1.405 1.384 -0.071
ENSG00000187240 E054 19.6612045 0.0023022165 6.437741e-01 7.993938e-01 11 103192097 103192117 21 + 1.210 1.178 -0.112
ENSG00000187240 E055 40.0017311 0.0048052491 6.929405e-01 8.310069e-01 11 103192118 103192264 147 + 1.502 1.485 -0.056
ENSG00000187240 E056 32.8163635 0.0014793178 2.275196e-01 4.623879e-01 11 103197933 103198063 131 + 1.429 1.345 -0.291
ENSG00000187240 E057 45.1246885 0.0074870866 8.249356e-02 2.497158e-01 11 103199228 103199476 249 + 1.569 1.442 -0.437
ENSG00000187240 E058 31.5934960 0.0136723570 3.765673e-02 1.487339e-01 11 103200046 103200154 109 + 1.427 1.217 -0.731
ENSG00000187240 E059 26.4153251 0.0015411700 9.351062e-01 9.697712e-01 11 103203663 103203776 114 + 1.324 1.345 0.074
ENSG00000187240 E060 20.5889657 0.0166392747 6.987116e-01 8.347858e-01 11 103204822 103204910 89 + 1.231 1.198 -0.118
ENSG00000187240 E061 19.7003111 0.0034159354 8.015204e-01 8.971980e-01 11 103204911 103204964 54 + 1.198 1.236 0.136
ENSG00000187240 E062 19.2379514 0.0021691795 2.760734e-01 5.160920e-01 11 103209876 103209960 85 + 1.214 1.113 -0.358
ENSG00000187240 E063 31.4523686 0.0014058677 3.256145e-01 5.648412e-01 11 103211789 103211943 155 + 1.412 1.345 -0.231
ENSG00000187240 E064 41.9219443 0.0011253214 4.392687e-01 6.581609e-01 11 103215721 103215858 138 + 1.527 1.486 -0.140
ENSG00000187240 E065 0.0000000       11 103215859 103215891 33 +      
ENSG00000187240 E066 43.4103951 0.0010293464 8.186468e-01 9.072374e-01 11 103219915 103220028 114 + 1.534 1.533 -0.004
ENSG00000187240 E067 44.9875118 0.0029069346 9.819999e-01 9.927761e-01 11 103220623 103220783 161 + 1.544 1.559 0.052
ENSG00000187240 E068 35.6350623 0.0011138146 6.846054e-01 8.256816e-01 11 103222030 103222153 124 + 1.450 1.433 -0.059
ENSG00000187240 E069 28.7777884 0.0270721505 2.723795e-01 5.122347e-01 11 103222965 103223086 122 + 1.333 1.458 0.431
ENSG00000187240 E070 33.4277489 0.0027899878 4.675621e-01 6.784499e-01 11 103231260 103231346 87 + 1.407 1.476 0.240
ENSG00000187240 E071 38.7963813 0.0041900363 4.452215e-01 6.622274e-01 11 103234034 103234160 127 + 1.473 1.542 0.237
ENSG00000187240 E072 40.5707164 0.0021784761 8.439560e-02 2.535078e-01 11 103235672 103235813 142 + 1.482 1.614 0.451
ENSG00000187240 E073 43.7260697 0.0029204301 2.545743e-01 4.930840e-01 11 103236430 103236539 110 + 1.522 1.614 0.314
ENSG00000187240 E074 0.0000000       11 103241527 103241547 21 +      
ENSG00000187240 E075 51.5444062 0.0007119722 9.532547e-01 9.785816e-01 11 103243693 103243791 99 + 1.603 1.622 0.063
ENSG00000187240 E076 53.9023705 0.0056800407 1.852786e-01 4.109362e-01 11 103245251 103245374 124 + 1.642 1.558 -0.286
ENSG00000187240 E077 56.6546296 0.0091469436 6.137598e-01 7.793869e-01 11 103253285 103253448 164 + 1.653 1.633 -0.068
ENSG00000187240 E078 48.1607199 0.0009363977 5.713093e-01 7.512658e-01 11 103255415 103255534 120 + 1.581 1.559 -0.074
ENSG00000187240 E079 51.2056395 0.0074489571 1.305229e-01 3.326448e-01 11 103256106 103256240 135 + 1.577 1.702 0.425
