ENSG00000186960

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399387 ENSG00000186960 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01551 lncRNA lncRNA 11.94341 19.90005 0.4773248 8.228142 0.1134945 -5.35247 0.07185382 0.03951281 0.05806629 0.02043735 0.01846521 0.4591387 0.07500000 0.001500000 0.14243333 0.14093333 8.612955e-05 8.355466e-09 FALSE TRUE
ENST00000548213 ENSG00000186960 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01551 lncRNA lncRNA 11.94341 19.90005 0.4773248 8.228142 0.1134945 -5.35247 0.13829112 0.09941435 0.03201661 0.06879435 0.03201661 -1.3807702 0.02942917 0.004000000 0.07566667 0.07166667 4.296444e-01 8.355466e-09   FALSE
ENST00000552957 ENSG00000186960 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01551 lncRNA lncRNA 11.94341 19.90005 0.4773248 8.228142 0.1134945 -5.35247 0.11151616 0.06618168 0.12685167 0.01102681 0.05335402 0.8450970 0.05112500 0.006300000 0.24696667 0.24066667 8.355466e-09 8.355466e-09 FALSE FALSE
ENST00000653638 ENSG00000186960 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01551 lncRNA lncRNA 11.94341 19.90005 0.4773248 8.228142 0.1134945 -5.35247 6.48244744 10.48217288 0.00000000 4.10777199 0.00000000 -10.0350978 0.43473333 0.537966667 0.00000000 -0.53796667 1.241246e-07 8.355466e-09 FALSE FALSE
ENST00000671672 ENSG00000186960 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01551 lncRNA lncRNA 11.94341 19.90005 0.4773248 8.228142 0.1134945 -5.35247 4.77694819 8.93683250 0.00000000 4.25708849 0.00000000 -9.8052332 0.19597083 0.428733333 0.00000000 -0.42873333 1.821908e-05 8.355466e-09 FALSE TRUE
ENST00000675861 ENSG00000186960 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01551 lncRNA lncRNA 11.94341 19.90005 0.4773248 8.228142 0.1134945 -5.35247 0.17764152 0.15710401 0.06667917 0.15710401 0.06667917 -1.1238399 0.07649583 0.006733333 0.15760000 0.15086667 6.949647e-01 8.355466e-09 FALSE TRUE
MSTRG.9292.1 ENSG00000186960 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01551 lncRNA   11.94341 19.90005 0.4773248 8.228142 0.1134945 -5.35247 0.16653853 0.10459727 0.18307651 0.05293445 0.11675499 0.7525999 0.12315833 0.013000000 0.35030000 0.33730000 1.940566e-01 8.355466e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000186960 E001 1.3696567 0.01852085 0.871256021   14 28764387 28764401 15 + 0.401 0.375 -0.147
ENSG00000186960 E002 2.4586378 0.01093344 0.001216317 0.01155572 14 28765640 28765677 38 + 0.139 0.686 3.345
ENSG00000186960 E003 5.8678803 0.01833291 0.734475038 0.85696744 14 28765678 28766013 336 + 0.800 0.833 0.128
ENSG00000186960 E004 2.0993279 0.01289598 0.145645085 0.35586788 14 28771676 28772780 1105 + 0.606 0.375 -1.143
ENSG00000186960 E005 0.1779838 0.03444938 0.372344592   14 28772781 28772783 3 + 0.140 0.000 -11.552
ENSG00000186960 E006 0.1779838 0.03444938 0.372344592   14 28772784 28772793 10 + 0.140 0.000 -11.552
ENSG00000186960 E007 0.8509857 0.01890653 0.424514792   14 28772794 28772855 62 + 0.330 0.190 -1.050
ENSG00000186960 E008 1.2685282 0.01701369 0.784846586   14 28773360 28773433 74 + 0.330 0.375 0.270
ENSG00000186960 E009 0.0000000       14 28774880 28774939 60 +      
ENSG00000186960 E010 0.0000000       14 28775105 28775205 101 +      
ENSG00000186960 E011 0.2027342 0.04086031 0.627174313   14 28777858 28777991 134 + 0.000 0.106 10.041
ENSG00000186960 E012 0.0000000       14 28777992 28778105 114 +      
ENSG00000186960 E013 1.2013439 0.01795476 0.434324337   14 28778106 28778560 455 + 0.401 0.261 -0.880
ENSG00000186960 E014 0.0000000       14 28785254 28785870 617 +      
ENSG00000186960 E015 0.0000000       14 28785871 28785941 71 +      
ENSG00000186960 E016 0.0000000       14 28785942 28786487 546 +      
ENSG00000186960 E017 0.0000000       14 28786488 28786537 50 +      
ENSG00000186960 E018 0.1614157 0.05086156 0.371705297   14 28786538 28786768 231 + 0.140 0.000 -11.544
ENSG00000186960 E019 0.0000000       14 28790000 28790041 42 +      
ENSG00000186960 E020 1.7306137 0.02278407 0.410130350 0.63611341 14 28791880 28792469 590 + 0.516 0.374 -0.739
ENSG00000186960 E021 0.6071052 0.02258941 0.483074357   14 28792470 28793234 765 + 0.139 0.261 1.121
ENSG00000186960 E022 0.4950181 0.02460196 0.765957261   14 28812973 28813453 481 + 0.140 0.190 0.537
ENSG00000186960 E023 0.2735028 0.03048642 0.815924499   14 28818464 28823817 5354 + 0.139 0.105 -0.465