ENSG00000187240 E080 52.0305582 0.0106199906 1.344145e-02 7.215801e-02 11 103257608 103257751 144 + 1.568 1.772 0.690
ENSG00000187240 E081 38.6144782 0.0013981334 1.189906e-01 3.142079e-01 11 103259888 103259977 90 + 1.461 1.584 0.421
ENSG00000187240 E082 32.0958465 0.0012545047 1.676337e-01 3.874101e-01 11 103280348 103280413 66 + 1.386 1.505 0.409
ENSG00000187240 E083 0.3447487 0.7160352720 7.273602e-02   11 103282157 103282178 22 + 0.000 0.388 13.874
ENSG00000187240 E084 36.5860820 0.0010904824 4.125131e-01 6.379759e-01 11 103282179 103282229 51 + 1.450 1.524 0.254
ENSG00000187240 E085 19.3566757 0.0633645339 7.327288e-01 8.558199e-01 11 103283008 103283016 9 + 1.183 1.286 0.365
ENSG00000187240 E086 28.5845485 0.0082336939 2.933800e-01 5.340795e-01 11 103283017 103283085 69 + 1.339 1.452 0.392
ENSG00000187240 E087 38.6444035 0.0011316385 1.467089e-02 7.685450e-02 11 103286255 103286386 132 + 1.450 1.629 0.612
ENSG00000187240 E088 35.3184566 0.0010761554 1.773266e-05 3.451872e-04 11 103287533 103287605 73 + 1.376 1.677 1.031
ENSG00000187240 E089 0.1779838 0.0353369076 1.000000e+00   11 103287606 103287744 139 + 0.060 0.000 -8.367
ENSG00000187240 E090 54.3647358 0.0039664307 1.132403e-05 2.333553e-04 11 103303093 103303253 161 + 1.567 1.848 0.955
ENSG00000187240 E091 57.6744923 0.0007290108 1.065208e-03 1.041351e-02 11 103304595 103304720 126 + 1.615 1.809 0.658
ENSG00000187240 E092 54.0367381 0.0139464860 1.428274e-02 7.546317e-02 11 103307721 103307831 111 + 1.582 1.786 0.690
ENSG00000187240 E093 65.9843815 0.0006838670 1.822304e-03 1.585639e-02 11 103311878 103312033 156 + 1.673 1.850 0.598
ENSG00000187240 E094 45.8575956 0.0070883283 3.159247e-03 2.436590e-02 11 103316545 103316620 76 + 1.506 1.727 0.752
ENSG00000187240 E095 65.4768207 0.0228871760 1.027234e-03 1.012349e-02 11 103321029 103321237 209 + 1.637 1.929 0.987
ENSG00000187240 E096 0.1614157 0.0332174455 1.000000e+00   11 103321238 103321241 4 + 0.060 0.000 -8.365
ENSG00000187240 E097 50.3582488 0.0053212303 1.849345e-06 4.865534e-05 11 103323886 103323990 105 + 1.516 1.834 1.082
ENSG00000187240 E098 56.4647463 0.0088055959 2.305699e-08 9.970989e-07 11 103358243 103358359 117 + 1.540 1.928 1.315
ENSG00000187240 E099 78.4243961 0.0044503781 6.328346e-11 4.668544e-09 11 103399663 103399872 210 + 1.690 2.054 1.228
ENSG00000187240 E100 54.5061838 0.0060572153 1.190132e-04 1.726861e-03 11 103435943 103436032 90 + 1.565 1.833 0.909
ENSG00000187240 E101 0.7282998 0.5322562118 2.630202e-01   11 103454999 103455185 187 + 0.113 0.398 2.336
ENSG00000187240 E102 64.2166489 0.0022344373 1.633839e-07 5.761285e-06 11 103455186 103455295 110 + 1.626 1.922 1.000
ENSG00000187240 E103 58.5491611 0.0007444138 8.425682e-10 4.994327e-08 11 103456275 103456356 82 + 1.577 1.910 1.128
ENSG00000187240 E104 0.7485721 0.5502125858 2.091079e-01   11 103468389 103468588 200 + 0.115 0.472 2.690
ENSG00000187240 E105 67.3746614 0.0007632611 2.481939e-12 2.388047e-10 11 103468589 103468705 117 + 1.629 1.983 1.196
ENSG00000187240 E106 90.2971889 0.0117737213 5.507549e-06 1.253933e-04 11 103479095 103479863 769 + 1.766 2.082 1.062